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MENA isoform-driven taxane resistance affects progression through the cell cycle

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The active use of digital technology by older adults will directly promote active and healthy aging, which will have a positive effect not only on the older adults themselves but also on society in...

A 2 × 2 3-dB coupler is one of the essential photonic components, as a building block of Mach-Zehnder interferometers, to realize large-scale photonic integrated circuits. Unlike typical 2 × 2 3-dB couplers based on direction couplers or multimode interference couplers, adiabatic couplers offer various advantages such as broadband operation and superior fabrication tolerance thanks to their unique operating mechanism of adiabatic mode evolution. However, an adiabatic coupler typically requires a long device length for ideal adiabatic operation without the excitations of unwanted modes. Here, we report on a compact 2 × 2 3-dB adiabatic coupler designed using the shortest mode transformer method. By optimizing the profile of the waveguide widths and the gap spacing, the compact 3-dB coupler was designed with a short coupling length of 23.2 μm. The fabricated device exhibits a 3-dB splitting ratio with less than ± 0.3 dB power oscillation and a low excess loss of 0.23 dB over a broad wavelength range of 1485–1620 nm. To the best of our knowledge, our coupler has the shortest length among the adiabatic couplers with a minimum feature size of 200 nm, reported to date.

We have experimentally demonstrated feedforward and recirculating FPPGAs with MEMS-tunable elements. The static power of the elements is less than 50 nW, and energy required to change the state of the actuator is 8 pJ.

We propose and demonstrate an ultra-low-power 3×3 unitary matrix multiplier with MEMS-based tunable couplers and phase shifters. The static power consumption and tuning energy per tuning element are less than 0.13 µW and 115 pJ, respectively.

We report a supercontinuum generation (SCG) in a waveguide that spontaneously forms without an etching process during the deposition of a core material on a preformed ${\rm{Si}}{{\rm{O}}_2}$ substructure. The mechanism of dispersion control for this new, to the best of our knowledge, type of waveguide is analyzed by numerical simulation, which results in a design rule to achieve a target dispersion profile by adjusting the substructure geometry. SCG is experimentally demonstrated with a waveguide made of ${\rm{A}}{{\rm{s}}_2}{{\rm{S}}_3}$, chalcogenide glass, which has low material absorption over the mid-IR range. A dispersion-controlled waveguide with a length of 10 mm pumped with 77 pJ pulses at a telecommunication wavelength of 1560 nm resulted in a supercontinuum that extends by more than 1.5 octaves.

We report on a 32 × 32 silicon photonic micro-electro-mechanical-system (MEMS) switch with gap-adjustable directional couplers. The switch is fabricated on 200-mm silicon-on-insulator wafers in a commercial complementary metal-oxide-semiconductor (CMOS) foundry. The fabricated device has a maximum on-chip loss of 7.7 dB and an extinction ratio of 50.8 dB. The switching voltage is 9.45 V and the 20-dB bandwidth is 28.7 nm. Our work shows a promising path for mass production of silicon photonic MEMS switches in commercial CMOS foundries.

Four-dimensional (4D) films, which provide special physical effects to the audience with audiovisual stimuli, are gaining more popularity and acceptance. One of the most frequent 4D effects is the object-based motion effect, which refers to the vestibular stimulus generated by a motion chair to emphasize a moving object of interest, e.g., the flying iron man, displayed on the screen. In this paper, we present an algorithm for synthesizing convincing object-based motion effects automatically from a given object motion trajectory. While previous approaches use the 2D object position on the screen as input, our method takes the 3D position and orientation of the object in the camera space and computes its motion proxy that reflects both the object translation and rotation, as well as its size to the viewers' eyes. The proxy is determined based on the results of a perceptual experiment that presents an optimal additive rule of the translation and rotation information scaled by the object's visual size. The motion proxy is fed to a motion cueing algorithm (MCA) that computes the command using a washout filter or model predictive control. The most appropriate MCA for our purpose is selected from six candidates by a user study. We also consider the effects of visual perception by incorporating two types of motion field equations into the computation of the visually perceived velocity. The results of a user study indicate that our algorithm can generate compelling object-based motion effects that better enhance the 4D film viewing experience than the previous methods.

We report on a 16-core recirculating programmable photonic array based on MEMS-tunable directional couplers. The photonic array has a compact footprint (0.04mm2/cell) and negligible static power consumption. Waveguide-coupled single-ring resonators, CROWs, and add-drop filters are demonstrated.

We present a new device platform which defines on-chip chalcogenide waveguide/resonators without directly etching chalcogenide. Using our platform, we have demonstrated chalcogenide ring resonators with record high Q-factor exceeding 1.1x107 which is 10 times larger than previous record on on-chip chalcogenide resonators. A ring cavity is designed and fabricated for Stimulated Brillouin lasing on our platform. Thanks to the high-Q factor, Brillouin lasing with threshold power of 1 mW is demonstrated. This value is more than an order of magnitude improvement than previous world record for on-chip chalcogenide Brillouin lasers. We also developed an efficient and flexible method for resonator waveguide coupling with our device platform. Coupling between a resonator and a waveguide can be varied from under coupled region to over-coupled region.

Detection of single nanoparticles or molecules has often relied on fluorescent schemes. However, fluorescence detection approaches limit the range of investigable nanoparticles or molecules. Here, we propose and demonstrate a non-fluorescent nanoscopic trapping and monitoring platform that can trap a single sub-5-nm particle and monitor it with a pair of floating nonlinear point sources. The resonant photon funnelling into an extremely small volume of ~5 × 5 × 7 nm3 through the three-dimensionally tapered 5-nm-gap plasmonic nanoantenna enables the trapping of a 4-nm CdSe/ZnS quantum dot with low intensity of a 1560-nm continuous-wave laser, and the pumping of 1560-nm femtosecond laser pulses creates strong background-free second-harmonic point illumination sources at the two vertices of the nanoantenna. Under the stable trapping conditions, intermittent but intense nonlinear optical spikes are observed on top of the second-harmonic signal plateau, which is identified as the 3.0-Hz Kramers hopping of the quantum dot trapped in the 5-nm gap., Detection of single nanoparticles or molecules often relies on the attachment of fluorescent labels. Here, the authors demonstrate trapping a single nanoparticle on a bowtie nanoantenna and monitoring via second harmonic generation from the particle.

We report on 50 × 50 silicon photonic micro-electromechanical-system (MEMS) switches with reduced polarization dependence. The switches make use of two-level waveguide crossbars and MEMS-actuated adiabatic couplers. Simulations indicate that by eliminating all polarization-dependent elements (e.g., waveguide crossings), low polarization-dependent losses (

To efficiently access light waves confined in a high-quality-factor (Q) microcavity over a wide spectral range, it is necessary to independently control coupling efficiency at different wavelengths. Here we suggest an approach to add a degree of freedom to control the coupling efficiency based on a two-point coupling geometry. By changing the phase difference between two paths connecting two coupling points, various combinations of coupling efficiencies at multiple wavelengths can be achieved. An analytic model describing the coupling property is derived and confirmed by experimental results. It is also shown that the coupling property can be modified by adjusting the effective refractive index difference between a waveguide and a resonator.

Recommendations to improve older adults' health and well-being focus on enhancing meaning in life through social interaction. Research studies have suggested that a tablet-based intervention can create opportunities to enhance meaning in life, thus reducing social isolation and loneliness. The purpose of this study was to examine the feasibility of using a tablet-based intervention to enhance meaning in life among older adults. Senior Meaning in Life Enhancement (SMiLE) is a tablet-based application developed and implemented based on person-centered counseling, logotherapy, and Acceptance Commitment Therapy (ACT). Thirty-one participants (adults aged over 65 years) were randomized for intervention (n = 15) or waitlist control (n = 16). The intervention group received a tablet with our embedded app. Participants were invited to participate in the app-based 2-month program for 30-minutes each day with the tablet. We evaluated pre-and post-semi-structured interviews, meaning in life scales, and usability tests. Data were analyzed using thematic analyses, descriptive statistics, and Mann–Whitney and Wilcoxon tests. Findings confirmed that at two months after the intervention, there was a statistically significant difference in the gap between pre-and post-meaning in life scores between the two groups (Z = -2.08, p < .05). Furthermore, qualitative findings included positive changes in behavior, relationships, and usability. This pilot study suggests the feasibility of a tablet-based intervention in older adults and demonstrates its potential benefit for meaning in life. These findings are valuable to researchers, practitioners, and designers interested in technological interventions for older adults.

We describe a universal, reconfigurable waveguide coupler based on an alignment-tolerant design to access microresonators. The coupler can be made of any material so as to cover a wide range of refractive index for phase-matching.

We show a two-point resonator-waveguide coupling method which allows optimizing coupling independently at distinct wavelengths. An intuitive equation is provided to predict the coupling behavior of the method and the equation is verified by experiments. [10-point type, centred]

We report octave-spanning supercontinuum generation in etch-less As2S3 film waveguide platform. The spectrum is extended from 1.05 to 2.71 μm pumped by 45 pJ pulse energy at 1.56 μm telecommunication wavelength. © 2020 The Author(s)

We propose a universal, reconfigurable waveguide coupler designed to access optical microcavities easily. As the coupler can consist of any material, it can cover a wide range of refractive indices for phase-matching. © 2020 The Author(s)

We have experimentally demonstrated on-chip chalcogenide resonators with Q-factor of 1.1x107 using a new fabrication method which avoids direct etching of chalcogenide film. Low threshold power (12mW) Brillouin laser is implemented using the fabrication method. Also, cascaded lasing up to 3rd stokes have been observed with 42 mW of pump power.