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7. Prognostic analysis and outcomes of metastatic pancreatic cancer patients receiving nab‐paclitaxel plus gemcitabine as second or later‐line treatment.

Author

Giordano, Guido, Milella, Michele, Landriscina, Matteo, Bergamo, Francesca, Tirino, Giuseppe, Santaniello, Antonio, Zaniboni, Alberto, Vasile, Enrico, De Vita, Ferdinando, Re, Giovanni Lo, Vaccaro, Vanja, Giommoni, Elisa, Natale, Donato, Conca, Raffaele, Santini, Daniele, Maiorino, Luigi, Sanna, Gianni, Ricci, Vincenzo, Iop, Aldo, and Montesarchio, Vincenzo

Subjects
PANCREATIC cancer, CANCER patients, METASTASIS, OVERALL survival, PROGRESSION-free survival, PANCREATIC intraepithelial neoplasia
Abstract

Background: Pancreatic cancer (PC) first‐line therapy often consists of polychemotherapy regimens, but choosing a second‐line therapy after disease progression, especially following first‐line FOLFIRINOX, remains a clinical challenge. This study presents results from a large, multicenter, retrospective analysis of Italian patients with metastatic PC (mPC) treated with Nab‐paclitaxel/Gemcitabine (AG) as second or later line of treatment. Main objective of the study is to identify prognostic factors that could inform treatment decisions. Methods: The study included 160 mPC patients treated with AG in 17 Italian institutions. AG was administered according to labelling dose, until disease progression, unacceptable toxicity or patient refusal. Variations in schedules, dose modifications, supportive measures, and response evaluation were determined by individual clinicians' practice. Results: AG was well‐tolerated and exhibited promising clinical activity. The overall response rate (ORR) and the disease control rate (DCR) were 22.5% and 45.6%, respectively. Median progression‐free survival (PFS) and overall survival (OS) were 3.9 and 6.8 months, respectively. Among the patients who received AG as a second‐line therapy (n = 111, 66.9%), median PFS and OS were 4.2 and 7.4 months, respectively. Notably, in the 76 patients (68%) receiving AG after first‐line FOLFIRINOX, an ORR of 19.7% and a DCR of 46.0% were observed, resulting in a median PFS of 3.5 and median OS of 5.7 months. The study identified specific clinical or laboratory parameters (LDH, NLR, fasting serum glucose, liver metastases, ECOG PS, and first‐line PFS) as independent prognostic factors at multivariate level. These factors were used to create a prognostic nomogram that divided patients into three risk classes, helping to predict second‐line OS and PFS. Conclusions: This study represents the largest real‐world population of mPC patients treated with AG as a second or later line of therapy. It supports the feasibility of this regimen following first‐line FOLFIRINOX, particularly in patients with specific clinical and laboratory characteristics who derived prolonged benefit from first‐line therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Gestione del contatto con animali nei bambini oncoematologici

Author

Fiumana, Giulia, primary, Botta, Debora, additional, Dalla Porta, Maria Francesca, additional, Macchi, Simone, additional, Soncini, Elena, additional, Santaniello, Antonio, additional, Paciello, Orlando, additional, Cellini, Monica, additional, and Cesaro, Simone, additional

Published
2023
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10. Consensus Statement on Animals’ Relationship with Pediatric Oncohematological Patients, on Behalf of Infectious Diseases and Nurse Working Groups of the Italian Association of Pediatric Hematology-Oncology

Author

Fiumana, Giulia, primary, Botta, Debora, additional, Dalla Porta, Maria Francesca, additional, Macchi, Simone, additional, Soncini, Elena, additional, Santaniello, Antonio, additional, Paciello, Orlando, additional, Amicucci, Matteo, additional, Cellini, Monica, additional, and Cesaro, Simone, additional

Published
2023
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11. SARS-CoV-2 Affects Both Humans and Animals: What Is the Potential Transmission Risk? A Literature Review

Author

Santaniello, Antonio, primary, Perruolo, Giuseppe, additional, Cristiano, Serena, additional, Agognon, Ayewa Lawoe, additional, Cabaro, Serena, additional, Amato, Alessia, additional, Dipineto, Ludovico, additional, Borrelli, Luca, additional, Formisano, Pietro, additional, Fioretti, Alessandro, additional, and Oriente, Francesco, additional

Published
2023
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15. Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy

Author

Pisapia, Pasquale, primary, Iaccarino, Antonino, additional, De Luca, Caterina, additional, Acanfora, Gennaro, additional, Bellevicine, Claudio, additional, Bianco, Roberto, additional, Daniele, Bruno, additional, Ciampi, Luisa, additional, De Felice, Marco, additional, Fabozzi, Teresa, additional, Formisano, Luigi, additional, Giordano, Pasqualina, additional, Gridelli, Cesare, additional, Ianniello, Giovanni Pietro, additional, Libroia, Annamaria, additional, Maione, Paolo, additional, Nacchio, Mariantonia, additional, Pagni, Fabio, additional, Palmieri, Giovanna, additional, Pepe, Francesco, additional, Russo, Gianluca, additional, Salatiello, Maria, additional, Santaniello, Antonio, additional, Scamarcio, Rachele, additional, Seminati, Davide, additional, Troia, Michele, additional, Troncone, Giancarlo, additional, Vigliar, Elena, additional, and Malapelle, Umberto, additional

Published
2022
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16. FOLFIRINOX or nab-paclitaxel plus gemcitabine in metastatic pancreatic adenocarcinoma: an observational study

Author

Servetto, Alberto, primary, Santaniello, Antonio, additional, Napolitano, Fabiana, additional, Foschini, Francesca, additional, Marciano, Roberta, additional, Cascetta, Priscilla, additional, Amato, Anna Rita, additional, Augurio, Maria Rosaria, additional, Maresca, Lucia, additional, De Placido, Pietro, additional, De Placido, Sabino, additional, Formisano, Luigi, additional, and Bianco, Roberto, additional

Published
2022
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17. Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy

Author

Pisapia, P, Iaccarino, A, De Luca, C, Acanfora, G, Bellevicine, C, Bianco, R, Daniele, B, Ciampi, L, De Felice, M, Fabozzi, T, Formisano, L, Giordano, P, Gridelli, C, Ianniello, G, Libroia, A, Maione, P, Nacchio, M, Pagni, F, Palmieri, G, Pepe, F, Russo, G, Salatiello, M, Santaniello, A, Scamarcio, R, Seminati, D, Troia, M, Troncone, G, Vigliar, E, Malapelle, U, Pisapia, Pasquale, Iaccarino, Antonino, De Luca, Caterina, Acanfora, Gennaro, Bellevicine, Claudio, Bianco, Roberto, Daniele, Bruno, Ciampi, Luisa, De Felice, Marco, Fabozzi, Teresa, Formisano, Luigi, Giordano, Pasqualina, Gridelli, Cesare, Ianniello, Giovanni Pietro, Libroia, Annamaria, Maione, Paolo, Nacchio, Mariantonia, Pagni, Fabio, Palmieri, Giovanna, Pepe, Francesco, Russo, Gianluca, Salatiello, Maria, Santaniello, Antonio, Scamarcio, Rachele, Seminati, Davide, Troia, Michele, Troncone, Giancarlo, Vigliar, Elena, Malapelle, Umberto, Pisapia, P, Iaccarino, A, De Luca, C, Acanfora, G, Bellevicine, C, Bianco, R, Daniele, B, Ciampi, L, De Felice, M, Fabozzi, T, Formisano, L, Giordano, P, Gridelli, C, Ianniello, G, Libroia, A, Maione, P, Nacchio, M, Pagni, F, Palmieri, G, Pepe, F, Russo, G, Salatiello, M, Santaniello, A, Scamarcio, R, Seminati, D, Troia, M, Troncone, G, Vigliar, E, Malapelle, U, Pisapia, Pasquale, Iaccarino, Antonino, De Luca, Caterina, Acanfora, Gennaro, Bellevicine, Claudio, Bianco, Roberto, Daniele, Bruno, Ciampi, Luisa, De Felice, Marco, Fabozzi, Teresa, Formisano, Luigi, Giordano, Pasqualina, Gridelli, Cesare, Ianniello, Giovanni Pietro, Libroia, Annamaria, Maione, Paolo, Nacchio, Mariantonia, Pagni, Fabio, Palmieri, Giovanna, Pepe, Francesco, Russo, Gianluca, Salatiello, Maria, Santaniello, Antonio, Scamarcio, Rachele, Seminati, Davide, Troia, Michele, Troncone, Giancarlo, Vigliar, Elena, and Malapelle, Umberto

Abstract

Background: Immune-checkpoint inhibitors (ICIs) have increased and improved the treatment options for patients with non-oncogene-addicted advanced stage non-small cell lung cancer (NSCLC). However, the role of ICIs in oncogene-addicted advanced stage NSCLC patients is still debated. In this study, in an attempt to fill in the informational gap on the effect of ICIs on other driver mutations, we set out to provide a molecular landscape of clinically relevant oncogenic drivers in programmed death-ligand 1 (PD-L1) positive NSCLC patients. Methods: We retrospectively reviewed data on 167 advanced stage NSCLC PD-L1 positive patients (≥1%) who were referred to our clinic for molecular evaluation of five driver oncogenes, namely, EGFR, KRAS, BRAF, ALK and ROS1. Results: Interestingly, n = 93 (55.7%) patients showed at least one genomic alteration within the tested genes. Furthermore, analyzing a subset of patients with PD-L1 tumor proportion score (TPS) ≥ 50% and concomitant gene alterations (n = 8), we found that n = 3 (37.5%) of these patients feature clinical benefit with ICIs administration, despite the presence of a concomitant KRAS gene alteration. Conclusions: In this study, we provide a molecular landscape of clinically relevant biomarkers in NSCLC PD-L1 positive patients, along with data evidencing the clinical benefit of ICIs in patient NSCLC PD-L1 positive alterations.

Published
2022

18. Affiliative bonds and cruel behavior in childhood interspecific relationships: A conceptual framework on the psychodynamics of affect regulation

Author

Mezzalira, Selene, Scandurra, Cristiano, Santaniello, Antonio, Mezza, Fabrizio, Saturnino, Claudia, Cristiano, Serena, Pizzo, Rosa, Maldonato, Nelson Mauro, Menna, Lucia Francesca, Bochicchio, Vincenzo, Mezzalira, S., Scandurra, C., Santaniello, A., Mezza, F., Saturnino, C., Cristiano, S., Pizzo, R., Maldonato, N. M., Menna, L. F., and Bochicchio, V.

Subjects
Affect regulation, Childhood interspecific relationship, Conduct disorder, Antisocial traits, Clinical psychology, Affect regulation, Childhood interspecific relationship, Conduct disorder, Antisocial traits, Clinical psychology
Abstract

Background: Childhood interspecific relationships can be viewed as a mirror of the person’s capacity to interact with other living beings. The interspecific relationship can involve different attachment styles, affect regulation skills, transitional object dynamics, and self-awareness and mentalization processes. Yet interspecific relationships can also be disrupted, since they can be associated with cruel behavior toward animals, which is in turn related to possible psychopathology. Method: We provided a conceptual framework based on the literature addressing the interspecific relationship in both its adaptive and positive features as well as in its disrupted aspects. Discussion: Pets have often been regarded as attachment figures that can aid children in socialization and growth processes. They have been deemed to represent “social catalysts” that tend to facilitate human relationships, thus increasing prosocial behaviors. On the dark side of the pet-child interaction, childhood abuse of animals tends to be associated with behavioral and emotional problems that have been thought of as underlying psychopathology (e.g., conduct disorder and antisocial personality traits). Childhood cruelty to animals seems to accompany emotion dysregulation, poor social information processing, and low empathy. Conclusions: Since the child-pet relationship has substantial implications for the individual’s mental health and for the potential development of psychopathology, addressing children’s attitudes toward animals can aid in understanding the affective and emotional dimensions of their interpersonal experience., Mediterranean Journal of Clinical Psychology, Vol 10, No 3 (2022)

Published
2022

19. Use of FOLFIRINOX or Nab-Paclitaxel Plus Gemcitabine for the Treatment of Locally Advanced Pancreatic Adenocarcinoma: A Single Institution Observational Study

Author

Servetto, Alberto, primary, Santaniello, Antonio, additional, Napolitano, Fabiana, additional, Foschini, Francesca, additional, Marciano, Roberta, additional, Mozzillo, Eleonora, additional, Cascetta, Priscilla, additional, Amato, Anna Rita, additional, Augurio, Maria Rosaria, additional, Maresca, Lucia, additional, De Placido, Pietro, additional, De Placido, Sabino, additional, Formisano, Luigi, additional, and Bianco, Roberto, additional

Published
2021
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20. Zoonotic Risk of Encephalitozoon cuniculi in Animal-Assisted Interventions: Laboratory Strategies for the Diagnosis of Infections in Humans and Animals

Author

Santaniello, Antonio, primary, Cimmino, Ilaria, additional, Dipineto, Ludovico, additional, Agognon, Ayewa Lawoe, additional, Beguinot, Francesco, additional, Formisano, Pietro, additional, Fioretti, Alessandro, additional, Menna, Lucia Francesca, additional, and Oriente, Francesco, additional

Published
2021
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24. Supplementary_Materials_1 – Supplemental material for FOLFIRINOX after first-line gemcitabine-based chemotherapy in advanced pancreatic cancer: a retrospective comparison with FOLFOX and FOLFIRI schedules

Author

Foschini, Francesca, Napolitano, Fabiana, Servetto, Alberto, Marciano, Roberta, Mozzillo, Eleonora, Carratù, Anna Chiara, Santaniello, Antonio, Placido, Pietro De, Cascetta, Priscilla, Butturini, Giovanni, Frigerio, Isabella, Regi, Paolo, Silvestris, Nicola, Delcuratolo, Sabina, Vasile, Enrico, Vivaldi, Caterina, Bianco, Cataldo, Placido, Sabino De, Formisano, Luigi, and Bianco, Roberto

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_Materials_1 for FOLFIRINOX after first-line gemcitabine-based chemotherapy in advanced pancreatic cancer: a retrospective comparison with FOLFOX and FOLFIRI schedules by Francesca Foschini, Fabiana Napolitano, Alberto Servetto, Roberta Marciano, Eleonora Mozzillo, Anna Chiara Carratù, Antonio Santaniello, Pietro De Placido, Priscilla Cascetta, Giovanni Butturini, Isabella Frigerio, Paolo Regi, Nicola Silvestris, Sabina Delcuratolo, Enrico Vasile, Caterina Vivaldi, Cataldo Bianco, Sabino De Placido, Luigi Formisano and Roberto Bianco in Therapeutic Advances in Medical Oncology

Published
2020
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30. Abstract P3-06-08: Pak1 as a novel mediator of resistance to endocrine therapy and CDK4/6 inhibitors in ER+/PAK-1amplifiedbreast cancer

Author

Belli, Stefania, primary, Servetto, Alberto, additional, Mauro, Concetta Di, additional, Esposito, Daniela, additional, Pesapane, Ada, additional, Napolitano, Fabiana, additional, Santaniello, Antonio, additional, De Placido, Pietro, additional, Cascetta, Priscilla, additional, Carratù, Annachiara, additional, Mozzillo, Eleonora, additional, Marciano, Roberta, additional, Bianco, Roberto, additional, and Formisano, Luigi, additional

Published
2020
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31. Abstract P5-04-17: Hedgehog pathway is involved in cancer immune surveillance through PDL1 modulation

Author

De Placido, Pietro, primary, Mauro, Concetta Di, additional, Esposito, Daniela, additional, Pesapane, Ada, additional, Belli, Stefania, additional, Napolitano, Fabiana, additional, Santaniello, Antonio, additional, Cascetta, Priscilla, additional, Carratù, Annachiara, additional, Mozzillo, Eleonora, additional, Marciano, Roberta, additional, Servetto, Alberto, additional, Bianco, Roberto, additional, and Formisano, Luigi, additional

Published
2020
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32. FOLFIRINOX after first-line gemcitabine-based chemotherapy in advanced pancreatic cancer: a retrospective comparison with FOLFOX and FOLFIRI schedules

Author

Foschini, Francesca, primary, Napolitano, Fabiana, additional, Servetto, Alberto, additional, Marciano, Roberta, additional, Mozzillo, Eleonora, additional, Carratù, Anna Chiara, additional, Santaniello, Antonio, additional, De Placido, Pietro, additional, Cascetta, Priscilla, additional, Butturini, Giovanni, additional, Frigerio, Isabella, additional, Regi, Paolo, additional, Silvestris, Nicola, additional, Delcuratolo, Sabina, additional, Vasile, Enrico, additional, Vivaldi, Caterina, additional, Bianco, Cataldo, additional, De Placido, Sabino, additional, Formisano, Luigi, additional, and Bianco, Roberto, additional

Published
2020
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35. Neoadjuvant Treatment in Locally Advanced Pancreatic Cancer (LAPC) Patients with FOLFIRINOX or Gemcitabine NabPaclitaxel: A Single-Center Experience and a Literature Review

Author

Napolitano, Fabiana, primary, Formisano, Luigi, additional, Giardino, Alessandro, additional, Girelli, Roberto, additional, Servetto, Alberto, additional, Santaniello, Antonio, additional, Foschini, Francesca, additional, Marciano, Roberta, additional, Mozzillo, Eleonora, additional, Carratù, Anna Chiara, additional, Cascetta, Priscilla, additional, De Placido, Pietro, additional, De Placido, Sabino, additional, and Bianco, Roberto, additional

Published
2019
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39. The application of FLOTAC for faecal egg counts in sheep

Author

CRINGOLI, GIUSEPPE, RINALDI, LAURA, MAURELLI, MARIA PAOLA, MUSELLA, VINCENZO, SANTANIELLO, ANTONIO, BOSCO, ANTONIO, Coles, Gerald C., Cringoli, Giuseppe, Rinaldi, Laura, Maurelli, MARIA PAOLA, Musella, Vincenzo, Santaniello, Antonio, Bosco, Antonio, and Coles, Gerald C.

Published
2010

41. The gastrointestinal parasites of rabbits in intensive management farms

Author

Santaniello, Antonio, Santaniello, Mirella, Guariglia, Ida, Borrelli, Luca, Musella, Vincenzo, Tremigliozzi, C, FIORETTI, ALESSANDRO, RINALDI, LAURA, CRINGOLI, GIUSEPPE, Santaniello, Antonio, Santaniello, Mirella, Guariglia, Ida, Borrelli, Luca, Fioretti, Alessandro, Rinaldi, Laura, Musella, Vincenzo, Tremigliozzi, C, and Cringoli, Giuseppe

Published
2009

43. Parasitic infections in dogs involved in animal-assisted interventions.

Author

Gerardi, Federica, Santaniello, Antonio, Del Prete, Luisa, Maurelli, Maria Paola, Menna, Lucia Francesca, and Rinaldi, Laura

Subjects
*PATHOGENIC microorganisms, *PUBLIC health, *NEMATODE infections, *ZOONOSES
Abstract

Animal Assisted Interventions (AAIs) programmes have been considered useful in different settings, such as hospital, therapeutic, educational and assisted living environments. In these contexts, all animals, and particularly dogs, should be subjected to appropriate health controls to prevent a potential risk of transmission of zoonotic agents. Domestic dogs are reservoirs of many zoonotic pathogens including several gastrointestinal parasites (protozoa and helminths). Therefore, the aim of the present study was to investigate the presence of the protozoanGiardia duodenalisand zoonotic gastrointestinal nematodes (geohelminths) in dogs hosted in a dog educational centre in the city of Naples (southern Italy) where the animals were trained to AAI. Between April and June 2016, 74 dog faecal samples were analysed using the FLOTAC dual technique to detectG. duodenaliscysts and other parasitic elements. Out of the 74 faecal samples examined, 18 (24.3%; 95% CI = 15.4–35.9) were positive for parasitic elements. Specifically, 8 were positive forG. duodenalis(44.4%; 95% CI = 22.4–68.7). In addition, some co-infections were also found: one sample (5.6%; 95% CI = 0.3–29.4) resulted positive to bothToxocara canisandTrichuris vulpisand two samples (11.1%; 95% CI = 1.9–36.1) were positive to bothG. duodenalisand Ancylostomidae. Given that children, young adults and immunocompromised individuals are among the main users of the AAIs, specific guidelines targetingG. duodenalisand other gastrointestinal zoonotic parasites should be formulated in order to develop effective control and prevention strategies and reduce the zoonotic risk favoured by the human-dog interaction. [ABSTRACT FROM PUBLISHER]

Published
2018
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49. Evaluation of the efficacy of animal-assisted therapy based on the reality orientation therapy protocol in Alzheimer's disease patients: a pilot study.

Author

Menna, Lucia Francesca, Santaniello, Antonio, Gerardi, Federica, Di Maggio, Annamaria, and Milan, Graziella

Subjects
*ALZHEIMER'S disease treatment, *AFFECT (Psychology), *ANALYSIS of variance, *COGNITION, *REALITY therapy, *QUESTIONNAIRES, *STATISTICS, *T-test (Statistics), *PET therapy, *PILOT projects, *DATA analysis, *TREATMENT effectiveness, *GERIATRIC Depression Scale
Abstract

The article presents a study on the efficacy of animal-assisted therapy (AAT) for elderly patients with Alzheimer's disease, based on the formal reality orientation therapy (ROT) protocol. Topics include pet therapy interventions, assessment of patients using the Mini-Mental State Examination (MMSE) and the 15-item Geriatric Depression Scale (GDS), and the study results which show that pet therapy interventions based on formal ROT protocol were statistically more effective compared to ROT.

Published
2016
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