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568 results on '"Sanders, Melinda E."'

1. MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer

Author

Doha, Zinab O., Wang, Xiaoyan, Calistri, Nicholas L., Eng, Jennifer, Daniel, Colin J., Ternes, Luke, Kim, Eun Na, Pelz, Carl, Munks, Michael, Betts, Courtney, Kwon, Sunjong, Bucher, Elmar, Li, Xi, Waugh, Trent, Tatarova, Zuzana, Blumberg, Dylan, Ko, Aaron, Kirchberger, Nell, Pietenpol, Jennifer A., Sanders, Melinda E., Langer, Ellen M., Dai, Mu-Shui, Mills, Gordon, Chin, Koei, Chang, Young Hwan, Coussens, Lisa M., Gray, Joe W., Heiser, Laura M., and Sears, Rosalie C.

Published
2023
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2. Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

Author

Parida, Pravat Kumar, Marquez-Palencia, Mauricio, Ghosh, Suvranil, Khandelwal, Nitin, Kim, Kangsan, Nair, Vidhya, Liu, Xiao-Zheng, Vu, Hieu S., Zacharias, Lauren G., Gonzalez-Ericsson, Paula I., Sanders, Melinda E., Mobley, Bret C., McDonald, Jeffrey G., Lemoff, Andrew, Peng, Yan, Lewis, Cheryl, Vale, Gonçalo, Halberg, Nils, Arteaga, Carlos L., Hanker, Ariella B., DeBerardinis, Ralph J., and Malladi, Srinivas

Published
2023
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4. Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

Author

Garcia-Recio, Susana, Hinoue, Toshinori, Wheeler, Gregory L., Kelly, Benjamin J., Garrido-Castro, Ana C., Pascual, Tomas, De Cubas, Aguirre A., Xia, Youli, Felsheim, Brooke M., McClure, Marni B., Rajkovic, Andrei, Karaesmen, Ezgi, Smith, Markia A., Fan, Cheng, Ericsson, Paula I. Gonzalez, Sanders, Melinda E., Creighton, Chad J., Bowen, Jay, Leraas, Kristen, Burns, Robyn T., Coppens, Sara, Wheless, Amy, Rezk, Salma, Garrett, Amy L., Parker, Joel S., Foy, Kelly K., Shen, Hui, Park, Ben H., Krop, Ian, Anders, Carey, Gastier-Foster, Julie, Rimawi, Mothaffar F., Nanda, Rita, Lin, Nancy U., Isaacs, Claudine, Marcom, P. Kelly, Storniolo, Anna Maria, Couch, Fergus J., Chandran, Uma, Davis, Michael, Silverstein, Jonathan, Ropelewski, Alexander, Liu, Minetta C., Hilsenbeck, Susan G., Norton, Larry, Richardson, Andrea L., Symmans, W. Fraser, Wolff, Antonio C., Davidson, Nancy E., Carey, Lisa A., Lee, Adrian V., Balko, Justin M., Hoadley, Katherine A., Laird, Peter W., Mardis, Elaine R., King, Tari A., and Perou, Charles M.

Published
2023
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6. Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer.

Author

Axelrod, Margaret L, Nixon, Mellissa J, Gonzalez-Ericsson, Paula I, Bergman, Riley E, Pilkinton, Mark A, McDonnell, Wyatt J, Sanchez, Violeta, Opalenik, Susan R, Loi, Sherene, Zhou, Jing, Mackay, Sean, Rexer, Brent N, Abramson, Vandana G, Jansen, Valerie M, Mallal, Simon, Donaldson, Joshua, Tolaney, Sara M, Krop, Ian E, Garrido-Castro, Ana C, Marotti, Jonathan D, Shee, Kevin, Miller, Todd W, Sanders, Melinda E, Mayer, Ingrid A, Salgado, Roberto, and Balko, Justin M

Subjects
CD8-Positive T-Lymphocytes, Lymphocytes, Tumor-Infiltrating, Humans, Neoplasm Recurrence, Local, Paclitaxel, Albumins, Neoplasm Proteins, Antineoplastic Combined Chemotherapy Protocols, Prognosis, Treatment Outcome, Neoadjuvant Therapy, Gene Expression Regulation, Neoplastic, Adult, Aged, Middle Aged, Female, Tumor Microenvironment, Programmed Cell Death 1 Receptor, Triple Negative Breast Neoplasms, B7-H1 Antigen, Progression-Free Survival, Clinical Research, Genetics, Breast Cancer, Cancer, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeThe recent approval of anti-programmed death-ligand 1 immunotherapy in combination with nab-paclitaxel for metastatic triple-negative breast cancer (TNBC) highlights the need to understand the role of chemotherapy in modulating the tumor immune microenvironment (TIME).Experimental designWe examined immune-related gene expression patterns before and after neoadjuvant chemotherapy (NAC) in a series of 83 breast tumors, including 44 TNBCs, from patients with residual disease (RD). Changes in gene expression patterns in the TIME were tested for association with recurrence-free (RFS) and overall survival (OS). In addition, we sought to characterize the systemic effects of NAC through single-cell analysis (RNAseq and cytokine secretion) of programmed death-1-high (PD-1HI) CD8+ peripheral T cells and examination of a cytolytic gene signature in whole blood.ResultsIn non-TNBC, no change in expression of any single gene was associated with RFS or OS, while in TNBC upregulation of multiple immune-related genes and gene sets were associated with improved long-term outcome. High cytotoxic T-cell signatures present in the peripheral blood of patients with breast cancer at surgery were associated with persistent disease and recurrence, suggesting active antitumor immunity that may indicate ongoing disease burden.ConclusionsWe have characterized the effects of NAC on the TIME, finding that TNBC is uniquely sensitive to the immunologic effects of NAC, and local increases in immune genes/sets are associated with improved outcomes. However, expression of cytotoxic genes in the peripheral blood, as opposed to the TIME, may be a minimally invasive biomarker of persistent micrometastatic disease ultimately leading to recurrence.

Published
2020

7. Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity

Author

Pareja, Fresia, da Silva, Edaise M, Frosina, Denise, Geyer, Felipe C, Lozada, John R, Basili, Thais, Da Cruz Paula, Arnaud, Zhong, Elaine, Derakhshan, Fatemeh, D’Alfonso, Timothy, Wen, Hannah Y, Giri, Dilip D, Hayes, Malcolm M, Krings, Gregor, Bhargava, Rohit, Palazzo, Juan P, Rakha, Emad A, Hoda, Syed A, Sanders, Melinda E, Collins, Laura C, Schnitt, Stuart J, Chen, Yunn-Yi, Weigelt, Britta, Jungbluth, Achim A, Reis-Filho, Jorge S, and Brogi, Edi

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Biotechnology, Aged, Aged, 80 and over, Biomarkers, Tumor, Breast Neoplasms, Carcinoma, Papillary, Cell Polarity, Female, Humans, Immunohistochemistry, Isocitrate Dehydrogenase, Middle Aged, Mutation, Medical and Health Sciences, Pathology, Clinical sciences
Abstract

Tall cell carcinoma with reverse polarity is a rare subtype of breast carcinoma with solid and papillary growth and nuclear features reminiscent of those of the tall cell variant of papillary thyroid carcinoma. These tumors harbor recurrent IDH2 R172 hotspot mutations or TET2 mutations, co-occurring with mutations in PI3K pathway genes. Diagnosis of tall cell carcinomas with reverse polarity is challenging in view of their rarity and the range of differential diagnosis. We sought to determine the sensitivity and specificity of IDH2 R172 immunohistochemistry for the detection of IDH2 R172 hotspot mutations in this entity. We evaluated 14 tall cell carcinomas with reverse polarity (ten excision and five core needle biopsy specimens), 13 intraductal papillomas, 16 solid papillary carcinomas, and 5 encapsulated papillary carcinomas by Sanger sequencing of the IDH2 R172 hotspot locus and of exons 9 and 20 of PIK3CA, and by immunohistochemistry using monoclonal antibodies (11C8B1) to the IDH2 R172S mutation. The 14 tall cell carcinomas with reverse polarity studied harbored IDH2 R172 hotspot mutations, which co-occurred with PIK3CA hotspot mutations in 50% of cases. None of the other papillary neoplasms analyzed displayed IDH2 R172 mutations, however PIK3CA hotspot mutations were detected in 54% of intraductal papillomas, 6% of solid papillary carcinomas, and 20% of encapsulated papillary carcinomas tested. Immunohistochemical analysis with anti-IDH2 R172S antibodies (11C8B1) detected IDH2 R172 mutated protein in 93% (14/15) of tall cell carcinomas with reverse polarity samples including excision (n = 9/10) and core needle biopsy specimens (n = 5), whereas the remaining papillary neoplasms (n = 34) were negative. Our findings demonstrate that immunohistochemical analysis of IDH2 R172 is highly sensitive and specific for the detection of IDH2 R172 hotspot mutations, and likely suitable as a diagnostic tool in the evaluation of excision and core needle biopsy material of tall cell carcinomas with reverse polarity.

Published
2020

10. FIGURE 6 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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11. Figure S2 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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12. FIGURE 3 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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13. FIGURE 2 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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14. Table S4 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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15. FIGURE 4 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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16. FIGURE 5 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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17. Data from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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18. FIGURE 1 from Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer

Author

Wescott, Elizabeth C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula, primary, Hanna, Ann, primary, Taylor, Brandie C., primary, Sanchez, Violeta, primary, Bronzini, Juliana, primary, Opalenik, Susan R., primary, Sanders, Melinda E., primary, Wulfkuhle, Julia, primary, Gallagher, Rosa I., primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Bharti, Vijaya, primary, Wilson, John T., primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Hirst, Gillian L., primary, Brown Swigart, Lamorna, primary, van ˈt Veer, Laura J., primary, Esserman, Laura J., primary, Petricoin, Emanuel F., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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19. Data from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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20. Supplementary Figure 5 from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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21. Supplementary tables from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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22. Supplementary Figure 2 from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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23. Supplementary Figure 4 from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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24. Supplementary Figure 3 from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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25. Supplementary Figure 1 from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, primary, Parida, Pravat Kumar, primary, Ghosh, Suvranil, primary, Kim, Kangsan, primary, Das, Nikitha M., primary, Gonzalez-Ericsson, Paula I., primary, Sanders, Melinda E., primary, Mobley, Bret C., primary, Diegeler, Sebastian, primary, Aguilera, Todd A., primary, Peng, Yan, primary, Lewis, Cheryl M., primary, Arteaga, Carlos L., primary, Hanker, Ariella B., primary, Whitehurst, Angelique W., primary, Lorens, James B., primary, Brekken, Rolf A., primary, Davis, Anthony J., primary, and Malladi, Srinivas, primary

Published
2024
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26. Supplementary Figure 5 from NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer

Author

Taylor, Brandie C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula I., primary, Sanchez, Violeta, primary, Sanders, Melinda E., primary, Wescott, Elizabeth C., primary, Opalenik, Susan R., primary, Hanna, Ann, primary, Chou, Shu-Ting, primary, Van Kaer, Luc, primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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27. Supplementary Figure 2 from NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer

Author

Taylor, Brandie C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula I., primary, Sanchez, Violeta, primary, Sanders, Melinda E., primary, Wescott, Elizabeth C., primary, Opalenik, Susan R., primary, Hanna, Ann, primary, Chou, Shu-Ting, primary, Van Kaer, Luc, primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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28. Supplementary Figure 7 from NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer

Author

Taylor, Brandie C., primary, Sun, Xiaopeng, primary, Gonzalez-Ericsson, Paula I., primary, Sanchez, Violeta, primary, Sanders, Melinda E., primary, Wescott, Elizabeth C., primary, Opalenik, Susan R., primary, Hanna, Ann, primary, Chou, Shu-Ting, primary, Van Kaer, Luc, primary, Gomez, Henry, primary, Isaacs, Claudine, primary, Ballinger, Tarah J., primary, Santa-Maria, Cesar A., primary, Shah, Payal D., primary, Dees, Elizabeth C., primary, Lehmann, Brian D., primary, Abramson, Vandana G., primary, Pietenpol, Jennifer A., primary, and Balko, Justin M., primary

Published
2024
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29. Atezolizumab in Combination With Carboplatin and Survival Outcomes in Patients With Metastatic Triple-Negative Breast Cancer

Author

Lehmann, Brian D., primary, Abramson, Vandana G., additional, Dees, E. Claire, additional, Shah, Payal D., additional, Ballinger, Tarah J., additional, Isaacs, Claudine, additional, Santa-Maria, Cesar A., additional, An, Hanbing, additional, Gonzalez-Ericsson, Paula I., additional, Sanders, Melinda E., additional, Newsom, Kimberly C., additional, Abramson, Richard G., additional, Sheng, Quanhu, additional, Hsu, Chih-Yuan, additional, Shyr, Yu, additional, Wolff, Antonio C., additional, and Pietenpol, Jennifer A., additional

Published
2024
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33. Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

Author

Parida, Pravat Kumar, Marquez-Palencia, Mauricio, Nair, Vidhya, Kaushik, Akash K., Kim, Kangsan, Sudderth, Jessica, Quesada-Diaz, Eduardo, Cajigas, Ambar, Vemireddy, Vamsidhara, Gonzalez-Ericsson, Paula I., Sanders, Melinda E., Mobley, Bret C., Huffman, Kenneth, Sahoo, Sunati, Alluri, Prasanna, Lewis, Cheryl, Peng, Yan, Bachoo, Robert M., Arteaga, Carlos L., Hanker, Ariella B., DeBerardinis, Ralph J., and Malladi, Srinivas

Published
2022
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34. AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Author

Marquez-Palencia, Mauricio, primary, Reza Herrera, Luis, additional, Parida, Pravat Kumar, additional, Ghosh, Suvranil, additional, Kim, Kangsan, additional, Das, Nikitha M., additional, Gonzalez-Ericsson, Paula I., additional, Sanders, Melinda E., additional, Mobley, Bret C., additional, Diegeler, Sebastian, additional, Aguilera, Todd A., additional, Peng, Yan, additional, Lewis, Cheryl M., additional, Arteaga, Carlos L., additional, Hanker, Ariella B., additional, Whitehurst, Angelique W., additional, Lorens, James B., additional, Brekken, Rolf A., additional, Davis, Anthony J., additional, and Malladi, Srinivas, additional

Published
2024
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35. Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance

Author

James, Jamaal L, primary, Taylor, Brandie C, additional, Axelrod, Margaret L, additional, Sun, Xiaopeng, additional, Guerin, Lindsey N, additional, Gonzalez-Ericsson, Paula I, additional, Wang, Yu, additional, Sanchez, Violeta, additional, Fahey, Catherine, additional, Sanders, Melinda E, additional, Xu, Yaomin, additional, Hodges, Emily, additional, Johnson, Douglas B, additional, and Balko, Justin M, additional

Published
2023
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37. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

Author

Zhang, Hui, Liu, Tao, Zhang, Zhen, Payne, Samuel H, Zhang, Bai, McDermott, Jason E, Zhou, Jian-Ying, Petyuk, Vladislav A, Chen, Li, Ray, Debjit, Sun, Shisheng, Yang, Feng, Chen, Lijun, Wang, Jing, Shah, Punit, Cha, Seong Won, Aiyetan, Paul, Woo, Sunghee, Tian, Yuan, Gritsenko, Marina A, Clauss, Therese R, Choi, Caitlin, Monroe, Matthew E, Thomas, Stefani, Nie, Song, Wu, Chaochao, Moore, Ronald J, Yu, Kun-Hsing, Tabb, David L, Fenyö, David, Bafna, Vineet, Wang, Yue, Rodriguez, Henry, Boja, Emily S, Hiltke, Tara, Rivers, Robert C, Sokoll, Lori, Zhu, Heng, Shih, Ie-Ming, Cope, Leslie, Pandey, Akhilesh, Zhang, Bing, Snyder, Michael P, Levine, Douglas A, Smith, Richard D, Chan, Daniel W, Rodland, Karin D, Investigators, the CPTAC, Carr, Steven A, Gillette, Michael A, Klauser, Karl R, Kuhn, Eric, Mani, DR, Mertins, Philipp, Ketchum, Karen A, Thangudu, Ratna, Cai, Shuang, Oberti, Mauricio, Paulovich, Amanda G, Whiteaker, Jeffrey R, Edwards, Nathan J, McGarvey, Peter B, Madhavan, Subha, Wang, Pei, Whiteley, Gordon A, Skates, Steven J, White, Forest M, Kinsinger, Christopher R, Mesri, Mehdi, Shaw, Kenna M, Stein, Stephen E, Fenyo, David, Rudnick, Paul, Snyder, Michael, Zhao, Yingming, Chen, Xian, Ransohoff, David F, Hoofnagle, Andrew N, Liebler, Daniel C, Sanders, Melinda E, Shi, Zhiao, and Slebos, Robbert JC

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Genetics, Biotechnology, Ovarian Cancer, Rare Diseases, Cancer, Acetylation, Chromosomal Instability, DNA Repair, DNA, Neoplasm, Female, Gene Dosage, Humans, Mass Spectrometry, Neoplasm Proteins, Neoplasms, Cystic, Mucinous, and Serous, Ovarian Neoplasms, Phosphoproteins, Protein Processing, Post-Translational, Proteome, Survival Analysis, CPTAC Investigators, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). Integrating our proteomic measurements with the genomic data yielded a number of insights into disease, such as how different copy-number alternations influence the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways that diverse genome rearrangements converge on, and the ones most associated with short overall survival. Specific protein acetylations associated with homologous recombination deficiency suggest a potential means for stratifying patients for therapy. In addition to providing a valuable resource, these findings provide a view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC. VIDEO ABSTRACT.

Published
2016

38. NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer

Author

Taylor, Brandie C., primary, Sun, Xiaopeng, additional, Gonzalez-Ericsson, Paula I., additional, Sanchez, Violeta, additional, Sanders, Melinda E., additional, Wescott, Elizabeth C., additional, Opalenik, Susan R., additional, Hanna, Ann, additional, Chou, Shu-Ting, additional, Van Kaer, Luc, additional, Gomez, Henry, additional, Isaacs, Claudine, additional, Ballinger, Tarah J., additional, Santa-Maria, Cesar A., additional, Shah, Payal D., additional, Dees, Elizabeth C., additional, Lehmann, Brian D., additional, Abramson, Vandana G., additional, Pietenpol, Jennifer A., additional, and Balko, Justin M., additional

Published
2023
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40. A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis

Author

Johnson, Douglas B., McDonnell, Wyatt J., Gonzalez-Ericsson, Paula I., Al-Rohil, Rami N., Mobley, Bret C., Salem, Joe-Elie, Wang, Daniel Y., Sanchez, Violeta, Wang, Yu, Chastain, Cody A., Barker, Kristi, Liang, Yan, Warren, Sarah, Beechem, Joseph M., Menzies, Alexander M., Tio, Martin, Long, Georgina V., Cohen, Justine V., Guidon, Amanda C., O’Hare, Méabh, Chandra, Sunandana, Chowdhary, Akansha, Lebrun-Vignes, Bénédicte, Goldinger, Simone M., Rushing, Elisabeth J., Buchbinder, Elizabeth I., Mallal, Simon A., Shi, Chanjuan, Xu, Yaomin, Moslehi, Javid J., Sanders, Melinda E., Sosman, Jeffrey A., and Balko, Justin M.

Published
2019
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43. Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

Author

Balko, Justin M, Giltnane, Jennifer M, Wang, Kai, Schwarz, Luis J, Young, Christian D, Cook, Rebecca S, Owens, Phillip, Sanders, Melinda E, Kuba, Maria G, Sánchez, Violeta, Kurupi, Richard, Moore, Preston D, Pinto, Joseph A, Doimi, Franco D, Gómez, Henry, Horiuchi, Dai, Goga, Andrei, Lehmann, Brian D, Bauer, Joshua A, Pietenpol, Jennifer A, Ross, Jeffrey S, Palmer, Gary A, Yelensky, Roman, Cronin, Maureen, Miller, Vincent A, Stephens, Phillip J, and Arteaga, Carlos L

Subjects
Biotechnology, Human Genome, Breast Cancer, Clinical Research, Genetics, Cancer, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Cluster Analysis, DNA Copy Number Variations, Drug Resistance, Neoplasm, Female, Gene Amplification, Gene Expression Profiling, Genes, myc, Humans, Ki-67 Antigen, Myeloid Cell Leukemia Sequence 1 Protein, Neoadjuvant Therapy, Neoplasm, Residual, Prognosis, Treatment Outcome, Triple Negative Breast Neoplasms, Oncology and Carcinogenesis
Abstract

UnlabelledNeoadjuvant chemotherapy (NAC) induces a pathologic complete response (pCR) in approximately 30% of patients with triple-negative breast cancers (TNBC). In patients lacking a pCR, NAC selects a subpopulation of chemotherapy-resistant tumor cells. To understand the molecular underpinnings driving treatment-resistant TNBCs, we performed comprehensive molecular analyses on the residual disease of 74 clinically defined TNBCs after NAC, including next-generation sequencing (NGS) on 20 matched pretreatment biopsies. Combined NGS and digital RNA expression analysis identified diverse molecular lesions and pathway activation in drug-resistant tumor cells. Ninety percent of the tumors contained a genetic alteration potentially treatable with a currently available targeted therapy. Thus, profiling residual TNBCs after NAC identifies targetable molecular lesions in the chemotherapy-resistant component of the tumor, which may mirror micrometastases destined to recur clinically. These data can guide biomarker-driven adjuvant studies targeting these micrometastases to improve the outcome of patients with TNBC who do not respond completely to NAC.SignificanceThis study demonstrates the spectrum of genomic alterations present in residual TNBC after NAC. Because TNBCs that do not achieve a CR after NAC are likely to recur as metastatic disease at variable times after surgery, these alterations may guide the selection of targeted therapies immediately after mastectomy before these metastases become evident.

Published
2014

45. MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

Author

Lee, Kyung-min, Giltnane, Jennifer M., Balko, Justin M., Schwarz, Luis J., Guerrero-Zotano, Angel L., Hutchinson, Katherine E., Nixon, Mellissa J., Estrada, Mónica V., Sánchez, Violeta, Sanders, Melinda E., Lee, Taekyu, Gómez, Henry, Lluch, Ana, Pérez-Fidalgo, J. Alejandro, Wolf, Melissa Magdalene, Andrejeva, Gabriela, Rathmell, Jeffrey C., Fesik, Stephen W., and Arteaga, Carlos L.

Published
2017
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46. Data from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

Author

Balko, Justin M., primary, Giltnane, Jennifer M., primary, Wang, Kai, primary, Schwarz, Luis J., primary, Young, Christian D., primary, Cook, Rebecca S., primary, Owens, Phillip, primary, Sanders, Melinda E., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Kurupi, Richard, primary, Moore, Preston D., primary, Pinto, Joseph A., primary, Doimi, Franco D., primary, Gómez, Henry, primary, Horiuchi, Dai, primary, Goga, Andrei, primary, Lehmann, Brian D., primary, Bauer, Joshua A., primary, Pietenpol, Jennifer A., primary, Ross, Jeffrey S., primary, Palmer, Gary A., primary, Yelensky, Roman, primary, Cronin, Maureen, primary, Miller, Vincent A., primary, Stephens, Phillip J., primary, and Arteaga, Carlos L., primary

Published
2023
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47. Supplementary Data Figure 5 from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

Author

Balko, Justin M., primary, Giltnane, Jennifer M., primary, Wang, Kai, primary, Schwarz, Luis J., primary, Young, Christian D., primary, Cook, Rebecca S., primary, Owens, Phillip, primary, Sanders, Melinda E., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Kurupi, Richard, primary, Moore, Preston D., primary, Pinto, Joseph A., primary, Doimi, Franco D., primary, Gómez, Henry, primary, Horiuchi, Dai, primary, Goga, Andrei, primary, Lehmann, Brian D., primary, Bauer, Joshua A., primary, Pietenpol, Jennifer A., primary, Ross, Jeffrey S., primary, Palmer, Gary A., primary, Yelensky, Roman, primary, Cronin, Maureen, primary, Miller, Vincent A., primary, Stephens, Phillip J., primary, and Arteaga, Carlos L., primary

Published
2023
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48. Supplementary Data Tables from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

Author

Balko, Justin M., primary, Giltnane, Jennifer M., primary, Wang, Kai, primary, Schwarz, Luis J., primary, Young, Christian D., primary, Cook, Rebecca S., primary, Owens, Phillip, primary, Sanders, Melinda E., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Kurupi, Richard, primary, Moore, Preston D., primary, Pinto, Joseph A., primary, Doimi, Franco D., primary, Gómez, Henry, primary, Horiuchi, Dai, primary, Goga, Andrei, primary, Lehmann, Brian D., primary, Bauer, Joshua A., primary, Pietenpol, Jennifer A., primary, Ross, Jeffrey S., primary, Palmer, Gary A., primary, Yelensky, Roman, primary, Cronin, Maureen, primary, Miller, Vincent A., primary, Stephens, Phillip J., primary, and Arteaga, Carlos L., primary

Published
2023
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