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1. Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG

Author

Wieczorek, Lindsay, Chang, David, Sanders-Buell, Eric, Zemil, Michelle, Martinez, Elizabeth, Schoen, Jesse, Chenine, Agnes-Laurence, Molnar, Sebastian, Barrows, Brittani, Poltavee, Kultida, Charurat, Man E., Abimiku, Alash’le, Blattner, William, Iroezindu, Michael, Kokogho, Afoke, Michael, Nelson L., Crowell, Trevor A., Ake, Julie A., Tovanabutra, Sodsai, and Polonis, Victoria R.

Published
2024
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2. Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study

Author

Marichannegowda, Manukumar Honnayakanahalli, Zemil, Michelle, Wieczorek, Lindsay, Sanders-Buell, Eric, Bose, Meera, O'Sullivan, Anne Marie, King, David, Francisco, Leilani, Diaz-Mendez, Felisa, Setua, Saini, Chomont, Nicolas, Phanuphak, Nittaya, Ananworanich, Jintanat, Hsu, Denise, Vasan, Sandhya, Michael, Nelson L., Eller, Leigh Anne, Tovanabutra, Sodsai, Tagaya, Yutaka, Robb, Merlin L., Polonis, Victoria R., and Song, Hongshuo

Published
2023
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3. Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria

Author

Nowak, Rebecca G, Schumaker, Lisa M, Ambulos, Nicholas P, Ndembi, Nicaise, Dauda, Wuese, Nnaji, Chinedu H, Mitchell, Andrew, Mathias, Trevor J, Jibrin, Paul, Darragh, Teresa M, Olaomi, Oluwole, Crowell, Trevor A, Baral, Stefan D, Charurat, Manhattan E, Bentzen, Søren M, Palefsky, Joel M, Cullen, Kevin J, Group, TRUST RV368 Study, Charurat, Manhattan, Ake, Julie, Abayomi, Aka, Adebajo, Sylvia, Baral, Stefan, Crowell, Trevor, Gaydos, Charlotte, Ketende, Sosthenes, Kokogho, Afoke, Malia, Jennifer, Makanjuola, Olumide, Michael, Nelson, Ndemb, Nicaise, Nowak, Rebecca, Olawore, Oluwasolape, Parker, Zahra, Peel, Sheila, Ramadhani, Habib, Robb, Merlin, Rodriguez-Hart, Cristina, Sanders-Buell, Eric, Shoyemi, Elizabeth, Tovanabutra, Sodsai, and Vasan, Sandhya

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, Cervical Cancer, Cancer, Infection, Good Health and Well Being, Adult, Anus Neoplasms, Cohort Studies, DNA, Viral, Early Detection of Cancer, High-Throughput Nucleotide Sequencing, Homosexuality, Male, Humans, Male, Nigeria, Papillomaviridae, Papillomavirus Infections, Prevalence, Young Adult, HPV in MSM, Anal cancer screening, Sub-Saharan Africa, Next-generation sequencing, TRUST/RV368 Study Group, Medical microbiology, Oncology and carcinogenesis
Abstract

BackgroundAnal precancers and cancers can be detected during screening with high-resolution anoscopy (HRA). The sensitivity of HRA depends on the burden and duration of human papillomavirus (HPV) among those screened as well as anoscopist proficiency, which is highly correlated with prior screening experience. Our objective was to compare the identification and type of HPV and the likelihood of HRA-detected precancer for men who have sex with men (MSM) undergoing their first HRA-screening in Nigeria.MethodsMSM were recruited from an HIV test-and-treat cohort, TRUST/RV368, into a new anal cancer screening program. Anal swabs obtained during screening underwent Ion Torrent next-generation sequencing using barcoded HPV PCR broad-spectrum primers 5+/6+ to detect up to 161 HPVs. All high-risk (HR) HPVs and the most abundant low-risk (LR)-HPVs were evaluated as type-specific infections with some categorized as belonging to a multiple infection. HRA screening results included benign, low-grade squamous intraepithelial lesions (LSIL), or HSIL as detected by cytology or histology. Multivariable logistic regression was used to assess the association of HPV and other cofactors with any SIL.ResultsAmong 342 MSM, 60% were HIV-infected, 89% were under 35 years of age, and 51% had 8 or more years since anal coital debut. Of those with SIL, 89% had LSIL and only 11% had HSIL. Prevalence of any HPV and high-risk (HR)-HPV was 92% and 74%, respectively. The most prevalent genotypes in rank order were HPV6 (31%), HPV16 (23%), HPV42 (20%), HPV11 (18%), HPV45 (18%), and HPV51 (17%). For multiple HR-HPVs, 31% had a single HR-HPV, 32% had 2-3, and 10% had 4 or more. Low-risk HPVs, type 6 and/or 11, were common (42%) and were significantly associated with SIL (adjusted odds ratio [aOR]:1.8, 95% confidence interval [CI]: 1.1-3.1) together with perianal warts (aOR:6.7, 95% CI: 3.3-13.5). In contrast, HR-HPV and multiple HR-HPVs were not significantly associated with SIL (all p > 0.05).ConclusionsDetection of HSIL was low. Although HR-HPV was abundant, HSIL development also depends on the duration of HR-HPV infections and the anoscopist's level of experience. As our cohort ages and the anoscopist becomes more skilled, detection of HSIL will likely improve.

Published
2020

4. Determinants of Preexposure Prophylaxis Cascade Among Sexual and Gender Minorities in Nigeria

Author

Ramadhani, Habib Omari, Crowell, Trevor A., Nowak, Rebecca G., Adebajo, Sylvia, Kayode, Blessing O., Ononaku, Uchenna, Baral, Stefan D., Ndembi, Nicaise, Charurat, Man E., Charurat, Manhattan, Ake, Julie, Abayomi, Aka, Adebajo, Sylvia, Baral, Stefan, Crowell, Trevor, Gaydos, Charlotte, Hu, Fengming, Kokogho, Afoke, Lombardi, Kara, Malia, Jennifer, Makanjuola, Olumide, Michael, Nelson, Ndembi, Nicaise, Nowak, Rebecca, Olawore, Oluwasolape, Parker, Zahra, Peel, Sheila, Ramadhani, Habib Omari, Robb, Merlin, Rodriguez-Hart, Cristina, Sanders-Buell, Eric, Shoyemi, Elizabeth, Tiamiyu, Abdulwasiu, Tovanabutra, Sodsai, and Vasan, Sandhya

Published
2023
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5. Prevalence of Mycoplasma genitalium Infection and Macrolide and Fluoroquinolone Resistance Mutations Among US Air Force Service Members With HIV, 2016–2020.

Author

Hakre, Shilpa, Sanders-Buell, Eric, Casimier, Rosemary O, O'Sullivan, Anne Marie, Peel, Sheila A, Tovanabutra, Sodsai, Scott, Paul T, and Okulicz, Jason F

Subjects
*HIV infections, *SEXUALLY transmitted diseases, *PROPORTIONAL hazards models, *CHLAMYDIA infections, *PUBLIC health, *GONORRHEA
Abstract

Background Mycoplasma genitalium (MG) infection is a public health concern due to antimicrobial resistance (AMR). Data are limited on repeat MG infection and AMR among US Air Force service members with HIV. Methods US Air Force service members seeking HIV care were screened for MG infection during the surveillance period (16 May 2016–16 March 2020). Baseline and repeat MG prevalence rates were estimated. An extended Cox proportional hazards regression model evaluated characteristics associated with repeat MG infection. MG-positive rectal samples were tested for macrolide or fluoroquinolone resistance. Results Among 299 male patients from a total of 308 patients followed during the surveillance period, baseline prevalence of MG infection was 19.7% (n = 59); among the 101 patients who screened positive for MG at any time during the surveillance period, repeat MG was 35% (n = 36). Characteristics independently associated with increased risk of repeat infection were sexually transmitted infection history vs none (adjusted hazard ratio [aHR], 2.33; 95% CI, 1.26–4.31), a sexually transmitted infection coinfection vs no positive test result in the medical records (aHR, 5.13; 95% CI, 2.78–9.49), and a new HIV diagnosis (<1 vs ≥1 year; aHR, 2.63; 95% CI, 1.45–3.73). AMR in MG-positive rectal specimens was 88% (43/49) indicating macrolide resistance, 18% (10/56) quinolone resistance, and 18% (10/56) both. Conclusions Macrolide and fluoroquinolone resistance mutations were common. Testing for co-occurring MG infection and AMR mutations may be warranted in guiding treatment for sexually transmitted infections such as chlamydia or gonorrhea detected at HIV diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States

Author

Wieczorek, Lindsay, primary, Sanders-Buell, Eric, additional, Zemil, Michelle, additional, Lewitus, Eric, additional, Kavusak, Erin, additional, Heller, Jonah, additional, Molnar, Sebastian, additional, Rao, Mekhala, additional, Smith, Gabriel, additional, Bose, Meera, additional, Nguyen, Amy, additional, Dhungana, Adwitiya, additional, Okada, Katherine, additional, Parisi, Kelly, additional, Silas, Daniel, additional, Slike, Bonnie, additional, Ganesan, Anuradha, additional, Okulicz, Jason, additional, Lalani, Tahaniyat, additional, Agan, Brian K., additional, Crowell, Trevor A., additional, Darden, Janice, additional, Rolland, Morgane, additional, Vasan, Sandhya, additional, Ake, Julie, additional, Krebs, Shelly J., additional, Peel, Sheila, additional, Tovanabutra, Sodsai, additional, and Polonis, Victoria R., additional

Published
2023
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7. Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound

Author

Cale, Evan M., Bai, Hongjun, Bose, Meera, Messina, Michael A., Colby, Donn J., Sanders-Buell, Eric, Dearlove, Bethany, Li, Yifan, Engeman, Emily, Silas, Daniel, O'Sullivan, Anne Marie, Mann, Brendan, Pinyakorn, Suteeraporn, Intasan, Jintana, Benjapornpong, Khunthalee, Sacdalan, Carlo, Kroon, Eugene, Phanuphak, Nittaya, Gramzinski, Robert, Vasan, Sandhya, Robb, Merlin L., Michael, Nelson L., Lynch, Rebecca M., Bailer, Robert T., Pagliuzza, Amelie, Chomont, Nicolas, Pegu, Amarendra, Doria-Rose, Nicole A., Trautmann, Lydie, Crowell, Trevor A., Mascola, John R., Ananworanich, Jintanat, Tovanabutra, Sodsai, and Rolland, Morgane

Subjects
Highly active antiretroviral therapy -- Health aspects, HIV -- Genetic aspects -- Prevention, Antiretroviral agents -- Health aspects, Antibodies -- Genetic aspects -- Health aspects, Antigenic determinants -- Genetic aspects -- Health aspects, Health care industry
Abstract

Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions affected viral rebound after cessation of antiretroviral therapy (ART) in 18 acutely treated and durably suppressed individuals. Viral rebound occurred in all individuals, yet VRC01 infusions modestly delayed rebound and participants who showed a faster decay of VRC01 in serum rebounded more rapidly. Participants with strains most sensitive to VRC01 or with VRC01 epitope motifs similar to known VRC01- susceptible strains rebounded later. Upon rebound, HIV-1 sequences were indistinguishable from those sampled at diagnosis. Across the cohort, participant-derived Env showed different sensitivity to VRC01 neutralization (including 2 resistant viruses), yet neutralization sensitivity was similar at diagnosis and after rebound, indicating the lack of selection for VRC01 resistance during treatment interruption. Our results showed that viremia rebounded despite the absence of HIV-1 adaptation to VRC01 and an average VRC01 trough of 221 micro]g/mL. Although VRC01 levels were insufficient to prevent a resurgent infection, knowledge that they did not mediate Env mutations in acute-like viruses is relevant for antibody-based strategies in acute infection., Introduction Analytic treatment interruption (ATI) studies can help evaluate strategies to mediate long-term remission in HIV-1-infected persons. An ATI study tested the impact of the administration of the broadly neutralizing [...]

Published
2020
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8. Comparable Antigenicity and Immunogenicity of Oligomeric Forms of a Novel, Acute HIV-1 Subtype C gp145 Envelope for Use in Preclinical and Clinical Vaccine Research

Author

Wieczorek, Lindsay, Krebs, Shelly J, Kalyanaraman, Vaniambadi, Whitney, Stephen, Tovanabutra, Sodsai, Moscoso, Carlos G, Sanders-Buell, Eric, Williams, Constance, Slike, Bonnie, Molnar, Sebastian, Dussupt, Vincent, Alam, S Munir, Chenine, Agnes-Laurence, Tong, Tina, Hill, Edgar L, Liao, Hua-Xin, Hoelscher, Michael, Maboko, Leonard, Zolla-Pazner, Susan, Haynes, Barton F, Pensiero, Michael, McCutchan, Francine, Malek-Salehi, Shawyon, Cheng, R Holland, Robb, Merlin L, VanCott, Thomas, Michael, Nelson L, Marovich, Mary A, Alving, Carl R, Matyas, Gary R, Rao, Mangala, and Polonis, Victoria R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Infectious Diseases, Biotechnology, Prevention, Immunization, Vaccine Related (AIDS), HIV/AIDS, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, AIDS Vaccines, Animals, Drug Evaluation, Preclinical, HIV Antibodies, HIV Infections, HIV-1, Humans, Leukocytes, Mononuclear, Molecular Sequence Data, Neutralization Tests, Rabbits, Vaccination, env Gene Products, Human Immunodeficiency Virus, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences
Abstract

UnlabelledEliciting broadly reactive functional antibodies remains a challenge in human immunodeficiency virus type 1 (HIV-1) vaccine development that is complicated by variations in envelope (Env) subtype and structure. The majority of new global HIV-1 infections are subtype C, and novel antigenic properties have been described for subtype C Env proteins. Thus, an HIV-1 subtype C Env protein (CO6980v0c22) from an infected person in the acute phase (Fiebig stage I/II) was developed as a research reagent and candidate immunogen. The gp145 envelope is a novel immunogen with a fully intact membrane-proximal external region (MPER), extended by a polylysine tail. Soluble gp145 was enriched for trimers that yielded the expected "fan blade" motifs when visualized by cryoelectron microscopy. CO6980v0c22 gp145 reacts with the 4E10, PG9, PG16, and VRC01 HIV-1 neutralizing monoclonal antibodies (MAbs), as well as the V1/V2-specific PGT121, 697, 2158, and 2297 MAbs. Different gp145 oligomers were tested for immunogenicity in rabbits, and purified dimers, trimers, and larger multimers elicited similar levels of cross-subtype binding and neutralizing antibodies to tier 1 and some tier 2 viruses. Immunized rabbit sera did not neutralize the highly resistant CO6980v0c22 pseudovirus but did inhibit the homologous infectious molecular clone in a peripheral blood mononuclear cell (PBMC) assay. This Env is currently in good manufacturing practice (GMP) production to be made available for use as a clinical research tool and further evaluation as a candidate vaccine.ImportanceAt present, the product pipeline for HIV vaccines is insufficient and is limited by inadequate capacity to produce large quantities of vaccine to standards required for human clinical trials. Such products are required to evaluate critical questions of vaccine formulation, route, dosing, and schedule, as well as to establish vaccine efficacy. The gp145 Env protein presented in this study forms physical trimers, binds to many of the well-characterized broad neutralizing MAbs that target conserved Env epitopes, and induce cross-subtype neutralizing antibodies as measured in both cell line and primary cell assays. This subtype C Env gp145 protein is currently undergoing good manufacturing practice production for use as a reagent for preclinical studies and for human clinical research. This product will serve as a reagent for comparative studies and may represent a next-generation candidate HIV immunogen.

Published
2015

9. Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial.

Author

Edlefsen, Paul T, Rolland, Morgane, Hertz, Tomer, Tovanabutra, Sodsai, Gartland, Andrew J, deCamp, Allan C, Magaret, Craig A, Ahmed, Hasan, Gottardo, Raphael, Juraska, Michal, McCoy, Connor, Larsen, Brendan B, Sanders-Buell, Eric, Carrico, Chris, Menis, Sergey, Kijak, Gustavo H, Bose, Meera, RV144 Sequencing Team, Arroyo, Miguel A, O'Connell, Robert J, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Robb, Merlin L, Kirys, Tatsiana, Georgiev, Ivelin S, Kwong, Peter D, Scheffler, Konrad, Pond, Sergei L Kosakovsky, Carlson, Jonathan M, Michael, Nelson L, Schief, William R, Mullins, James I, Kim, Jerome H, and Gilbert, Peter B

Subjects
RV144 Sequencing Team, Humans, HIV-1, HIV Infections, AIDS Vaccines, Sequence Alignment, Sequence Analysis, Protein, Binding Sites, Genome, Viral, Models, Molecular, Molecular Sequence Data, Human Immunodeficiency Virus Proteins, Sequence Analysis, Protein, Genome, Viral, Models, Molecular, Mathematical Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo recipients). A V1/V2-targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites that differed between the vaccine and placebo groups. Here we extended the V1/V2 analysis to the entire HIV-1 genome using an array of methods based on individual sites, k-mers and genes/proteins. We identified 56 amino acid sites or "signatures" and 119 k-mers that differed between the vaccine and placebo groups. Of those, 19 sites and 38 k-mers were located in the regions comprising the RV144 vaccine (Env-gp120, Gag, and Pro). The nine signature sites in Env-gp120 were significantly enriched for known antibody-associated sites (p = 0.0021). In particular, site 317 in the third variable loop (V3) overlapped with a hotspot of antibody recognition, and sites 369 and 424 were linked to CD4 binding site neutralization. The identified signature sites significantly covaried with other sites across the genome (mean = 32.1) more than did non-signature sites (mean = 0.9) (p < 0.0001), suggesting functional and/or structural relevance of the signature sites. Since signature sites were not preferentially restricted to the vaccine immunogens and because most of the associations were insignificant following correction for multiple testing, we predict that few of the genetic differences are strongly linked to the RV144 vaccine-induced immune pressure. In addition to presenting results of the first complete-genome analysis of the breakthrough infections in the RV144 trial, this work describes a set of statistical methods and tools applicable to analysis of breakthrough infection genomes in general vaccine efficacy trials for diverse pathogens.

Published
2015

10. Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

Author

Ake, Julie A., Akapirat, Siriwat, Bose, Meera, Cale, Evan, Chan, Phillip, Chanthaburanun, Sararut, Churikanont, Nampueng, Dawson, Peter, Dumrongpisutikul, Netsiri, Getchalarat, Saowanit, Jongrakthaitae, Surat, Jongsakul, Krisada, Lerdlum, Sukalaya, Manasnayakorn, Sopark, McCullough, Corinne, Milazzo, Mark, Nuntapinit, Bessara, On, Kier, Ouellette, Madelaine, Phanuphak, Praphan, Sanders-Buell, Eric, Sangnoi, Nongluck, Shangguan, Shida, Sirivichayakul, Sunee, Tragonlugsana, Nipattra, Trichavaroj, Rapee, Ubolyam, Sasiwimol, Vasan, Sandhya, Wattanaboonyongcharoen, Phandee, Yamchuenpong, Thipvadee, Crowell, Trevor A, Colby, Donn J, Pinyakorn, Suteeraporn, Sacdalan, Carlo, Pagliuzza, Amélie, Intasan, Jintana, Benjapornpong, Khunthalee, Tangnaree, Kamonkan, Chomchey, Nitiya, Kroon, Eugène, de Souza, Mark S, Tovanabutra, Sodsai, Rolland, Morgane, Eller, Michael A, Paquin-Proulx, Dominic, Bolton, Diane L, Tokarev, Andrey, Thomas, Rasmi, Takata, Hiroshi, Trautmann, Lydie, Krebs, Shelly J, Modjarrad, Kayvon, McDermott, Adrian B, Bailer, Robert T, Doria-Rose, Nicole, Patel, Bijal, Gorelick, Robert J, Fullmer, Brandie A, Schuetz, Alexandra, Grandin, Pornsuk V, O'Connell, Robert J, Ledgerwood, Julie E, Graham, Barney S, Tressler, Randall, Mascola, John R, Chomont, Nicolas, Michael, Nelson L, Robb, Merlin L, Phanuphak, Nittaya, and Ananworanich, Jintanat

Published
2019
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11. Next-generation sequencing of HIV-1 single genome amplicons

Author

Kijak, Gustavo H., Sanders-Buell, Eric, Pham, Phuc, Harbolick, Elizabeth A., Oropeza, Celina, O’Sullivan, Anne Marie, Bose, Meera, Beckett, Charmagne G., Milazzo, Mark, Robb, Merlin L., Peel, Sheila A., Scott, Paul T., Michael, Nelson L., Armstrong, Adam W., Kim, Jerome H., Brett-Major, David M., and Tovanabutra, Sodsai

Published
2019
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12. Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

Author

Song, Hongshuo, primary, Marichannegowda, Manukumar, additional, Setua, Saini, additional, Bose, Meera, additional, Sanders-Buell, Eric, additional, King, David, additional, Zemil, Michelle, additional, Wieczorek, Lindsay, additional, Diaz-Mendez, Felisa, additional, Chomont, Nicolas, additional, Thomas, Rasmi, additional, Francisco, Leilani, additional, Eller, Leigh Anne, additional, Polonis, Victoria, additional, Tovanabutra, Sodsai, additional, Tagaya, Yutaka, additional, Michael, Nelson, additional, and Robb, Merlin, additional

Published
2023
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13. Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

Author

Marichannegowda, Manukumar Honnayakanahalli, primary, Setua, Saini, additional, Bose, Meera, additional, Sanders-Buell, Eric, additional, King, David, additional, Zemil, Michelle, additional, Wieczorek, Lindsay, additional, Diaz-Mendez, Felisa, additional, Chomont, Nicolas, additional, Thomas, Rasmi, additional, Francisco, Leilani, additional, Eller, Leigh Anne, additional, Polonis, Victoria R., additional, Tovanabutra, Sodsai, additional, Tagaya, Yutaka, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, and Song, Hongshuo, additional

Published
2023
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14. Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo

Author

Geretz, Aviva, primary, Ehrenberg, Philip K., additional, Clifford, Robert J., additional, Laliberté, Alexandre, additional, Prelli Bozzo, Caterina, additional, Eiser, Daina, additional, Kundu, Gautam, additional, Yum, Lauren K., additional, Apps, Richard, additional, Creegan, Matthew, additional, Gunady, Mohamed, additional, Shangguan, Shida, additional, Sanders-Buell, Eric, additional, Sacdalan, Carlo, additional, Phanuphak, Nittaya, additional, Tovanabutra, Sodsai, additional, Russell, Ronnie M., additional, Bibollet-Ruche, Frederic, additional, Robb, Merlin L., additional, Michael, Nelson L., additional, Ake, Julie A., additional, Vasan, Sandhya, additional, Hsu, Denise C., additional, Hahn, Beatrice H., additional, Kirchhoff, Frank, additional, and Thomas, Rasmi, additional

Published
2023
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15. Molecular epidemiology of a primarily MSM acute HIV-1 cohort in Bangkok, Thailand and connections within networks of transmission in Asia

Author

Chang, David, Sanders-Buell, Eric, Bose, Meera, O'Sullivan, Anne Marie, Pham, Phuc, Kroon, Eugene, Colby, Donn J., Sirijatuphat, Rujipas, Billings, Erik, Pinyakorn, Suteeraporn, Chomchey, Nitiya, Rutvisuttinunt, Wiriya, Kijak, Gustavo, Souza, Mark de, Excler, Jean-Louis, Phanuphak, Praphan, Phanuphak, Nittaya, O'Connell, Robert J., Kim, Jerome H., Robb, Merlin L., Michael, Nelson L., Ananworanich, Jintanat, and Tovanabutra, Sodsai

Subjects
AIDS vaccines -- Usage -- Research, HIV infections -- Prevention -- Care and treatment -- Research, Disease transmission -- Development and progression -- Analysis -- Health aspects -- Research, MSM (Men who have sex with men) -- Health aspects, Epidemiology -- Analysis, Health
Abstract

Introduction: Thailand plays a substantial role in global HIV-1 transmission of CRF01_AE. Worldwide, men who have sex with men (MSM) are at elevated risk for HIV-1 infection. Hence, understanding HIV-1 diversity in a primarily Thai MSM cohort with acute infection, and its connections to the broader HIV-1 transmission network in Asia is crucial for research and development of HIV-1 vaccines, treatment and cure. Methods: Subtypes and diversity of infecting viruses from individuals sampled from 2009 to 2015 within the RV254/SEARCH 010 cohort were assessed by multiregion hybridization assay (MHAbce), multiregion subtype-specific PCR assay (MSSPbce) and full-length single-genome sequencing (SGS). Phylogenetic analysis was performed by maximum likelihood. Pairwise genetic distances of envelope gp160 sequences obtained from the cohort and from Asia (Los Alamos National Laboratory HIV Database) were calculated to identify potential transmission networks. Results: MHAbce/MSSPbce results identified 81.6% CRF01AE infecting strains in RV254. CRF01AE/B recombinants and sub-type B were found at 7.3% and 2.8% respectively. Western subtype B strains outnumbered Thai B' strains. Phylogenetic analysis revealed one C, one CRF01_AE/CRF02_AG recombinant and one CRF01_AE/B/C recombinant. Asian network analysis identified one hundred and twenty-three clusters, including five clusters of RV254 participants. None of the RV254 sequences clustered with non-RV254 sequences. The largest international cluster involved 15 CRF01AE strains from China and Vietnam. The remaining clusters were mostly intracountry connections, of which 31.7% included Thai nodes and 43.1% included Chinese nodes. Conclusion: While the majority of strains in Thailand are CRF01AE and subtype B, emergence of unique recombinant forms (URFs) are found in a moderate fraction of new HIV-1 infections. Approaches to vaccine design and immunotherapeutics will need to monitor and consider the expanding proportion of recombinants and the increasing genetic diversity in the region. Identified HIV-1 transmission networks indicate ongoing spread of HIV-1 among MSM. As HIV-1 epidemics continue to expand in other Asian countries, transmission network analyses can inform strategies for prevention, intervention, treatment and cure. Keywords: HIV-1 molecular epidemiology; Thailand; Asia transmission network; MSM; acute infection; recombinants; vaccine; intervention, Additional Supporting Information may be found online in the Supporting information tab for this article. 1 INTRODUCTION Over 30 years have passed since the first case of HIV-1 was reported [...]

Published
2018
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17. Evolution of Antibody Responses in HIV-1 CRF01_AE Acute Infection: Founder Envelope V1V2 Impacts the Timing and Magnitude of Autologous Neutralizing Antibodies

Author

Kuriakose Gift, Syna, primary, Wieczorek, Lindsay, additional, Sanders-Buell, Eric, additional, Zemil, Michelle, additional, Molnar, Sebastian, additional, Donofrio, Gina, additional, Townsley, Samantha, additional, Chenine, Agnes L., additional, Bose, Meera, additional, Trinh, Hung V., additional, Barrows, Brittani M., additional, Sriplienchan, Somchai, additional, Kitsiripornchai, Suchai, additional, Nitayapan, Sorachai, additional, Eller, Leigh-Anne, additional, Rao, Mangala, additional, Ferrari, Guido, additional, Michael, Nelson L., additional, Ake, Julie A., additional, Krebs, Shelly J., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Polonis, Victoria R., additional

Published
2023
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19. Transmission dynamics among participants initiating anti-retroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand

Author

Kroon, Eugène, Pham, Phuc T., Sirivichayakul, Sunee, Trichavaroj, Rapee, Colby, Donn J., Pinyakorn, Suteeraporn, Phanuphak, Nittaya, Sanders-Buell, Eric, Van Griensven, Frits, Kijak, Gustavo H., Kim, Jerome H., Michael, Nelson L., Robb, Merlin.L., Ananworanich, Jintanat, De Souza, Mark S., and Tovanabutra, Sodsai

Published
2018
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20. New Subtype B Containing HIV-1 Circulating Recombinant of sub-Saharan Africa Origin in Nigerian Men Who Have Sex With Men

Author

Billings, Erik, Kijak, Gustavo H., Sanders-Buell, Eric, Ndembi, Nicaise, OʼSullivan, Anne Marie, Adebajo, Sylvia, Kokogho, Afoke, Milazzo, Mark, Lombardi, Kara, Baral, Stefan, Nowak, Rebecca, Ramadhani, Habib, Gramzinski, Robert, Robb, Merlin L., Michael, Nelson L., Charurat, Manhattan E., Ake, Julie, Crowell, Trevor A., and Tovanabutra, Sodsai

Published
2019
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21. Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

Author

Marichannegowda, Manukumar Honnayakanahalli, primary, Zemil, Michelle, additional, Wieczorek, Lindsay, additional, Sanders-Buell, Eric, additional, Bose, Meera, additional, O’Sullivan, Anne Marie, additional, King, David, additional, Francisco, Leilani, additional, Diaz-Mendez, Felisa, additional, Setua, Saini, additional, Chomont, Nicolas, additional, Phanuphak, Nittaya, additional, Ananworanich, Jintanat, additional, Hsu, Denise, additional, Vasan, Sandhya, additional, Michael, Nelson L., additional, Eller, Leigh Anne, additional, Tovanabutra, Sodsai, additional, Tagaya, Yutaka, additional, Robb, Merlin L., additional, Polonis, Victoria R., additional, and Song, Hongshuo, additional

Published
2023
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22. Tracking Coreceptor Switch of the Transmitted/Founder HIV-1 Identifies Co-Evolution of HIV-1 Antigenicity, Coreceptor Usage and CD4 Subset Targeting: The RV217 Acute Infection Cohort Study

Author

Marichannegowda, Manukumar Honnayakanahalli, primary, Zemil, Michelle, additional, Wieczorek, Lindsay, additional, Sanders-Buell, Eric, additional, Bose, Meera, additional, O&apos;Sullivan, Anne Marie, additional, King, David, additional, Francisco, Leilani, additional, Diaz-Mendez, Felisa, additional, Setua, Saini, additional, Chomont, Nicolas, additional, Phanuphak, Nittaya, additional, Ananworanich, Jintanat, additional, Hsu, Denise, additional, Vasan, Sandhya, additional, Michael, Nelson L., additional, Eller, Leigh Anne, additional, Tovanabutra, Sodsai, additional, Tagaya, Yutaka, additional, Robb, Merlin L., additional, Polonis, Victoria R., additional, and Song, Hongshuo, additional

Published
2023
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24. Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Author

Barrows, Brittani M., primary, Krebs, Shelly J., additional, Jian, Ningbo, additional, Zemil, Michelle, additional, Slike, Bonnie M., additional, Dussupt, Vincent, additional, Tran, Ursula, additional, Mendez-Rivera, Letzibeth, additional, Chang, David, additional, O’Sullivan, Anne Marie, additional, Mann, Brendan, additional, Sanders-Buell, Eric, additional, Shubin, Zhanna, additional, Creegan, Matt, additional, Paquin-Proulx, Dominic, additional, Ehrenberg, Philip, additional, Laurence-Chenine, Agnes, additional, Srithanaviboonchai, Kriengkrai, additional, Thomas, Rasmi, additional, Eller, Michael A., additional, Ferrari, Guido, additional, Robb, Merlin, additional, Rao, Venigalla, additional, Tovanabutra, Sodsai, additional, Polonis, Victoria R., additional, and Wieczorek, Lindsay, additional

Published
2022
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25. Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

Author

Marichannegowda, Manukumar Honnayakanahalli, Zemil, Michelle, Wieczorek, Lindsay, Sanders-Buell, Eric, Bose, Meera, O’Sullivan, Anne Marie, King, David, Francisco, Leilani, Diaz-Mendez, Felisa, Setua, Saini, Chomont, Nicolas, Phanuphak, Nittaya, Ananworanich, Jintanat, Hsu, Denise, Vasan, Sandhya, Michael, Nelson L., Eller, Leigh Anne, Tovanabutra, Sodsai, Tagaya, Yutaka, Robb, Merlin L., Polonis, Victoria R., and Song, Hongshuo

Subjects
Article
Abstract

The CCR5 (R5) to CXCR4 (X4) coreceptor switch in natural HIV-1 infection is associated with faster progression to AIDS, but the underlying mechanisms remain unclear. The difficulty in capturing the earliest moment of coreceptor switchin vivolimits our understanding of this phenomenon. Here, by tracking the evolution of the transmitted/founder (T/F) HIV-1 in a prospective cohort of individuals at risk for HIV-1 infection identified very early in acute infection, we investigated this process with high resolution. The earliest X4 variants evolved from the R5 tropic T/F strains. Strong X4 usage can be conferred by a single mutation. The mutations responsible for coreceptor switch can confer escape to neutralization and drive X4 variants to replicate mainly in the central memory and naïve CD4+ T cells. We propose a novel concept to explain the co-evolution of virus antigenicity and entry tropism termed “escape by shifting”. This concept posits that for viruses with receptor or coreceptor flexibility, entry tropism alteration represents a mechanism of immune evasionin vivo.

Published
2023

26. Retention of a cohort of men who have sex with men and transgender women at risk for and living with HIV in Abuja and Lagos, Nigeria: a longitudinal analysis

Author

Kayode, Blessing O., Mitchell, Andrew, Ndembi, Nicaise, Kokogho, Afoke, Ramadhani, Habib O., Adebajo, Sylvia, Robb, Merlin L., Baral, Stefan D., Ake, Julie A., Charurat, Manhattan E., Crowell, Trevor A., Nowak, Rebecca G., Ake, Julie, Abayomi, Aka, Baral, Stefan, Crowell, Trevor, Gaydos, Charlotte, Malia, Jennifer, Makanjuola, Olumide, Michael, Nelson, Nowak, Rebecca, Olawore, Oluwasolape, Parker, Zahra, Peel, Sheila, Ramadhani, Habib, Robb, Merlin, Rodriguez?Hart, Cristina, Sanders?Buell, Eric, Shoyemi, Elizabeth, Tovanabutra, Sodsai, and Vasan, Sandhya

Subjects
Transgender people -- Health aspects, MSM (Men who have sex with men) -- Health aspects, Health behavior -- Evaluation, HIV infection -- Diagnosis -- Care and treatment, Health
Abstract

: Introduction: Men who have sex with men (MSM), and transgender women (TGW), face specific obstacles to retention in care, particularly in settings with stigmatization such as sub‐Saharan Africa. We evaluated the impacts of HIV status and other factors on loss‐to‐follow‐up (LTFU) and visit adherence among MSM and TGW in Abuja and Lagos, Nigeria. Methods: TRUST/RV368 is an open cohort that provides comprehensive and integrated prevention and treatment services for HIV and sexually transmitted infections (STIs) at community venues supportive of sexual and gender minorities. Recruitment began in March 2013 and participants were followed every three months for up to 18 months. LTFU was defined as not presenting for an expected visit in the past 180 days. Visit adherence was calculated as a rate of completed visits adjusted by the number of three‐month intervals elapsed since enrolment. HIV and other factors predictive of LTFU and visit adherence were evaluated using Cox proportional hazards and Poisson regression models, respectively. Results: A total of 1447 participants who completed enrolment evaluations over two visits as of November 2018 were included in these analyses. Their median age was 24 years (interquartile range [IQR]: 21 to 28) and 53% (n = 766) were living with HIV. LTFU occurred in 56% (n = 808) and visit adherence was 0.62 (95% confidence interval: 0.61 to 0.64) visits per three‐month interval. Participants at risk and living with HIV had median follow‐up times of 12 months (IQR: 6 to 22), and 21 months (IQR: 12 to 30), respectively (p < 0.01). After controlling for other factors, LTFU was less common among participants living with HIV or other STIs and more common among those who did not own a cell phone, sold sex and had never undergone HIV testing prior to enrolment. These factors had parallel associations with visit adherence. Conclusions: Retention was suboptimal in Nigerian clinics designed to serve MSM and TGW. Particularly high LTFU and low visit adherence among participants at risk for HIV could complicate deployment of HIV prevention interventions. Marketing the benefits of testing, improving access to cell phones and nurturing more trust with clients may improve retention among marginalized communities in Nigeria., INTRODUCTION Retention of people at risk for and living with HIV (PLWH) in evidence‐based programmes has its challenges in countries across sub‐Saharan Africa where loss to follow‐up (LTFU) estimates range [...]

Published
2020
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28. Transmission dynamics among participants initiating antiretroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand

Author

Kroon, Eugène, Pham, Phuc T., Sirivichayakul, Sunee, Trichavaroj, Rapee, Colby, Donn J., Pinyakorn, Suteeraporn, Phanuphak, Nittaya, Sanders-Buell, Eric, van Griensven, Frits, Kijak, Gustavo H., Kim, Jerome H., Michael, Nelson L., Robb, Merlin L., Ananworanich, Jintanat, De Souza, Mark S., and Tovanabutra, Sodsai

Published
2018
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29. Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand

Author

Robb, Merlin L., Eller, Leigh A., Kibuuka, Hannah, Rono, Kathleen, Maganga, Lucas, Nitayaphan, Sorachai, Kroon, Eugene, Sawe, Fred K., Sinei, Samuel, Sriplienchan, Somchai, Jagodzinski, Linda L., Malia, Jennifer, Manak, Mark, de Souza, Mark S., Tovanabutra, Sodsai, Sanders-Buell, Eric, Rolland, Morgane, Dorsey-Spitz, Julie, Eller, Michael A., Milazzo, Mark, Li, Qun, Lewandowski, Andrew, Wu, Hao, Swann, Edith, OʼConnell, Robert J., Peel, Sheila, Dawson, Peter, Kim, Jerome H., and Michael, Nelson L.

Published
2016
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31. Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials

Author

Montefiori, David C., Karnasuta, Chitraporn, Huang, Ying, Ahmed, Hasan, Gilbert, Peter, de Souza, Mark S., McLinden, Robert, Tovanabutra, Sodsai, Laurence-Chenine, Agnes, Sanders-Buell, Eric, Moody, M. Anthony, Bonsignori, Mattia, Ochsenbauer, Christina, Kappes, John, Tang, Haili, Greene, Kelli, Gao, Hongmei, LaBranche, Celia C., Andrews, Charla, Polonis, Victoria R., Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Self, Steve G., Berman, Phillip W., Francis, Donald, Sinangil, Faruk, Lee, Carter, Tartaglia, Jim, Robb, Merlin L., Haynes, Barton F., Michael, Nelson L., and Kim, Jerome H.

Published
2012
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32. HIV-1 infections with multiple founders associate with the development of neutralization breadth

Author

Lewitus, Eric, primary, Townsley, Samantha M., additional, Li, Yifan, additional, Donofrio, Gina C., additional, Dearlove, Bethany L., additional, Bai, Hongjun, additional, Sanders-Buell, Eric, additional, O’Sullivan, Anne Marie, additional, Bose, Meera, additional, Kibuuka, Hannah, additional, Maganga, Lucas, additional, Nitayaphan, Sorachai, additional, Sawe, Fredrick K., additional, Eller, Leigh Anne, additional, Michael, Nelson L., additional, Polonis, Victoria R., additional, Ake, Julie A., additional, Vasan, Sandhya, additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, Krebs, Shelly J., additional, and Rolland, Morgane, additional

Published
2022
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33. Limited Evidence for a Relationship between HIV-1 Glycan Shield Features in Early Infection and the Development of Neutralization Breadth

Author

Li, Yifan, primary, Bai, Hongjun, additional, Sanders-Buell, Eric, additional, Dussupt, Vincent, additional, Townsley, Samantha, additional, Donofrio, Gina, additional, Bose, Meera, additional, O’Sullivan, Anne Marie, additional, Kibuuka, Hannah, additional, Maganga, Lucas, additional, Nitayaphan, Sorachai, additional, Kosgei, Josphat, additional, Pitisuttithum, Punnee, additional, Rerks-Ngarm, Supachai, additional, Eller, Leigh Anne, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Ake, Julie, additional, Vasan, Sandhya, additional, Tovanabutra, Sodsai, additional, Krebs, Shelly J., additional, and Rolland, Morgane, additional

Published
2021
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34. RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection

Author

Lewitus, Eric, primary, Sanders-Buell, Eric, additional, Bose, Meera, additional, O’Sullivan, Anne Marie, additional, Poltavee, Kultida, additional, Li, Yifan, additional, Bai, Hongjun, additional, Mdluli, Thembi, additional, Donofrio, Gina, additional, Slike, Bonnie, additional, Zhao, Hong, additional, Wong, Kim, additional, Chen, Lennie, additional, Miller, Shana, additional, Lee, Jenica, additional, Ahani, Bahar, additional, Lepore, Steven, additional, Muhammad, Sevan, additional, Grande, Rebecca, additional, Tran, Ursula, additional, Dussupt, Vincent, additional, Mendez-Rivera, Letzibeth, additional, Nitayaphan, Sorachai, additional, Kaewkungwal, Jaranit, additional, Pitisuttithum, Punnee, additional, Rerks-Ngarm, Supachai, additional, O’Connell, Robert J, additional, Janes, Holly, additional, Gilbert, Peter B, additional, Gramzinski, Robert, additional, Vasan, Sandhya, additional, Robb, Merlin L, additional, Michael, Nelson L, additional, Krebs, Shelly J, additional, Herbeck, Joshua T, additional, Edlefsen, Paul T, additional, Mullins, James I, additional, Kim, Jerome H, additional, Tovanabutra, Sodsai, additional, and Rolland, Morgane, additional

Published
2021
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35. Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses

Author

Mdluli, Thembi, primary, Jian, Ningbo, additional, Slike, Bonnie, additional, Paquin-Proulx, Dominic, additional, Donofrio, Gina, additional, Alrubayyi, Aljawharah, additional, Gift, Syna, additional, Grande, Rebecca, additional, Bryson, Mary, additional, Lee, Anna, additional, Dussupt, Vincent, additional, Mendez-Rivera, Letzibeth, additional, Sanders-Buell, Eric, additional, Chenine, Agnès-Laurence, additional, Tran, Ursula, additional, Li, Yifan, additional, Brown, Eric, additional, Edlefsen, Paul T., additional, O’Connell, Robert, additional, Gilbert, Peter, additional, Nitayaphan, Sorachai, additional, Pitisuttihum, Punnee, additional, Rerks-Ngarm, Supachai, additional, Robb, Merlin L., additional, Gramzinski, Robert, additional, Alter, Galit, additional, Tovanabutra, Sodsai, additional, Georgiev, Ivelin S., additional, Ackerman, Margaret E., additional, Polonis, Victoria R., additional, Vasan, Sandhya, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Eller, Michael A., additional, Krebs, Shelly J., additional, and Rolland, Morgane, additional

Published
2021
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36. RV144 HIV-1 vaccination impacts post-infection antibody responses

Author

Mdluli, Thembi, primary, Jian, Ningbo, additional, Slike, Bonnie, additional, Paquin-Proulx, Dominic, additional, Donofrio, Gina, additional, Alrubayyi, Aljawharah, additional, Gift, Syna, additional, Grande, Rebecca, additional, Bryson, Mary, additional, Lee, Anna, additional, Dussupt, Vincent, additional, Mendez-Riveria, Letzibeth, additional, Sanders-Buell, Eric, additional, Chenine, Agnès-Laurence, additional, Tran, Ursula, additional, Li, Yifan, additional, Brown, Eric, additional, Edlefsen, Paul T., additional, O’Connell, Robert, additional, Gilbert, Peter, additional, Nitayaphan, Sorachai, additional, Pitisuttihum, Punnee, additional, Rerks-Ngarm, Supachai, additional, Robb, Merlin L., additional, Gramzinski, Robert, additional, Alter, Galit, additional, Tovanabutra, Sodsai, additional, Georgiev, Ivelin S., additional, Ackerman, Margaret E., additional, Polonis, Victoria R., additional, Vasan, Sandhya, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Eller, Michael A., additional, Krebs, Shelly J., additional, and Rolland, Morgane, additional

Published
2020
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37. Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria

Author

Nowak, Rebecca G., primary, Schumaker, Lisa M., additional, Ambulos, Nicholas P., additional, Ndembi, Nicaise, additional, Dauda, Wuese, additional, Nnaji, Chinedu H., additional, Mitchell, Andrew, additional, Mathias, Trevor J., additional, Jibrin, Paul, additional, Darragh, Teresa M., additional, Olaomi, Oluwole, additional, Crowell, Trevor A., additional, Baral, Stefan D., additional, Charurat, Manhattan E., additional, Bentzen, Søren M., additional, Palefsky, Joel M., additional, Cullen, Kevin J., additional, Charurat, Manhattan, additional, Ake, Julie, additional, Abayomi, Aka, additional, Adebajo, Sylvia, additional, Baral, Stefan, additional, Crowell, Trevor, additional, Gaydos, Charlotte, additional, Ketende, Sosthenes, additional, Kokogho, Afoke, additional, Malia, Jennifer, additional, Makanjuola, Olumide, additional, Michael, Nelson, additional, Ndemb, Nicaise, additional, Nowak, Rebecca, additional, Olawore, Oluwasolape, additional, Parker, Zahra, additional, Peel, Sheila, additional, Ramadhani, Habib, additional, Robb, Merlin, additional, Rodriguez-Hart, Cristina, additional, Sanders-Buell, Eric, additional, Shoyemi, Elizabeth, additional, Tovanabutra, Sodsai, additional, and Vasan, Sandhya, additional

Published
2020
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39. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Author

Rolland, Morgane, Edlefsen, Paul T., Larsen, Brendan B., Tovanabutra, Sodsai, Sanders-Buell, Eric, Hertz, Tomer, deCamp, Allan C., Carrico, Chris, Menis, Sergey, Magaret, Craig A., Ahmed, Hasan, Juraska, Michal, Chen, Lennie, Konopa, Philip, Nariya, Snehal, Stoddard, Julia N., Wong, Kim, Zhao, Hong, Deng, Wenjie, Maust, Brandon S., Bose, Meera, Howell, Shana, Bates, Adam, Lazzaro, Michelle, O’Sullivan, Annemarie, Lei, Esther, Bradfield, Andrea, Ibitamuno, Grace, Assawadarachai, Vatcharain, O’Connell, Robert J., deSouza, Mark S., Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Robb, Merlin L., McLellan, Jason S., Georgiev, Ivelin, Kwong, Peter D., Carlson, Jonathan M., Michael, Nelson L., Schief, William R., Gilbert, Peter B., Mullins, James I., and Kim, Jerome H.

Published
2012
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40. Transfusion-transmissible viral infections among US military recipients of whole blood and platelets during Operation Enduring Freedom and Operation Iraqi Freedom

Author

Hakre, Shilpa, Peel, Sheila A., OʼConnell, Robert J., Sanders-Buell, Eric E., Jagodzinski, Linda L., Eggleston, John C., Myles, Otha, Waterman, Paige E., McBride, Richard H., Eader, Scott A., Davis, Kenneth W., Rentas, Francisco J., Sateren, Warren B., Naito, Neal A., Tobler, Steven K., Tovanabutra, Sodsai, Petruccelli, Bruno P., McCutchan, Francine E., Michael, Nelson L., Cersovsky, Steven B., and Scott, Paul T.

Published
2011
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41. Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

Author

Song, Hongshuo, primary, Bose, Meera, additional, Pinyakorn, Suteeraporn, additional, Sanders-Buell, Eric, additional, O’Sullivan, Anne Marie, additional, Silas, Daniel, additional, Trichavaroj, Rapee, additional, Nuntapinit, Bessara, additional, Pham, Phuc T, additional, Akapirat, Siriwat, additional, Kroon, Eugène, additional, de Souza, Mark, additional, Gramzinski, Robert, additional, Michael, Nelson L, additional, Robb, Merlin L, additional, Vasan, Sandhya, additional, Tovanabutra, Sodsai, additional, and Ananworanich, Jintanat, additional

Published
2020
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42. Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand

Author

Wieczorek, Lindsay, primary, Peachman, Kristina, additional, Adams, Daniel J., additional, Barrows, Brittani, additional, Molnar, Sebastian, additional, Schoen, Jesse, additional, Dawson, Peter, additional, Bryant, Chris, additional, Chenine, Agnès-Laurence, additional, Sanders-Buell, Eric, additional, Srithanaviboonchai, Kriengkrai, additional, Pathipvanich, Panita, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, Rao, Mangala, additional, and Polonis, Victoria R., additional

Published
2020
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43. Subtype C/CRF01_AE recombinant HIV-1 found in Thailand

Author

Watanaveeradej, Veerachai, deSouza, Mark S, Benenson, Michael W, Sirisopana, Narongrid, Nitayaphan, Sorachai, Chanbancherd, Penprapa, Brown, Arthur E, Sanders-Buell, Eric, Birx, Deborah L, McCutchan, Francine E, and Carr, Jean K

Published
2003

45. First CRF01_AE/B recombinant of HIV-1 is found in Thailand

Author

Tovanabutra, Sodsai, Polonis, Victoria, De Souza, Mark, Trichavaroj, Rapee, Chanbancherd, Penprapa, Kim, Bohye, Sanders-Buell, Eric, Nitayaphan, Sorachai, Brown, Arthur, Robb, Merlin R., Birx, Deborah L., McCutchan, Francine E., and Carr, Jean K.

Published
2001

47. Correction: Trinh, H.V., et al. Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort. Cells 2019, 8, 365

Author

Trinh, Hung V., primary, Gohain, Neelakshi, additional, Pham, Peter T., additional, Hamlin, Christopher, additional, Song, Hongshuo, additional, Sanders-Buell, Eric, additional, Bose, Meera, additional, Eller, Leigh A., additional, Jain, Swati, additional, Uritskiy, Gherman, additional, Rao, Venigalla B., additional, Tovanabutra, Sodsai, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Joyce, M. Gordon, additional, and Rao, Mangala, additional

Published
2019
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48. HIV-1 genetic diversity and demographic characteristics in Bulgaria

Author

Billings, Erik, primary, Heipertz, Richard A., additional, Varleva, Tonka, additional, Sanders-Buell, Eric, additional, O'Sullivan, Anne Marie, additional, Bose, Meera, additional, Howell, Shana, additional, Kijak, Gustavo H., additional, Taskov, Hristo, additional, Elenkov, Ivailo, additional, Nenova, Marina, additional, Popivanova, Nedialka, additional, Valenzuela, Aimee Bolen, additional, Myles, Otha, additional, Bautista, Christian T., additional, Robb, Merlin L., additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Scott, Paul T., additional, Tovanabutra, Sodsai, additional, and Ake, Julie A., additional

Published
2019
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49. Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

Author

Crowell, Trevor A, primary, Colby, Donn J, additional, Pinyakorn, Suteeraporn, additional, Sacdalan, Carlo, additional, Pagliuzza, Amélie, additional, Intasan, Jintana, additional, Benjapornpong, Khunthalee, additional, Tangnaree, Kamonkan, additional, Chomchey, Nitiya, additional, Kroon, Eugène, additional, de Souza, Mark S, additional, Tovanabutra, Sodsai, additional, Rolland, Morgane, additional, Eller, Michael A, additional, Paquin-Proulx, Dominic, additional, Bolton, Diane L, additional, Tokarev, Andrey, additional, Thomas, Rasmi, additional, Takata, Hiroshi, additional, Trautmann, Lydie, additional, Krebs, Shelly J, additional, Modjarrad, Kayvon, additional, McDermott, Adrian B, additional, Bailer, Robert T, additional, Doria-Rose, Nicole, additional, Patel, Bijal, additional, Gorelick, Robert J, additional, Fullmer, Brandie A, additional, Schuetz, Alexandra, additional, Grandin, Pornsuk V, additional, O'Connell, Robert J, additional, Ledgerwood, Julie E, additional, Graham, Barney S, additional, Tressler, Randall, additional, Mascola, John R, additional, Chomont, Nicolas, additional, Michael, Nelson L, additional, Robb, Merlin L, additional, Phanuphak, Nittaya, additional, Ananworanich, Jintanat, additional, Ake, Julie A., additional, Akapirat, Siriwat, additional, Bose, Meera, additional, Cale, Evan, additional, Chan, Phillip, additional, Chanthaburanun, Sararut, additional, Churikanont, Nampueng, additional, Dawson, Peter, additional, Dumrongpisutikul, Netsiri, additional, Getchalarat, Saowanit, additional, Jongrakthaitae, Surat, additional, Jongsakul, Krisada, additional, Lerdlum, Sukalaya, additional, Manasnayakorn, Sopark, additional, McCullough, Corinne, additional, Milazzo, Mark, additional, Nuntapinit, Bessara, additional, On, Kier, additional, Ouellette, Madelaine, additional, Phanuphak, Praphan, additional, Sanders-Buell, Eric, additional, Sangnoi, Nongluck, additional, Shangguan, Shida, additional, Sirivichayakul, Sunee, additional, Tragonlugsana, Nipattra, additional, Trichavaroj, Rapee, additional, Ubolyam, Sasiwimol, additional, Vasan, Sandhya, additional, Wattanaboonyongcharoen, Phandee, additional, and Yamchuenpong, Thipvadee, additional

Published
2019
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50. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Author

Krebs, Shelly J., primary, Kwon, Young D., additional, Schramm, Chaim A., additional, Law, William H., additional, Donofrio, Gina, additional, Zhou, Kenneth H., additional, Gift, Syna, additional, Dussupt, Vincent, additional, Georgiev, Ivelin S., additional, Schätzle, Sebastian, additional, McDaniel, Jonathan R., additional, Lai, Yen-Ting, additional, Sastry, Mallika, additional, Zhang, Baoshan, additional, Jarosinski, Marissa C., additional, Ransier, Amy, additional, Chenine, Agnes L., additional, Asokan, Mangaiarkarasi, additional, Bailer, Robert T., additional, Bose, Meera, additional, Cagigi, Alberto, additional, Cale, Evan M., additional, Chuang, Gwo-Yu, additional, Darko, Samuel, additional, Driscoll, Jefferson I., additional, Druz, Aliaksandr, additional, Gorman, Jason, additional, Laboune, Farida, additional, Louder, Mark K., additional, McKee, Krisha, additional, Mendez, Letzibeth, additional, Moody, M. Anthony, additional, O’Sullivan, Anne Marie, additional, Owen, Christopher, additional, Peng, Dongjun, additional, Rawi, Reda, additional, Sanders-Buell, Eric, additional, Shen, Chen-Hsiang, additional, Shiakolas, Andrea R., additional, Stephens, Tyler, additional, Tsybovsky, Yaroslav, additional, Tucker, Courtney, additional, Verardi, Raffaello, additional, Wang, Keyun, additional, Zhou, Jing, additional, Zhou, Tongqing, additional, Georgiou, George, additional, Alam, S. Munir, additional, Haynes, Barton F., additional, Rolland, Morgane, additional, Matyas, Gary R., additional, Polonis, Victoria R., additional, McDermott, Adrian B., additional, Douek, Daniel C., additional, Shapiro, Lawrence, additional, Tovanabutra, Sodsai, additional, Michael, Nelson L., additional, Mascola, John R., additional, Robb, Merlin L., additional, Kwong, Peter D., additional, and Doria-Rose, Nicole A., additional

Published
2019
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