Search

Your search keyword '"Santilli, Veronica"' showing total 164 results
Start Over Author "Santilli, Veronica"
164 results on '"Santilli, Veronica"'

1. Towards personalized vaccines.

Author

Montin, Davide, Santilli, Veronica, Beni, Alessandra, Costagliola, Giorgio, Martire, Baldassarre, Mastrototaro, Maria Felicia, Ottaviano, Giorgio, Rizzo, Caterina, Sgrulletti, Mayla, Del Giudice, Michele Miraglia, and Moschese, Viviana

Abstract

The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored to individual genetic and immunological profiles. Integrating insights from genomics, transcriptomics, proteomics, and immunology, personalized vaccines offer the promise of enhanced efficacy and safety, revolutionizing the field of vaccinology. However, the development of personalized vaccines presents multifaceted challenges, including technical, ethical, economic, and regulatory considerations. Addressing these challenges is essential to ensure equitable access and safety of personalized vaccination strategies. Despite these hurdles, the potential of personalized vaccines to optimize responses and mitigate disease burden underscores the significance of ongoing research and collaboration in advancing precision medicine in immunization. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

2. Vaccines and allergy: Back to the right places.

Author

Moschese, Viviana, Montin, Davide, Ottaviano, Giorgio, Sgrulletti, Mayla, Beni, Alessandra, Costagliola, Giorgio, Sangerardi, Maria, Santilli, Veronica, Miraglia Del Giudice, Michele, Rizzo, Caterina, and Martire, Baldassarre

Subjects
VACCINATION of children, ANAPHYLAXIS, MEDICAL personnel, VACCINATION, ALLERGIES
Abstract

Hypersensitivity reactions represent one of the most common causes of hesitancy for adherence to national vaccination programs. The majority of hypersensitivity reactions after vaccination are mild, and anaphylaxis is reported to be rare, although it remains challenging to estimate the frequency attributed to each single vaccine, either because of the lower number of administered doses of less common vaccines, or the administration of simultaneous vaccine in most of the vaccination programs. Although literature remains scattered, international consensus guides clinicians in identifying patients who might need the administration of vaccines in protected environments due to demonstrated hypersensitivity to vaccine components or adjuvants. Here we provide the current guidance on hypersensitivity reactions to vaccines and on vaccination of children with allergy disorders. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Clinical, Immunological, and Molecular Variability of RAG Deficiency: A Retrospective Analysis of 22 RAG Patients

Author

Cifaldi, Cristina, Rivalta, Beatrice, Amodio, Donato, Mattia, Algeri, Pacillo, Lucia, Di Cesare, Silvia, Chiriaco, Maria, Ursu, Giorgiana Madalina, Cotugno, Nicola, Giancotta, Carmela, Manno, Emma C., Santilli, Veronica, Zangari, Paola, Federica, Galaverna, Palumbo, Giuseppe, Merli, Pietro, Palma, Paolo, Rossi, Paolo, Di Matteo, Gigliola, Locatelli, Franco, Finocchi, Andrea, and Cancrini, Caterina

Published
2022
Full Text
View/download PDF

4. Epstein–Barr virus‐associated smooth muscle tumor in a female with ataxia telangiectasia: A case report

Author

Rivalta, Beatrice, primary, Zangari, Paola, additional, Pacillo, Lucia, additional, Manno, Emma Concetta, additional, Santilli, Veronica, additional, Rotulo, Gioacchino Andrea, additional, Cotugno, Nicola, additional, Rossetti, Chiara, additional, Vallese, Silvia, additional, Paglietti, Maria Giovanna, additional, Tomà, Paolo, additional, Pardi, Valerio, additional, Inserra, Alessandro, additional, Francalanci, Paola, additional, Milano, Giuseppe Maria, additional, Alaggio, Rita, additional, Cancrini, Caterina, additional, Finocchi, Andrea, additional, Palma, Paolo, additional, and Amodio, Donato, additional

Published
2024
Full Text
View/download PDF

5. Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine

Author

Cotugno, Nicola, primary, Neri, Alessia, additional, Sanna, Marco, additional, Santilli, Veronica, additional, Manno, Emma Concetta, additional, Pascucci, Giuseppe Rubens, additional, Morrocchi, Elena, additional, Amodio, Donato, additional, Ruggiero, Alessandra, additional, Ciofi degl Atti, Marta Luisa, additional, Barneschi, Irene, additional, Grappi, Silvia, additional, Cocchi, Ilaria, additional, Giacomet, Vania, additional, Trabattoni, Daria, additional, Olivieri, Giulio, additional, Bernardi, Stefania, additional, O’Connor, Daniel, additional, Montomoli, Emanuele, additional, Pollard, Andrew J., additional, and Palma, Paolo, additional

Published
2024
Full Text
View/download PDF

6. Use of dupilumab for atopic dermatitis in pediatric and young adult patients with inborn errors of immunity.

Author

Zangari, Paola, Giancotta, Carmela, Pacillo, Lucia, Colantoni, Nicole, Leone, Fabrizio, Amodio, Donato, Santilli, Veronica, Manno, Emma Concetta, Cotugno, Nicola, Rivalta, Beatrice, Rotulo, Gioacchino Andrea, Di Cesare, Silvia, Diociaiuti, Andrea, El Hachem, May, Cancrini, Caterina, Finocchi, Andrea, and Palma, Paolo

Subjects
MONONUCLEAR leukocytes, HEMATOPOIETIC stem cell transplantation, INFLAMMATORY bowel diseases, RESPIRATORY infections, LEUCOCYTES, WARTS, ATOPY
Abstract

This article discusses the use of dupilumab, a biologic medication, for the treatment of atopic dermatitis (AD) in pediatric and young adult patients with inborn errors of immunity (IEIs). The medication has been approved for use in children with moderate to severe AD who have inadequate control with topical therapies. The article presents case studies of patients with IEIs and AD who were treated with dupilumab, showing significant clinical improvement as early as week 4 of treatment. However, further studies are needed to evaluate the long-term safety and efficacy of dupilumab in this patient population. [Extracted from the article]

Published
2024
Full Text
View/download PDF

7. BNT162B2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed?

Author

Cotugno, Nicola, Pighi, Chiara, Morrocchi, Elena, Ruggiero, Alessandra, Amodio, Donato, Medri, Chiara, Colagrossi, Luna, Russo, Cristina, Di Cesare, Silvia, Santilli, Veronica, Manno, Emma Concetta, Zangari, Paola, Giancotta, Carmela, Bernardi, Stefania, Nicolosi, Luciana, Ciofi Degli Atti, Marta, Raponi, Massimiliano, Zaffina, Salvatore, Alfieri, Sara, Kirk, Richard, Perno, Carlo Federico, Rossi, Paolo, Amodeo, Antonio, and Palma, Paolo

Published
2022
Full Text
View/download PDF

8. Vita umana e dignità: un dialogo tra etica e diritto.

Author

Ruggiero, Rossana, Kaczmarek, Stefano, Spiezia, Francesco Saverio, Moncada, Rebecca, Kolaj, Antonela, Tenneroni, Giorgio, Morichetti, Perla, Scatena, Emma, and Santilli, Veronica

Abstract

Copyright of Medicina e Morale is the property of PAGEPress and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
Full Text
View/download PDF

9. The Clinical Course of SARS-CoV-2 Infection in Patients With Autoimmune Neutropenia: A Retrospective Case Series Study

Author

Rotulo, Gioacchino Andrea, primary, Ceglie, Giulia, additional, Candino, Annalisa, additional, Merola, Antonella, additional, Profeti, Elisa, additional, Giancotta, Carmela, additional, Mercadante, Stefania, additional, Santilli, Veronica, additional, Cotugno, Nicola, additional, Palma, Paolo, additional, Palumbo, Giuseppe, additional, and Finocchi, Andrea, additional

Published
2023
Full Text
View/download PDF

10. A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations

Author

Olivini, Nicole, Calò Carducci, Francesca Ippolita, Santilli, Veronica, De Ioris, Maria Antonietta, Scarselli, Alessia, Alario, Dario, Geremia, Caterina, Lombardi, Mary Haywood, Marabotto, Caterina, Mariani, Rosanna, Papa, Raffaele Edo, Peschiaroli, Emanuela, Scrocca, Raffaella, Sinibaldi, Serena, Smarrazzo, Andrea, Stella, Pietro, Bernardi, Stefania, Chiurchiù, Sara, Pansa, Paola, Romani, Lorenza, Michaela, Carletti, Concato, Carlo, De Rose, Domenico Umberto, Salvatori, Gugliemo, Rossi, Paolo, Villani, Alberto, Dotta, Andrea, D’Argenio, Patrizia, and Campana, Andrea

Published
2020
Full Text
View/download PDF

11. The case of an APDS patient: Defects in maturation and function and decreased in vitro anti-mycobacterial activity in the myeloid compartment

Author

Chiriaco, Maria, Brigida, Immacolata, Ariganello, Paola, Di Cesare, Silvia, Di Matteo, Gigliola, Taus, Francesco, Cittaro, Davide, Lazarevic, Dejan, Scarselli, Alessia, Santilli, Veronica, Attardi, Enrico, Stupka, Elia, Giannelli, Stefania, Fraziano, Maurizio, Finocchi, Andrea, Rossi, Paolo, Aiuti, Alessandro, Palma, Paolo, and Cancrini, Caterina

Published
2017
Full Text
View/download PDF

12. Relapsing Myocarditis following Initial Recovery of post COVID-19 Vaccination in two Adolescent Males – Case reports

Author

Amodio, Donato, primary, Manno, Emma, additional, Cotugno, Nicola, additional, Santilli, Veronica, additional, Franceschini, Alessio, additional, Alfonso Perrone, Marco, additional, Chinali, Marcello, additional, Drago, Fabrizio, additional, Cantarutti, Nicoletta, additional, Curione, Davide, additional, Engler, Renata, additional, Secinaro, Aurelio, additional, and Palma, Paolo, additional

Published
2023
Full Text
View/download PDF

13. Tailored treatments in inborn errors of immunity associated with atopy (IEIs-A) with skin involvement

Author

Giancotta, Carmela, primary, Colantoni, Nicole, additional, Pacillo, Lucia, additional, Santilli, Veronica, additional, Amodio, Donato, additional, Manno, Emma Concetta, additional, Cotugno, Nicola, additional, Rotulo, Gioacchino Andrea, additional, Rivalta, Beatrice, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Diociaiuti, Andrea, additional, El Hachem, May, additional, and Zangari, Paola, additional

Published
2023
Full Text
View/download PDF

15. Higher Troponin Levels on Admission are associated With Persistent Cardiac Magnetic Resonance Lesions in Children Developing Myocarditis After mRNA-Based COVID-19 Vaccination

Author

Manno, Emma Concetta, primary, Amodio, Donato, additional, Cotugno, Nicola, additional, Rossetti, Chiara, additional, Giancotta, Carmela, additional, Santilli, Veronica, additional, Zangari, Paola, additional, Rotulo, Gioacchino Andrea, additional, Villani, Alberto, additional, Giglioni, Emanuele, additional, Turchetta, Attilio, additional, Cafiero, Giulia, additional, Franceschini, Alessio, additional, Chinali, Marcello, additional, Porzio, Ottavia, additional, Secinaro, Aurelio, additional, and Palma, Paolo, additional

Published
2022
Full Text
View/download PDF

17. Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood

Author

Santilli, Veronica, Cagigi, Alberto, Guzzo, Isabella, Rinaldi, Stefano, Mora, Nadia, Zotta, Federica, Piazza, Antonina, Rossi, Paolo, Emma, Francesco, Dello Strologo, Luca, and Palma, Paolo

Subjects
Children -- Research -- Health aspects, Kidney transplantation -- Usage -- Health aspects, Immunosuppressive agents -- Research -- Health aspects, Health
Abstract

Background In the field of kidney transplantation, identifying early signatures of humoral rejection is a key challenge. Methods We investigated the presence of anti-HLA antibodies and the distribution of lymphocyte subpopulations in 77 kidney-transplanted children and young adults compared to 23 healthy controls. Moreover, we tested whether the presence of anti-HLA antibodies could be related to modification in lymphocyte phenotype. Finally, we correlated the presence of anti-HLA antibodies and specific alteration of lymphocyte subsets with clinical outcomes. Results In kidney-transplanted children who developed anti-HLA antibodies, we observed an expansion of double-negative B cells (CD19 + CD27-IgD-), indicating premature aging of this compartment. Moreover, we reported signs of impaired B cell regulation, indicated by a higher IL-21R+ B cell frequency associated with an abnormal increase of follicular helper T cells. Finally, a considerable reduction in CD8+ effector T and invariant Natural killer T (NKT) cells was observed. The stability of graft function over time is significantly correlated with the frequency of peripheral effector CD4+ and CD8+ T cells and invariant NKT cells. Conclusions This study supports the usefulness of lymphocyte subset as one of a spectrum of early diagnostic tools required to identify patients at risk of developing donor alloimmune response., Author(s): Veronica Santilli[sup.1] , Alberto Cagigi[sup.1] , Isabella Guzzo[sup.2] , Stefano Rinaldi[sup.3] , Nadia Mora[sup.1] , Federica Zotta[sup.1] , Antonina Piazza[sup.4] , Paolo Rossi[sup.1] [sup.3] , Francesco Emma[sup.2] , Luca [...]

Published
2016
Full Text
View/download PDF

18. Common bone marrow signature in COVID‐19‐associated multisystem inflammatory syndrome in children: A first‐wave small case series experience

Author

De Ioris, Maria Antonietta, primary, Scarselli, Alessia, additional, Bracaglia, Claudia, additional, Perrotta, Daniela, additional, Bernardi, Stefania, additional, Santilli, Veronica, additional, Ceglie, Giulia, additional, Fabozzi, Francesco, additional, Agrati, Chiara, additional, Prencipe, Giusi, additional, Alaggio, Rita, additional, Mastronuzzi, Angela, additional, and De Vito, Rita, additional

Published
2022
Full Text
View/download PDF

19. Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History

Author

Santilli, Veronica, primary, Manno, Emma Concetta, additional, Giancotta, Carmela, additional, Rossetti, Chiara, additional, Cotugno, Nicola, additional, Amodio, Donato, additional, Rotulo, Gioacchino Andrea, additional, Deodati, Annalisa, additional, Bianchi, Roberto, additional, Lucignani, Giulia, additional, Longo, Daniela, additional, Valeriani, Massimiliano, additional, and Palma, Paolo, additional

Published
2022
Full Text
View/download PDF

20. Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens

Author

Cotugno, Nicola, primary, Franzese, Enrica, additional, Angelino, Giulia, additional, Amodio, Donato, additional, Romeo, Erminia Francesca, additional, Rea, Francesca, additional, Faraci, Simona, additional, Tambucci, Renato, additional, Profeti, Elisa, additional, Manno, Emma Concetta, additional, Santilli, Veronica, additional, Rotulo, Gioacchino Andrea, additional, Pighi, Chiara, additional, Medri, Chiara, additional, Morrocchi, Elena, additional, Colagrossi, Luna, additional, Pascucci, Giuseppe Rubens, additional, Valentini, Diletta, additional, Villani, Alberto, additional, Rossi, Paolo, additional, De Angelis, Paola, additional, and Palma, Paolo, additional

Published
2022
Full Text
View/download PDF

21. Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment

Author

Rivalta, Beatrice, primary, Amodio, Donato, additional, Giancotta, Carmela, additional, Santilli, Veronica, additional, Pacillo, Lucia, additional, Zangari, Paola, additional, Cotugno, Nicola, additional, Manno, Emma Concetta, additional, Finocchi, Andrea, additional, Bernardi, Stefania, additional, Colagrossi, Luna, additional, Gentile, Leonarda, additional, Russo, Cristina, additional, Perno, Carlo Federico, additional, Rossi, Paolo, additional, Cancrini, Caterina, additional, and Palma, Paolo, additional

Published
2022
Full Text
View/download PDF

22. BNT162B2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed?

Author

Cotugno, Nicola, primary, Pighi, Chiara, additional, Morrocchi, Elena, additional, Ruggiero, Alessandra, additional, Amodio, Donato, additional, Medri, Chiara, additional, Colagrossi, Luna, additional, Russo, Cristina, additional, Di Cesare, Silvia, additional, Santilli, Veronica, additional, Manno, Emma Concetta, additional, Zangari, Paola, additional, Giancotta, Carmela, additional, Bernardi, Stefania, additional, Nicolosi, Luciana, additional, Ciofi Degli Atti, Marta, additional, Raponi, Massimiliano, additional, Zaffina, Salvatore, additional, Alfieri, Sara, additional, Kirk, Richard, additional, Perno, Carlo Federico, additional, Rossi, Paolo, additional, Amodeo, Antonio, additional, and Palma, Paolo, additional

Published
2021
Full Text
View/download PDF

25. Higher Troponin Levels on Admission are associated With Persistent Cardiac Magnetic Resonance Lesions in Children Developing Myocarditis After mRNA-Based COVID-19 Vaccination.

Author

Manno, Emma Concetta, Amodio, Donato, Cotugno, Nicola, Rossetti, Chiara, Giancotta, Carmela, Santilli, Veronica, Zangari, Paola, Rotulo, Gioacchino Andrea, Villani, Alberto, Giglioni, Emanuele, Turchetta, Attilio, Cafiero, Giulia, Franceschini, Alessio, Chinali, Marcello, Porzio, Ottavia, Secinaro, Aurelio, and Palma, Paolo

Published
2023
Full Text
View/download PDF

26. Clinical, Immunological, and Molecular Variability of RAG Deficiency: A Retrospective Analysis of 22 RAG Patients

Author

Cifaldi, Cristina, primary, Rivalta, Beatrice, additional, Amodio, Donato, additional, Mattia, Algeri, additional, Pacillo, Lucia, additional, Di Cesare, Silvia, additional, Chiriaco, Maria, additional, Ursu, Giorgiana Madalina, additional, Cotugno, Nicola, additional, Giancotta, Carmela, additional, Manno, Emma C., additional, Santilli, Veronica, additional, Zangari, Paola, additional, Federica, Galaverna, additional, Palumbo, Giuseppe, additional, Merli, Pietro, additional, Palma, Paolo, additional, Rossi, Paolo, additional, Di Matteo, Gigliola, additional, Locatelli, Franco, additional, Finocchi, Andrea, additional, and Cancrini, Caterina, additional

Published
2021
Full Text
View/download PDF

27. Humoral and Cellular Response Following Vaccination With the BNT162b2 mRNA COVID-19 Vaccine in Patients Affected by Primary Immunodeficiencies

Author

Amodio, Donato, primary, Ruggiero, Alessandra, additional, Sgrulletti, Mayla, additional, Pighi, Chiara, additional, Cotugno, Nicola, additional, Medri, Chiara, additional, Morrocchi, Elena, additional, Colagrossi, Luna, additional, Russo, Cristina, additional, Zaffina, Salvatore, additional, Di Matteo, Gigliola, additional, Cifaldi, Cristina, additional, Di Cesare, Silvia, additional, Rivalta, Beatrice, additional, Pacillo, Lucia, additional, Santilli, Veronica, additional, Giancotta, Carmela, additional, Manno, Emma Concetta, additional, Ciofi Degli Atti, Marta, additional, Raponi, Massimiliano, additional, Rossi, Paolo, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Perno, Carlo Federico, additional, Moschese, Viviana, additional, and Palma, Paolo, additional

Published
2021
Full Text
View/download PDF

28. Case Report: EBV Chronic Infection and Lymphoproliferation in Four APDS Patients: The Challenge of Proper Characterization, Therapy, and Follow-Up

Author

Rivalta, Beatrice, primary, Amodio, Donato, additional, Milito, Cinzia, additional, Chiriaco, Maria, additional, Di Cesare, Silvia, additional, Giancotta, Carmela, additional, Conti, Francesca, additional, Santilli, Veronica, additional, Pacillo, Lucia, additional, Cifaldi, Cristina, additional, Desimio, Maria Giovanna, additional, Doria, Margherita, additional, Quinti, Isabella, additional, De Vito, Rita, additional, Di Matteo, Gigliola, additional, Finocchi, Andrea, additional, Palma, Paolo, additional, Trizzino, Antonino, additional, Tommasini, Alberto, additional, and Cancrini, Caterina, additional

Published
2021
Full Text
View/download PDF

29. VIROLOGICAL AND IMMUNOLOGICAL FEATURES OF SARS-COV-2 INFECTED CHILDREN WITH DISTINCT SYMPTOMATOLOGY

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Pascucci, Giuseppe, additional, Bonfante, Francesco, additional, Petrara, Maria, additional, Zicari, Sonia, additional, Cifaldi, Loredana, additional, Zangari, Paola, additional, Bernardi, Stefania, additional, Cursi, Laura, additional, Medri, Chiara, additional, Santilli, Veronica, additional, Manno, Emma, additional, Amodio, Donato, additional, Linardos, Giulia, additional, Piccioni, Livia, additional, Barbieri, Maria, additional, Perrotta, Daniela, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Team, Cactus Study, additional, Concato, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, Rossi, Anita De, additional, and Palma, Paolo, additional

Published
2021
Full Text
View/download PDF

30. Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Bonfante, Francesco, additional, Petrara, Maria Raffaella, additional, Zicari, Sonia, additional, Pascucci, Giuseppe Rubens, additional, Zangari, Paola, additional, De Ioris, Maria Antonietta, additional, Santilli, Veronica, additional, Manno, E.C., additional, Amodio, Donato, additional, Bortolami, Alessio, additional, Pagliari, Matteo, additional, Concato, Carlo, additional, Linardos, Giulia, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, De Rossi, Anita, additional, Palma, Paolo, additional, Bernardi, Stefania, additional, Romani, Lorenza, additional, Pansa, Paola, additional, Chiurchiú, Sara, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Lancella, Laura, additional, Cursi, Laura, additional, De Luca, Maia, additional, Cutrera, Renato, additional, Sessa, Libera, additional, Morrocchi, Elena, additional, Medri, Chiara, additional, Putignani, Lorenza, additional, Calò Carducci, F.I., additional, D’Argenio, Patrizia, additional, Ciofi degli Atti, Marta, additional, D’Amore, Carmen, additional, Piccioni, Livia, additional, Di Giuseppe, Martina, additional, Jenkner, Alessandro, additional, Giancotta, Carmela, additional, and Krzysztofiak, Andrzej, additional

Published
2021
Full Text
View/download PDF

31. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

Author

Consiglio, Camila Rosat, Cotugno, Nicola, Sardh, Fabian, Pou, Christian, Amodio, Donato, Rodriguez, Lucie, Tan, Ziyang, Zicari, Sonia, Ruggiero, Alessandra, Pascucci, Giuseppe Rubens, Santilli, Veronica, Campbell, Tessa, Bryceson, Yenan, Eriksson, Daniel, Wang, Jun, Marchesi, Alessandra, Lakshmikanth, Tadepally, Campana, Andrea, Villani, Alberto, Rossi, Paolo, Landegren, Nils, Palma, Paolo, Brodin, Petter, Consiglio, Camila Rosat, Cotugno, Nicola, Sardh, Fabian, Pou, Christian, Amodio, Donato, Rodriguez, Lucie, Tan, Ziyang, Zicari, Sonia, Ruggiero, Alessandra, Pascucci, Giuseppe Rubens, Santilli, Veronica, Campbell, Tessa, Bryceson, Yenan, Eriksson, Daniel, Wang, Jun, Marchesi, Alessandra, Lakshmikanth, Tadepally, Campana, Andrea, Villani, Alberto, Rossi, Paolo, Landegren, Nils, Palma, Paolo, and Brodin, Petter

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. Weapply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.

Published
2020
Full Text
View/download PDF

32. Seletalisib for Activated PI3Kδ Syndromes: Open-Label Phase 1b and Extension Studies

Author

Diaz, Nieves, primary, Juarez, Maria, additional, Cancrini, Caterina, additional, Heeg, Maximilian, additional, Soler-Palacín, Pere, additional, Payne, Andrew, additional, Johnston, Geoffrey I., additional, Helmer, Eric, additional, Cain, Dionne, additional, Mann, Joanne, additional, Yuill, Daisy, additional, Conti, Francesca, additional, Di Cesare, Silvia, additional, Ehl, Stephan, additional, Garcia-Prat, Marina, additional, Maccari, Maria Elena, additional, Martín-Nalda, Andrea, additional, Martínez-Gallo, Mónica, additional, Moshous, Despina, additional, Santilli, Veronica, additional, Semeraro, Michaela, additional, Simonetti, Alessandra, additional, Suarez, Felipe, additional, Cavazzana, Marina, additional, and Kracker, Sven, additional

Published
2020
Full Text
View/download PDF

33. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

Author

Consiglio, Camila Rosat, primary, Cotugno, Nicola, additional, Sardh, Fabian, additional, Pou, Christian, additional, Amodio, Donato, additional, Rodriguez, Lucie, additional, Tan, Ziyang, additional, Zicari, Sonia, additional, Ruggiero, Alessandra, additional, Pascucci, Giuseppe Rubens, additional, Santilli, Veronica, additional, Campbell, Tessa, additional, Bryceson, Yenan, additional, Eriksson, Daniel, additional, Wang, Jun, additional, Marchesi, Alessandra, additional, Lakshmikanth, Tadepally, additional, Campana, Andrea, additional, Villani, Alberto, additional, Rossi, Paolo, additional, Landegren, Nils, additional, Palma, Paolo, additional, and Brodin, Petter, additional

Published
2020
Full Text
View/download PDF

34. Artificial Intelligence Applied to in vitro Gene Expression Testing (IVIGET) to Predict Trivalent Inactivated Influenza Vaccine Immunogenicity in HIV Infected Children

Author

Cotugno, Nicola, primary, Santilli, Veronica, additional, Pascucci, Giuseppe Rubens, additional, Manno, Emma Concetta, additional, De Armas, Lesley, additional, Pallikkuth, Suresh, additional, Deodati, Annalisa, additional, Amodio, Donato, additional, Zangari, Paola, additional, Zicari, Sonia, additional, Ruggiero, Alessandra, additional, Fortin, Martina, additional, Bromley, Christina, additional, Pahwa, Rajendra, additional, Rossi, Paolo, additional, Pahwa, Savita, additional, and Palma, Paolo, additional

Published
2020
Full Text
View/download PDF

36. Dynamic Viral Severe Acute Respiratory Syndrome Coronavirus 2 RNA Shedding in Children: Preliminary Data and Clinical Consideration from a Italian Regional Center

Author

De Ioris, Maria A, primary, Scarselli, Alessia, primary, Ciofi degli Atti, Marta L, primary, Ravà, Lucilla, primary, Smarrazzo, Andrea, primary, Concato, Carlo, primary, Romani, Lorenza, primary, Scrocca, Raffaella, primary, Geremia, Caterina, primary, Carletti, Michaela, primary, Calò Carducci, Francesca I, primary, Bernardi, Stefania, primary, Coltella, Luana, primary, Santilli, Veronica, primary, Chiurchiu, Sara, primary, Peschiaroli, Emanuela, primary, Mariani, Rosanna, primary, Marabotto, Caterina, primary, Perrotta, Daniela, primary, Villani, Alberto, primary, Rossi, Paolo, primary, D’Argenio, Patrizia, primary, Campana, Andrea, primary, and Raponi, Massimiliano, primary

Published
2020
Full Text
View/download PDF

37. Virological and Immunological Features of SARS-CoV-2 Infected Children Developing Specific and Neutralizing Antibodies

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Bonfante, Francesco, additional, Pertrara, Maria Raffella, additional, Zicari, Sonia, additional, Pascucci, Giuseppe Rubens, additional, Zangari, Paola, additional, De Ioris, Maria Antonietta, additional, Santilli, Veronica, additional, Manno, Emma, additional, Amodio, Donato, additional, Bortolami, Alessio, additional, Pagliari, Matteo, additional, Concato, Carlo, additional, Linardos, Giulia, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Team, CACTUS Study, additional, Brodin, Petter, additional, Rossi, Paolo, additional, De Rossi, Anita, additional, and Palma, Paolo, additional

Published
2020
Full Text
View/download PDF

38. OMIC technologies and vaccine development: from the identification of vulnerable individuals to the formulation of invulnerable vaccines

Author

Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Cotugno, Nicola, Ruggiero, Alessandra, Santilli, Veronica, Manno, Emma Concetta, Rocca, Salvatore, Zicari, Sonia, Amodio, Donato, Colucci, Manuela, Rossi, Paolo, Levy, Ofer, Martinón Torres, Federico, Pollard, Andrew J., Palma, Paolo, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Cotugno, Nicola, Ruggiero, Alessandra, Santilli, Veronica, Manno, Emma Concetta, Rocca, Salvatore, Zicari, Sonia, Amodio, Donato, Colucci, Manuela, Rossi, Paolo, Levy, Ofer, Martinón Torres, Federico, Pollard, Andrew J., and Palma, Paolo

Abstract

Routine vaccination is among the most effective clinical interventions to prevent diseases as it is estimated to save over 3 million lives every year. However, the full potential of global immunization programs is not realised because population coverage is still suboptimal. This is also due to the inadequate immune response and paucity of informative correlates of protection upon immunization of vulnerable individuals such as newborns, preterm infants, pregnant women, and elderly individuals as well as those patients affected by chronic and immune compromising medical conditions. In addition, these groups are undervaccinated for a number of reasons, including lack of awareness of vaccine-preventable diseases and uncertainty or misconceptions about the safety and efficacy of vaccination by parents and healthcare providers. The presence of these nonresponders/undervaccinated individuals represents a major health and economic burden to society, which will become particularly difficult to address in settings with limited public resources. This review describes innovative and experimental approaches that can help identify specific genomic profiles defining nonresponder individuals for whom specific interventions might be needed. We will provide examples that show how such information can be useful to identify novel biomarkers of safety and immunogenicity for future vaccine trials. Finally, we will discuss how system biology “OMICs” data can be used to design bioinformatic tools to predict the vaccination outcome providing genetic and molecular “signatures” of protective immune response. This strategy may soon enable identification of signatures highly predictive of vaccine safety, immunogenicity, and efficacy/protection thereby informing personalized vaccine interventions in vulnerable populations.

Published
2019

39. Virological and immunological features of SARS‐COV‐2 infected children with distinct symptomatology.

Author

Cotugno, Nicola, Ruggiero, Alessandra, Pascucci, Giuseppe Rubens, Bonfante, Francesco, Petrara, Maria Raffaella, Pighi, Chiara, Cifaldi, Loredana, Zangari, Paola, Bernardi, Stefania, Cursi, Laura, Santilli, Veronica, Manno, Emma Concetta, Amodio, Donato, Linardos, Giulia, Piccioni, Livia, Barbieri, Maria Antonietta, Perrotta, Daniela, Campana, Andrea, Donà, Daniele, and Giaquinto, Carlo

Subjects
SARS-CoV-2, BLOOD proteins, SYMPTOMS, HERD immunity, IMMUNOGLOBULIN G
Abstract

Background: Although SARS‐CoV‐2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti‐SARS‐CoV‐2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti‐SARS‐CoV‐2 immunity in children with distinct symptomatology. Methods: Between March and July 2020, we recruited 15 SARS‐CoV‐2 asymptomatic (AS) and 51 symptomatic (SY) children, stratified according to WHO clinical classification. We measured SARS‐CoV‐2 viral load using ddPCR and qPCR in longitudinally collected nasopharyngeal swab samples. To define anti‐SARS‐CoV‐2 antibodies, we measured neutralization activity and total IgG load (DiaSorin). We also evaluated antigen‐specific B and CD8+T cells, using a labeled S1+S2 protein and ICAM expression, respectively. Plasma protein profiling was performed with Olink. Results: Virological profiling showed that AS patients had lower viral load at diagnosis (p =.004) and faster virus clearance (p =.0002) compared with SY patients. Anti‐SARS‐CoV‐2 humoral and cellular response did not appear to be associated with the presence of symptoms. AS and SY patients showed similar titers of SARS‐CoV‐2 IgG, levels of neutralizing activity, and frequency of Ag‐specific B and CD8+ T cells, whereas pro‐inflammatory plasma protein profile was found to be associated with symptomatology. Conclusion: We demonstrated the development of anti‐SARS‐CoV‐2 humoral and cellular response with any regard to symptomatology, suggesting the ability of both SY and AS patients to contribute toward herd immunity. The virological profiling of AS patients suggested that they have lower virus load associated with faster virus clearance. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

40. OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Santilli, Veronica, additional, Manno, Emma Concetta, additional, Rocca, Salvatore, additional, Zicari, Sonia, additional, Amodio, Donato, additional, Colucci, Manuela, additional, Rossi, Paolo, additional, Levy, Ofer, additional, Martinon-Torres, Federico, additional, Pollard, Andrew J., additional, and Palma, Paolo, additional

Published
2019
Full Text
View/download PDF

41. Burkitt's lymphoma mimicking EBV disease as first sign of vertical HIV infection in an adolescent

Author

Lombardi Alessandra, De Vito Rita, Pontrelli Giuseppe, Tchidjou Hyppolite K, Aquilani Angela, Mora Nadia, Santilli Veronica, Bernardi Stefania, and Palma Paolo

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Burkitt's Lymphoma (BL) rarely represents the first clinical manifestation of vertical HIV infection in adolescent in Western Europe. We report the case of a 17 year-old boy with two week history of fever and enlarged cervical lymph nodes firstly misdiagnosed as EBV infection, subsequently diagnosed as Burkitt's Lymphoma and vertical HIV infection.

Published
2010
Full Text
View/download PDF

42. Dynamic Viral Severe Acute Respiratory Syndrome Coronavirus 2 RNA Shedding in Children: Preliminary Data and Clinical Consideration from a Italian Regional Center.

Author

Ioris, Maria A De, Scarselli, Alessia, Atti, Marta L Ciofi degli, Ravà, Lucilla, Smarrazzo, Andrea, Concato, Carlo, Romani, Lorenza, Scrocca, Raffaella, Geremia, Caterina, Carletti, Michaela, Carducci, Francesca I Calò, Bernardi, Stefania, Coltella, Luana, Santilli, Veronica, Chiurchiu, Sara, Peschiaroli, Emanuela, Mariani, Rosanna, Marabotto, Caterina, Perrotta, Daniela, and Villani, Alberto

Subjects
RNA physiology, FECAL analysis, CONFIDENCE intervals, CORONAVIRUS diseases, CORONAVIRUSES, CLINICAL pathology, KAPLAN-Meier estimator, CHILDREN
Abstract

We evaluated severe acute respiratory syndrome coronavirus 2 RNA clearance in 22 children. The estimation of positivity at day 14 was 52% for nasopharyngeal swab and 31% for stool samples. These data underline the significance of nasopharyngeal and stoolsample for detecting infected children. Additional studies are needed for transmissibility. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

43. Seasonal Influenza Vaccination in Health Care Workers. A Pre-Post Intervention Study in an Italian Paediatric Hospital

Author

Gilardi, Francesco, primary, Castelli Gattinara, Guido, additional, Vinci, Maria, additional, Ciofi Degli Atti, Marta, additional, Santilli, Veronica, additional, Brugaletta, Rita, additional, Santoro, Annapaola, additional, Montanaro, Rosina, additional, Lavorato, Luisa, additional, Raponi, Massimiliano, additional, and Zaffina, Salvatore, additional

Published
2018
Full Text
View/download PDF

47. B-Sides Serologic Markers of Immunogenicity in Kidney Transplanted Patients

Author

Rinaldi, Stefano, primary, Cagigi, Alberto, additional, Santilli, Veronica, additional, Zotta, Federica, additional, di Martino, Angela, additional, Castrucci, Maria Rita, additional, Donatelli, Isabella, additional, Poggi, Elvira, additional, Piazza, Antonina, additional, Campana, Andrea, additional, Guzzo, Isabella, additional, Villani, Alberto, additional, Rossi, Paolo, additional, Dello Strologo, Luca, additional, and Palma, Paolo, additional

Published
2014
Full Text
View/download PDF

48. Immunotherapy with an HIV-DNA Vaccine in Children and Adults

Author

Palma, Paolo, primary, Gudmundsdotter, Lindvi, additional, Finocchi, Andrea, additional, Eriksson, Lars, additional, Mora, Nadia, additional, Santilli, Veronica, additional, Aquilani, Angela, additional, Manno, Emma, additional, Zangari, Paola, additional, Romiti, Maria, additional, Montesano, Carla, additional, Grifoni, Alba, additional, Brave, Andreas, additional, Ljungberg, Karl, additional, Blomberg, Pontus, additional, Bernardi, Stefania, additional, Sandström, Eric, additional, Hejdeman, Bo, additional, Rossi, Paolo, additional, and Wahren, Britta, additional

Published
2014
Full Text
View/download PDF

49. Early Highly Active Antiretroviral Therapy Enhances B-cell Longevity

Author

Cagigi, Alberto, primary, Rinaldi, Stefano, additional, Cotugno, Nicola, additional, Manno, Emma Concetta, additional, Santilli, Veronica, additional, Mora, Nadia, additional, Zangari, Paola, additional, Aquilani, Angela, additional, Tchidjou, Kuekou Hyppolite, additional, Giaquinto, Carlo, additional, Bernardi, Stefania, additional, Rossi, Paolo, additional, and Palma, Paolo, additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results