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We describe MGARD, a software providing MultiGrid Adaptive Reduction for floating-point scientific data on structured and unstructured grids. With exceptional data compression capability and precise error control, MGARD addresses a wide range of requirements, including storage reduction, high-performance I/O, and in-situ data analysis. It features a unified application programming interface (API) that seamlessly operates across diverse computing architectures. MGARD has been optimized with highly-tuned GPU kernels and efficient memory and device management mechanisms, ensuring scalable and rapid operations.

This paper proposes a new time-respecting graph (TRG) representation for contact sequence temporal graphs. Our representation is more memory-efficient than previously proposed representations and has run-time advantages over the ordered sequence of edges (OSE) representation, which is faster than other known representations. While our proposed representation clearly outperforms the OSE representation for shallow neighborhood search problems, it is not evident that it does so for different problems. We demonstrate the competitiveness of our TRG representation for the single-source all-destinations fastest, min-hop, shortest, and foremost paths problems.

Road safety has always been a crucial priority for municipalities, as vehicle accidents claim lives every day. Recent rapid improvements in video collection and processing technologies enable traffic researchers to identify and alleviate potentially dangerous situations. This paper illustrates cutting-edge methods by which conflict hotspots can be detected in various situations and conditions. Both pedestrian–vehicle and vehicle–vehicle conflict hotspots can be discovered, and we present an original technique for including more information in the graphs with shapes. Conflict hotspot detection, volume hotspot detection, and intersection-service evaluation allow us to understand the safety and performance issues and test countermeasures comprehensively. The selection of appropriate countermeasures is demonstrated by extensive analysis and discussion of two intersections in Gainesville, Florida, USA. Just as important is the evaluation of the efficacy of countermeasures. This paper advocates for selection from a menu of countermeasures at the municipal level, with safety as the top priority. Performance is also considered, and we present a novel concept of a performance–safety trade-off at intersections.

Hybrid multicore processors (HMPs) are poised to dominate the landscape of the next generation of computing on the desktop as well as on exascale systems. HMPs consist of general purpose CPU cores along with specialized coprocessors and can provide high performance for a wide spectrum of applications at significantly lower energy requirements per floating-point operations per second (FLOP). In this article, we develop parallel algorithms and software for constructing multiresolution synthetic aperture radar images on HMPs. We develop several load balancing algorithms for optimizing time performance and energy on HMPs. We also present a systematic approach for deriving the energy-time performance tradeoffs on HMPs in the presence of dynamic voltage frequency scaling. Pareto-optimal curves are presented on a system consisting of 24 traditional cores and a GPU.

BackgroundSmartwatches enable physicians to monitor symptoms in patients with knee osteoarthritis, their behavior, and their environment. Older adults experience fluctuations in their pain and related symptoms (mood, fatigue, and sleep quality) that smartwatches are ideally suited to capture remotely in a convenient manner. ObjectiveThe aim of this study was to evaluate satisfaction, usability, and compliance using the real-time, online assessment and mobility monitoring (ROAMM) mobile app designed for smartwatches for individuals with knee osteoarthritis. MethodsParticipants (N=28; mean age 73.2, SD 5.5 years; 70% female) with reported knee osteoarthritis were asked to wear a smartwatch with the ROAMM app installed. They were prompted to report their prior night’s sleep quality in the morning, followed by ecological momentary assessments (EMAs) of their pain, fatigue, mood, and activity in the morning, afternoon, and evening. Satisfaction, comfort, and usability were evaluated using a standardized questionnaire. Compliance with regard to answering EMAs was calculated after excluding time when the watch was not being worn for technical reasons (eg, while charging). ResultsA majority of participants reported that the text displayed was large enough to read (22/26, 85%), and all participants found it easy to enter ratings using the smartwatch. Approximately half of the participants found the smartwatch to be comfortable (14/26, 54%) and would consider wearing it as their personal watch (11/24, 46%). Most participants were satisfied with its battery charging system (20/26, 77%). A majority of participants (19/26, 73%) expressed their willingness to use the ROAMM app for a 1-year research study. The overall EMA compliance rate was 83% (2505/3036 responses). The compliance rate was lower among those not regularly wearing a wristwatch (10/26, 88% vs 16/26, 71%) and among those who found the text too small to read (4/26, 86% vs 22/26, 60%). ConclusionsOlder adults with knee osteoarthritis positively rated the ROAMM smartwatch app and were generally satisfied with the device. The high compliance rates coupled with the willingness to participate in a long-term study suggest that the ROAMM app is a viable approach to remotely collecting health symptoms and behaviors for both research and clinical endeavors.

Abstract Background High utilizers receive great attention in health care research because they have a largely disproportionate spending. Existing analyses usually identify high utilizers with an empirical threshold on the number of health care visits or associated expenditures. However, such count-and-cost based criteria might not be best for identifying impactable high utilizers. Methods We propose an approach to identify impactable high utilizers using residuals from regression-based health care utilization risk adjustment models to analyze the variations in health care expenditures. We develop linear and tree-based models to best adjust per-member per-month health care cost by clinical and socioeconomic risk factors using a large administrative claims dataset from a state public insurance program. Results The risk adjustment models identify a group of patients with high residuals whose demographics and categorization of comorbidities are similar to other patients but who have a significant amount of unexplained health care utilization. Deeper analysis of the essential hypertension cohort and chronic kidney disease cohort shows these variations in expenditures could be within individual ICD-9-CM codes and from different mixtures of ICD-9-CM codes. Additionally, correlation analysis with 3M™ Potentially Preventable Events (PPE) software shows that a portion of this utilization may be preventable. In addition, the high utilizers persist from year to year. Conclusions After risk adjustment, patients with higher than expected expenditures (high residuals) are associated with more potentially preventable events. These residuals are temporally consistent and hence may be useful in identifying and intervening impactable high utilizers.

Scientific applications continue to grow and produce extremely large amounts of data, which require efficient compression algorithms for long-term storage. Compression errors in scientific applications can have a deleterious impact on downstream processing. Thus, it is crucial to preserve all the “known” Quantities of Interest (QoI) during compression. To address this issue, most existing approaches guarantee the reconstruction error of the original data or primary data (PD), but cannot directly control the problem of preserving the QoI. In this work, we propose a physics-informed compression technique that is composed of two parts: (i) reduction of the PD with bounded errors and (ii) preservation of the QoI. In the first step, we combine tensor decompositions, autoencoders, product quantizers, and error-bounded lossy compressors to bound the reconstruction error at high levels of compression. In the second step, we use constraint satisfaction post-processing followed by quantization to preserve the QoI. To illustrate the challenges of reducing the reconstruction errors of the PD and QoI, we focus on simulation data generated by a large-scale fusion code, XGC, which can produce tens of petabytes in a single day. The results show that our approach can achieve a high compression amount while accurately preserving the QoI within scientifically acceptable bounds.

Abstract Background There has been an increasing interest in understanding the usefulness of wrist-based accelerometer data for physical activity (PA) assessment due to the ease of use and higher user compliance than other body placements. PA assessment studies have relied on machine learning methods which take accelerometer data in forms of variables, or feature vectors. Methods In this work, we introduce automated shape feature derivation methods to transform epochs of accelerometer data into feature vectors. As the first step, recurring patterns in the collected data are identified and placed in a codebook. Similarities between epochs of accelerometer data and codebook’s patterns are the basis of feature calculations. In this paper, we demonstrate supervised and unsupervised approaches to learn codebooks. We evaluated these methods and compared them with the standard statistical measures for PA assessment. The experiments were performed on 146 participants who wore an ActiGraph GT3X+ accelerometer on the right wrist and performed 33 activities of daily living. Results Our evaluations show that the shape feature derivation methods were able to perform comparably with the standard wrist model (F1-score: 0.89) for identifying sedentary PAs (F1-scores of 0.86 and 0.85 for supervised and unsupervised methods, respectively). This was also observed for identifying locomotion activities (F1-scores: 0.87, 0.83, and 0.81 for the standard wrist, supervised, unsupervised models, respectively). All the wrist models were able to estimate energy expenditure required for PAs with low error (rMSE: 0.90, 0.93, and 0.90 for the standard wrist, supervised, and unsupervised models, respectively). Conclusion The automated shape feature derivation methods offer insights into the performed activities by providing a summary of repeating patterns in the accelerometer data. Furthermore, they could be used as efficient alternatives (or additions) for manually engineered features, especially important for cases where the latter fail to provide sufficient information to machine learning methods for PA assessment.

Abstract Background This paper studies the temporal consistency of health care expenditures in a large state Medicaid program. Predictive machine learning models were used to forecast the expenditures, especially for the high-cost, high-need (HCHN) patients. Results We systematically tests temporal correlation of patient-level health care expenditures in both the short and long terms. The results suggest that medical expenditures are significantly correlated over multiple periods. Our work demonstrates a prevalent and strong temporal correlation and shows promise for predicting future health care expenditures using machine learning. Temporal correlation is stronger in HCHN patients and their expenditures can be better predicted. Including more past periods is beneficial for better predictive performance. Conclusions This study shows that there is significant temporal correlation in health care expenditures. Machine learning models can help to accurately forecast the expenditures. These results could advance the field toward precise preventive care to lower overall health care costs and deliver care more efficiently.

Travel-time estimation of traffic flow is an important problem with critical implications for traffic congestion analysis. We developed techniques for using intersection videos to identify vehicle trajectories across multiple cameras and analyze corridor travel time. Our approach consists of (1) multi-object single-camera tracking, (2) vehicle re-identification among different cameras, (3) multi-object multi-camera tracking, and (4) travel-time estimation. We evaluated the proposed framework on real intersections in Florida with pan and fisheye cameras. The experimental results demonstrate the viability and effectiveness of our method.

In this paper, we propose a novel approach to commodity classification from surveillance videos by utilizing logo data on trucks. Broadly, most logos can be classified as predominantly text or predominantly images. For the former, we leverage state-of-the-art deep-learning-based text recognition algorithms on images. For the latter, we develop a two-stage image retrieval algorithm consisting of a universal logo detection stage that outputs all potential logo positions, followed by a logo recognition stage designed to incorporate advanced image representations. We develop an integrated approach to combine predictions from both the text-based and image-based solutions, which can help determine the commodity type that is potentially being hauled by trucks. We evaluated these models on videos collected in collaboration with the state transportation entity and achieved promising performance. This, along with prior work on trailer classification, can be effectively used for automatically deriving commodity types for trucks moving on highways.

Microscopic simulation-based approaches are extensively used for determining good signal timing plans on traffic intersections. Measures of Effectiveness (MOEs) such as wait time, throughput, fuel consumption, emission, and delays can be derived for variable signal timing parameters, traffic flow patterns, etc. However, these techniques are computationally intensive, especially when the number of signal timing scenarios to be simulated are large. In this paper, we propose InterTwin, a Deep Neural Network architecture based on Spatial Graph Convolution and Encoder-Decoder Recurrent networks that can predict the MOEs efficiently and accurately for a wide variety of signal timing and traffic patterns. Our methods can generate probability distributions of MOEs and are not limited to mean and standard deviation. Additionally, GPU implementations using InterTwin can derive MOEs, at least four to five orders of magnitude faster than microscopic simulations on a conventional 32 core CPU machine.

Abstract Background Very frequent outpatient emergency department (ED) use—so called “superutilization”—at the state level is not well-studied. To address this gap, we examined frequent ED utilization in the largest state Medicaid population to date. Methods Using Texas Medicaid (the third largest in the USA) claims data, we examined the variability in expenditures, sociodemographics, comorbidities, and persistence across seven levels of ED utilization/year (i.e., 1, 2, 3–4, 5–6, 7–9, 10–14, and ≥ 15 visits). We classified visits into emergent and non-emergent categories using the most recent New York University algorithm. Results Thirty-one percent (n = 346,651) of Texas Medicaid adult enrollees visited the ED at least once in 2014. Enrollees with ≥ 3 ED visits accounted for 8.5% of all adult patients, 60.4% of the total ED visits, and 62.1% of the total ED expenditures. Extremely frequent ED users (≥ 10 ED visits) represented

Marginal deficiency of vitamin B-6 is common among segments of the population worldwide. Because pyridoxal 5'-phosphate (PLP) serves as a coenzyme in the metabolism of amino acids, carbohydrates, organic acids, and neurotransmitters, as well as in aspects of one-carbon metabolism, vitamin B-6 deficiency could have many effects. Healthy men and women (age: 20-40 y; n = 23) were fed a 2-day controlled, nutritionally adequate diet followed by a 28-day low-vitamin B-6 diet (