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3. A mega-analysis of vertex and gyral cortical thickness differences in adults with and without PTSD

Author

Hong Xie, Erin O'Leary, Chia-Hao Shih, Andrew Cotton, John Wall, Tian Chen, Rong Liu, Kevin Xu, Chadi Abdallah, Elpiniki Andrew, C. Lexi Baird, Lee Baugh, Jessica Bomyea, Steven Bruce, Richard Bryant, Kyle Choi, Judith Daniels, Nicholas Davenport, Richard Davidson, Micheal De Bellis, Emily Dennis, Terri deRoon-Cassini, Seth Disner, Negar Fani, Kelene Fercho, Jacklynn Fitzgerald, Gina Forster, Jessie Frijling, Elbert Geuze, Hassan Gomaa, Evan Gordon, Daniel Grupe, Ilan Harpaz-Rotem, Courtney Haswell, Julia Herzog, Davia Hofmann, Micheal Hollifield, Bobak Hosseini, Anna Hudson, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa Kaufman, Anthony King, Saskia koch, Inga Koerte, Sheri-Michelle Koopowitz, Mayuresh Korgaonkar, John Krystal, Christine Larson, Lauren Lebois, Ifat Levy, Gen Li, Mark Logue, Vincent Magnotta, Antje Manthey, Geoffrey May, Katie McLaughlin, Sven Mueller, Laura Nawijn, null Nelson, Yuval Neria, Jack Nitschke, Miranda Olff, Elizabeth Olson, Matthew Peverill, K Luan Phan, Faisal Rashid, Kerry Ressler, Isabelle Rosso, Lauren Salminen, Kelly Sambrook, Freda Scheffler, Christian Schmahl, Martha Shenton, Anika Sierk, Jeffrey Simons, Raluca Simons, Scott Sponheim, Dan Stein, Murray Stein, Jennifer Stevens, Thomas Straube, Benjamin Suarez-Jimenez, Marijo Tamburrino, Sophia Thomopoulos, Nic van der Wee, Steven van der Werff, Theo van Erp, Sanne van Rooij, Mirjam van Zuiden, Tim Varkevisser, Dick Veltman, Robert Vermeiren, Henrik Walter, Li Wang, Xi Zhu, Ye Zhu, Paul Thompson, Xin Wang, Rajendra Morey, and Israel Liberzon

Abstract

A number of studies of posttraumatic stress disorder (PTSD) report thinner cerebral cortical gyri using gyrus-based analysis or thinner foci within the gyri using vertex-based analysis. However, the locations of these findings are inconsistent across studies, and the spatial transformations required during vertex-based analysis may affect the focal findings. A mega-analysis using a large number of subjects from multiple PTSD studies could potentially identify more reproducible cortical thickness abnormalities. Investigating both the vertex and gyral thicknesses simultaneously may verify the vertex-based focal findings using gyral data without imposing any spatial transformation. Here we aggregated data from 24 international laboratories using ENIGMA standardized procedures for 949 adult PTSD patients and 1493 controls without PTSD (age 18 to 65 years). We examined whether gyral and vertex cortical thickness are (a) different between subjects with PTSD and controls and (b) associated with PTSD symptom severity in trauma-exposed subjects. Regions with overlapping thinner cortical gyri and thinner vertex clusters were located in frontal, temporal, parietal, and occipital cortices. Thinner right lateral orbitofrontal and right lingual gyri and concomitantly thinner vertex clusters in the anterior portions of both gyri were associated with PTSD symptom severity. Convergent findings in these locations suggest focally thinner cortex in these gyri, which may be involved in altered processing and regulation of emotion and sensory inputs underlying posttraumatic stress symptoms.

Published
2022

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