1. Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection
- Author
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Sandler, Netanya G, Zhang, Xinyan, Bosch, Ronald J, Funderburg, Nicholas T, Choi, Andrew I, Robinson, Janet K, Fine, Derek M, Coombs, Robert W, Jacobson, Jeffrey M, Landay, Alan L, Douek, Daniel C, Tressler, Randall, Read, Sarah W, Wilson, Cara C, Deeks, Steven G, Lederman, Michael M, Gandhi, Rajesh T, Tiu, Jennifer, Janik, Jennifer, Ebiasah, Ruth, Sise, Thucuma, Morse, Gene, Bishopric, George, Klebert, Michael, Borowski, LuAnn, Harding, Paul, Gonzalez, Amy, Tracy, Russell, Claggett, Brian, Alvarez, Alicarmen, James, Tamara, Walton, Patricia, Allen, Kristen, Daar, Eric, Lopez, Ruben, Tebas, Pablo, Thomas, Aleshia, Sbrolla, Amy, Flynn, Teri, Whitely, Kim, Davis, Traci, McGregor, Donna, Taiwo, Babafemi, Hurley, Christine, Lake, Jordan, Luetkemeyer, Annie, Smith, Anna, Fichtenbaum, Carl J, Stockton, Jan M, Griesmer, Kristine, Ray, Graham, Bolivar, Hector H, Fischl, Margaret A, Adams, Mary, Klebert, Michael K, and Royal, Michael
- Subjects
HIV/AIDS ,Cardiovascular ,Infectious Diseases ,Clinical Research ,Heart Disease ,Atherosclerosis ,Evaluation of treatments and therapeutic interventions ,2.1 Biological and endogenous factors ,6.1 Pharmaceuticals ,Aetiology ,Infection ,Good Health and Well Being ,Adult ,Bacterial Translocation ,Cardiovascular Agents ,Cardiovascular Diseases ,Cholesterol ,LDL ,HIV Infections ,Humans ,Lipopolysaccharide Receptors ,Lipopolysaccharides ,Lipoproteins ,LDL ,Male ,Middle Aged ,Polyamines ,Sevelamer ,Thromboplastin ,Treatment Outcome ,Young Adult ,HIV ,sevelamer ,microbial translocation ,LPS ,sCD14 ,soluble tissue factor ,LDL ,oxLDL ,AIDS Clinical Trials Group A5296 Team ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
UnlabelledAbnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial translocation, inflammation, or T-cell activation. During sevelamer treatment, however, levels of soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, whereas D-dimer levels increased. Thus, in this study population, sevelamer did not reduce microbial translocation but may have yielded cardiovascular benefits.Clinical trials registrationNCT 01543958.
- Published
- 2014