1. Prebiotic potencial of juçara berry on changes in gut bacteria and acetate of individuals with obesity.
- Author
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Jamar, Giovana, Santamarina, Aline Boveto, Casagrande, Breno Picin, Estadella, Débora, de Rosso, Veridiana Vera, Wagner, Roger, Fagundes, Mariane Bittencourt, and Pisani, Luciana Pellegrini
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ACETIC acid , *DIETARY fiber , *FRUIT juices , *INGESTION , *OBESITY , *POLYPHENOLS , *STATISTICAL sampling , *PLANT extracts , *GUT microbiome , *RANDOMIZED controlled trials , *PREBIOTICS , *SHORT-chain fatty acids - Abstract
Purpose: Whole plant foods can be fermentable by SCFA-producing bacteria and positively influence host adipose tissue development and obesity related-metabolic disorders, conferring a prebiotic role. Considering the juçara berry composition, rich in fiber and polyphenols, we hypothesized the probable prebiotic role of juçara in individuals with obesity. Methods: It was a randomized double-blind placebo-controlled trial with 35 volunteers with obesity I and II of both sexes aged from 31 to 59 years, divided into juçara group (5 g lyophilized juçara) or placebo group (5 g of maltodextrin) for 6 weeks. Before and after supplementation, food intake and blood and stool samples were collected to evaluate serum LPS, SCFA, and microbial bacteria. Results: Significant increase in fecal acetate (g = 0.809; p = 0.038) and in relative abundance of A. muciniphila, Bifidobacterium spp. and C. coccoides were observed in response to juçara supplementation (Δ% = 239.6%, 182.6%, and 214%, respectively), with a significant mediator role of Bifidobacterium spp. in high amounts of fecal acetate (z = 2.925; p = 0.003). To certify the prebiotic role of juçara, the averages were adjusted for total fiber intake; and there was no effect of the fiber intake on the SCFA nor on the intestinal bacteria. Conclusion: Juçara berry may haveprebiotic function, with emphasis on the bifidogenic effect, leading to increased excretion of acetate. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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