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8 results on '"Sano, Taishi"'

1. Complex scaling calculation of phase shifts for positron collisions with positive ions

Author

Sano, Taishi, Yamashita, Takuma, and Kino, Yasushi

Subjects
Physics - Atomic Physics
Abstract

We present phase-shift calculations for positron collisions with positive ions using a complex scaling method (CSM). Based on the findings of this study [R. Suzuki, T. Myo, and K. Kat\={o}, Prog. Theor. Phys. 113, 1273 (2005).], we propose a modification of the phase shift in the CSM calculation, in which phase shifts are derived only from the complex eigenenergies of the CSM Hamiltonian. This modification is based on the fact that the contributions of high-lying complex eigenenergies can be approximated as a constant value in the case of a small collision energy, where neither target excitation nor positronium formation occurs. The proposed modification limits the contribution of the complex eigenenergies to the vicinity of the collision energy, which is also intuitively acceptable. We present a geometrical formulation of the modification and demonstrative calculations of positron scattering off positive ions. Our results agree well with those reported in the literature for the targets Ne, Ar, Kr, Xe, H, He, He$^+$, and Li$^{2+}$. The phase shifts of positron scattering off a Li$^+$ ion have also been reported., Comment: 13 pages, 12 figures; Revised theory part and corrected typos

Published
2024
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3. Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice

Author

Terasaki, Masaru, Uehara, Osamu, Ogasa, Shinya, Sano, Taishi, Kubota, Atsuhiko, Kojima, Hiroyuki, Tanaka, Takuji, Maeda, Hayato, Miyashita, Kazuo, Mutoh, Michihiro, Terasaki, Masaru, Uehara, Osamu, Ogasa, Shinya, Sano, Taishi, Kubota, Atsuhiko, Kojima, Hiroyuki, Tanaka, Takuji, Maeda, Hayato, Miyashita, Kazuo, and Mutoh, Michihiro

Abstract

application/pdf, Fucoxanthin (Fx), a marine carotenoid found in edible brown algae, is well known for having anticancer properties. The gut microbiota has been demonstrated as a hallmark for colorectal cancer progression in both humans and rodents. However, it remains unclear whether the gut microbiota is associated with the anticancer effect of Fx. We investigated the chemopreventive potency of Fx and its effect on gut microbiota in a mouse model of inflammation-associated colorectal cancer (by azoxymethane/dextran sulfate sodium treatment). Fx administration (30 mg/kg bw) during a 14 week period significantly inhibited the multiplicity of colorectal adenocarcinoma in mice. The number of apoptosis-like cleaved caspase-3high cells increased significantly in both colonic adenocarcinoma and mucosal crypts. Fx administration significantly suppressed Bacteroidlales (f_uc; g_uc) (0.3-fold) and Rikenellaceae (g_uc) (0.6-fold) and increased Lachnospiraceae (g_uc) (2.2-fold), compared with those of control mice. Oral administration of a fecal suspension obtained from Fx-treated mice, aimed to enhance Lachnospiraceae, suppress the number of colorectal adenocarcinomas in azoxymethane/dextran sulfate sodium-treated mice with a successful increase in Lachnospiraceae in the gut. Our findings suggested that an alteration in gut microbiota by dietary Fx might be an essential factor in the cancer chemopreventive effect of Fx in azoxymethane/dextran sulfate sodium-treated mice.

Published
2021

8. Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice.

Author

Terasaki M, Uehara O, Ogasa S, Sano T, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, and Mutoh M

Subjects
Adenocarcinoma immunology, Adenocarcinoma microbiology, Adenocarcinoma pathology, Animals, Azoxymethane administration & dosage, Azoxymethane toxicity, Colitis, Ulcerative chemically induced, Colitis, Ulcerative immunology, Colitis, Ulcerative microbiology, Colitis-Associated Neoplasms immunology, Colitis-Associated Neoplasms microbiology, Colitis-Associated Neoplasms pathology, Dextran Sulfate administration & dosage, Dextran Sulfate toxicity, Disease Models, Animal, Drug Screening Assays, Antitumor, Feces microbiology, Gastrointestinal Microbiome immunology, Humans, Intestinal Mucosa drug effects, Intestinal Mucosa immunology, Intestinal Mucosa microbiology, Intestinal Mucosa pathology, Male, Mice, Adenocarcinoma prevention & control, Colitis, Ulcerative drug therapy, Colitis-Associated Neoplasms prevention & control, Gastrointestinal Microbiome drug effects, Xanthophylls administration & dosage
Abstract

Fucoxanthin (Fx), a marine carotenoid found in edible brown algae, is well known for having anticancer properties. The gut microbiota has been demonstrated as a hallmark for colorectal cancer progression in both humans and rodents. However, it remains unclear whether the gut microbiota is associated with the anticancer effect of Fx. We investigated the chemopreventive potency of Fx and its effect on gut microbiota in a mouse model of inflammation-associated colorectal cancer (by azoxymethane/dextran sulfate sodium treatment). Fx administration (30 mg/kg bw) during a 14 week period significantly inhibited the multiplicity of colorectal adenocarcinoma in mice. The number of apoptosis-like cleaved caspase-3high cells increased significantly in both colonic adenocarcinoma and mucosal crypts. Fx administration significantly suppressed Bacteroidlales (f_uc; g_uc) (0.3-fold) and Rikenellaceae (g_uc) (0.6-fold) and increased Lachnospiraceae (g_uc) (2.2-fold), compared with those of control mice. Oral administration of a fecal suspension obtained from Fx-treated mice, aimed to enhance Lachnospiraceae, suppress the number of colorectal adenocarcinomas in azoxymethane/dextran sulfate sodium-treated mice with a successful increase in Lachnospiraceae in the gut. Our findings suggested that an alteration in gut microbiota by dietary Fx might be an essential factor in the cancer chemopreventive effect of Fx in azoxymethane/dextran sulfate sodium-treated mice., (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2021
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