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1. Predicting the baryon asymmetry with degenerate right-handed neutrinos

Author

Sandner, S., Hernandez, P., Lopez-Pavon, J., and Rius, N.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We consider the generation of a baryon asymmetry in an extension of the Standard Model with two singlet Majorana fermions that are degenerate above the electroweak phase transition. The model can explain neutrino masses as well as the observed matter-antimatter asymmetry, for masses of the heavy singlets below the electroweak scale. The only physical CP violating phases in the model are those in the PMNS mixing matrix, i.e. the Dirac phase and a Majorana phase that enter light neutrino observables. We present an accurate analytic approximation for the baryon asymmetry in terms of CP flavour invariants, and derive the correlations with neutrino observables. We demonstrate that the measurement of CP violation in neutrino oscillations as well as the mixings of the heavy neutral leptons with the electron, muon and tau flavours suffice to pin down the matter-antimatter asymmetry from laboratory measurements., Comment: 28 + 4 pages, 8 figures

Published
2023

2. Feebly Interacting Particles: FIPs 2022 workshop report

Author

Antel, C., Battaglieri, M., Beacham, J., Boehm, C., Buchmüller, O., Calore, F., Carenza, P., Chauhan, B., Cladè, P., Coloma, P., Crivelli, P., Dandoy, V., Darmé, L., Dey, B., Deppisch, F. F., De Roeck, A., Drewes, M., Echenard, B., Flambaum, V. V., Foldenauer, P., Gatti, C., Giannotti, M., Golutvin, A., Gonzalez-Garcia, M. C., Gori, S., Goudzovski, E., Granelli, A., Grote, H., Guellati-Khelifa, S., Hajer, J., Harris, P., Hearty, C., Heuchel, D., Hostert, M., Junius, S., Kahlhoefer, F., Klaric, J., Kling, F., Klose, P., Knolle, J., Kopp, J., Kwon, O., Lantwin, O., Lanfranchi, G., Li, L., Lindner, A., Lopez-Pavon, J., Marocco, J., Martin, J. W., Middleton, S., Milstead, S., Oceano, I., O'Hare, C. A. J., Paoloni, A., Pascoli, S., Petcov, S. T., Pospelov, M., Pöttgen, R., Raggi, M., Ripellino, G., Samsonov, I. B., Sandner, S., Söldner-Rembold, S., Shelton, J., Song, N., Sun, C., Stadnik, Y. V., Tastet, J. L., Toro, N., Tran, N., Trevisani, N., Ulmer, S., Urrea, S., Velghe, B., Wallisch, B., Wong, Y. Y. Y., Zorbilmez, C., and Zurek, K.

Subjects
High Energy Physics - Phenomenology
Abstract

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs., Comment: 383 pp, 176 figures

Published
2023

3. Feebly-Interacting Particles: FIPs 2022 Workshop Report

Author

Antel, C., primary, Battaglieri, M., additional, Beacham, J., additional, Boehm, C., additional, Buchmüller, O., additional, Calore, F., additional, Carenza, P., additional, Chauhan, B., additional, Cladè, P., additional, Coloma, P., additional, Crivelli, P., additional, Dandoy, V., additional, Darmé, L., additional, Dey, B., additional, Deppisch, F. F., additional, De Roeck, A., additional, Drewes, M., additional, Echenard, B., additional, Flambaum, V. V., additional, Foldenauer, P., additional, Gatti, C., additional, Giannotti, M., additional, Golutvin, A., additional, Gonzalez-Garcia, M. C., additional, Gori, S., additional, Goudzovski, E., additional, Granelli, A., additional, Grote, H., additional, Guellati-Khelifa, S., additional, Hajer, J., additional, Harris, P., additional, Hearty, C., additional, Heuchel, D., additional, Hostert, M., additional, Junius, S., additional, Kahlhoefer, F., additional, Klaric, J., additional, Kling, F., additional, Klose, P., additional, Knolle, J., additional, Kopp, J., additional, Kwon, O., additional, Lantwin, O., additional, Lanfranchi, G., additional, Li, L., additional, Lindner, A., additional, Lopez-Pavon, J., additional, Marocco, J., additional, Martin, J. W., additional, Middleton, S., additional, Milstead, S., additional, Oceano, I., additional, O’Hare, C. A. J., additional, Paoloni, A., additional, Pascoli, S., additional, Petcov, S. T., additional, Pospelov, M., additional, Pöttgen, R., additional, Raggi, M., additional, Ripellino, G., additional, Samsonov, I. B., additional, Sandner, S., additional, Söldner-Rembold, S., additional, Shelton, J., additional, Song, N., additional, Sun, C., additional, Stadnik, Y. V., additional, Tastet, J.-L., additional, Toro, N., additional, Tran, N., additional, Trevisani, N., additional, Ulmer, S., additional, Urrea, S., additional, Velghe, B., additional, Wallisch, B., additional, Wong, Y. Y. Y., additional, Zorbilmez, C., additional, and Zurek, K., additional

Published
2023
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6. Expert systematic review on the choice of conduits for coronary artery bypass grafting: endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and The Society of Thoracic Surgeons (STS).

Author

Gaudino, M, Bakaeen, FG, Sandner, S, Aldea, GS, Arai, H, Chikwe, J, Firestone, S, Fremes, SE, Gomes, WJ, Bong-Kim, K, Kisson, K, Kurlansky, P, Lawton, J, Navia, D, Puskas, JD, Ruel, M, Sabik, JF, Schwann, TA, Taggart, DP, Tatoulis, J, Wyler von Ballmoos, M, Gaudino, M, Bakaeen, FG, Sandner, S, Aldea, GS, Arai, H, Chikwe, J, Firestone, S, Fremes, SE, Gomes, WJ, Bong-Kim, K, Kisson, K, Kurlansky, P, Lawton, J, Navia, D, Puskas, JD, Ruel, M, Sabik, JF, Schwann, TA, Taggart, DP, Tatoulis, J, and Wyler von Ballmoos, M

Published
2023

7. Feebly-interacting particles: FIPs 2022 Workshop Report

Author

#NODATA#, Antel, C., Battaglieri, M., Beacham, J., Boehm, C., Buchmüller, O., Calore, F., Carenza, P., Chauhan, B., Cladè, P., Coloma, P., Crivelli, P., Dandoy, V., Darmé, L., Dey, B., Deppisch, F. F., De Roeck, A., Drewes, M., Echenard, B., Flambaum, V. V., Foldenauer, P., Gatti, C., Giannotti, M., Golutvin, A., Gonzalez-Garcia, M. C., Gori, S., Goudzovski, E., Granelli, A., Grote, H., Guellati-Khelifa, S., Hajer, J., Harris, P., Hearty, C., Heuchel, D., Hostert, M., Junius, S., Kahlhoefer, F., Klaric, J., Kling, F., Klose, P., Knolle, J., Kopp, J., Kwon, O., Lantwin, O., Lanfranchi, G., Li, L., Lindner, A., Lopez-Pavon, J., Marocco, J., Martin, J. W., Middleton, S., Milstead, S., Oceano, I., O’Hare, C. A.J., Paoloni, A., Pascoli, S., Petcov, S. T., Pospelov, M., Pöttgen, R., Raggi, M., Ripellino, G., Samsonov, I. B., Sandner, S., Söldner-Rembold, S., Shelton, J., Song, N., Sun, C., Stadnik, Y. V., Tastet, J. L., Toro, N., Tran, N., Trevisani, N., Ulmer, S., Urrea, S., Velghe, B., Wallisch, B., Wong, Y. Y.Y., Zorbilmez, C., Zurek, K., #NODATA#, Antel, C., Battaglieri, M., Beacham, J., Boehm, C., Buchmüller, O., Calore, F., Carenza, P., Chauhan, B., Cladè, P., Coloma, P., Crivelli, P., Dandoy, V., Darmé, L., Dey, B., Deppisch, F. F., De Roeck, A., Drewes, M., Echenard, B., Flambaum, V. V., Foldenauer, P., Gatti, C., Giannotti, M., Golutvin, A., Gonzalez-Garcia, M. C., Gori, S., Goudzovski, E., Granelli, A., Grote, H., Guellati-Khelifa, S., Hajer, J., Harris, P., Hearty, C., Heuchel, D., Hostert, M., Junius, S., Kahlhoefer, F., Klaric, J., Kling, F., Klose, P., Knolle, J., Kopp, J., Kwon, O., Lantwin, O., Lanfranchi, G., Li, L., Lindner, A., Lopez-Pavon, J., Marocco, J., Martin, J. W., Middleton, S., Milstead, S., Oceano, I., O’Hare, C. A.J., Paoloni, A., Pascoli, S., Petcov, S. T., Pospelov, M., Pöttgen, R., Raggi, M., Ripellino, G., Samsonov, I. B., Sandner, S., Söldner-Rembold, S., Shelton, J., Song, N., Sun, C., Stadnik, Y. V., Tastet, J. L., Toro, N., Tran, N., Trevisani, N., Ulmer, S., Urrea, S., Velghe, B., Wallisch, B., Wong, Y. Y.Y., Zorbilmez, C., and Zurek, K.

Abstract

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.

Published
2023

14. The association between coronary graft patency and clinical status in patients with coronary artery disease

Author

Gaudino, Mario Fulvio Luigi, Di Franco, A., Bhatt, D. L., Alexander, J. H., Abbate, A., Azzalini, L., Sandner, S., Sharma, G., Rao, S. V., Crea, Filippo, Fremes, S. E., Bangalore, S., Gaudino M. (ORCID:0000-0001-7529-438X), Crea F. (ORCID:0000-0001-9404-8846), Gaudino, Mario Fulvio Luigi, Di Franco, A., Bhatt, D. L., Alexander, J. H., Abbate, A., Azzalini, L., Sandner, S., Sharma, G., Rao, S. V., Crea, Filippo, Fremes, S. E., Bangalore, S., Gaudino M. (ORCID:0000-0001-7529-438X), and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

The concept of a direct association between coronary graft patency and clinical status is generally accepted. However, the relationship is more complex and variable than usually thought. Key issues are the lack of a common definition of graft occlusion and of a standardized imaging protocol for patients undergoing coronary bypass surgery. Factors like the type of graft, the timing of the occlusion, and the amount of myocardium at risk, as well as baseline patients' characteristics, modulate the patency-to-clinical status association. Available evidence suggests that graft occlusion is more often associated with non-fatal events rather than death. Also, graft failure due to competitive flow is generally a benign event, while graft occlusion in a graft-dependent circulation is associated with clinical symptoms. In this systematic review, we summarize the evidence on the association between graft status and clinical outcomes.

Published
2021

22. Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial

Author

Thuijs, D. J. F. M., Kappetein, A. P., Serruys, P. W., Mohr, F. -W., Morice, M. -C., Mack, M. J., Holmes, D. R., Curzen, N., Davierwala, P., Noack, T., Milojevic, M., Dawkins, K. D., da Costa, B. R., Juni, P., Head, S. J., Casselman, F., de Bruyne, B., Hoj Christiansen, E., Ruiz-Nodar, J. M., Vermeersch, P., Schultz, W., Sabatelli, Mario, Guagliumi, G., Grubitzsch, H., Stangl, K., Darremont, O., Bentala, M., den Heijer, P., Preda, I., Stoler, R., Szerafin, T., Buckner, J. K., Guber, M. S., Verberkmoes, N., Akca, F., Feldman, T., Beyersdorf, F., Drieghe, B., Oldroyd, K., Berger, Gerit, Jeppsson, A., Barber, K., Wolschleger, K., Heiser, J., van der Harst, P., Mariani, M. A., Reichenspurner, H., Stark, C., Laineri Milazzo, Marco, Ho, P. C., Chen, J. C., Zelman, R., Horwitz, P. A., Bochenek, A., Krauze, A., Grothusen, C., Dudek, D., Heyrich, G., Kolh, P., Legrand, V., Coelho, P., Ensminger, S., Nasseri, B., Ingemansson, R., Olivecrona, G., Escaned, J., Guera, R., Berti, S., Chieffo, A., Burke, N., Mooney, M., Spolaor, A., Hagl, C., Nabauer, M., Suttorp, M. J., Stine, R. A., Mcgarry, T., Lucas, S., Endresen, K., Taussig, A., Accola, K., Canosi, U., Horvath, I., Cannon, L., Talbott, J. D., Akins, C. W., Kramer, R., Aschermann, M., Killinger, W., Narbute, I., Burzotta, Francesco, Bogers, A., Zijlstra, F., Eltchaninoff, H., Berland, J., Stefanini, G., Cruz Gonzalez, I., Hoppe, U., Kiesz, S., Gora, B., Ahlsson, A., Corbascio, M., Bilfinger, T., Carrie, D., Tchetche, D., Hauptman, K. -E., Stahle, E., James, S., Sandner, S., Laufer, G., Lang, I., Witkowski, A., Thourani, V., Suryapranata, H., Redwood, S., Knight, C., Maccarthy, P., de Belder, A., Banning, A., Gershlick, A., Sabate M. (ORCID:0000-0001-6635-4985), Berg G., Laine M., Burzotta F. (ORCID:0000-0002-6569-9401), Thuijs, D. J. F. M., Kappetein, A. P., Serruys, P. W., Mohr, F. -W., Morice, M. -C., Mack, M. J., Holmes, D. R., Curzen, N., Davierwala, P., Noack, T., Milojevic, M., Dawkins, K. D., da Costa, B. R., Juni, P., Head, S. J., Casselman, F., de Bruyne, B., Hoj Christiansen, E., Ruiz-Nodar, J. M., Vermeersch, P., Schultz, W., Sabatelli, Mario, Guagliumi, G., Grubitzsch, H., Stangl, K., Darremont, O., Bentala, M., den Heijer, P., Preda, I., Stoler, R., Szerafin, T., Buckner, J. K., Guber, M. S., Verberkmoes, N., Akca, F., Feldman, T., Beyersdorf, F., Drieghe, B., Oldroyd, K., Berger, Gerit, Jeppsson, A., Barber, K., Wolschleger, K., Heiser, J., van der Harst, P., Mariani, M. A., Reichenspurner, H., Stark, C., Laineri Milazzo, Marco, Ho, P. C., Chen, J. C., Zelman, R., Horwitz, P. A., Bochenek, A., Krauze, A., Grothusen, C., Dudek, D., Heyrich, G., Kolh, P., Legrand, V., Coelho, P., Ensminger, S., Nasseri, B., Ingemansson, R., Olivecrona, G., Escaned, J., Guera, R., Berti, S., Chieffo, A., Burke, N., Mooney, M., Spolaor, A., Hagl, C., Nabauer, M., Suttorp, M. J., Stine, R. A., Mcgarry, T., Lucas, S., Endresen, K., Taussig, A., Accola, K., Canosi, U., Horvath, I., Cannon, L., Talbott, J. D., Akins, C. W., Kramer, R., Aschermann, M., Killinger, W., Narbute, I., Burzotta, Francesco, Bogers, A., Zijlstra, F., Eltchaninoff, H., Berland, J., Stefanini, G., Cruz Gonzalez, I., Hoppe, U., Kiesz, S., Gora, B., Ahlsson, A., Corbascio, M., Bilfinger, T., Carrie, D., Tchetche, D., Hauptman, K. -E., Stahle, E., James, S., Sandner, S., Laufer, G., Lang, I., Witkowski, A., Thourani, V., Suryapranata, H., Redwood, S., Knight, C., Maccarthy, P., de Belder, A., Banning, A., Gershlick, A., Sabate M. (ORCID:0000-0001-6635-4985), Berg G., Laine M., and Burzotta F. (ORCID:0000-0002-6569-9401)

Abstract

Background: The Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial was a non-inferiority trial that compared percutaneous coronary intervention (PCI) using first-generation paclitaxel-eluting stents with coronary artery bypass grafting (CABG) in patients with de-novo three-vessel and left main coronary artery disease, and reported results up to 5 years. We now report 10-year all-cause death results. Methods: The SYNTAX Extended Survival (SYNTAXES) study is an investigator-driven extension of follow-up of a multicentre, randomised controlled trial done in 85 hospitals across 18 North American and European countries. Patients with de-novo three-vessel and left main coronary artery disease were randomly assigned (1:1) to the PCI group or CABG group. Patients with a history of PCI or CABG, acute myocardial infarction, or an indication for concomitant cardiac surgery were excluded. The primary endpoint of the SYNTAXES study was 10-year all-cause death, which was assessed according to the intention-to-treat principle. Prespecified subgroup analyses were performed according to the presence or absence of left main coronary artery disease and diabetes, and according to coronary complexity defined by core laboratory SYNTAX score tertiles. This study is registered with ClinicalTrials.gov, NCT03417050. Findings: From March, 2005, to April, 2007, 1800 patients were randomly assigned to the PCI (n=903) or CABG (n=897) group. Vital status information at 10 years was complete for 841 (93%) patients in the PCI group and 848 (95%) patients in the CABG group. At 10 years, 244 (27%) patients had died after PCI and 211 (24%) after CABG (hazard ratio 1·17 [95% CI 0·97–1·41], p=0·092). Among patients with three-vessel disease, 151 (28%) of 546 had died after PCI versus 113 (21%) of 549 after CABG (hazard ratio 1·41 [95% CI 1·10–1·80]), and among patients with left main coronary artery disease, 93 (26%) of 357 had died after PCI versus 98 (28%) of 348 after CABG (0·90 [0·68–

Published
2019

24. Transketolase-like 1 (TKTL1) Expression und Funktion in Primärkarzinomen des Kopf-Hals-Bereichs

Author

Hartmannsberger, D, Betz, C, Stepp, H, Mack, B, Gires, O, Maetzel, D, Denzel, S, and Sandner, S

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Das Enzym Transketolase-like 1 (TKTL1) nimmt eine zentrale Rolle im nicht-oxidativen Abschnitt des Pentosephosphatwegs ein. In Malignomen kann die Überexpression von TKTL1 Tumorzellen einen Selektionsvorteil vermitteln, da sie damit weitestgehend sauerstoffunabhängig wachsen können (Warburg-Effekt).[for full text, please go to the a.m. URL], 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2009
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