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2. The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

Author

Li Destri Giovanni, Santagati Maria, Bertuccio Taschia, Cafiso Viviana, La Cava Piera, Palumbo Giuseppe A, Tandurella Igor, Triberio Patrizio, D'Agostino Vito, Valenti Salvo, Pernagallo Salvo, Tomasello Luisa, Salito Loredana, Statello Luisa, Scalia Marina, Angelica Rosario, Majorana Alessandra, Guglielmino Maria R, Duro Laura R, Barbagallo Davide, Ragusa Marco, Di Pietro Cinzia, Lanzafame Salvatore, Di Raimondo Francesco, Stefani Stefania, Mishra Bud, and Purrello Michele

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Apoptosis is a critical biological phenomenon, executed under the guidance of the Apoptotic Machinery (AM), which allows the physiologic elimination of terminally differentiated, senescent or diseased cells. Because of its relevance to BioMedicine, we have sought to obtain a detailed characterization of AM Omics in Homo sapiens, namely its Genomics and Evolution, Transcriptomics, Proteomics, Interactomics, Oncogenomics, and Pharmacogenomics. Methods This project exploited the methodology commonly used in Computational Biology (i.e., mining of many omics databases of the web) as well as the High Throughput biomolecular analytical techniques. Results In Homo sapiens AM is comprised of 342 protein-encoding genes (possessing either anti- or pro-apoptotic activity, or a regulatory function) and 110 MIR-encoding genes targeting them: some have a critical role within the system (core AM nodes), others perform tissue-, pathway-, or disease-specific functions (peripheral AM nodes). By overlapping the cancer type-specific AM mutation map in the fourteen most frequent cancers in western societies (breast, colon, kidney, leukaemia, liver, lung, neuroblastoma, ovary, pancreas, prostate, skin, stomach, thyroid, and uterus) to their transcriptome, proteome and interactome in the same tumour type, we have identified the most prominent AM molecular alterations within each class. The comparison of the fourteen mutated AM networks (both protein- as MIR-based) has allowed us to pinpoint the hubs with a general and critical role in tumour development and, conversely, in cell physiology: in particular, we found that some of these had already been used as targets for pharmacological anticancer therapy. For a better understanding of the relationship between AM molecular alterations and pharmacological induction of apoptosis in cancer, we examined the expression of AM genes in K562 and SH-SY5Y after anticancer treatment. Conclusion We believe that our data on the Apoptotic Machinery will lead to the identification of new cancer genes and to the discovery of new biomarkers, which could then be used to profile cancers for diagnostic purposes and to pinpoint new targets for pharmacological therapy. This approach could pave the way for future studies and applications in molecular and clinical Medicine with important perspectives both for Oncology as for Regenerative Medicine.

Published
2009
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6. Biofilm and bacterial membrane vesicles: recent advances

Author

Puca, Valentina, Marinacci, Beatrice, Pellegrini, Benedetta, Campanile, Floriana, Santagati, Maria, and Grande, Rossella

Abstract

ABSTRACTIntroductionBacterial Membrane Vesicles (MVs) play important roles in cell-to-cell communication and transport of several molecules. Such structures are essential components of Extracellular Polymeric Substances (EPS) biofilm matrix of many bacterial species displaying a structural function and a role in virulence and pathogenesis.Areas coveredIn this review were included original articles from the last ten years by searching the keywords ‘biofilm’ and ‘vesicles’ on PUBMED and Scopus databases. The articles available in literature mainly describe a positive correlation between bacterial MVs and biofilms formation. The research on Espacenet and Google Patent databases underlines the available patents related to the application of both biofilm MVs and planktonic MVs in inhibiting biofilm formation.Expert opinionThis review covers and analyzes recent advances in the study of the relationship between bacterial vesicles and biofilm. The huge number of papers discussing the role of MVs confirms the interest aimed at developing new applications in the medical field. The study of the MVs composition and biogenesis may contribute to the identification of components which could be (i) the target for the development of new drugs inhibiting the biofilm establishment; (ii) candidates for the development of vaccines; (iii) biomarkers for the diagnosis of bacterial infections.

Published
2024
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9. Single-nucleotide polymorphism and downstream signaling associated with chronic rhinosinusitis, asthma, allergy and acetylsalicylic-acid intolerance: a narrative review

Author

MANIACI, Antonino, primary, ROSOLIA, Guglielmo, additional, MUSSO, Nicolò, additional, BUONGIORNO, Dafne, additional, DI STEFANO, Maria E., additional, GIUNTA, Giorgia, additional, COCUZZA, Salvatore, additional, IANNELLA, Giannicola, additional, LECHIEN, Jerome R., additional, CALVO-HENRIQUEZ, Christian, additional, MAYO, Miguel, additional, GRIGALIUTE, Egle, additional, STRAQUADANIO, Stefano, additional, SANTAGATI, Maria, additional, STEFANI, Stefania, additional, and LA MANTIA, Ignazio, additional

Published
2022
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11. Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes

Author

O'Leary, Renée, Polosa, Riccardo, Li Volti, Giovanni, Bertino, Gaetano, Ferlito, Salvatore, Tomaselli, Venera, Nocera, Francesco, Zanoli, Luca, Alaimo, Salvatore, Anfuso, CARMELINA DANIELA, Barbagallo, IGNAZIO ALBERTO, Basile, Francesco, Battiato, Sebastiano, Bianchi, Alberto, Antonio, G Biondi, Maria Luisa Brandi, Cacciola, Emma, Cacciola, Rossella Rosaria, Cacopardo, Bruno Santi, Calogero, Aldo Eugenio, Cambria, Maria Teresa, Campagna, Davide, Caraci, Filippo, Cariola, Agatino, Caruso, Massimo, Caponnetto, Pasquale, Fabio, Cibella, DI MAURO, Maurizio, DI NUOVO, Santo, Adriana Di Stefano, Drago, Filippo, Failla, Salvatore, Rosario, Faraci, Salvatore, Ferlito, Ferrante, Margherita, Alfredo, Ferro, Giancarlo, A Ferro, Frasca, Francesco, Frittitta, Lucia, Furneri, Pio Maria, Giovanni, Gallo, Galvano, Fabio, Gagliano, Antonio, Grasso, Giuseppe, Francesca, Guarino, Gulino, Antonino, Emmanuele, A Jannini, LA VIGNERA, SANDRO SALVUCCIO MARIA, Lazzarino, Giuseppe, Antonio, Longo, Lupo, Gabriella, Mario, Malerba, Marletta, Luigi, Nicolosi, Guido, OLIVERI CONTI, GEA MARZIA, Parenti, Rosalba, Pulvirenti, Alfredo, Purrello, Francesco, Rapisarda, Francesco, Rapisarda, Venerando, Michele, Reibaldi, Rizzo, Renata, Ronsisvalle, Simone, Ruggieri, Martino, Santagati, Maria Carmela, Satriano, Cristina, Sciacca, Laura, Signorelli, MARIA SALVINA, Marco, Tatullo, Daniele, Tibullo, Venera, Tomaselli, Zanoli, LUCA MARIA, and Zappala', Agata

Subjects
Opinion, Adolescent, Medicine (miscellaneous), SCHEER, Population health, Electronic Nicotine Delivery Systems, 030204 cardiovascular system & hematology, Scientific evidence, European Union Tobacco Products Directive, 03 medical and health sciences, 0302 clinical medicine, Political science, e-cigarettes, ENDS, Gateway, Risk assessment, Tobacco harm reduction, Humans, media_common.cataloged_instance, European Union, 030212 general & internal medicine, European union, media_common, Social work, business.industry, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Tobacco Products, Public relations, Psychiatry and Mental health, Health psychology, Critical appraisal, Smoking Cessation, business, Citation, Environmental Health
Abstract

Background In preparation for the 2021 revision of the European Union Tobacco Products Directive, the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) has posted its Preliminary Opinion on Electronic Cigarettes. They concluded that e-cigarettes only achieve a sub-optimal level of protection of human health. In this paper, we provide evidence that the Opinion’s conclusions are not adequately backed up by scientific evidence and did not discuss the potential health benefits of using alternative combustion-free nicotine-containing products as substitute for tobacco cigarettes. Methods Searches for articles were conducted in PubMed and by citation chasing in Google Scholar. Articles were also retrieved with a review of references in major publications. Primary data from World Health Organization surveys, the conclusions of reviews, and peer-reviewed non-industry studies were cited to address errors and omissions identified in the Opinion. Results The Opinion omitted reporting on the individual and population health benefits of the substitution of e-cigarettes (ENDS) for cigarette smoking. Alternative hypotheses to the gateway theory were not evaluated. Its assessment of cardiovascular risk is contradicted by numerous reviews. It cites ever-use data that do not represent current patterns of use. It did not report non-nicotine use. It presented erroneous statements on trends in ENDS prevalence. It over-emphasized the role of flavours in youth ENDS initiation. It did not discuss cessation in sufficient length. Conclusions For the delivery of a robust and comprehensive final report, the members of the Working Group of the Scientific Committee on Health, Environmental and Emerging Risks will need to consider (1) the potential health benefits of ENDS substitution for cigarette smoking, (2) alternative hypotheses and contradictory studies on the gateway effect, (3) its assessment of cardiovascular risk, (4) the measurements of frequency of use, (5) non-nicotine use, (6) the role of flavours, and (7) a fulsome discussion of cessation.

Published
2021

15. Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research

Author

Hajat, C., Stein, E., Selya, A., Polosa, Riccardo, Bertino, Gaetano, Tomaselli, Venera, Ronsisvalle, Simone, Galvano, Fabio, OLIVERI CONTI, GEA MARZIA, Santagati, Maria Carmela, The CoEHAR study group, and Zanoli, LUCA MARIA

Subjects
Epidemiology, Vaping, Smoking, e-cigarettes, Electronic Nicotine Delivery Systems, Epidemiologic Studies, Electronic nicotine delivery systems (ENDS), Emergency Medicine, Internal Medicine, Critical Analysis, Humans, Smoking Cessation, Vape pens, Vapes
Abstract

The prevalence of vaping, also known as using e-cigarettes, vapes and vape pens, has prompted a demand for reliable, evidence-based research. However, published literature on the topic of vaping often raises concerns, characterized by serious flaws and a failure to adhere to accepted scientific methodologies. In this narrative review, we analyze popular vaping studies published in medical journals that purport to evaluate the association of vaping and smoking cessation, smoking initiation or health outcomes. We analyzed 24 included studies to identify the questions they claimed to address, stated methods, manner of implementation, discussions, and stated conclusions. After critical appraisal, we noted a multiplicity of flaws in these studies, and identified patterns as to the nature of such flaws. Many studies lacked a clear hypothesis statement: to the extent that a hypothesis could be inferred, the methods were not tailored to address the question of interest. Moreover, main outcome measures were poorly identified, and data analysis was further complicated by failure to control for confounding factors. The body of literature on “gateway” theory for the initiation of smoking was particularly unreliable. Overall, the results and discussion contained numerous unreliable assertions due to poor methods, including data collection that lacked relevance, and assertions that were unfounded. Many researchers claimed to find a causal association while not supporting such findings with meaningful data: the discussions and conclusions of such studies were, therefore, misleading. Herein, we identify the common flaws in the study design, methodology, and implementation found in published vaping studies. We present our summary recommendations for future vaping research. Our aim is to prompt future researchers to adhere to scientific methods to produce more reliable findings and conclusions in the field of vaping research.

Published
2022

16. Single-nucleotide polymorphism in chronic rhinosinusitis: A systematic review

Author

Stefani Stefania, Maniaci Antonino, Musso Nicolò, Cocuzza Salvatore, Viglianisi Chiara, Christian Calvo-Henriquez, Merlino Federico, Lechien Jerome Renee, Stracquadanio Stefano, Bonanno Antonio, Santagati Maria, and Ignazio La Mantia

Subjects
medicine.medical_specialty, Chronic rhinosinusitis, SNP, Single-nucleotide polymorphism, Comorbidity, Polymorphism, Single Nucleotide, polymorphism, Atopy, Pathogenesis, Polymorphism (computer science), Internal medicine, medicine, Eosinophilia, Humans, Genetic Predisposition to Disease, Sinusitis, Asthma, Rhinitis, metagenomics, business.industry, chronic rhinosinusitis, sequencing, medicine.disease, Otorhinolaryngology, Chronic Disease, medicine.symptom, business
Abstract

Objectives We performed a systematic review on single nucleotide polymorphisms and risk-related chronic rhinosinusitis. Design and setting A comprehensive review of the last 20 years' English language literature regarding chronic rhinosinusitis and single nucleotide polymorphisms was performed. We included in the synthesis all the papers reporting gene variation implicated in the pathogenesis of chronic inflammation and polyps. Results We found 12 papers with 9,127 patients, of which 2,739 CRS cases and 6388 controls. The major comorbidities reported related to chronic rhinosinusitis were Atopy in 4,555 (49.9%), Asthma in 4594 (50.33%), Samter Triad in 448 (4.9%), and Eosinophilia in 391 subjects (4.28%). Conclusion Our systematic review revealed the major SNPs significantly associated with chronic rhinosinusitis and the specific pathways involved. Given the presence of different extraction methods and samples sequencing, further studies with larger courts are necessary to identify significative single nucleotide polymorphisms.

Published
2022

17. Rapidly fatal hemorrhagic pneumonia and group A Streptococcus serotype M1

Author

Santagati, Maria, Spanu, Teresa, Scillato, Marina, Santangelo, Rosaria, Cavallaro, Fabio, Arena, Vincenzo, Castiglione, Giacomo, Falcone, Marco, Venditti, Mario, and Stefani, Stefania

Subjects
Bacterial pneumonia -- Health aspects, Pneumonia -- Health aspects, Proteins -- Health aspects, Health
Abstract

Streptococcus pyogenes or group A Streptococcus (GAS) Ois a versatile pathogen that can cause serious diseases, including bacteremia, cellulitis, puerperal sepsis, meningitis, pneumonia, and necrotizing fasciitis (1,2). This pathogen also [...]

Published
2014
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18. MSNA dal Sud al Nord Italia. Prassi e modelli di inserimento scolastico-formativo

Author

Santagati Maria Grazia, Colussi Erica, Di Rosa Roberta Teresa, Vetrugno Roberto, Santagati, M, Colussi, E, and Santagati Maria Grazia, Colussi Erica, Di Rosa Roberta Teresa, Vetrugno Roberto

Subjects
unaccompanied foreign minors, school, integration, minori stranieri non accompagnati, scuola, integrazione, Settore SPS/07 - Sociologia Generale
Abstract

Gli alunni stranieri non accompagnati costituiscono un universo eterogeneo che rappresenta una sfida per la governante dei processi formativi. Da qui la scelta di offrire uno spaccato sull'inserimento formativo dei MSNA nei contesti locali, attraverso una ricognizione delle rilevazioni svolte in realtà del Nord, Centro e Sud Italia. Unaccompanied foreign pupils constitute a heterogeneous universe which represents a challenge for the governing of educational processes. Hence the choice to offer an insight into the training insertion of MSNA in local contexts, through a survey of the surveys carried out in reality in Northern, Central and Southern Italy.

Published
2020

23. A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance. (Report)

Author

Di Paola, Rosa, Frittitta, Lucia, Miscio, Giuseppe, Bozzali, Maura, Baratta, Roberto, Centra, Marta, Spampinato, Daniela, Santagati, Maria Grazia, Ercolino, Tonino, Cisternino, Carmela, Soccio, Teresa, Mastroianno, Sandra, Tassi, Vittorio, Almgren, Peter, Pizzuti, Antonio, Vigneri, Riccardo, and Trischitta, Vincenzo

Subjects
Insulin resistance -- Genetic aspects, Phosphatases -- Genetic aspects, Biological sciences
Published
2002

24. Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children

Author

Ragusa, Marco, primary, Santagati, Maria, additional, Mirabella, Federica, additional, Lauretta, Giovanni, additional, Cirnigliaro, Matilde, additional, Brex, Duilia, additional, Barbagallo, Cristina, additional, Domini, Carla Noemi, additional, Gulisano, Mariangela, additional, Barone, Rita, additional, Trovato, Laura, additional, Oliveri, Salvatore, additional, Mongelli, Gino, additional, Spitale, Ambra, additional, Barbagallo, Davide, additional, Di Pietro, Cinzia, additional, Stefani, Stefania, additional, Rizzo, Renata, additional, and Purrello, Michele, additional

Published
2020
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27. Vancomycin-resistant Enterococcus faecium endemic outbreak in Trieste hospital

Author

Knezevich, Anna, Santolo, Manuela DI, Fabris, Clara, Busetti, Marina, Campanile, Floriana, Santagati, Maria, Bongiorno, Dafne, Stefani, A., Monticelli, Jacopo, LAGATOLLA, CRISTINA, BRESSAN, RAFFAELA, DOLZANI, LUCILLA, LUZZATI, ROBERTO, Knezevich A, Di Santolo M, Fabris C, Busetti M, Lagatolla C, Bressan R, Dolzani L, Campanile F, Santagati M, Bongiorno D, Stefani S, Monticelli J, Luzzati R., Knezevich, Anna, Santolo, Manuela DI, Fabris, Clara, Busetti, Marina, Lagatolla, Cristina, Bressan, Raffaela, Dolzani, Lucilla, Campanile, Floriana, Santagati, Maria, Bongiorno, Dafne, Stefani, A., Monticelli, Jacopo, and Luzzati, Roberto

Subjects
Enterococcus faecium, endemic, Vancomycin resistance
Published
2017

28. A Cluster of Three Single Nucleotide Polymorphisms in the 3′-Untranslated Region of Human Glycoprotein PC-1 Gene Stabilizes PC-1 mRNA and Is Associated With Increased PC-1 Protein Content and Insulin Resistance-Related Abnormalities

Author

Frittitta, Lucia, Ercolino, Tonino, Bozzali, Maura, Argiolas, Alessandra, Graci, Salvo, Santagati, Maria G., Spampinato, Daniela, Di Paola, Rosa, Cisternino, Carmela, Tassi, Vittorio, Vigneri, Riccardo, Pizzuti, Antonio, and Trischitta, Vincenzo

Published
2001

29. Gut Microbiota and Cancer: From Pathogenesis to Therapy

Author

Vivarelli, Silvia, primary, Salemi, Rossella, additional, Candido, Saverio, additional, Falzone, Luca, additional, Santagati, Maria, additional, Stefani, Stefania, additional, Torino, Francesco, additional, Banna, Giuseppe Luigi, additional, Tonini, Giuseppe, additional, and Libra, Massimo, additional

Published
2019
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37. Spread of Vancomycin-ResistantEnterococcus faeciumIsolates Despite Validated Infection Control Measures in an Italian Hospital: Antibiotic Resistance and Genotypic Characterization of the Endemic Strain

Author

Bressan, Raffaela, primary, Knezevich, Anna, additional, Monticelli, Jacopo, additional, Campanile, Floriana, additional, Busetti, Marina, additional, Santagati, Maria, additional, Dolzani, Lucilla, additional, Milan, Annalisa, additional, Bongiorno, Dafne, additional, Di Santolo, Manuela, additional, Tonin, Enrico A., additional, Stefani, Stefania, additional, Luzzati, Roberto, additional, and Lagatolla, Cristina, additional

Published
2018
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38. Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily

Author

Iannelli, Francesco, primary, Santoro, Francesco, additional, Santagati, Maria, additional, Docquier, Jean-Denis, additional, Lazzeri, Elisa, additional, Pastore, Gabiria, additional, Cassone, Marco, additional, Oggioni, Marco R., additional, Rossolini, Gian M., additional, Stefani, Stefania, additional, and Pozzi, Gianni, additional

Published
2018
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44. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, primary, Staiano, Annamaria, additional, Biasin, Eleonora, additional, Matarazzo, Patrizia, additional, Einaudi, Silvia, additional, Manicone, Rosaria, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Fagioli, Franca, additional, Bignamini, Elisabetta, additional, Nave, Elena, additional, Callea, F., additional, Concato, C., additional, Fiscarelli, E., additional, Garrone, S., additional, de Gasperis, M.Rossi, additional, Calzi, Patrizia, additional, Marinelli, Grazia, additional, Besana, Roberto, additional, Caffarelli, Carlo, additional, Di Peri, Antonio, additional, Lapetina, Irene, additional, Cincinnati, Patrizia, additional, Da Riol, Rosalia Maria, additional, De Curtis, Mario, additional, Dito, Lucia, additional, Protano, Chiara, additional, Esposito, Susanna, additional, Ferrara, Dante, additional, Galiano, Rossella, additional, Novellino, Pasquale, additional, Kossoff, Eric Heath, additional, Krzysztofiak, Andrzej, additional, Bozzola, Elena, additional, Lancella, Laura, additional, Marchesi, Alessandra, additional, Villani, Alberto, additional, Lago, Paola, additional, Garetti, Elisabetta, additional, Pirelli, Anna, additional, Marchisio, Paola, additional, Santagati, Maria, additional, Stefani, Stefania, additional, Principi, Nicola, additional, d’Apolito, Valeria, additional, Memo, Luigi, additional, Selicorni, Angelo, additional, Miniello, Vito Leonardo, additional, Diaferio, Lucia, additional, Palmieri, Antonella, additional, Parola, Luciana, additional, Piro, Ettore, additional, Romano, Claudio, additional, Catena, Maria Ausilia, additional, Cardile, Sabrina, additional, Sacco, Oliviero, additional, Girosi, Donata, additional, Olcese, Roberta, additional, Tosca, Mariangela, additional, Rossi, Giovanni Arturo, additional, Salerno, Sergio, additional, Terranova, Maria Chiara, additional, Santamaria, Francesca, additional, Mancano, Giorgia, additional, Maitz, Silvia, additional, Stallings, Virginia A., additional, Berlolaso, Chiara, additional, McAnlis, Carolyn, additional, Schall, Joan I., additional, Striano, Pasquale, additional, Tanas, Rita, additional, De Iaco, Giulia, additional, Marsella, Maria, additional, Caggese, Guido, additional, Toma, Paolo, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Pata, David, additional, Ceccarelli, Manuela, additional, Verduci, Elvira, additional, Brambilla, Marta, additional, Mariani, Benedetta, additional, Lassandro, Carlotta, additional, Dionigi, Alice Re, additional, Vizzuso, Sara, additional, Banderali, Giuseppe, additional, Panzarino, Gianvito, additional, Di Paolantonio, Claudia, additional, Verrotti, Alberto, additional, Cursi, Laura, additional, Grandin, Annalisa, additional, Virdis, Raffaele, additional, Carletti, Patrizia, additional, Weber, Giovanna, additional, Caiulo, Silvana, additional, and Vigone, Maria Cristina, additional

Published
2017
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48. Application of bacteriotherapy in human rhinopharynx

Author

Santagati, Maria Carmela, Scillato, M., Damiani, V., LA MANTIA, Ignazio, and Stefani, Stefania

Subjects
Streptococcus salivarius, bacteriotherapy, chronic otitis media in pediatric age patients
Published
2014

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