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16. List of Contributors

Author

Aguieiras, Erika C.G., primary, Ahluwalia, Vivek, additional, Amorim, Graziella M., additional, Ángeles Sanromán, Ma, additional, Barreto, Maysa S., additional, Barrios-González, Javier, additional, Binod, Parameswaran, additional, Bissoqui, Lucas, additional, Cammarota, Magali C., additional, Cavalcanti-Oliveira, Elisa D., additional, Chen, Hong-Zhang, additional, Costa, Jorge A.V., additional, da Silva, Roberto, additional, de Carvalho, Júlio C., additional, de Cassia Pereira, Josiani, additional, de Oliveira, Priscilla Z., additional, de Oliveira Mendes, Gilberto, additional, Destéfanis Vítola, Francisco M., additional, Farinas, Cristiane S., additional, Favela-Torres, Ernesto, additional, Ferreira da Costa, Eduardo S., additional, Figueroa-Montero, Arturo, additional, Fragoso dos Santos, Anderson, additional, Freire, Denise M.G., additional, Garg, Vinod Kumar, additional, Godoy, Mateus G., additional, Gomes, Eleni, additional, Junior Letti, Luiz A., additional, Kachrimanidou, Vasiliki, additional, Karp, Susan G., additional, Koutinas, Apostolis A., additional, Krishania, Meena, additional, Kumar, Vinod, additional, Ladino-Orjuela, Guillermo, additional, Liu, Yang, additional, Loera-Corral, Octavio, additional, Machado de Castro, Aline, additional, Martins, Vilásia G., additional, Méndez-González, Fernando, additional, Nampoothiri, Kesavan Madhavan, additional, Pandey, Ashok, additional, Pazos, Marta, additional, Pedroni Medeiros, Adriane B., additional, Rodrigues, Cristine, additional, Rodríguez-Couto, Susana, additional, Rodríguez-Fernández, Daniel E., additional, Rodríguez-León, Jose A., additional, Rosales-Zamora, Gabriel, additional, Rosales, Emilio, additional, Sangwan, Rajender Singh, additional, Santos, Lucielen O., additional, Saucedo-Castañeda, Gerardo, additional, Sharma, Kavita, additional, Sindhu, Raveendran, additional, Soccol, Carlos R., additional, Torres-Mancera, María T., additional, Treichel, Helen, additional, Vandenberghe, Luciana P.S., additional, Vassilev, Nikolay, additional, Vinícius de Melo Pereira, Gilberto, additional, and Wang, Lan, additional

Published
2018
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22. Preface

Author

Dubey, Suresh Kumar, primary, Pandey, Ashok, additional, and Sangwan, Rajender Singh, additional

Published
2017
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31. Neuro-protective potential of a vesicular system of a standardized extract of a new chemotype of Withania somnifera Dunal (NMITLI118RT+) against cerebral stroke in rats*

Author

Ahmad, Hafsa, Khandelwal, Kiran, Sheeba Saji Samuel, Shivangi Tripathi, Mitra, Kalyan, Sangwan, Rajender Singh, Shukla, Rakesh, and Dwivedi, Anil Kumar

Abstract

Withania somnifera Dunal is an Indian medicinal plant with significant pharmacological properties, such as adaptogenic, anti-inflammatory, anti-oxidant, anti-platelet, anti-hypertensive, hypoglycemic and hypolipidemic effects. Several chemotypes of W. somnifera include NMITLI-101, NMITLI-118 and NMITLI-128. The present work elaborates the optimization and development of a liposomal delivery system for efficient delivery of NMITLI118RT+ [a standardized ethanolic extract of a new chemotype of W. somnifera Dunal (NMITLI-118) roots] against cerebral stroke in rats. Liposomal systems were prepared using thin-film hydration method and characterized on the basis of size, zeta potential, physical stability, FT-IR, DSC-TGA analysis and surface morphological studies by TEM. NMITLI118RT+ and its formulations (NMITLI118RT+LF) were evaluated for biological activity utilizing middle cerebral artery occlusion model in rats. The Z average of the developed liposomal formulation was about 142.6 ± 0.09 nm with a zeta potential of −31.20 ± 1.0 mV. Results of TEM revealed spherical particles in the range of 200 nm. The entrapment efficiency was found to be 94.603 ± 2%. The formulation was found to be physically stable over a 3-week period. Results were suggestive of the fact that both NMITLI118RT+ and its delivery system possess significant neuroprotective activity in cerebral ischemia. The liposomal system largely exhibits better performance over NMITLI118RT+ precisely in the post-treatment group. The present studies could elucidate the successful development of a delivery system for NMITLI118RT+ and demonstrate their beneficial neuro-protective potential in overcoming and reversing the consequences of I/R injury following stroke.

Published
2021
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42. Berry transcriptome: insights into a novel resource to understand development dependent secondary metabolism in Withania somnifera (Ashwagandha).

Author

Tripathi, Sandhya, Sangwan, Rajender Singh, Mishra, Bhawana, Jadaun, Jyoti Singh, and Sangwan, Neelam Singh

Subjects
*SECONDARY metabolism, *BERRIES, *WITHANIA somnifera, *SERUM response factor, *MYB gene, *PLANT proteins, *TRANSCRIPTION factors, *MOLECULAR cloning
Abstract

Withania somnifera (Ashwagandha) is considered as Rasayana in Indian systems of medicine. This study reports a novel transcriptome of W. somnifera berries, with high depth, quality and coverage. Assembled and annotated transcripts for nearly all genes related with the withanolide biosynthetic pathway were obtained. Tissue‐wide gene expression analysis reflected almost similar definitions for the terpenoid pathway in leaf, root and berry tissues with relatively higher abundance of transcripts linked to steroid, phenylpropanoid metabolism as well as flavonoid metabolism in berries. The metabolome map generated from the data embodied transcripts from 143 metabolic pathways connected together and mediated collectively by about 1792 unique enzyme functions specific to berry, leaf and root tissues, respectively. Transcripts specific to cytochrome p450 (CYP450), methyltransferases and glycosyltransferases were distinctively located in a tissue specific manner and exhibited a complex network. Significant distribution of transcription factor genes such as MYB, early light inducible protein (ELI), minichromosome maintenance1, agamous, deficiens and serum response factor (MADS) and WRKY etc. was observed, as the major transcriptional regulators of secondary metabolism. Validation of the assembly was ascertained by cloning WsELI, which has a light dependent regulatory role in development. Quantitative expression of WsELI was observed to be considerably modulated upon exposure to abiotic stress and elicitors. Co‐relation of over‐expression of WsELI, may provide new aspects for the functional role of ELI proteins in plants linked to secondary metabolism. The study offers the first comprehensive and comparative evaluation of W. somnifera transcriptome data between the three tissues and across other members of Solanaceae (Nicotiana, Solanum and Capsicum) with respect to major pathways and their metabolome regulation. [ABSTRACT FROM AUTHOR]

Published
2020
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