Author: "Sanisoglu, Sy" - Searchworks@Jio Institute Digital Library Search Results

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1. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: A comparative risk assessment

Author: Danaei, G, Lu, Y, Singh, Gm, Carnahan, E, Stevens, Ga, Cowan, Mj, Farzadfar, F, Lin, Jk, Finucane, Mm, Rao, M, Khang, Yh, Riley, Lm, Mozaffarian, D, Lim, Ss, Ezzati, M, Aamodt, G, Abdeen, Z, Abdella, Na, Rahim, Hf, Addo, J, Aekplakorn, W, Afifi, Mm, Agabiti Rosei, E, Salinas, Ca, Agyemang, C, Ali, Mk, Ali, Mm, Al Nsour, M, Al Nuaim AR, Ambady, R, Di Angelantonio, E, Aro, P, Azizi, F, Babu, Bv, Bahalim, An, Barbagallo, Cm, Barbieri, Ma, Barceló, A, Barreto, Sm, Barros, H, Bautista, Le, Benetos, A, Bjerregaard, P, Björkelund, C, Bo, S, Bobak, M, Bonora, Enzo, Botana, Ma, Bovet, P, Breckenkamp, J, Breteler, Mm, Broda, G, Brown, Ij, Bursztyn, M, de León AC, Campos, H, Cappuccio, Fp, Capuano, V, Casiglia, E, Castellano, M, Castetbon, K, Cea, L, Chang, Cj, Chaouki, N, Chatterji, S, Chen, Cj, Chen, Z, Choi, Js, Chua, L, Cífková, R, Cobiac, Lj, Cooper, Rs, Corsi, Am, Costanza, Mc, Craig, Cl, Dankner, Rs, Dastgiri, S, Delgado, E, Dinc, G, Doi, Y, Dong, Gh, Dorsi, E, Dragano, N, Drewnowski, A, Eggertsen, R, Elliott, P, Engeland, A, Erem, C, Esteghamati, A, Fall, Ch, Fan, Jg, Ferreccio, C, Fezeu, L, Firmo, Jo, Florez, Hj, Fornés, Ns, Fowkes, Fg, Franceschini, G, Frisk, F, Fuchs, Fd, Fuller, El, Getz, L, Giampaoli, S, Gómez, Lf, Gomez Zumaquero JM, Graff Iversen, S, Grant, Jf, Carvajal, Rg, Gulliford, Mc, Gupta, R, Gupta, Pc, Gureje, O, Gutierrez, Hr, Hansen, Tw, Hata, J, He, J, Heim, N, Heinrich, J, Hemmingsson, T, Hennis, A, Herman, Wh, Herrera, Vm, Ho, S, Holdsworth, M, Frisman, Gh, Hopman, Wm, Hussain, A, Husseini, A, Ibrahim, Mm, Ikeda, N, Jacobsen, Bk, Jaddou, Hy, Jafar, Th, Janghorbani, M, Jasienska, G, Joffres, Mr, Jonas, Jb, Kadiki, Oa, Kalter Leibovici, O, Kamadjeu, Rm, Kaptoge, S, Karalis, I, Kastarinen, Mj, Katz, J, Keinan Boker, L, Kelly, P, Khalilzadeh, O, Kiechl, S, Kim, Kw, Kiyohara, Y, Kobayashi, J, Krause, Mp, Kubínová, R, Kurjata, P, Kusuma, Ys, Lam, Th, Langhammer, A, Lawes, Cm, Le, C, Lee, J, Lévy Marchal, C, Lewington, S, Li, Y, Lim, To, Lin, X, Lin, Cc, Lin, Hh, Lind, L, Lissner, L, Liu, X, Lopez Jaramillo, P, Lorbeer, R, Ma, G, Ma, S, Macià, F, Maclean, Dr, Maggi, S, Magliano, Dj, Makdisse, M, Mancia, G, Mannami, T, Marques Vidal, P, Mbanya, Jc, McFarlane Anderson, N, Miccoli, R, Miettola, J, Minh, Hv, Miquel, Jf, Miranda, Jj, Mohamed, Mk, Mohan, V, Mohanna, S, Mokdad, A, Mollentze, Wf, Morales, Dd, Morgan, K, Muiesan, Lm, Muntoni, S, Nabipour, I, Nakagami, T, Nangia, V, Nemesure, B, Neovius, M, Nerhus, Ka, Nervi, F, Neuhauser, H, Nguyen, M, Ninomiya, T, Noale, M, Oh, Sw, Ohkubo, T, Olivieri, Oliviero, Önal, Ae, Onat, A, Oróstegui, M, Ouedraogo, H, Pan, Wh, Panagiotakos, Db, Panza, F, Park, Y, Passos, Vm, Pednekar, Ms, Pelizzari, Pm, Peres, Ma, Pérez, C, Pérez Fernández, R, Pichardo, R, Phua, Hp, Pistelli, F, Plans, P, Polakowska, M, Poulter, N, Prabhakaran, D, Qiao, Q, Rafiei, M, Raitakari, Ot, Ramos, Lr, Rampal, S, Rampal, L, Rasmussen, F, Reddy, Kk, Redon, J, Revilla, L, Reyes García, V, Roaeid, Rb, Robinson, Ca, Rodriguez Artalejo, F, Rojas Martinez, R, Ronkainen, K, Rosero Bixby, L, Roth, Ga, Sachdev, Hs, Sánchez, Jr, Sanisoglu, Sy, Sans, S, Sarraf Zadegan, N, Scazufca, M, Schaan, Bd, Schapochnik, N, Schelleman, H, Schneider, Ij, Schooling, Cm, Schwarz, B, Sekuri, C, Sereday, Ms, Serra Majem, L, Shaw, J, Shera, As, Shi, Z, Shiri, R, Shu, Xo, Silva, Da, Silva, E, Simons, La, Smith, M, Söderberg, S, Soebardi, S, Solfrizzi, V, Sonestedt, E, Soysal, A, Stattin, P, Stein, Ad, Stergiou, Gs, Stessman, J, Sudo, A, Suka, M, Sundh, V, Sundquist, K, Sundström, J, Swai, Ab, Tai, Es, Tambs, K, Tesfaye, F, Thomas, Gn, Thorogood, M, Tilvis, Rs, Tobias, M, Torheim, Le, Trenkwalder, P, Tuomilehto, Jo, Tur, Ja, Tzourio, C, Uhernik, Ai, Ukoli, Fa, Unwin, N, Hoorn, Sv, Vanderpump, Mp, Varo, Jj, Veierød, Mb, Velásquez Meléndez, G, Verschuren, M, Viet, L, Villalpando, S, Vioque, J, Vollenweider, P, Volpato, S, Wang, N, Wang, Yx, Ward, M, Waspadji, S, Welin, Lx, Whitlock, G, Wilhelmsen, L, Willeit, J, Woodward, M, Wormser, D, Xavier, Aj, Xu, F, Xu, L, Yamamoto, A, Yang, G, Yang, X, Yeh, Lc, Yoon, Js, You, Q, Yu, Z, Zhang, J, Zhang, L, Zheng, W, Zhou, M, Ward, M., Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration, Danaei, G., Lu, Y., Singh, G.M., Carnahan, E., Stevens, G.A., Cowan, M.J., Farzadfar, F., Lin, J.K., Finucane, M.M., Rao, M., Khang, Y.H., Riley, L.M., Mozaffarian, D., Lim, S.S., Ezzati, M., Aamodt, G., Abdeen, Z., Abdella, N.A., Rahim, H.F., Addo, J., Aekplakorn, W., Afifi, M.M., Agabiti-Rosei, E., Salinas, C.A., Agyemang, C., Ali, M.K., Ali, M.M., Al-Nsour, M., Al-Nuaim, A.R., Ambady, R., Di Angelantonio, E., Aro, P., Azizi, F., Babu, B.V., Bahalim, A.N., Barbagallo, C.M., Barbieri, M.A., Barceló, A., Barreto, S.M., Barros, H., Bautista, L.E., Benetos, A., Bjerregaard, P., Björkelund, C., Bo, S., Bobak, M., Bonora, E., Botana, M.A., Bovet, P., Breckenkamp, J., Breteler, M.M., Broda, G., Brown, I.J., Bursztyn, M., de León, A.C., Campos, H., Cappuccio, F.P., Capuano, V., Casiglia, E., Castellano, M., Castetbon, K., Cea, L., Chang, C.J., Chaouki, N., Chatterji, S., Chen, C.J., Chen, Z., Choi, J.S., Chua, L., Cífková, R., Cobiac, L.J., Cooper, R.S., Corsi, A.M., Costanza, M.C., Craig, C.L., Dankner, R.S., Dastgiri, S., Delgado, E., Dinc, G., Doi, Y., Dong, G.H., Dorsi, E., Dragano, N., Drewnowski, A., Eggertsen, R., Elliott, P., Engeland, A., Erem, C., Esteghamati, A., Fall, C.H., Fan, J.G., Ferreccio, C., Fezeu, L., Firmo, J.O., Florez, H.J., Fornés, N.S., Fowkes, F.G., Franceschini, G., Frisk, F., Fuchs, F.D., Fuller, E.L., Getz, L., Giampaoli, S., Gómez, L.F., Gomez-Zumaquero, J.M., Graff-Iversen, S., Grant, J.F., Carvajal, R.G., Gulliford, M.C., Gupta, R., Gupta, P.C., Gureje, O., Gutierrez, H.R., Hansen, T.W., Hata, J., He, J., Heim, N., Heinrich, J., Hemmingsson, T., Hennis, A., Herman, W.H., Herrera, V.M., Ho, S., Holdsworth, M., Frisman, G.H., Hopman, W.M., Hussain, A., Husseini, A., Ibrahim, M.M., Ikeda, N., Jacobsen, B.K., Jaddou, H.Y., Jafar, T.H., Janghorbani, M., Jasienska, G., Joffres, M.R., Jonas, J.B., Kadiki, O.A., Kalter-Leibovici, O., Kamadjeu, R.M., Kaptoge, S., Karalis, I., Kastarinen, M.J., Katz, J., Keinan-Boker, L., Kelly, P., Khalilzadeh, O., Kiechl, S., Kim, K.W., Kiyohara, Y., Kobayashi, J., Krause, M.P., Kubínová, R., Kurjata, P., Kusuma, Y.S., Lam, T.H., Langhammer, A., Lawes, C.M., Le, C., Lee, J., Lévy-Marchal, C., Lewington, S., Li, Y., Lim, T.O., Lin, X., Lin, C.C., Lin, H.H., Lind, L., Lissner, L., Liu, X., Lopez-Jaramillo, P., Lorbeer, R., Ma, G., Ma, S., Macià, F., MacLean, D.R., Maggi, S., Magliano, D.J., Makdisse, M., Mancia, G., Mannami, T., Marques-Vidal, P., Mbanya, J.C., McFarlane-Anderson, N., Miccoli, R., Miettola, J., Minh, H.V., Miquel, J.F., Miranda, J.J., Mohamed, M.K., Mohan, V., Mohanna, S., Mokdad, A., Mollentze, W.F., Morales, D.D., Morgan, K., Muiesan, L.M., Muntoni, S., Nabipour, I., Nakagami, T., Nangia, V., Nemesure, B., Neovius, M., Nerhus, K.A., Nervi, F., Neuhauser, H., Nguyen, M., Ninomiya, T., Noale, M., Oh, S.W., Ohkubo, T., Olivieri, O., Önal, A.E., Onat, A., Oróstegui, M., Ouedraogo, H., Pan, W.H., Panagiotakos, D.B., Panza, F., Park, Y., Passos, V.M., Pednekar, M.S., Pelizzari, P.M., Peres, M.A., Pérez, C., Pérez-Fernández, R., Pichardo, R., Phua, H.P., Pistelli, F., Plans, P., Polakowska, M., Poulter, N., Prabhakaran, D., Qiao, Q., Rafiei, M., Raitakari, O.T., Ramos, L.R., Rampal, S., Rampal, L., Rasmussen, F., Reddy, K.K., Redon, J., Revilla, L., Reyes-García, V., Roaeid, R.B., Robinson, C.A., Rodriguez-Artalejo, F., Rojas-Martinez, R., Ronkainen, K., Rosero-Bixby, L., Roth, G.A., Sachdev, H.S., Sánchez, J.R., Sanisoglu, S.Y., Sans, S., Sarraf-Zadegan, N., Scazufca, M., Schaan, B.D., Schapochnik, N., Schelleman, H., Schneider, I.J., Schooling, C.M., Schwarz, B., Sekuri, C., Sereday, M.S., Serra-Majem, L., Shaw, J., Shera, A.S., Shi, Z., Shiri, R., Shu, X.O., Silva, D.A., Silva, E., Simons, L.A., Smith, M., Söderberg, S., Soebardi, S., Solfrizzi, V., Sonestedt, E., Soysal, A., Stattin, P., Stein, A.D., Stergiou, G.S., Stessman, J., Sudo, A., Suka, M., Sundh, V., Sundquist, K., Sundström, J., Swai, A.B., Tai, E.S., Tambs, K., Tesfaye, F., Thomas, G.N., Thorogood, M., Tilvis, R.S., Tobias, M., Torheim, L.E., Trenkwalder, P., Tuomilehto, J.O., Tur, J.A., Tzourio, C., Uhernik, A.I., Ukoli, F.A., Unwin, N., Hoorn, S.V., Vanderpump, M.P., Varo, J.J., Veierød, M.B., Velásquez-Meléndez, G., Verschuren, M., Viet, L., Villalpando, S., Vioque, J., Vollenweider, P., Volpato, S., Wang, N., Wang, Y.X., Ward, M., Waspadji, S., Welin, L.X., Whitlock, G., Wilhelmsen, L., Willeit, J., Woodward, M., Wormser, D., Xavier, A.J., Xu, F., Xu, L., Yamamoto, A., Yang, G., Yang, X., Yeh, L.C., Yoon, J.S., You, Q., Yu, Z., Zhang, J., Zhang, L., Zheng, W., Zhou, M., ACS - Amsterdam Cardiovascular Sciences, APH - Amsterdam Public Health, Public and occupational health, Danaei G, Lu Y, Singh GM, Stevens GA, Cowan MJ, Farzadfar F, Lin JK, Finucane MM, Rao M, Khang Y-H, Riley LM, Mozaffarian D, Lim SS, Ezzati M, Aamodt G, Abdeen Z, Abdella NA, Abdul Rahim HF, Addo J, Aekplakorn W, Afi fi MM, Agabiti-Rosei E, Aguilar Salinas CA, Agyemang C, Ali MK, Ali MM, Al-Nsour M, Al-Nuaim AR, Ambady R, Di Angelantonio E, Aro P, Azizi F, Babu BV, Bahalim AN, Barbagallo CM, Barbieri MA, Barcelo A, Barreto SM, Barros H, Bautista LE, Benetos A, Bjerregaard P, Bjorkelund C, Bo S, Bobak M, Bonora E, Botana MA, Bovet P, Breckenkamp J, Breteler MM, Broda G, Brown IJ, Bursztyn M, Cabrera de Leon A, Campos H, Cappuccio FP, Capuano V, Casiglia E, Castellano M, Castetbon K, Cea L, Chang C-J, Chaouki N, Chatterji S, Chen C-J, Chen Z, Choi J-S, Chua L, Cifkova R, Cobiac LJ, Cooper RS, Corsi AM, Costanza MC, Craig CL, Dankner RS, Dastgiri S, Delgado E, Dinc G, Doi Y, Dong G-H, Dorsi E, Dragano N, Drewnowski A, Eggertsen R, Elliott P, Anders Engeland, Erem C, Esteghamati A, Fall CHD, Fan J-G, Ferreccio C, Fezeu L, Firmo JO, Florez HF, Fornes NF, Fowkes FGR, Franceschini G, Frisk F, Fuchs FD, Fuller EL, Getz L, Giampaoli S, Gomez LF, Gomez-Zumaquero JM, Graff –Iversen S, Grant JF, Guerrero Carvajal R, Gulliford MC, Gupta R, Gupta PC, Gureje O, Gutierrez HR, Hansen TW, Hata J, He J, Heim N, Heinrich J, Hemmingsson T, Hennis A, Herman WH, Herrera VM, Ho S, Holdsworth M, Hollman Frisman G, Hopman WM, Hussain A, Husseini A, Ibrahim MM, Ikeda N, Jacobsen BK, Jaddou HY, Jafar TH, Janghorbani M, Jasienska G, Joffres MR, Jonas JB, Kadiki OA, Kalter-Leibovici O, Kamadjeu RM, Kaptoge S, Karalis I, Kastarinen MJ, Katz J, Keinan-Boker L, Kelly P, Khalilzadeh O, Kiechl S, Woong Kim KW, Kiyohara Y, Kobayashi J, Krause MP, Kubinova R, Kurjata P, Kusuma YS, Lam TH, Langhammer A, Lawes CMM, Le C, Lee J, Levy-Marchal C, Lewington S, Li Y, Lim TO, Lin X, Lin C-C, Lin H-H, Lind L, Lissner L, Liu X, Lopez-Jaramillo P, Lorbeer R, Ma G, Ma S, Macia F, MacLean DR, Maggi S, Magliano DJ, Makdisse M, Mancia G, Mannami T, Marques-Vidal P, Mbanya JCN, McFarlane-Anderson N, Miccoli R, Miettola J, Minh HV, Miquel JF, J Miranda JJ, Mohamed MK, Mohan V, Mohanna S, Mokdad A, Mollentze WF, Morales DD, Morgan K, Muiesan LM, Muntoni S, Nabipour I, Nakagami T, Nangia V, Nemesure B, Neovius M, Nerhus KA, Nervi F, Neuhauser H, Nguyen M, Ninomiya T, Noale M, Oh SW, Ohkubo T, Olivieri O, Onal AE, Onat A, Orostegui M, Ouedraogo H, Pan W-A, Panagiotakos DB, Panza F, Park Y, Passos VMA, Pednekar MS, Pelizzari PM, Peres MA, Perez C, Perez-Fernandez R, Pichardo R, Hwee Pin Phua, Francesco Pistelli, Plans P, Polakowska M, Poulter N, Prabhakaran D, Qiao Q, Rafiei M, Raitakari OT, Ramos LR, Rampal S, Rampal L, Rasmussen F, Reddy KKR, Josep Redon J, Revilla L, Reyes-GarciaV, Roaeid RB, Robinson CA, Rodriguez-Artalejo F, Rojas-Martinez R, Ronkainen K, Rosero-Bixby L, Roth GA, Sachdev HS, Sanchez JR, Sanisoglu SY, Sans S, Sarraf-Zadegan N, Scazufca M, Schaan BD, Schapochnik N, Schelleman H, Schneider IJC, Schooling CM, Schwarz B, Sekuri C, Sereday MS, Serra-Majem L, Shaw J, Shera AS, Shi Z, Shiri R, Shu XO, Santos Silva DA, Silva E, Simons LA, Smith M, Soderberg S, Soebardi S, Solfrizzi V, Sonestedt E, Soysal A, StattinP, Stein AD, Stergiou GS, Stessman J, Sudo A, Suka M, Sundh V, Sundquist K, Sundstrom J, Swai AB, Tai ES, Tambs K, Tesfaye F, Thomas GN, Thorogood M, Tilvis RS, Tobias M, Torheim LE, Trenkwalder P, Tuomilehto JO, Tur JA, Tzourio C, Uhernik A, Ukoli FA, Unwin N, Vander Hoorn S, Vanderpump MP, Varo JJ, Veierod MB, Velasquez-Melendez G, Verschuren M, Viet L, Villalpando S, Vioque J, Vollenweider P, Volpato S, Wang N, Wang YX, Ward M, Waspadji S, Welin LX, Whitlock G, Wilhelmsen L, Willeit J, Woodward M, Wormser D, Xavier AJ, Xu F, Xu L, Yamamoto A, Yang G, Yang X, Yeh L-C, Yoon J-S, You Q, Yu Z, Zhang J, Zhang L, Zheng W, Zhou M, Danaei, G, Lu, Y, Singh, G, Carnahan, E, Stevens, G, Cowan, M, Farzadfar, F, Lin, J, Finucane, M, Rao, M, Khang, Y, Riley, L, Arian, D, Lim, S, Ezzati, M, Aamodt, G, Abdeen, Z, Abdella, N, Rahim, H, Addo, J, Aekplakorn, W, Afifi, M, Agabiti-Rosei, E, Salinas, C, Agyemang, C, Ali, M, Al-Nsour, M, Al-Nuaim, A, Ambady, R, Angelantonio, E, Aro, P, Azizi, F, Babu, B, Bahalim, A, Barbagallo, C, Barbieri, M, Barceló, A, Barreto, S, Barros, H, Bautista, L, Benetos, A, Bjerregaard, P, Björkelund, C, Bo, S, Bobak, M, Bonora, E, Botana, M, Bovet, P, Breckenkamp, J, Breteler, M, Broda, G, Brown, I, Bursztyn, M, de León, A, Campos, H, Cappuccio, F, Capuano, V, Casiglia, E, Castellano, M, Castetbon, K, Cea, L, Chang, C, Chaouki, N, Chatterji, S, Chen, C, Chen, Z, Choi, J, Chua, L, Cífková, R, Cobiac, L, Cooper, R, Corsi, A, Costanza, M, Craig, C, Dankner, R, Dastgiri, S, Delgado, E, Dinc, G, Doi, Y, Dong, G, Dorsi, E, Dragano, N, Drewnowski, A, Eggertsen, R, Elliott, P, Engeland, A, Erem, C, Esteghamati, A, Fall, C, Fan, J, Ferreccio, C, Fezeu, L, Firmo, J, Florez, H, Fornés, N, Fowkes, F, Franceschini, G, Frisk, F, Fuchs, F, Fuller, E, Getz, L, Giampaoli, S, Gómez, L, Gomez-Zumaquero, J, Iversen, S, Grant, J, Carvajal, R, Gulliford, M, Gupta, R, Gupta, P, Gureje, O, Gutierrez, H, Hansen, T, Hata, J, He, J, Heim, N, Heinrich, J, Hemmingsson, T, Hennis, A, Herman, W, Herrera, V, Ho, S, Holdsworth, M, Frisman, G, Hopman, W, Hussain, A, Husseini, A, Ibrahim, M, Ikeda, N, Jacobsen, B, Jaddou, H, Jafar, T, Janghorbani, M, Jasienska, G, Joffres, M, Jonas, J, Kadiki, O, Kalter-Leibovici, O, Kamadjeu, R, Kaptoge, S, Karalis, I, Kastarinen, M, Katz, J, Keinan-Boker, L, Kelly, P, Khalilzadeh, O, Kiechl, S, Kim, K, Kiyohara, Y, Kobayashi, J, Krause, M, Kubínová, R, Kurjata, P, Kusuma, Y, Lam, T, Langhammer, A, Lawes, C, Le, C, Lee, J, Lévy-Marchal, C, Lewington, S, Li, Y, Lim, T, Lin, X, Lin, C, Lin, H, Lind, L, Lissner, L, Liu, X, Lopez-Jaramillo, P, Lorbeer, R, Ma, G, Ma, S, Macià, F, Maclean, D, Maggi, S, Magliano, D, Makdisse, M, Mancia, G, Mannami, T, Marques-Vidal, P, Mbanya, J, McFarlane-Anderson, N, Miccoli, R, Miettola, J, Minh, H, Miquel, J, Miranda, J, Mohamed, M, Mohan, V, Mohanna, S, Mokdad, A, Mollentze, W, Morales, D, Morgan, K, Lorenza M Muiesan, N, Muntoni, S, Nabipour, I, Nakagami, T, Nangia, V, Nemesure, B, Neovius, M, Nerhus, K, Nervi, F, Neuhauser, H, Nguyen, M, Ninomiya, T, Noale, M, Oh, S, Ohkubo, T, Olivieri, O, Önal, A, Onat, A, Oróstegui, M, Ouedraogo, H, Pan, W, Panagiotakos, D, Panza, F, Park, Y, Passos, V, Pednekar, M, Pelizzari, P, Peres, M, Cynthia Pérez, N, Pérez-Fernández, R, Pichardo, R, Phua, H, Pistelli, F, Plans, P, Polakowska, M, Poulter, N, Prabhakaran, D, Qiao, Q, Rafiei, M, Raitakari, O, Ramos, L, Rampal, S, Rampal, L, Rasmussen, F, Reddy, K, Redon, J, Revilla, L, Reyes-García, V, Roaeid, R, Robinson, C, Rodriguez-Artalejo, F, Rojas-Martinez, R, Ronkainen, K, Rosero-Bixby, L, Roth, G, Sachdev, H, Sánchez, J, Sanisoglu, S, Sans, S, Sarraf-Zadegan, N, Scazufca, M, Schaan, B, Schapochnik, N, Schelleman, H, Schneider, I, Schooling, C, Schwarz, B, Sekuri, C, Sereday, M, Serra-Majem, L, Shaw, J, Shera, A, Shi, Z, Shiri, R, Shu, X, Silva, D, Silva, E, Simons, L, Smith, M, Söderberg, S, Soebardi, S, Solfrizzi, V, Sonestedt, E, Soysal, A, Stattin, P, Stein, A, Stergiou, G, Stessman, J, Sudo, A, Suka, M, Sundh, V, Sundquist, K, Sundström, J, Swai, A, Tai, E, Tambs, K, Tesfaye, F, Thomas, G, Thorogood, M, Tilvis, R, Tobias, M, Torheim, L, Trenkwalder, P, Tuomilehto, J, Tur, J, Tzourio, C, Uhernik, A, Ukoli, F, Unwin, N, Hoorn, S, Vanderpump, M, Varo, J, Veierød, M, Velásquez-Meléndez, G, Verschuren, M, Viet, L, Villalpando, S, Vioque, J, Vollenweider, P, Volpato, S, Wang, N, Wang, Y, Ward, M, Waspadji, S, Lennart X Welin, N, Whitlock, G, Wilhelmsen, L, Willeit, J, Woodward, M, Wormser, D, André J Xavier, N, Xu, F, Xu, L, Yamamoto, A, Yang, G, Yang, X, Yeh, L, Yoon, J, You, Q, Yu, Z, Zhang, J, Zhang, L, Zheng, W, and Zhou, M
Subjects: Male, Settore MED/09 - Medicina Interna, kidney disease, Endocrinology, Diabetes and Metabolism, humanos, coste de las enfermedades, Disease, Global Health, Cohort Studies, Endocrinology, Cost of Illness, cardiovascular disease, Health Transition, Risk Factors, transición sanitaria, estudios prospectivos, Renal Insufficiency, Chronic -- complications -- epidemiology -- mortality, evaluación de riesgos, Renal Insufficiency, Prospective Studies, Chronic, estudios de cohortes, Metabolic Syndrome, education.field_of_study, diabetes, Mortality rate, Age Factors, Cardiovascular Diseases, Diabetes Complications, Female, Health Surveys, Humans, Metabolic Syndrome X, Renal Insufficiency, Chronic, Risk Assessment, Sex Factors, Spatio-Temporal Analysis, Internal Medicine, Cardiovascular Diseases -- complications -- epidemiology -- mortality, Cardiovascular disease,Diabetes Mellitus, chronic kidney disease, Diabetes Complications -- epidemiology -- mortality, Sciences bio-médicales et agricoles, Diabetes and Metabolism, encuestas de salud, análisis temporoespacial, Risk assessment, complicaciones de la diabetes, insuficiencia renal, medicine.medical_specialty, Cardiovascular disease, diabetes mortality, Population, enfermedades cardiovasculares, Metabolic Syndrome X -- complications -- epidemiology -- mortality, Article, chronic kidney disease, mortality, Internal medicine, Environmental health, Diabetes mellitus, medicine, factores de riesgo, Risk factor, education, business.industry, medicine.disease, Relative risk, Cardiovascular Diseases/complications, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/mortality, Diabetes Complications/epidemiology, Diabetes Complications/mortality, Metabolic Syndrome X/complications, Metabolic Syndrome X/epidemiology, Metabolic Syndrome X/mortality, Renal Insufficiency, Chronic/complications, Renal Insufficiency, Chronic/epidemiology, Renal Insufficiency, Chronic/mortality, business, Kidney disease
Abstract: High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic risk factors for all countries and regions from 1980 to 2010., 0, info:eu-repo/semantics/published
Published: 2014

2. National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3·0 million participants

Author: Farzadfar F, Finucane MM, Danaei G, Pelizzari PM, Cowan MJ, Paciorek CJ, Singh GM, Lin JK, Stevens GA, Riley LM, Ezzati M, Salinas CA, Al Nsour M, Ali MM, Al Nuaim AR, Ambady R, Antonio M, Azizi F, Barbieri M, Barros H, Bautista LE, Bjerregaard P, Björkelund C, Bovet P, Brekenkamp J, Bursztyn M, de León AC, Campos H, Capuano V, Castetbon K, Chang CJ, Chen CJ, Choi JS, Chua L, Cífková R, Costanza MC, Eggertsen RW, Esteghamati A, Fan JG, Ferreccio C, Florez HJ, Fornés NS, Fowkes FG, Franceschini G, Frisk F, Giampaoli S, Gómez LF, Gomez Zumaquero JM, Graff Iversen S, Carvajal RG, Gupta R, Hansen TW, Hata J, He J, Herrera VM, Ho SC, Frisman GH, Ikeda N, Jaddou HY, Jafar TH, Janghorbani M, Joffres MR, Jonas JB, Kadiki OA, Karalis I, Kastarinen MJ, Katz J, Khalilzadeh O, Khang YH, Kiechl S, Kobayashi J, Kubínová R, Lam TH, Lawes CM, Lee J, Lim S, Lin HH, Lin X, Lin CC, Ma S, MacLean DR, Magliano DJ, Mannami T, Marques Vidal P, Miettola J, Miquel JF, Miranda JJ, Mohamed MK, Mohan V, Mokdad A, Mollentze WF, Morales DD, Muiesan LM, Nabipour I, Nangia V, Nerhus KA, Neuhauser H, Oh SW, Ohkubo T, Onat A, Oróstegui M, Pan WH, Panagiotakos DB, Panza F, Passos VM, Pérez C, Pichardo R, Phua HP, Polakowska M, Rafiei M, Ramos LR, Reddy KK, Redon J, Revilla L, Roaeid RB, Ronkainen K, Roth GA, Sanisoglu SY, Sarraf Zadegan N, Schooling CM, Schwarz B, Silva E, Simons LA, Solfrizzi V, Stein AD, Stessman J, Suka M, Swai AB, Tai ES, Thomas GN, Thorogood M, Tuomilehto JO, Unwin N, Vander Hoorn S, Vanderpump MP, Volpato S, Welin LX, Willeit J, Woodward M, Xu L, Yamamoto A, Yang X, Yeh LC, Yoon JS, You Q, Zhang J., BARBAGALLO, Carlo Maria, and Farzadfar F, Finucane MM, Danaei G, Pelizzari PM, Cowan MJ, Paciorek CJ, Singh GM, Lin JK, Stevens GA, Riley LM, Ezzati M, Salinas CA, Al Nsour M, Ali MM, Al-Nuaim AR, Ambady R, Antonio M, Azizi F, Barbagallo CM, Barbieri M, Barros H, Bautista LE, Bjerregaard P, Björkelund C, Bovet P, Brekenkamp J, Bursztyn M, de León AC, Campos H, Capuano V, Castetbon K, Chang CJ, Chen CJ, Choi JS, Chua L, Cífková R, Costanza MC, Eggertsen RW, Esteghamati A, Fan JG, Ferreccio C, Florez HJ, Fornés NS, Fowkes FG, Franceschini G, Frisk F, Giampaoli S, Gómez LF, Gomez-Zumaquero JM, Graff -Iversen S, Carvajal RG, Gupta R, Hansen TW, Hata J, He J, Herrera VM, Ho SC, Frisman GH, Ikeda N, Jaddou HY, Jafar TH, Janghorbani M, Joffres MR, Jonas JB, Kadiki OA, Karalis I, Kastarinen MJ, Katz J, Khalilzadeh O, Khang YH, Kiechl S, Kobayashi J, Kubínová R, Lam TH, Lawes CM, Lee J, Lim S, Lin HH, Lin X, Lin CC, Ma S, MacLean DR, Magliano DJ, Mannami T, Marques-Vidal P, Miettola J, Miquel JF, Miranda JJ, Mohamed MK, Mohan V, Mokdad A, Mollentze WF, Morales DD, Muiesan LM, Nabipour I, Nangia V, Nerhus KA, Neuhauser H, Oh SW, Ohkubo T, Onat A, Oróstegui M, Pan WH, Panagiotakos DB, Panza F, Passos VM, Pérez C, Pichardo R, Phua HP, Polakowska M, Rafiei M, Ramos LR, Reddy KK, Redon J, Revilla L, Roaeid RB, Ronkainen K, Roth GA, Sanisoglu SY, Sarraf-Zadegan N, Schooling CM, Schwarz B, Silva E, Simons LA, Solfrizzi V, Stein AD, Stessman J, Suka M, Swai AB, Tai ES, Thomas GN, Thorogood M, Tuomilehto JO, Unwin N, Vander Hoorn S, Vanderpump MP, Volpato S, Welin LX, Willeit J, Woodward M, Xu L, Yamamoto A, Yang X, Yeh LC, Yoon JS, You Q, Zhang J.
Subjects: Gerontology, Adult, Male, medicine.medical_specialty, Uncertainty interval, Population, Hypercholesterolemia, Socioeconomic Factor, Global Health, Southeast asia, Nutrition Policy, Health examination, blood, Total cholesterol, Epidemiology, Global health, Medicine, Humans, education, education.field_of_study, business.industry, Population mean, Bayes Theorem, General Medicine, Health Survey, Health Surveys, Adult, Bayes Theorem, Cholesterol, blood, Female, Health Surveys, Humans, Hypercholesterolemia, drug therapy, Income, Male, Nutrition Policy, Socioeconomic Factors, World Health, drug therapy, Cholesterol, Socioeconomic Factors, World Health, Income, lipids (amino acids, peptides, and proteins), Female, business, Demography, Human
Abstract: Summary Background Data for trends in serum cholesterol are needed to understand the effects of its dietary, lifestyle, and pharmacological determinants; set intervention priorities; and evaluate national programmes. Previous analyses of trends in serum cholesterol were limited to a few countries, with no consistent and comparable global analysis. We estimated worldwide trends in population mean serum total cholesterol. Methods We estimated trends and their uncertainties in mean serum total cholesterol for adults 25 years and older in 199 countries and territories. We obtained data from published and unpublished health examination surveys and epidemiological studies (321 country-years and 3·0 million participants). For each sex, we used a Bayesian hierarchical model to estimate mean total cholesterol by age, country, and year, accounting for whether a study was nationally representative. Findings In 2008, age-standardised mean total cholesterol worldwide was 4·64 mmol/L (95% uncertainty interval 4·51–4·76) for men and 4·76 mmol/L (4·62–4·91) for women. Globally, mean total cholesterol changed little between 1980 and 2008, falling by less than 0·1 mmol/L per decade in men and women. Total cholesterol fell in the high-income region consisting of Australasia, North America, and western Europe, and in central and eastern Europe; the regional declines were about 0·2 mmol/L per decade for both sexes, with posterior probabilities of these being true declines 0·99 or greater. Mean total cholesterol increased in east and southeast Asia and Pacific by 0·08 mmol/L per decade (−0·06 to 0·22, posterior probability=0·86) in men and 0·09 mmol/L per decade (−0·07 to 0·26, posterior probability=0·86) in women. Despite converging trends, serum total cholesterol in 2008 was highest in the high-income region consisting of Australasia, North America, and western Europe; the regional mean was 5·24 mmol/L (5·08–5·39) for men and 5·23 mmol/L (5·03–5·43) for women. It was lowest in sub-Saharan Africa at 4·08 mmol/L (3·82–4·34) for men and 4·27 mmol/L (3·99–4·56) for women. Interpretation Nutritional policies and pharmacological interventions should be used to accelerate improvements in total cholesterol in regions with decline and to curb or prevent the rise in Asian populations and elsewhere. Population-based surveillance of cholesterol needs to be improved in low-income and middle-income countries. Funding Bill & Melinda Gates Foundation and WHO.
Published: 2011

3. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

Author: Danaei, G, Finucane, Mm, Lu, Y, Singh, Gm, Cowan, Mj, Paciorek, Cj, Lin, Jk, Farzadfar, F, Khang, Yh, Stevens, Ga, Rao, M, Ali, Mk, Riley, Lm, Robinson, Ca, Ezzati, M, Abdeen, Z, Aekplakorn, W, Afifi, Mm, AGABITI ROSEI, Enrico, Salinas, Ca, Alnsour, M, Ambady, R, Barbagallo, Cm, Barceló, A, Barros, H, Bautista, Le, Benetos, A, Bjerregaard, P, Bo, S, Bovet, P, Bursztyn, M, Cabrera de León, A, Castellano, Maurizio, Castetbon, K, Chaouki, N, Chen, Cj, Chua, L, Cífková, R, Corsi, Am, Delgado, E, Doi, Y, Esteghamati, A, Fall, Ch, Fan, Jg, Ferreccio, C, Fezeu, L, Fuller, El, Giampaoli, S, Gómez, Lf, Carvajal, Rg, Herman, Wh, Herrera, Vm, Ho, S, Hussain, A, Ikeda, N, Jafar, Th, Jonas, Jb, Kadiki, Oa, Karalis, I, Katz, J, Khalilzadeh, O, Kiechl, S, Kurjata, P, Lee, J, Lim, S, Lim, To, Lin, Cc, Lin, X, Lin, Hh, Liu, X, Lorbeer, R, Ma, S, Maggi, S, Magliano, Dj, McFarlane Anderson, N, Miettola, J, Miranda, Jj, Mohamed, Mk, Mohan, V, Mokdad, A, Morales, Dd, Nabipour, I, Nakagami, T, Nangia, V, Neuhauser, H, Noale, M, Onat, A, Oróstegui, M, Panagiotakos, Db, Passos, Vm, Pérez, C, Pichardo, R, Pin Phua, H, Plans, P, Qiao, Q, Ramos, Lr, Rampal, S, Rampal, L, Redon, J, Revilla, L, Rosero Bixby, L, Sanisoglu, Sy, Scazufca, M, Schaan, Bd, Sekuri, C, Shera, As, Shi, Z, Silva, E, Simons, La, Söderberg, S, Solfrizzi, V, Soysal, A, Stein, Ad, Stessman, J, Vanderpump, Mp, Viet, L, Vollenweider, P, Wang, N, Wang, Yx, Waspadji, S, Willeit, J, Woodward, M, Xu, L, Yang, X, Yoon, Js, Yu, Z, Zhang, J, Zhang, L., Barbagallo, CM, Danaei, G, Finucane, M, Lu, Y, Singh, G, Cowan, M, Paciorek, C, Lin, J, Farzadfar, F, Khang, Y, Stevens, G, Rao, M, Ali, M, Riley, L, Robinson, C, and Ezzati, M
Subjects: Gerontology, Adult, Blood Glucose, Male, medicine.medical_specialty, Latin Americans, Psychological intervention, Global Health, Body Mass Index, Settore MED/43 - Medicina Legale, Diabetes mellitus, Epidemiology, medicine, Global health, Diabetes Mellitus, Prevalence, Population growth, Humans, Hemoglobin A, Glycosylated, Glycated Hemoglobin, business.industry, Public health, Diabetes Mellitu, General Medicine, Fasting, Health Survey, medicine.disease, Health Surveys, World Health, Female, business, Body mass index, Demography, Human
Abstract: Summary Background Data for trends in glycaemia and diabetes prevalence are needed to understand the effects of diet and lifestyle within populations, assess the performance of interventions, and plan health services. No consistent and comparable global analysis of trends has been done. We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories. Methods We obtained data from health examination surveys and epidemiological studies (370 country-years and 2·7 million participants). We converted systematically between different glycaemic metrics. For each sex, we used a Bayesian hierarchical model to estimate mean FPG and its uncertainty by age, country, and year, accounting for whether a study was nationally, subnationally, or community representative. Findings In 2008, global age-standardised mean FPG was 5·50 mmol/L (95% uncertainty interval 5·37–5·63) for men and 5·42 mmol/L (5·29–5·54) for women, having risen by 0·07 mmol/L and 0·09 mmol/L per decade, respectively. Age-standardised adult diabetes prevalence was 9·8% (8·6–11·2) in men and 9·2% (8·0–10·5) in women in 2008, up from 8·3% (6·5–10·4) and 7·5% (5·8–9·6) in 1980. The number of people with diabetes increased from 153 (127–182) million in 1980, to 347 (314–382) million in 2008. We recorded almost no change in mean FPG in east and southeast Asia and central and eastern Europe. Oceania had the largest rise, and the highest mean FPG (6·09 mmol/L, 5·73–6·49 for men; 6·08 mmol/L, 5·72–6·46 for women) and diabetes prevalence (15·5%, 11·6–20·1 for men; and 15·9%, 12·1–20·5 for women) in 2008. Mean FPG and diabetes prevalence in 2008 were also high in south Asia, Latin America and the Caribbean, and central Asia, north Africa, and the Middle East. Mean FPG in 2008 was lowest in sub-Saharan Africa, east and southeast Asia, and high-income Asia-Pacific. In high-income subregions, western Europe had the smallest rise, 0·07 mmol/L per decade for men and 0·03 mmol/L per decade for women; North America had the largest rise, 0·18 mmol/L per decade for men and 0·14 mmol/L per decade for women. Interpretation Glycaemia and diabetes are rising globally, driven both by population growth and ageing and by increasing age-specific prevalences. Effective preventive interventions are needed, and health systems should prepare to detect and manage diabetes and its sequelae. Funding Bill & Melinda Gates Foundation and WHO.
Published: 2011

4. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Cholesterol). National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321country-years and 3·0 million participants

Author: Farzadfar, F, Finucane, Mm, Danaei, G, Pelizzari, Pm, Cowan, Mj, Paciorek, Cj, Singh, Gm, Lin, Jk, Stevens, Ga, Riley, Lm, collaborators Farzadfar F, Ezzati M., Ezzati, M, Salinas, Ca, Al Nsour, M, Ali, Mm, Al Nuaim AR, Ambady, R, Antonio, M, Azizi, F, Barbagallo, Cm, Barbieri, M, Barros, H, Bautista, Le, Bjerregaard, P, Björkelund, C, Bovet, P, Brekenkamp, J, Bursztyn, M, de León AC, Campos, H, Capuano, V, Castetbon, K, Chang, Cj, Chen, Cj, Choi, Js, Chua, L, Cífková, R, Costanza, Mc, Eggertsen, Rw, Esteghamati, A, Fan, Jg, Ferreccio, C, Florez, Hj, Fornés, Ns, Fowkes, Fg, Franceschini, G, Frisk, F, Giampaoli, S, Gómez, Lf, Gomez Zumaquero JM, Graff Iversen, S, Carvajal, Rg, Gupta, R, Hansen, Tw, Hata, J, He, J, Herrera, Vm, Ho, Sc, Frisman, Gh, Ikeda, N, Jaddou, Hy, Jafar, Th, Janghorbani, M, Joffres, Mr, Jonas, Jb, Kadiki, Oa, Karalis, I, Kastarinen, Mj, Katz, J, Khalilzadeh, O, Khang, Yh, Kiechl, S, Kobayashi, J, Kubínová, R, Lam, Th, Lawes, Cm, Lee, J, Lim, S, Lin, Hh, Lin, X, Lin, Cc, Ma, S, Maclean, Dr, Magliano, Dj, Mannami, T, Marques Vidal, P, Miettola, J, Miquel, Jf, Miranda, Jj, Mohamed, Mk, Mohan, V, Mokdad, A, Mollentze, Wf, Morales, Dd, Muiesan, Maria Lorenza, Nabipour, I, Nangia, V, Nerhus, Ka, Neuhauser, H, Oh, Sw, Ohkubo, T, Onat, A, Oróstegui, M, Pan, Wh, Panagiotakos, Db, Panza, F, Passos, Vm, Pérez, C, Pichardo, R, Phua, Hp, Polakowska, M, Rafiei, M, Ramos, Lr, Reddy, Kk, Redon, J, Revilla, L, Roaeid, Rb, Ronkainen, K, Roth, Ga, Sanisoglu, Sy, Sarraf Zadegan, N, Schooling, Cm, Schwarz, B, Silva, E, Simons, La, Solfrizzi, V, Stein, Ad, Stessman, J, Suka, M, Swai, Ab, Tai, Es, Thomas, Gn, Thorogood, M, Tuomilehto, Jo, Unwin, N, Vander Hoorn, S, Vanderpump, Mp, Volpato, S, Welin, Lx, Willeit, J, Woodward, M, Xu, L, Yamamoto, A, Yang, X, Yeh, Lc, Yoon, Js, You, Q, and Zhang, J.
Published: 2011

5. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and5·4 million participants

Author: Danaei, G, Finucane, Mm, Lin, Jk, Singh, Gm, Paciorek, Cj, Cowan, Mj, Farzadfar, F, Stevens, Ga, Lim, Ss, Riley, Lm, Ezzati, M, Abdeen, Z, Agyemang, C, Al Nsour, M, Ali, Mm, Ambady, R, Babu, Bv, Barbagallo, Cm, Barceló, A, Barreto, S, Barros, H, Bautista, Le, Bjerregaard, P, Björkelund, C, Bo, S, Bobak, M, Bonora, E, Botana, Ma, Bovet, P, Breckenkamp, J, Breteler, Mm, Broda, G, Brown, Ij, Bursztyn, M, de León, Ac, Casiglia, E, Castetbon, K, Chatterji, S, Chen, Z, Chen, Cj, Chua, L, Cífková, R, Cobiac, Lj, Cooper, Rs, Dankner, Rs, Dong, Gh, Elliott, P, Erem, C, Esteghamati, A, Fan, Jg, Ferreccio, C, Firmo, Jo, Fornés, Ns, Fuchs, Fd, Getz, L, Giampaoli, S, Gómez, Lf, Graff Iversen, S, Carvajal, Rg, Gulliford, Mc, Gupta, P, Gureje, O, Hansen, Tw, He, J, Heinrich, J, Hennis, A, Herrera, Vm, Sc, Ho, Ibrahim, Mm, Ikeda, N, Jafar, Th, Joffres, Mr, Jonas, Jb, Kamadjeu, Rm, Karalis, I, Kastarinen, Mj, Katz, J, Kelly, P, Khalilzadeh, O, Khang, Yh, Kiechl, S, Kim, Kw, Kobayashi, J, Kubínová, R, Kusuma, Ys, Lam, Th, Lawes, Cm, Le, C, Lee, J, Lin, X, Lin, Hh, Lin, Cc, Liu, X, Lorbeer, R, Ma, S, Ma, G, Magliano, Dj, Makdisse, M, Mancia, G, Mbanya, Jc, Miettola, J, Minh, Hv, Miranda, Jj, Mohamed, Mk, Mohan, V, Mokdad, Ah, Morales, Dd, Morgan, K, Muiesan, Maria Lorenza, Muntoni, S, Nabipour, I, Nangia, V, Neuhauser, H, Ninomiya, T, Olivieri, O, Onal, Ae, Onat, A, Oróstegui, M, Panagiotakos, Db, Panza, F, Pednekar, Ms, Pérez, C, Pérez Fernández, R, Pichardo, R, Phua, Hp, Plans, P, Poulter, N, Raitakari, Ot, Rampal, S, Rampal, L, Redon, J, Revilla, L, Roaeid, Rb, Rojas Martinez, R, Sanisoglu, Sy, Sans, S, Schelleman, H, Schneider, Ij, Silva, Da, Silva, E, Simons, La, Smith, M, Soebardi, S, Solfrizzi, V, Stein, Ad, Stergiou, Gs, Stessman, J, Suka, M, Tambs, K, Tesfaye, F, Thorogood, M, Tilvis, Rs, Trenkwalder, P, Tuomilehto, Jo, Tzourio, C, Vander Hoorn, S, Vanderpump, Mp, Verschuren, M, Vioque, J, Waspadji, S, Wilhelmsen, L, Willeit, J, Woodward, M, Xavier, Aj, Xu, L, Yang, G, Yeh, Lc, Yoon, Js, You, Q, and Zhou, M.
Subjects: Blood Pressure, Epidemiology, Epidemiology, Blood Pressure
Published: 2011

6. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5•4 million participants

Author: Danaei, G, Finucane, Mm, Lin, Jk, Singh, Gm, Cowan, Mj, Paciorek, Cj, Farzadfar, F, Stevens, Ga, Riley, Lm, Ezzati, M, Abdeen, Z, Agyemang, C, Al Nsour, M, Ali, Mm, Ambady, R, Babu, Bv, Barbagallo, Cm, Barceló, A, Barreto, S, Barros, H, Bautista, Le, Bjerregaard, P, Björkelund, C, Bo, Simona, Bobak, M, Bonora, E, Botana, Ma, Bovet, P, Breckenkamp, J, Breteler, Mm, Broda, G, Brown, Ij, Bursztyn, M, de León AC, Casiglia, E, Castetbon, K, Chatterji, S, Chen, Z, Chen, Cj, Chua, L, Cífková, R, Cobiac, Lj, Cooper, Rs, Dankner, Rs, Dong, Gh, Elliott, P, Erem, C, Esteghamati, A, Fan, Jg, Ferreccio, C, Firmo, Jo, Fornés, Ns, Fuchs, Fd, Getz, L, Giampaoli, S, Gómez, Lf, Graff Iversen, S, Carvajal, Rg, Gulliford, Mc, Gupta, P, Gureje, O, Hansen, Tw, He, J, Heinrich, J, Hennis, A, Herrera, Vm, Ho, Sc, Ibrahim, Mm, Ikeda, N, Jafar, Th, Joffres, Mr, Jonas, Jb, Kamadjeu, Rm, Karalis, I, Kastarinen, Mj, Katz, J, Kelly, P, Khalilzadeh, O, Khang, Yh, Kiechl, S, Kim, Kw, Kobayashi, J, Kubínová, R, Kusuma, Ys, Lam, Th, Lawes, Cm, Le, C, Lee, J, Lin, X, Lin, Hh, Lin, Cc, Liu, X, Lorbeer, R, Ma, S, Ma, G, Magliano, Dj, Makdisse, M, Mancia, G, Mbanya, Jc, Miettola, J, Minh, Hv, Miranda, Jj, Mohamed, Mk, Mohan, V, Mokdad, Ah, Morales, Dd, Morgan, K, Muiesan, Lm, Muntoni, S, Nabipour, I, Nangia, V, Neuhauser, H, Ninomiya, T, Olivieri, O, Onal, Ae, Onat, A, Oróstegui, M, Panagiotakos, Db, Panza, F, Pednekar, Ms, Pérez, C, Pérez Fernández, R, Pichardo, R, Phua, Hp, Plans, P, Poulter, N, Raitakari, Ot, Rampal, S, Rampal, L, Redon, J, Revilla, L, Roaeid, Rb, Rojas Martinez, R, Sanisoglu, Sy, Sans, S, Schelleman, H, Schneider, Ij, Silva, Da, Silva, E, Simons, La, Smith, M, Soebardi, S, Solfrizzi, V, Stein, Ad, Stergiou, Gs, Stessman, J, Suka, M, Tambs, K, Tesfaye, F, Thorogood, M, Tilvis, Rs, Trenkwalder, P, Tuomilehto, Jo, Tzourio, C, Vander Hoorn, S, Vanderpump, Mp, Verschuren, M, Vioque, J, Waspadji, S, Wilhelmsen, L, Willeit, J, Woodward, M, Xavier, Aj, Xu, L, Yang, G, Yeh, Lc, Yoon, Js, You, Q, and Zhou, M.
Published: 2011

7. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

Author: Finucane, Mm, Stevens, Ga, Cowan, Mj, Danaei, G, Lin, Jk, Paciorek, Cj, Singh, Gm, Gutierrez, Hr, Lu, Y, Bahalim, An, Farzadfar, F, Riley, Lm, Ezzati, M, Cowan, M, Singh, G, Aamodt, G, Abdeen, Z, Abdella, Na, Rahim, Hf, Addo, J, Ali, Mm, Al Nsour, M, Ambady, R, Aro, P, Babu, Bv, Barbagallo, Cm, Barceló, A, Barros, H, Bautista, Le, Bjerregaard, P, Bonora, E, Bovet, P, Breckenkamp, J, Broda, G, Brown, Ij, Bursztyn, M, de León, Ac, Cappuccio, Fp, Castetbon, K, Chatterji, S, Chen, Z, Chen, Cj, Chua, L, Cífková, R, Cobiac, Lj, Corsi, Am, Craig, Cl, Dastgiri, S, de Sereday, Ms, Dinc, G, Dorsi, E, Dragano, N, Drewnowski, A, Elliott, P, Engeland, A, Esteghamati, A, Fan, Jg, Ferreccio, G, Fornés, Ns, Fuchs, Fd, Giampaoli, S, Gómez, Lf, Graff Iversen, S, Grant, Jf, Carvajal, Rg, Gulliford, Mc, Gupta, R, Gupta, Pc, Gureje, O, Heim, N, Heinrich, J, Hemmingsson, T, Herrera, Vm, Sc, Ho, Holdsworth, M, Hopman, Wm, Husseini, A, Ikeda, N, Jacobsen, Bk, Jafar, Th, Janghorbani, M, Jasienska, G, Joffres, Mr, Jonas, Jb, Kalter Leibovici, O, Karalis, I, Katz, J, Keinan Boker, L, Kelly, P, Khalilzadeh, O, Khang, Yh, Kiechl, S, Kiyohara, Y, Krause, Mp, Kusuma, Ys, Langhammer, A, Lee, J, Lévy Marchal, C, Li, Y, Lim, S, Lin, Cc, Lind, L, Lissner, L, Lopez Jaramillo, P, Lorbeer, R, Ma, G, Ma, S, Macià, F, Magliano, Dj, Makdisse, M, Marques Vidal, P, Miccoli, R, Miettola, J, Miranda, Jj, Mohamed, Mk, Mohan, V, Mohanna, S, Mokdad, A, Morales, Dd, Muiesan, Maria Lorenza, Nabipour, I, Nangia, V, Nemesure, B, Neovius, M, Nerhus, Ka, Nervi, F, Neuhauser, H, Nguyen, M, Onal, Ae, Onat, A, Oróstegui, M, Ouedraogo, H, Panagiotakos, Db, Panza, F, Park, Y, Pednekar, Ms, Peres, Ma, Pérez, C, Pichardo, R, Phua, Hp, Pistelli, F, Plans, P, Prabhakaran, D, Raitakari, Ot, Rampal, S, Rampal, L, Rasmussen, F, Redon, J, Revilla, L, Reyes García, V, Roaeid, Rb, Rodriguez Artalejo, F, Rosero Bixby, L, Sachdev, Hs, Sánchez, Jr, Sanisoglu, Sy, Schapochnik, N, Sereday, Ms, Serra Majem, L, Shaw, J, Shiri, R, Shu, Xo, Silva, E, Simons, La, Smith, M, Solfrizzi, V, Sonestedt, E, Stattin, P, Stein, Ad, Stergiou, Gs, Stessman, J, Sudo, A, Sundh, V, Sundquist, K, Sundström, J, Tobias, M, Torheim, Le, Tur, Ja, Uhernik, Ai, Ukoli, Fa, Vanderpump, Mp, Varo, Jj, Veierød, Mb, Velásquez Meléndez, G, Verschuren, M, Villalpando, S, Vioque, J, Ward, M, Waspadji, S, Willeit, J, Woodward, M, Xu, L, Xu, F, Yang, G, Yeh, Lc, Yoon, Js, You, Q, Zheng, W, and Zhou, M.
Subjects: Body Mass Index, Obesity, epidemiology, epidemiology, Obesity, Body Mass Index
Published: 2011

8. Gonadotropin treatment increases homocysteine levels in idiopathic hypogonadotropic hypogonadism: an indirect effect mediated by changes in body composition

Author: Oktenli, C, primary, Yesilova, Z, additional, Ozata, M, additional, Yaman, H, additional, Tuzun, A, additional, Dundar, S, additional, Sanisoglu, SY, additional, Musabak, U, additional, Erbil, MK, additional, and Dagalp, K, additional
Published: 2003
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9. The rate of pyrin mutations in critically ill patients with systemic inflammatory response syndrome and sepsis: a pilot study.

Author: Koc B, Oktenli C, Bulucu F, Karadurmus N, Sanisoglu SY, Gul D, Koc, Bayram, Oktenli, Cagatay, Bulucu, Fatih, Karadurmus, Nuri, Sanisoglu, S Yavuz, and Gul, Davut
Published: 2007

10. The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008

Author: Danaei, G., Singh, G., Paciorek, C., Lin, J., Cowan, M., Finucane, M., Farzadfar, F., Stevens, G., Riley, L., Lu, Y., Rao, M., Ezzati, M., Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group, Aamodt, G., Abdeen, Z., Abdella, N., Rahim, H., Addo, J., Aekplakorn, W., Afifi, M., Agabiti Rosei, E., Aguilar Salinas CA, Agyemang, C., Ali, M., Al Nsour, M., Al Nuaim AR, Ambady, R., Aro, P., Azizi, F., Barbagallo, C., Barbieri, M., Barceló, A., Barreto, S., Barros, H., Bautista, L., Benetos, A., Bjerregaard, P., Björkelund, C., Bo, S., Bobak, M., Bonora, E., Bontha, B., Botana, M., Bovet, P., Breckenkamp, J., Breteler, M., Broda, G., Brown, I., Bursztyn, M., Cabrera de León, A., Campos, H., Cappuccio, F., Capuano, V., Casiglia, E., Castellano, M., Castetbon, K., Cea, L., Chang, C., Chaouki, N., Chatterji, S., Chen, Z., Chen, C., Choi, J., Chua, L., Cífková, R., Cobiac, L., Cooper, R., Corsi, A., Costanza, M., Craig, C., Dankner, R., Dastgiri, S., Delgado, E., Dinc, G., Doi, Y., Dong, G., Dorsi, E., Dragano, N., Drewnowski, A., Eggertsen, W., Elliott, P., Engeland, A., Erem, C., Esteghamati, A., Fall, C., Fan, J., Ferreccio, C., Fezeu, L., Firmo, J., Florez, H., Fornés, N., Fowkes, F., Franceschini, G., Frisk, F., Fuchs, F., Fuller, E., Getz, L., Giampaoli, S., Gómez, L., Gomez Zumaquero JM, Graff Iversen, S., Grant, J., Guerrero Carvajal, R., Gulliford, M., Gupta, R., Gupta, P., Gureje, O., Hansen, T., Hata, J., He, J., Heim, N., Heinrich, J., Hemmingsson, T., Hennis, A., Herman, W., Herrera, V., Ho, S., Holdsworth, M., Hollman Frisman, G., Hopman, W., Hussain, A., Husseini, A., Ibrahim, M., Ikeda, N., Jacobsen, B., Jaddou, H., Jafar, T., Janghorbani, M., Jasienska, G., Joffres, M., Jonas, J., Kadiki, O., Kalter Leibovici, O., Kamadjeu, R., Karalis, I., Kastarinen, M., Katz, J., Keinan Boker, L., Kelly, P., Khalilzadeh, O., Khang, Y., Kiechl, S., Kim, K., Kiyohara, Y., Kobayashi, J., Krause, M., Kubínová, R., Kurjata, P., Kusuma, Y., Lam, T., Langhammer, A., Lawes, C., Le, C., Lee, J., Lévy Marchal, C., Li, Y., Lim, S., Lim, T., Lin, X., Lin, C., Lin, H., Lind, L., Lissner, L., Liu, X., Lopez Jaramillo, P., Lorbeer, R., Ma, G., Ma, S., Macià, F., Maclean, D., Maggi, S., Magliano, D., Makdisse, M., Mancia, G., Mannami, T., Marques Vidal, P., Mbanya, J., McFarlane Anderson, N., Miccoli, R., Miettola, J., Minh, H., Miquel, J., Miranda, J., Mohamed, M., Mohan, V., Mohanna, S., Mokdad, A., Mollentze, W., Morales, D., Morgan, K., Muiesan, L., Muntoni, S., Nabipour, I., Nakagami, T., Nangia, V., Nemesure, B., Neovius, M., Nerhus, K., Nervi, F., Neuhauser, H., Nguyen, M., Ninomiya, T., Noale, M., Oh, S., Ohkubo, T., Olivieri, O., Önal, A., Onat, A., Oróstegui, M., Ouedraogo, H., Pan, W., Panagiotakos, D., Panza, F., Park, Y., Passos, V., Pednekar, M., Peres, M., Pérez, C., Pérez Fernández, R., Pichardo, R., Phua, H., Pistelli, F., Plans, P., Polakowska, M., Poulter, N., Prabhakaran, D., Qiao, Q., Rafiei, M., Raitakari, O., Ramos, L., Rampal, S., Rampal, L., Rasmussen, F., Reddy, K., Redon, J., Revilla, L., Reyes García, V., Roaeid, R., Rodriguez Artalejo, F., Rojas Martinez, R., Ronkainen, K., Rosero Bixby, L., Roth, G., Sachdev, H., Sánchez, J., Sanisoglu, S., Sans, S., Sarraf Zadegan, N., Scazufca, M., Schaan, B., Schapochnik, N., Schelleman, H., Schneider, I., Schooling, C., Schwarz, B., Sekuri, C., Sereday, M., Serra Majem, L., Shaw, J., Shera, A., Shi, Z., Shiri, R., Shu, X., Silva, D., Silva, E., Simons, L., Smith, M., Söderberg, S., Soebardi, S., Solfrizzi, V., Sonestedt, E., Soysal, A., Stattin, P., Stein, A., Stergiou, G., Stessman, J., Sudo, A., Suka, M., Sundh, V., Sundquist, K., Sundström, J., Swai, A., Tai, E., Tambs, K., Tesfaye, F., Thomas, G., Thorogood, M., Tilvis, R., Tobias, M., Torheim, L., Trenkwalder, P., Tuomilehto, J., Tur, J., Tzourio, C., Uhernik, A., Ukoli, F., Unwin, N., Vander Hoorn, S., Vanderpump, M., Varo, J., Veierød, B., Velásquez Meléndez, G., Verschuren, M., Viet, L., Villalpando, S., Vioque, J., Vollenweider, P., Volpato, S., Wang, N., Wang, Y., Ward, M., Waspadji, S., Welin, L., Wilhelmsen, L., Willeit, J., Woodward, M., Xavier, A., Xu, F., Xu, L., Yamamoto, A., Yang, G., Yang, X., Yeh, L., Yoon, J., You, Q., Yu, Z., Zhang, J., Zhang, L., Zheng, W., Zhou, M., Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M and Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group, Aamodt G, Abdeen Z, Abdella NA, Rahim HF, Addo J, Aekplakorn W, Afifi MM, Agabiti-Rosei E, Aguilar Salinas CA, Agyemang C, Ali MM, Al-Nsour M, Al-Nuaim AR, Ambady R, Aro P, Azizi F, Barbagallo CM, Barbieri MA, Barceló A, Barreto SM, Barros H, Bautista LE, Benetos A, Bjerregaard P, Björkelund C, Bo S, Bobak M, Bonora E, Bontha BV, Botana MA, Bovet P, Breckenkamp J, Breteler MM, Broda G, Brown IJ, Bursztyn M, Cabrera de León A, Campos H, Cappuccio FP, Capuano V, Casiglia E, Castellano M, Castetbon K, Cea L, Chang CJ, Chaouki N, Chatterji S, Chen Z, Chen CJ, Choi JS, Chua L, Cífková R, Cobiac LJ, Cooper RS, Corsi AM, Costanza MC, Craig CL, Dankner RS, Dastgiri S, Delgado E, Dinc G, Doi Y, Dong GH, Dorsi E, Dragano N, Drewnowski A, Eggertsen W, Elliott P, Engeland A, Erem C, Esteghamati A, Fall CH, Fan JG, Ferreccio C, Fezeu L, Firmo JO, Florez HJ, Fornés NS, Fowkes FG, Franceschini G, Frisk F, Fuchs FD, Fuller EL, Getz L, Giampaoli S, Gómez LF, Gomez-Zumaquero JM, Graff-Iversen S, Grant JF, Guerrero Carvajal R, Gulliford MC, Gupta R, Gupta PC, Gureje O, Hansen TW, Hata J, He J, Heim N, Heinrich J, Hemmingsson T, Hennis A, Herman WH, Herrera VM, Ho S, Holdsworth M, Hollman Frisman G, Hopman WM, Hussain A, Husseini A, Ibrahim M, Ikeda N, Jacobsen BK, Jaddou HY, Jafar TH, Janghorbani M, Jasienska G, Joffres MR, Jonas JB, Kadiki OA, Kalter-Leibovici O, Kamadjeu RM, Karalis I, Kastarinen MJ, Katz J, Keinan-Boker L, Kelly P, Khalilzadeh O, Khang YH, Kiechl S, Kim KW, Kiyohara Y, Kobayashi J, Krause MP, Kubínová R, Kurjata P, Kusuma YS, Lam TH, Langhammer A, Lawes CM, Le C, Lee J, Lévy-Marchal C, Li Y, Lim S, Lim TO, Lin X, Lin CC, Lin HH, Lind L, Lissner L, Liu X, Lopez-Jaramillo P, Lorbeer R, Ma G, Ma S, Macià F, MacLean DR, Maggi S, Magliano DJ, Makdisse M, Mancia G, Mannami T, Marques-Vidal P, Mbanya JC, McFarlane-Anderson N, Miccoli R, Miettola J, Minh HV, Miquel JF, Miranda J, Mohamed MK, Mohan V, Mohanna S, Mokdad A, Mollentze WF, Morales DD, Morgan K, Muiesan LM, Muntoni S, Nabipour I, Nakagami T, Nangia V, Nemesure B, Neovius M, Nerhus KA, Nervi F, Neuhauser H, Nguyen M, Ninomiya T, Noale M, Oh SW, Ohkubo T, Olivieri O, Önal AE, Onat A, Oróstegui M, Ouedraogo H, Pan WH, Panagiotakos DB, Panza F, Park Y, Passos VM, Pednekar MS, Peres MA, Pérez C, Pérez-Fernández R, Pichardo R, Phua HP, Pistelli F, Plans P, Polakowska M, Poulter N, Prabhakaran D, Qiao Q, Rafiei M, Raitakari OT, Ramos LR, Rampal S, Rampal L, Rasmussen F, Reddy KK, Redon J, Revilla L, Reyes-García V, Roaeid RB, Rodriguez-Artalejo F, Rojas-Martinez R, Ronkainen K, Rosero-Bixby L, Roth GA, Sachdev HS, Sánchez JR, Sanisoglu SY, Sans S, Sarraf-Zadegan N, Scazufca M, Schaan BD, Schapochnik N, Schelleman H, Schneider IJ, Schooling C, Schwarz B, Sekuri C, Sereday MS, Serra-Majem L, Shaw J, Shera AS, Shi Z, Shiri R, Shu XO, Silva DA, Silva E, Simons LA, Smith M, Söderberg S, Soebardi S, Solfrizzi V, Sonestedt E, Soysal A, Stattin P, Stein AD, Stergiou GS, Stessman J, Sudo A, Suka M, Sundh V, Sundquist K, Sundström J, Swai AB, Tai E, Tambs K, Tesfaye F, Thomas GN, Thorogood M, Tilvis RS, Tobias M, Torheim LE, Trenkwalder P, Tuomilehto JO, Tur JA, Tzourio C, Uhernik AI, Ukoli FA, Unwin N, Vander Hoorn S, Vanderpump MP, Varo JJ, Veierød B, Velásquez-Meléndez G, Verschuren M, Viet L, Villalpando S, Vioque J, Vollenweider P, Volpato S, Wang N, Wang YX, Ward M, Waspadji S, Welin LX, Wilhelmsen L, Willeit J, Woodward M, Xavier AJ, Xu F, Xu L, Yamamoto A, Yang G, Yang X, Yeh LC, Yoon JS, You Q, Yu Z, Zhang J, Zhang L, Zheng W, Zhou M, ACS - Amsterdam Cardiovascular Sciences, APH - Amsterdam Public Health, and Public and occupational health
Subjects: Gerontology, Adult, Male, Risk, medicine.medical_specialty, Settore MED/09 - Medicina Interna, Measures of national income and output, Population, Hypercholesterolemia, OBESIDADE, Blood Pressure, Global Health, Body Mass Index, Age Distribution, Risk Factors, cardiovascular disease, Physiology (medical), Diabetes mellitus, risk factors, Epidemiology, medicine, Diabetes Mellitus, Humans, Obesity, Risk factor, Sex Distribution, education, Developing Countries, Cholesterolo, education.field_of_study, business.industry, Urbanization, Feeding Behavior, Middle Aged, medicine.disease, Blood pressure, Cholesterol, Socioeconomic Factors, Cardiovascular Diseases, Hypertension, Western World, Female, Cardiology and Cardiovascular Medicine, business, Body mass index, Demography
Abstract: Background— It is commonly assumed that cardiovascular disease risk factors are associated with affluence and Westernization. We investigated the associations of body mass index (BMI), fasting plasma glucose, systolic blood pressure, and serum total cholesterol with national income, Western diet, and, for BMI, urbanization in 1980 and 2008. Methods and Results— Country-level risk factor estimates for 199 countries between 1980 and 2008 were from a previous systematic analysis of population-based data. We analyzed the associations between risk factors and per capita national income, a measure of Western diet, and, for BMI, the percentage of the population living in urban areas. In 1980, there was a positive association between national income and population mean BMI, systolic blood pressure, and total cholesterol. By 2008, the slope of the association between national income and systolic blood pressure became negative for women and zero for men. Total cholesterol was associated with national income and Western diet in both 1980 and 2008. In 1980, BMI rose with national income and then flattened at ≈Int$7000; by 2008, the relationship resembled an inverted U for women, peaking at middle-income levels. BMI had a positive relationship with the percentage of urban population in both 1980 and 2008. Fasting plasma glucose had weaker associations with these country macro characteristics, but it was positively associated with BMI. Conclusions— The changing associations of metabolic risk factors with macroeconomic variables indicate that there will be a global pandemic of hyperglycemia and diabetes mellitus, together with high blood pressure in low-income countries, unless effective lifestyle and pharmacological interventions are implemented.
Published: 2013

11. High prevalence of obesity in Tokat, a northern province of Turkey.

Author: Ustu Y, Ugurlu M, Aslan O, Aksoy YM, Kasim I, Egici MT, and Sanisoglu SY
Subjects: Adolescent, Adult, Aged, Chi-Square Distribution, Cross-Sectional Studies, Female, Humans, Life Style, Logistic Models, Male, Middle Aged, Overweight epidemiology, Prevalence, Turkey epidemiology, Obesity epidemiology
Abstract: Objective: To determine the prevalence of overweight and obesity in the Tokat Region with demographic, socioeconomic and medical factors in the adult population., Methods: A sample was selected from the province of Tokat. A total of 5162 participants over 18 years (1885 women and 3277 men) were included in the study. Demographic factors, family history of selected medical conditions, and lifestyle factors were obtained and blood pressure levels were measured for all participants. Obesity was defined as BMI > or = 30 kg/m2 and overweight as BMI between 25.0 to 29.9 kg/m2., Results: The study demonstrated that the prevalence of overweight was 27.6% in men, 34.2% in women and 30% for overall. Obesity was prevalent in 33.6% men, 22.3% women, and 29.5% overall. The prevalence of obesity increased with age. Age, gender, educational level, marital status, hypertension, family histories of selected medical conditions were independently associated with obesity. Prevalence of hypertension increased with the degree of obesity. Results were in accordance with recent Turkish population-based obesity studies., Conclusion: The data obtained showed that obesity prevalence was high in the study area. Primary prevention through lifestyle modifications may have a critical role in the control of obesity.
Published: 2012

12. Diagnostic value of elastosonographically determined strain index in the differential diagnosis of benign and malignant thyroid nodules.

Author: Cakir B, Aydin C, Korukluoğlu B, Ozdemir D, Sisman IC, Tüzün D, Oguz A, Güler G, Güney G, Kuşdemir A, Sanisoglu SY, and Ersoy R
Subjects: Adult, Aged, Autoantibodies blood, Biopsy, Fine-Needle, Diagnosis, Differential, Elasticity, Female, Humans, Male, Middle Aged, Pressure, Prospective Studies, Sensitivity and Specificity, Thyroid Neoplasms pathology, Thyroid Nodule pathology, Thyrotropin blood, Thyroid Neoplasms diagnostic imaging, Thyroid Nodule diagnostic imaging, Ultrasonography methods
Abstract: Elastosonography (ES) is a newly developed method that is used for the differential diagnosis of benign and malignant thyroid nodules. In different studies, ES scoring has been compared with histopathological findings, and sensitivity and specificity of the scoring were calculated. In this study, it determines the strain index (SI) as well as the ES to score thyroid nodules, and establishes the role for these parameters in the differential diagnosis of thyroid nodules using histopathological analysis as a reference standard. Real-time ES in transverse axis (TA) and longitudinal axis (LA) was performed in 391 nodules of 292 patients. ES scoring was made for all the nodules. SI in TA and LA was calculated for four times in each nodule and mean values were determined. The results were compared with final histopathological diagnoses. In histopathological examinations, 125 (31.97%) of 391 nodules were malignant and 266 (68.03%) were benign. Of these histopathologically benign nodules, 189 (%71.05) were also probably benign according to elastosonographic scoring (scores of 1, 2, or 3), while 77 (28.95%) were probably malignant (scores of 4 or 5). Among 125 histopathologically malignant nodules, 52 (41.60%) were probably benign and 73 (58.40%) were probably malignant according to elastosonographic scoring. There was a significant relation between scoring and histopathological findings (χ(2) = 36.513; P < 0.001). Accordingly, sensitivity and specificity of ES scoring were 58.4 and 71.0%, respectively. ROC analysis value obtained for strain ratios in LA (AUC: 75.5%; P < 0.001) had a higher significance compared to ROC analysis value obtained for strain ratios in TA (AUC: 66.0%). Thus, ROC analysis evaluation was applied only for SI in LA. The optimal SI cut-off value in LA for all the nodules was found to be 16.709 (sensitivity: 73.4%, specificity: 70.0%) (AUC: 75.4 ± 0.03%; 70.2-80.5%). SI cut-off value corresponding to 90% sensitivity in this axis was 4.516 (specificity: 35.7%). Sensitivity and specificity of SI values that were determined according to morphological features of nodules in gray-scale ultrasonography were higher. For hypoechoic nodules with microcalcifications and without a halo, SI cut-off value, sensitivity, and specificity were 17.020, 84.3, and 81.1%, respectively. Our study is the first clinical-wide series study that measured, used, and compared the ES scoring and SI cut-off values for the differential diagnosis of benign and malignant thyroid nodules. This study indicates that measurement of SI with ES as a noninvasive procedure may be used as an adjunctive method to the conventional methods for the differential diagnosis of thyroid nodules.
Published: 2011
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13. Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).

Author: Ozgurtas T, Oktenli C, Dede M, Tapan S, Kenar L, Sanisoglu SY, Yesilova Z, Yenen MC, Erbil MK, and Baser I
Subjects: Adult, Androgens metabolism, Arginine blood, Body Mass Index, Case-Control Studies, Cyproterone Acetate pharmacology, Ethinyl Estradiol pharmacology, Female, Gonadotropins metabolism, Humans, Insulin Resistance, Time Factors, Arginine analogs & derivatives, Contraceptives, Oral pharmacology, Metformin pharmacology, Polycystic Ovary Syndrome blood
Abstract: There is a little information in literature about circulating asymmetric dimethylarginine (ADMA) concentrations in polycystic ovary syndrome (PCOS) and the results reported are discrepant. In this study, therefore, we aimed (1) to determine the circulating ADMA concentrations in 44 women with PCOS and 22 age- and BMI-matched healthy controls, (2) to evaluate its correlations with insulin resistance, gonadotrophins, and androgen secretion, and (3) to compare effects of metformin and ethinyl estradiol-cyproterone acetate (EE/CPA) treatments on circulating ADMA concentrations. In conclusion, our data indicate that circulating ADMA concentrations in non-obese, non-hypertensive and young women with PCOS are significantly higher than healthy controls and they improved by a 3-month course of metformin and oral contraceptive treatments.
Published: 2008
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14. Pubertal progression and serum lipid profile in obese children.

Author: Güven A and Sanisoglu SY
Subjects: Adipose Tissue, Adolescent, Blood Pressure, Body Composition, Body Mass Index, Child, Child, Preschool, Cholesterol, HDL blood, Cholesterol, LDL blood, Female, Humans, Male, Lipids blood, Obesity metabolism, Puberty physiology
Abstract: Background: During puberty, sex hormones are associated with decrease in serum lipids in healthy individuals., Aim: To investigate the relationships between pubertal development, serum lipid profile and atherogenic indices in obese children and adolescents., Methods: Body mass index (BMI), blood pressure, and serum lipids of 340 obese children (182 girls, 158 boys) aged 3.6-17.8 years were measured. Atherogenic index, total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C)/HDL-C were calculated as indices of atherogenic risk., Results: Weight (F = 62.078; p < 0.001), BMI (F = 21.083; p < 0.001), systolic blood pressure (SBP) (F = 11.956; p < 0.001) and diastolic blood pressure (DBP) (F = 3.947, p = 0.005) differed significantly between pubertal stages and increased with advance in stages in males. HDL-C (F = 4.586; p = 0.004) differed significantly between pubertal stages and decreased with advancing stages in males. Weight (F = 66.915; p <0.001), BMI (F = 23.101; p <0.001), SBP (F = 10.873; p <0.001), DBP (F = 2.839; p = 0.040) and LDL-C (F = 3.072; p = 0.029) differed significantly between pubertal stages and increased with advancing stages in girls. Triglyceride, TC, LDL-C and SBP were statistically significant determinants for HDL-C according to multivariate linear regression analysis. SBP was significantly affected by chronological age, BMI, glucose, TC and HDL-C according to stepwise linear regression analysis., Conclusion: The increasing rate of obesity is associated with an increase in cardiovascular risk factors in parallel with advance in pubertal stages, particularly in boys.
Published: 2008
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15. Association of metabolic syndrome with impaired heart rate recovery and low exercise capacity in young male adults.

Author: Deniz F, Katircibasi MT, Pamukcu B, Binici S, and Sanisoglu SY
Subjects: Adult, Blood Glucose analysis, Blood Pressure physiology, Case-Control Studies, Cholesterol blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Electrocardiography, Exercise Test, Humans, Logistic Models, Male, Metabolic Syndrome blood, Obesity blood, Obesity physiopathology, Overweight, Sympathetic Nervous System physiopathology, Triglycerides blood, Exercise Tolerance physiology, Heart Rate physiology, Metabolic Syndrome physiopathology
Abstract: Background: Impaired heart rate recovery (HRR) is a powerful predictor of overall mortality., Aim: The aim of the present study is to assess HRR in young adult males with metabolic syndrome and to compare HRR with those of obese patients who do not meet the criteria for metabolic syndrome., Patients and Methods: Sixty-four newly diagnosed and untreated young male subjects (24 +/- 3 years) with metabolic syndrome and 40 age and sex matched obese or overweight control subjects (ages 23 +/- 3 years) were enrolled in the study. All subjects performed a symptom limited exercise stress test under the standard Bruce protocol. HRR was calculated in the first, second and third minutes of the recovery period. The relationship between metabolic syndrome and HRR was evaluated via logistic regression analysis and a P-value < 0.05 was accepted as significant., Results: Body mass index (BMI) was 38.6 +/- 3.68 and 32.22 +/- 2.99 kg/m(2) in the study and control groups, respectively (P < 0.001). Total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, systolic and diastolic blood pressures and fasting glucose levels were significantly higher in the study group. HRR in the first minute of the recovery period and mean exercise capacity were significantly lower in the study-group patients with metabolic syndrome (P < 0.001 and P = 0.012, respectively)., Conclusion: We determined that HRR was impaired in young adult males with metabolic syndrome compared with obese ones who do not meet the criteria of metabolic syndrome. This decreased HRR may have prognostic value in the prediction of vascular events in patients with metabolic syndrome.
Published: 2007
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16. Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy.

Author: Sutcigil L, Oktenli C, Musabak U, Bozkurt A, Cansever A, Uzun O, Sanisoglu SY, Yesilova Z, Ozmenler N, Ozsahin A, and Sengul A
Subjects: Adult, Chemokine CCL2 biosynthesis, Chemokine CCL2 blood, Chemokine CCL2 drug effects, Depressive Disorder, Major blood, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interleukin-12 biosynthesis, Interleukin-12 blood, Interleukin-2 biosynthesis, Interleukin-2 blood, Interleukin-4 biosynthesis, Interleukin-4 blood, Male, Transforming Growth Factor beta1 biosynthesis, Transforming Growth Factor beta1 blood, Transforming Growth Factor beta1 drug effects, Tumor Necrosis Factor-alpha biosynthesis, Tumor Necrosis Factor-alpha blood, Tumor Necrosis Factor-alpha drug effects, Antidepressive Agents therapeutic use, Cytokines drug effects, Depressive Disorder, Major drug therapy, Depressive Disorder, Major immunology, Sertraline therapeutic use
Abstract: The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF-alpha, TGF-beta1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF-alpha) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF-beta1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF-beta1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment.
Published: 2007
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17. Prevalence of metabolic syndrome-related disorders in a large adult population in Turkey.

Author: Sanisoglu SY, Oktenli C, Hasimi A, Yokusoglu M, and Ugurlu M
Subjects: Adult, Age Distribution, Aged, Aged, 80 and over, Analysis of Variance, Blood Glucose analysis, Blood Pressure, Body Mass Index, Chi-Square Distribution, Diabetes Mellitus epidemiology, Female, Humans, Hypertension epidemiology, Lipids blood, Male, Metabolic Syndrome complications, Middle Aged, Obesity epidemiology, Prevalence, Sex Distribution, Turkey epidemiology, Health Surveys, Metabolic Syndrome epidemiology
Abstract: Background: There are few existing large population studies on the epidemiology of metabolic syndrome-related disorders of Turkey. The purpose of this study was to assess the prevalence of metabolic syndrome-related disorders in the Turkish adult population, to address sex, age, educational and geographical differences, and to examine blood pressure, body mass index, fasting blood glucose and serum lipids in Turkey., Methods: This study was executed under the population study "The Healthy Nutrition for Healthy Heart Study" conducted between December 2000 and December 2002 by the Health Ministry of Turkey. Overall, 15,468 Caucasian inhabitants aged over 30 were recruited in 14 centers in the seven main different regions of Turkey. The data were analyzed with the Students' t, ANOVA or Chi-Square tests., Results: Overall, more than one-third (35.08 %) of the participants was obese. The hypertensive people ratio in the population was 13.66 %, while these ratios for DM and metabolic syndrome were 4.16 % and 17.91 %, respectively. The prevalence of hypertension, metabolic syndrome and obesity were higher in females than males, whereas diabetes mellitus was higher in males than females. The prevalence of metabolic syndrome and related disorders were found to be significantly different across educational attainments for both men and women. The prevalence of hypertension increased with age, while it was remarkable that in the age group of 60-69 years, prevalence of diabetes mellitus and metabolic syndrome reached a peak value and than decreased. For obesity, the peak prevalence occurred in the 50-59 year old group. The prevalence of metabolic syndrome and related disorders were found to be significantly different according to geographical region., Conclusion: In conclusion, high prevalence of obesity and metabolic syndrome, particularly among women, is one of the major public health problems in Turkey. Interestingly, obesity prevalence is relatively high, but the prevalence of hypertension and hypercholesterolemia is relatively low in Turkish people. Future studies may focus on elucidating the reasons behind this controversy. Our findings may be helpful in formulating public health policy and prevention strategies on future health in Turkey.
Published: 2006
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18. Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque.

Author: Karaduman M, Oktenli C, Musabak U, Sengul A, Yesilova Z, Cingoz F, Olgun A, Sanisoglu SY, Baysan O, Yildiz O, Taslipinar A, Tatar H, Kutlu M, and Ozata M
Subjects: Aged, Blood Glucose analysis, C-Reactive Protein analysis, Cholesterol blood, Coronary Artery Bypass, Coronary Artery Disease surgery, Diabetic Angiopathies metabolism, Female, Humans, Leptin analysis, Male, Middle Aged, Receptors, Interleukin-6 analysis, Receptors, Leptin, Risk Factors, Smoking metabolism, Vascular Cell Adhesion Molecule-1 analysis, Coronary Artery Disease metabolism, Inflammation Mediators analysis
Abstract: The aim of the present study was to explore the relationship between tissue levels of leptin, soluble interleukin-6 receptor (sIL-6R), high-sensitive-C-reactive protein (hs-CRP) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in atherosclerotic plaques, and traditional risk factors. Coronary artery specimens were obtained from 35 consecutive patients (26 men and nine women) who underwent coronary artery bypass grafting procedure. The mean tissue levels of leptin, hs-CRP and sIL-6R were significantly higher in patients with diabetes mellitus than without diabetes mellitus. When patients were classified according to the smoking status, the mean tissue levels of leptin, hs-CRP and sIL-6R were significantly higher in current smokers than both former smokers and non-smokers. In addition, the mean tissue levels of leptin and sIL-6R were significantly higher in former smokers than non-smokers. There was a positive association between leptin and hs-CRP, sIL-6R and plasma glucose in all patients. Plasma HDL levels were associated negatively with atherosclerotic tissue levels of leptin. Tissue levels of sIL-6R were associated significantly in a positive manner with leptin, hs-CRP and plasma glucose, while tissue levels of hs-CRP were associated with both leptin and sIL-6R. In conclusion, it is attractive to speculate that hs-CRP, sIL-6R and leptin could act synergistically in course of local inflammatory activity and those molecules may not be just markers of inflammation and cardiovascular risk but are also likely to play a pathogenic role in atheromatous plaque. In addition, atherosclerotic tissue levels of CRP, sIL-6R and leptin were significantly higher in current smokers and patients with diabetes.
Published: 2006
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19. Evaluation of event-related potentials in Klinefelter syndrome and idiopathic hypogonadotrophic hypogonadism.

Author: Ulas UH, Bolu E, Unlu-Alanoglu E, Kutukcu Y, Ozdag MF, Odabasi Z, Ozata M, Sanisoglu SY, and Vural O
Abstract: Background: Many studies have evaluated patients with idiopathic hypogonadothropic hypogonadotropism (IHH), but few of these studies utilize event-related potentials (P300)., Aims: To assess the cognitive functions of hypergonadotropic vs. hypogonadotropic patients., Settings and Design: The study group consisted of 41 untreated IHH patients, 32 untreated Klinefelter syndrome (KS) patients, and 30 healthy control subjects., Methods and Material: In this study, the latency and amplitude of P300 was evaluated in 41 untreated IHH and 32 untreated KS patients and compared to healthy control subjects (average age: 30 years). Also evaluated were the patients' hormone levels., Results and Conclusions: In this study, the amplitude of P300 was found to be reduced, and the latency prolonged in IHH patients in comparison to KS patients and control subjects. In KS patients, there was no difference in latency of P300, but the amplitude was reduced when compared with the control group. Cognitive dysfunction in patients with hypogonadotropism is related to androgen hormone levels. This deficiency can affect development of the central nervous system (CNS), causing defects of CNS to varying degrees during the perinatal period. Androgen deficiency is considered to exert its effects during the period of cognitive ability development, manifest in IHH patients but not KS patients.
Published: 2006
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20. Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronary atherosclerotic plaques.

Author: Karaduman M, Sengul A, Oktenli C, Pekel A, Yesilova Z, Musabak U, Sanisoglu SY, Gunay C, Baysan O, Kocar IH, Tatar H, and Ozata M
Subjects: Blood Glucose analysis, Coronary Artery Bypass, Coronary Artery Disease complications, Coronary Vessels chemistry, Diabetic Angiopathies metabolism, Family Health, Fatty Acid Binding Protein 3, Female, Humans, Hypercholesterolemia complications, Hypercholesterolemia metabolism, Hypertension complications, Hypertension metabolism, Male, Middle Aged, Myocardial Infarction metabolism, Smoking metabolism, Adiponectin analysis, Coronary Artery Disease metabolism, Fatty Acid-Binding Proteins analysis, Intercellular Adhesion Molecule-1 analysis, Tumor Necrosis Factor-alpha analysis
Abstract: Background: There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens., Aim: To analyse tissue levels of adiponectin, ICAM-1, TNF-alpha and H-FABP in the plaques obtained from coronary artery bypass grafting (CABG) and to evaluate whether there is any relationship between these variables and other characteristics., Patients and Methods: Coronary artery specimens from 37 consecutive patients (28 men and nine women) at time of CABG procedure and preprocedural blood samples were obtained. Tissue concentrations of adiponectin, ICAM-1, TNF-alpha and H-FABP in the atherosclerotic plaques were measured., Results: Blood glucose and tissue levels of TNF-alpha and ICAM-1 were negatively correlated with tissue levels of adiponectin, whereas TNF-alpha was positively correlated with ICAM-1 in atherosclerotic plaques. In addition, there was a positive correlation between blood glucose and tissue levels of both TNF-alpha and ICAM-1. TNF-alpha and ICAM-1 levels in atherosclerotic plaques appear to progressively increase whereas adiponectin levels progressively decrease with smoking status. Atherosclerotic tissue levels of these substances are also altered in diabetes., Conclusions: The data are in accord with those in prior publications on the detection and quantification of various inflammatory cytokines in atherosclerotic plaques. Our results indicate that diabetic state and smoking, in addition to other physiopathological mechanisms, may create a chronic inflammatory situation in the atherosclerotic process.
Published: 2006
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21. Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease.

Author: Gulsen M, Yesilova Z, Bagci S, Uygun A, Ozcan A, Ercin CN, Erdil A, Sanisoglu SY, Cakir E, Ates Y, Erbil MK, Karaeren N, and Dagalp K
Subjects: Adult, Fatty Liver blood, Fatty Liver etiology, Female, Hepatitis blood, Hepatitis physiopathology, Homocysteine blood, Humans, Male, Middle Aged, Predictive Value of Tests, Fatty Liver physiopathology, Hepatitis etiology, Homocysteine adverse effects
Abstract: Background: Although steatosis is common in patients with severe hyperhomocysteinemia due to deficiency of cystathionine beta-synthase, there are no satisfactory data on homocysteine concentrations in patients with non-alcoholic fatty liver disease. The main aim of the present study was to evaluate the clinical significance of plasma homocysteine concentrations in patients with non-alcoholic fatty liver disease., Methods: Seventy-one non-alcoholic fatty liver disease patients, 36 patients with chronic viral hepatitis and 30 healthy persons were enrolled in the study. Homocysteine levels were measured by high-performance liquid chromatography. Insulin, folate, vitamin B(12) and lipoprotein levels were also determined in all groups., Results: Homocysteine in the non-alcoholic fatty liver disease group was found to be significantly higher than other groups. Homocysteine was found to be significantly higher in the non-alcoholic steatohepatitis group when compared with simple steatosis group. A positive correlation was found between homocysteine and triglyceride, very-low-density-lipoprotein (VLDL) cholesterol, insulin, and index of insulin resistance in the non-alcoholic fatty liver disease group, and a negative correlation was found between homocysteine and folate, or vitamin B(12) in all groups. The homocysteine threshold for the prediction of steatohepatitis was 11.935 ng/mL. Furthermore; plasma homocysteine was a statistically significant predictor for severity of necroinflammatory activity in non-alcoholic steatohepatitis., Conclusions: The plasma homocysteine concentrations were significantly higher in patients with non-alcoholic fatty liver disease, while the concentrations were not affected by chronic viral hepatitis. Plasma homocysteine is a parameter for discriminating steatohepatitis from simple steatosis. Determining the plasma homocysteine concentrations may facilitate selection of steatosis patients in whom a liver biopsy should be performed., (Copyright 2005 Blackwell Publishing Asia Pty Ltd.)
Published: 2005
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22. Hyperhomocysteinemia in patients with Behçet's disease: is it due to inflammation or therapy?

Author: Yesilova Z, Pay S, Oktenli C, Musabak U, Saglam K, Sanisoglu SY, Dagalp K, Erbil MK, and Kocar IH
Subjects: Adult, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Behcet Syndrome blood, Behcet Syndrome drug therapy, Behcet Syndrome pathology, Colchicine therapeutic use, Drug Therapy, Combination, Eye Diseases etiology, Eye Diseases pathology, Female, Folic Acid blood, Glucocorticoids therapeutic use, Humans, Hyperhomocysteinemia pathology, Immunosuppressive Agents therapeutic use, Male, Thrombosis etiology, Thrombosis pathology, Vitamin B 12 blood, Behcet Syndrome complications, C-Reactive Protein metabolism, Homocysteine blood, Hyperhomocysteinemia etiology
Abstract: Considerable discrepancies exist in the literature with respect to plasma total homocysteine (tHcy) levels in Behçet's disease (BD). The aim of this study was to evaluate tHcy concentrations in these patients. Thirty-two patients with BD and 20 age- and body mass index-matched healthy volunteers were enrolled. Plasma tHcy concentrations were significantly higher, while vitamin B12 and folate levels were significantly lower in patients with thrombosis and eye involvement than those without. C-reactive protein levels also correlated significantly in a negative manner with vitamin B12 and folate but positively with tHcy. In conclusion, increased use or accelerated catabolism of folate and vitamin B12 due to chronic inflammation and moderately increased tHcy concentrations related with deficiency of these cofactors, and immunosuppressive drug administration might be potential threats of vascular disease in BD.
Published: 2005
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23. Evaluation of insulin sensitivity in patients with Klinefelter's syndrome: a hyperinsulinemic euglycemic clamp study.

Author: Yesilova Z, Oktenli C, Sanisoglu SY, Musabak U, Cakir E, Ozata M, and Dagalp K
Subjects: Adult, Body Mass Index, Glucose Clamp Technique, Gonadal Steroid Hormones blood, Humans, Male, Insulin Resistance physiology, Klinefelter Syndrome physiopathology
Abstract: Patients with Klinefelter's syndrome have a higher incidence of diabetes mellitus and the percentage of insulin resistance was reported to be high in these patients. However, little is known about the insulin sensitivity assessed by the hyperinsulinemic euglycemic clamp in these patients. In the present study, subjects included 13 newly diagnosed patients with Klinefelter's syndrome, and 9 age- and body mass index-matched healthy males. The hyperinsulinemic euglycemic clamp was performed in all patients and controls. Insulin resistance was present in five (38.5%) patients with Klinefelter's syndrome. Compared with control subjects, patients with Klinefelter's syndrome had elevated plasma concentrations of fasting insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin, whereas they had reduced plasma free testosterone and total testosterone concentrations. The multivariate linear regression analysis showed that fasting glucose, fasting insulin, free testosterone, and total testosterone were independently associated with M-value. In conclusion, the present study by using hyperinsulinemic euglycemic clamp indicates the high prevalence of insulin resistance in Klinefelter's syndrome patients. However, these patients did not have reduced mean M-values compared with the controls, although their plasma insulin levels were significantly elevated. It is possible that hyperinsulinemia may be the primary metabolic abnormality rather than insulin resistance.
Published: 2005
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24. Evaluation of a new intraoral controlled fluoride release device.

Author: Altinova YB, Alaçam A, Aydin A, and Sanisoglu SY
Subjects: Adult, Delayed-Action Preparations administration & dosage, Dental Bonding, Humans, Molar, Saliva chemistry, Sodium Fluoride metabolism, Statistics, Nonparametric, Cariostatic Agents administration & dosage, Dental Caries prevention & control, Sodium Fluoride administration & dosage
Abstract: The aim of the study was to determine the pharmacokinetics of a new hydroxyapatite-Eudragit RS100 diffusion-controlled fluoride-releasing system designed for intraoral use with a 0.15 mg F(-)/day release for a 1-month period. Matrix tablets, each containing 18 mg of sodium fluoride, were bonded to the buccal surface of the first maxillary molar teeth of 20 subjects (age 20-23 years). Morning and evening salivary and urinary samples were collected 5 days before the study and every day for the 1st week, then once a week for 1 month. Fluoride ion measurements were done using the microdiffusion method. The salivary and urinary fluoride concentrations were significantly raised during the treatment period (p < 0.05). Morning salivary fluoride levels were higher than evening salivary fluoride levels (p < 0.05) whereas evening urinary fluoride levels were higher than morning urinary fluoride levels (p < 0.05). The statistically significant increase in salivary fluoride levels indicates a caries-preventive role for this device., (Copyright (c) 2005 S. Karger AG, Basel.)
Published: 2005
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25. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic Fatty liver disease.

Author: Yesilova Z, Yaman H, Oktenli C, Ozcan A, Uygun A, Cakir E, Sanisoglu SY, Erdil A, Ates Y, Aslan M, Musabak U, Erbil MK, Karaeren N, and Dagalp K
Subjects: Adult, Biomarkers blood, Body Composition physiology, Body Mass Index, Catalase blood, Coenzymes, Complement C3a metabolism, Fatty Liver diagnosis, Hepatitis B, Chronic diagnosis, Hepatitis B, Chronic physiopathology, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic physiopathology, Humans, Liver physiopathology, Liver Cirrhosis diagnosis, Liver Cirrhosis physiopathology, Male, Malondialdehyde blood, Middle Aged, Reference Values, Statistics as Topic, Superoxide Dismutase blood, Ubiquinone blood, Antioxidants metabolism, Complement C3a analogs & derivatives, Fatty Liver physiopathology, Insulin Resistance physiology, Lipid Peroxidation physiology, Oxidative Stress physiology, Ubiquinone analogs & derivatives
Abstract: Objectives: The aim of the present study was to examine the systemic parameters of oxidative stress and antioxidants in patients with nonalcoholic fatty liver disease and investigate the relationship between these parameters and clinical and biochemical outcomes., Methods: Fifty-one male patients with nonalcoholic fatty liver disease (group I), 30 age-matched and body mass index (BMI)-matched healthy male subjects, and 30 age-matched male patients with chronic viral hepatitis (group II) were enrolled in the study., Results: Increased systemic levels of malondialdehyde and depletion of antioxidants such as coenzyme Q10, CuZn-superoxide dismutase, and catalase activity were observed in group I. Coenzyme Q10 and CuZn-superoxide dismutase correlated negatively with increasing necroinflammatory activity and fibrosis. Body fat was negatively associated with plasma coenzyme Q10 levels, while an inverse association was found between plasma catalase levels and TG. However, LDL was positively associated with plasma malondialdehyde levels. CuZn-superoxide dismutase levels were negatively associated with glucose, insulin, and HOMA-IR. In addition, the levels of CuZn-superoxide dismutase correlated significantly in a negative manner with BMI., Conclusions: Our results concerning correlations suggest that disturbances in BMI, body fat, and lipid metabolism may contribute to altered oxidative status in NAFLD, and insulin resistance may be related to decreased antioxidants in NAFLD as well as products of lipid peroxidation. However, although our results suggest interesting correlations, this different mostly "weak" relationships must be taken with caution.
Published: 2005
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26. Increased acylation stimulating protein concentrations in nonalcoholic fatty liver disease are associated with insulin resistance.

Author: Yesilova Z, Ozata M, Oktenli C, Bagci S, Ozcan A, Sanisoglu SY, Uygun A, Yaman H, Karaeren N, and Dagalp K
Subjects: Adipocytes pathology, Adipocytes physiology, Adult, Biopsy, Needle, C-Peptide blood, Complement C3 metabolism, Fatty Liver diagnosis, Fatty Liver pathology, Hepatitis B, Chronic diagnosis, Hepatitis B, Chronic pathology, Hepatitis B, Chronic physiopathology, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic pathology, Hepatitis C, Chronic physiopathology, Humans, Lipoproteins, VLDL blood, Liver pathology, Liver physiopathology, Liver Cirrhosis diagnosis, Liver Cirrhosis pathology, Liver Cirrhosis physiopathology, Liver Function Tests, Male, Middle Aged, Reference Values, Statistics as Topic, Triglycerides metabolism, Complement C3a analogs & derivatives, Complement C3a metabolism, Fatty Liver physiopathology, Insulin Resistance physiology
Abstract: Objectives: As acylation stimulating protein (ASP) acts on adipocytes mainly as a paracrine factor to increase triglyceride synthesis and storage; hypothetically, it may play a similar role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)., Methods: Forty-six male patients with NAFLD (group A), age-matched 30 male patients with chronic viral hepatitis (group B) and 30 age-matched and body mass index (BMI)-matched healthy male subjects were enrolled in the study., Results: Among the NAFLD patients, 10 patients (24.4%) had simple steatosis and 36 patients (69.6%) had nonalcoholic steatohepatitis (NASH). The mean levels of ASP, complement 3, insulin, C-peptide, HOMA-IR, triglyceride, and very low-density lipoprotein (VLDL) were significantly higher in group A patients than both controls and group B. ASP levels correlated significantly in a positive manner with BMI, insulin, and HOMA-IR., Conclusions: Dysregulation of the ASP pathway may have important metabolic consequences in NASH and is associated with insulin resistance.
Published: 2005
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27. Does immune activation continue during an attack-free period in familial Mediterranean fever?

Author: Musabak U, Sengul A, Oktenli C, Pay S, Yesilova Z, Kenar L, Sanisoglu SY, Inal A, Tuzun A, Erdil A, and Bagci S
Subjects: Antigens, CD analysis, Antigens, Differentiation, T-Lymphocyte analysis, CD3 Complex analysis, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Cells, Cultured, Female, HLA-DR Antigens analysis, Humans, Interleukin-10 blood, Lectins, C-Type, Lymphocyte Activation immunology, Lymphocyte Count methods, Male, Phytohemagglutinins analysis, Receptors, Interleukin-2 analysis, Receptors, Interleukin-2 blood, Familial Mediterranean Fever immunology, T-Lymphocyte Subsets immunology
Abstract: Although some information is available regarding immune activation in familial Mediterranean fever (FMF), little is known about either peripheral blood T cell activation marker expression or the T cell proliferative response to phytohaemagglutinin (PHA). In the present study, we aimed to investigate the percentages of peripheral blood lymphocyte subsets, T cell expression of cellular activation markers (CD25, CD69, HLA-DR), the T cell response to PHA and serum levels of soluble interleukin-2 receptor (sIL-2R) and interleukin (IL)-10 in patients with FMF. Forty patients with FMF were enrolled into the study. Control groups were sex- and age-matched and consisted of 20 healthy blood donors and 15 patients with inactive Behcet's disease. The patients with FMF in an attack period had higher levels of sIL-2R than those in an attack-free period, and also in comparison with both control groups. The levels of sIL-2R were also found to be higher in patients with FMF in an attack-free period than those in both control groups. The mean levels of IL-10 were found to be lower in patients with FMF in an attack-free period than those in an attack period and were also lower than those in the healthy controls. In an acute attack period, the absolute counts of CD3+HLA-DR+, CD4+CD69+, CD8+CD25+ and CD8+CD69+ T cells in peripheral blood samples were also higher than those in both control groups. Both the percentages and absolute counts of CD4+CD69+ T cells in peripheral blood samples of patients with FMF in an attack-free period were slightly but significantly higher than those in the healthy controls. In conclusion, our study indicates that the T cell system is abnormally activated in patients with FMF in both the attack and attack-free period and that decreased IL-10 levels may create a tendency to perpetuate subclinical immune activation in the attack-free period.
Published: 2004
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28. Effect of supraphysiologic doses of testosterone on fasting plasma total homocysteine concentrations in men with Klinefelter's syndrome.

Author: Yesilova Z, Ozata M, Oktenli C, Sanisoglu SY, Erbil MK, and Dagalp K
Subjects: Adult, Body Mass Index, Fasting, Humans, Male, Prospective Studies, Homocysteine blood, Klinefelter Syndrome blood, Testosterone pharmacology
Abstract: Objective: To examine the effect of supraphysiologic doses of testosterone (T) on plasma total homocysteine (tHcy) concentrations in patients with Klinefelter's syndrome (KS)., Design: Prospective clinical study., Setting: University hospital., Patient(s): Thirty-two newly diagnosed male patients with KS, and 20 healthy, volunteer controls matched by age and body mass index., Intervention(s): Testosterone was administered IM every 2 weeks for 6 months. Initially, pretreatment fasting blood samples were collected after overnight fasting. Posttreatment blood samples were drawn 7 days after the last injection., Main Outcome Measure(s): Plasma total homocysteine., Result(s): The KS patients had lower tHcy levels than the controls. However, plasma fasting tHcy concentrations increased in a statistically significant manner after 6 months of treatment. As compared with the levels among controls, pretreatment levels of the serum creatinine, hemoglobin, and hematocrit were significantly lower, and increased in a statistically significant way following treatment. Posttreatment levels of total cholesterol were statistically significantly higher than the baseline. The pretreatment folate and cobalamin levels also were statistically significantly higher in patients when compared with controls, and decreased significantly after treatment. The linear regression analysis showed that only creatinine, cobalamin, and folate were independently associated with plasma tHcy levels in patients before and after treatment., Conclusion(s): The patients with KS showed lower tHcy concentrations than healthy, age-matched male controls. Testosterone treatment increased plasma tHcy levels.
Published: 2004
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29. Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of interleukin-1 beta on the secretion of GnRH.

Author: Oktenli C, Doganci L, Ozgurtas T, Araz RE, Tanyuksel M, Musabak U, Sanisoglu SY, Yesilova Z, Erbil MK, and Inal A
Subjects: Acute Disease, Adolescent, Case-Control Studies, Follicle Stimulating Hormone blood, Humans, Luteinizing Hormone blood, Male, Testosterone blood, Time Factors, Toxoplasmosis blood, Gonadotropin-Releasing Hormone metabolism, Hypogonadism parasitology, Interleukin-1 blood, Toxoplasmosis complications, Toxoplasmosis metabolism
Abstract: Background: In September 2002, an outbreak of toxoplasmosis was noted in a male boarding high school on the Aegean coast of Turkey. We have focused our efforts to investigate the sex hormones in this population., Methods: Blood samples were collected from 40 male patients, 17-18 years old, who also had positive titres of antibody to Toxoplasma gondii. Serum FSH, LH, free testosterone (FT), total testosterone (TT), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta) and macrophage-inflammatory protein-1alpha (MIP-1alpha) concentrations were measured in all patients and 20 control subjects. Initially, the patients were divided on the basis of the levels of sex hormones into the following groups: patients who had normal sex hormone levels (n = 31) as group A and patients with low sex hormone levels (n = 9) as group B., Results: IL-1beta levels were found to be higher in group B patients than group A. The levels of IL-1beta correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40)., Conclusions: Acute toxoplasma infection may cause temporary hypogonadotrophic gonadal insufficiency regardless of the course of the disease.
Published: 2004
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30. Does off-pump CABG reduce gastrointestinal complications?

Author: Sanisoglu I, Guden M, Bayramoglu Z, Sagbas E, Dibekoglu C, Sanisoglu SY, and Akpinar B
Subjects: Aged, Cause of Death, Coronary Disease mortality, Evaluation Studies as Topic, Female, Gastrointestinal Diseases etiology, Gastrointestinal Diseases mortality, Humans, Male, Middle Aged, Outcome and Process Assessment, Health Care statistics & numerical data, Postoperative Complications etiology, Postoperative Complications mortality, Regression Analysis, Retrospective Studies, Risk Factors, Survival Analysis, Cardiopulmonary Bypass, Coronary Artery Bypass methods, Coronary Disease surgery, Gastrointestinal Diseases prevention & control, Postoperative Complications prevention & control
Abstract: Background: The aim of this study was to compare gastrointestinal complications and associated risk factors among patients undergoing cardiac surgery using off- and on-pump revascularization techniques., Methods: A total of 1146 adult patients who underwent coronary artery surgery during a 6-year period were evaluated retrospectively. Group 1 consisted of 546 patients operated using off-pump techniques and group 2 consisted of 600 cases operated with cardiopulmonary bypass. Patients were compared and evaluated for gastrointestinal complications and possible associated risk factors using univariate and multivariate logistic regression analysis., Results: Overall mortality was 1.6% in group 1 and 2.2% in group 2 (p = 0.523). Mortality due to gastrointestinal complications was 38.5% and 35.7% respectively in group 1 and group 2. The mean EuroSCORE value was 5.1 +/- 2.8 in group 1 and 3.8 +/- 2.4 in group 2 (p < 0.001). The most common gastrointestinal complication in the off-pump group was gastrointestinal bleeding. The leading complication in group 2 was intestinal ischemia., Conclusions: The incidence rates of gastrointestinal complications were similar in the on- and off-pump coronary artery bypass groups, the type of gastrointestinal complications, however, was different. Mortality rate due to these complications was also similar and remained high, regardless of the type of surgery. Cardiopulmonary bypass did not emerge as a risk factor for gastrointestinal complications, but prolonged cardiopulmonary bypass (longer than 98 minutes) resulted in a high incidence of such complications. Old age and advanced arteriosclerosis emerged as risk factors in both groups resulting in gastrointestinal complications suggesting the ischemic nature of the injury.
Published: 2004
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31. Renal tubular dysfunction in beta-thalassemia minor.

Author: Cetin T, Oktenli C, Ozgurtas T, Yenicesu M, Sanisoglu SY, Oguz Y, Yildiz O, Kurt I, Musabak U, Bulucu F, and Kocar IH
Subjects: Adult, Bone Diseases, Metabolic etiology, Female, Hemoglobins analysis, Humans, Magnesium blood, Male, Natriuresis, Osteoporosis etiology, Phosphorus blood, Uric Acid blood, beta 2-Microglobulin urine, beta-Thalassemia complications, beta-Thalassemia metabolism, Kidney Tubules, Proximal physiopathology, beta-Thalassemia physiopathology
Abstract: Background: Persons with beta-thalassemia minor usually are symptomless. However, we previously reported renal tubular dysfunction in a patient with beta-thalassemia minor. The aim of this study is to investigate renal function in patients with beta-thalassemia minor., Methods: Forty-one subjects with beta-thalassemia minor and 20 sex- and age-matched healthy subjects were enrolled in the study. For analysis, patients were divided into 2 groups: group A, all patients with anemia (n = 19), and group B, patients without anemia (n = 22). Blood and 24-hour urine samples were obtained for hematologic and biochemical analysis., Results: Anemic patients had increased urinary zinc excretion (U(zinc)) and fractional excretion of sodium (FE(Na)) and uric acid (FE(UA)) compared with both controls and patients without anemia. Hemoglobin levels correlated significantly in a negative manner with U(zinc), FE(Na), and FE(UA) in patients with beta-thalassemia minor. However, serum lactate dehydrogenase levels correlated significantly in a positive manner with the same parameters. In addition, 6 of 41 patients (14.6%) with beta-thalassemia minor showed significant signs of renal tubulopathy, such as hypercalciuria, decreased tubular reabsorption of phosphorus with hypophosphatemia, hypomagnesemia with renal magnesium wasting, hypouricemia with renal uric acid wasting, and tubular proteinuria., Conclusion: Proximal renal tubular dysfunction is not rare in patients with beta-thalassemia minor.
Published: 2003
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32. Supraclavicular control of patent internal thoracic artery graft flow during aortic valve replacement.

Author: Kuralay E, Cingöz F, Günay C, Oz BS, Küçükarslan N, Yildirim V, Sanisoglu SY, Ozal E, Demirkiliç U, Arslan M, and Tatar H
Subjects: Aged, Aged, 80 and over, Aorta, Aortic Valve Insufficiency physiopathology, Aortic Valve Insufficiency surgery, Aortic Valve Stenosis physiopathology, Aortic Valve Stenosis surgery, Cardiopulmonary Bypass, Constriction, Female, Heart Arrest, Induced, Humans, Hypothermia, Induced, Male, Mammary Arteries injuries, Middle Aged, Myocardial Infarction etiology, Regional Blood Flow, Aortic Valve surgery, Coronary Artery Bypass, Heart Valve Prosthesis Implantation adverse effects, Mammary Arteries transplantation, Vascular Patency
Abstract: Background: The mortality and morbidity of aortic valve replacement (AVR) after prior coronary artery bypass surgery (CABG) with patent left internal thoracic artery (LITA) is significant. The risk of LITA injury and inadequate myocardial preservation during the cross-clamp period may cause myocardial pump failure., Methods: A total of 43 patients with a patent LITA graft underwent AVR. The patients were divided into the two groups. Group 1 included 19 patients who underwent AVR with deep hypothermia (20 degrees C) without LITA clamping. Group 2 included 24 patients in whom LITA flow was controlled through supraclavicular occlusion and AVR performed with moderate hypothermia (28 degrees C)., Results: Average cardiopulmonary bypass time (CPB) time was 118.79 +/- 20.36 minutes in group 1 and 102.67 +/- 9.66 minutes in group 2 (p = 0.006). Average cross-clamp time was 53.79 +/- 7.26 minutes in group 1 and 49.63 +/- 6.7 minutes in group 2 (p = 0.022). Inotropic support was required in 12 patients in group 1 and 4 patients in group 2 (p = 0.002). Average intensive care unit stay was 4.68 +/- 2.24 days in group 1 and 2.29 +/- 0.46 days in group 2 (p < 0.001). Average hospital stay was 11.84 +/- 2.91 days in group 1 and 8.04 +/- 2.38 days in group 2 (p < 0.001). Mortality due to myocardial failure developed in 4 patients in group 1 but in none of the patients in group 2 (p = 0.02)., Conclusions: Proximal control of LITA flow by extrathoracic supraclavicular occlusion reduces the incidence of myocardial failure due to nonhomogenous cardioplegia delivery to the anterior wall of the heart, resulting in improved myocardial protection and the elimination of the need for deep hypothermia.
Published: 2003
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33. Increased oxidative stress and hypozincemia in male obesity.

Author: Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E, Yilmaz MI, Sayal A, Isimer A, and Ozdemir IC
Subjects: Erythrocytes metabolism, Glutathione Peroxidase blood, Humans, Male, Middle Aged, Superoxide Dismutase blood, Thiobarbituric Acid Reactive Substances metabolism, Zinc deficiency, Obesity metabolism, Oxidative Stress physiology, Zinc blood
Abstract: Objectives: Antioxidants protect an organism from the detrimental effects of free radicals via scavenging or inhibiting their formation. Alterations in the levels of antioxidants and several essential trace elements in the plasma and various tissues of ob/ob mice have been reported previously. The aim of this study was to investigate oxidative status and trace elements in obese individuals., Design and Methods: Seventy-six obese men (body mass index (BMI) > 30 kg/m(2)) and 24 healthy, age-matched male control volunteers were enrolled in the study. Fasting plasma insulin, glucose, triglyceride (TG), total cholesterol, VLDL, and HDL levels, erythrocyte glutathione peroxidase (GSH-Px) and copper zinc-superoxide dismutase (CuZn-SOD) activities, and erythrocyte thiobarbituric acid reactive substances (TBARS) levels were measured in both groups. Erythrocyte copper (Cu), zinc (Zn) and iron (Fe) levels were also measured., Results: We found that the mean Cu and Fe levels in obese individuals were not significantly different than those in the control group, whereas the mean Zn levels were significantly lower than those of the control group (p = 0.023). The mean erythrocyte CuZn-SOD and GSH-Px levels in obese individuals were significantly lower than those in controls (p = 0.001) whereas erythrocyte TBARS levels were significantly higher (p = 0.001) than those of the control group., Conclusion: We conclude that male obesity is associated with defective antioxidant status and hypozincemia, which may have implications in the development of obesity related health problems., (Copyright 2002 The Canadian Society of Clinical Chemists)
Published: 2002
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34. Diurnal leptin secretion is intact in male hypogonadotropic hypogonadism and is not influenced by exogenous gonadotropins.

Author: Kilciler G, Ozata M, Oktenli C, Sanisoglu SY, Bolu E, Bingol N, Kilciler M, Ozdemir IC, and Kutlu M
Subjects: Adult, Chorionic Gonadotropin therapeutic use, Hormone Replacement Therapy, Humans, Male, Menotropins therapeutic use, Testosterone blood, Circadian Rhythm, Gonadotropins therapeutic use, Hypogonadism drug therapy, Hypogonadism physiopathology, Leptin metabolism
Abstract: Circulating leptin shows a pulsatile secretory pattern along with a nocturnal rise. We have previously shown that circulating leptin concentrations are high in males with untreated idiopathic hypogonadotropic hypogonadism (IHH). However, circadian leptin secretion in IHH before and after gonadotropin treatment is not known. Thus, we studied 14 adult males with IHH who had no history of previous hormonal therapy, and 12 age- and body mass index-matched healthy men. Plasma leptin concentrations were measured with 1-h intervals for 24 h before and 6 months after gonadotropin treatment. The 24-h mean leptin concentration showed a significant decrease, from 11.78 +/- 1.908 microg/liter at baseline to 10.85 +/- 1.939 microg/liter after 6 months of therapy (z = 3.107; P = 0.002). Before and after treatment, 24-h mean leptin concentrations were also significantly higher in the patient group when compared with controls (4.275 +/- 0.711 microg/liter) (z = 5.938; P = 0.0001). Hourly leptin levels demonstrated a diurnal pattern in hypogonadal patients, a surge in the midday, and a peak just after midnight, and this pattern did not differ before and after treatment. We observed a similar diurnal pattern in the control subjects too. Leptin levels were negatively and significantly correlated with free testosterone and total testosterone levels both before (r = -0.656, P = 0.011; and r = -0.639, P = 0.014, respectively) and after (r = -0.537, P = 0.048; and r = -0.563, P = 0.036, respectively) gonadotropin administration. Our observations suggest that the diurnal rhythm of leptin is intact in males with IHH, and short-term gonadotropin treatment does not effect its diurnal rhythm. Moreover, testosterone produced under the influence of the gonadotropin treatment led to decreases in the leptin levels.
Published: 2002
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34 results on '"Sanisoglu, Sy"'

1. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: A comparative risk assessment

2. National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3·0 million participants

3. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

5. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and5·4 million participants

6. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5•4 million participants

7. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

8. Gonadotropin treatment increases homocysteine levels in idiopathic hypogonadotropic hypogonadism: an indirect effect mediated by changes in body composition

9. The rate of pyrin mutations in critically ill patients with systemic inflammatory response syndrome and sepsis: a pilot study.

10. The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008

11. High prevalence of obesity in Tokat, a northern province of Turkey.

12. Diagnostic value of elastosonographically determined strain index in the differential diagnosis of benign and malignant thyroid nodules.

13. Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).

14. Pubertal progression and serum lipid profile in obese children.

15. Association of metabolic syndrome with impaired heart rate recovery and low exercise capacity in young male adults.

16. Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy.

17. Prevalence of metabolic syndrome-related disorders in a large adult population in Turkey.

18. Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque.

19. Evaluation of event-related potentials in Klinefelter syndrome and idiopathic hypogonadotrophic hypogonadism.

20. Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronary atherosclerotic plaques.

21. Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease.

22. Hyperhomocysteinemia in patients with Behçet's disease: is it due to inflammation or therapy?

23. Evaluation of insulin sensitivity in patients with Klinefelter's syndrome: a hyperinsulinemic euglycemic clamp study.

24. Evaluation of a new intraoral controlled fluoride release device.

25. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic Fatty liver disease.

26. Increased acylation stimulating protein concentrations in nonalcoholic fatty liver disease are associated with insulin resistance.

27. Does immune activation continue during an attack-free period in familial Mediterranean fever?

28. Effect of supraphysiologic doses of testosterone on fasting plasma total homocysteine concentrations in men with Klinefelter's syndrome.

29. Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of interleukin-1 beta on the secretion of GnRH.

30. Does off-pump CABG reduce gastrointestinal complications?

31. Renal tubular dysfunction in beta-thalassemia minor.

32. Supraclavicular control of patent internal thoracic artery graft flow during aortic valve replacement.

33. Increased oxidative stress and hypozincemia in male obesity.

34. Diurnal leptin secretion is intact in male hypogonadotropic hypogonadism and is not influenced by exogenous gonadotropins.

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