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2. Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics.

Author

Sanicas, Merlin, Torro, Rémy, Limozin, Laurent, and Chames, Patrick

Subjects
*FORCE density, *MICROFLUIDICS, *ANTIGENS, *IMMUNE response, *IMMUNOGLOBULINS
Abstract

In vitro display technologies such as yeast display have been instrumental in developing the selection of new antibodies, antibody fragments or nanobodies that bind to a specific target, with affinity towards the target being the main factor that influences selection outcome. However, the roles of mechanical forces are being increasingly recognized as a crucial factor in the regulation and activation of effector cell function. It would thus be of interest to isolate binders behaving optimally under the influence of mechanical forces. We developed a microfluidic assay allowing the selection of yeast displaying nanobodies through antigen-specific immobilization on a surface under controlled hydrodynamic flow. This approach enabled enrichment of model yeast mixtures using tunable antigen density and applied force. This new force-based selection method opens the possibility of selecting binders by relying on both their affinity and force resistance, with implications for the design of more efficient immunotherapeutics. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The formal ability of countries to deliver high-quality vaccination services: Introducing the Country Vaccination Score (CVS)

Author

Schmitt, Heinz-Josef, primary, Saidu, Yauba, additional, Hrynkevych, Khrystyna, additional, Adam, Ahmed M., additional, Ankunda, Collins, additional, Barro, Camille, additional, Chacon-Cruz, Enrique, additional, Cobanoglu, Özmen, additional, Costa, Bibiana, additional, Gutiérrez-Melo, Nicolás, additional, Kawalazira, Rachel Chihana, additional, Khatiwada, Madan, additional, Mahmood, Sultan, additional, Mukumbayi, Philippe Mulumba, additional, Müschenborg-Koglin, Simone, additional, Naidu, Akshayata, additional, Nikdel, Mohammad, additional, Ribeiro-Moraes, Julia, additional, Saha, Shampa, additional, Salloum, Maha, additional, Sanicas, Merlin Jalando-on, additional, Stoma, Igor, additional, Tan, Justin Vincent Go, additional, and Sanicas, Melvin, additional

Published
2022
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