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A new drimane sesquiterpene 11-methoxyl-danilol (1) was obtained from endophytic fungus Nigrospora chinensis of Gannan navel orange pulp. Its structure was established to possess a natural rarely-occurring tricyclic acetal fused ring system by means of spectroscopic data analyses. Meanwhile, five known compounds danilol (2), redoxcitrinin (3), euphorbol (4), ergosta-7,24(24')-dien-3β-ol (5), and ergosta-4,6,8(14),22-tetraen-3-one (6) were also co-isolated in this fungus. The results of antibacterial and cytotoxic activity screenings showed that compound 5 displayed antibacterial activities against Staphylococcus aureus and MRSA (methicillin-resistant S. aureus) with MIC value of 50 μg/mL. [ABSTRACT FROM AUTHOR]

Koninginins X-Z (1–3), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus Trichoderma koningiopsis SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, 13C NMR, DFT GIAO 13C NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against Candida albicans. [ABSTRACT FROM AUTHOR]

Three new indole diketopiperazines, ochrolines A-C (1–3), along with three known compounds (4–6), were isolated and identified from the EtOAc extract of the solid fermentation of Bionectria ochroleuca SLJB-2. Notably, compound 1 featured a natural rarely-occurring caged skeleton with a 6/5/6/7 heterotetracyclic bridged ring system. The structures including absolute configurations of 1–3 were fully accomplished by extensive spectroscopic analyses, DFT GIAO 13C NMR and electronic circular dichroism (ECD) calculations. The plausible biogenetic pathways of these new indole diketopiperazines were also proposed. Moreover, the cytotoxic activity screening revealed that compound 2 exhibited moderate inhibitory effect against A549 with inhibition rate of 57.44% at the concentration of 50 μM and compound 1 exhibited mild inhibitory activities against A549, Hela and MCF-7. [Display omitted] [ABSTRACT FROM AUTHOR]