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8 results on '"Santos, Erika Ferreira dos"'

1. Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α

Author

Queiroz, Maria Alice Freitas, Brito, Wandrey Roberto dos Santos, Pereira, Keise Adrielle Santos, Pereira, Leonn Mendes Soares, Amoras, Ednelza da Silva Graça, Lima, Sandra Souza, Santos, Erika Ferreira dos, Costa, Flávia Póvoa da, Sarges, Kevin Matheus Lima de, Cantanhede, Marcos Henrique Damasceno, Brito, Mioni Thieli Figueiredo Magalhães de, Silva, Andréa Luciana Soares da, Leite, Mauro de Meira, Viana, Maria de Nazaré do Socorro de Almeida, Rodrigues, Fabíola Brasil Barbosa, Silva, Rosilene da, Viana, Giselle Maria Rachid, Chaves, Tânia do Socorro Souza, Veríssimo, Adriana de Oliveira Lameira, Carvalho, Mayara da Silva, Henriques, Daniele Freitas, Silva, Carla Pinheiro da, Nunes, Juliana Abreu Lima, Costa, Iran Barros, Cayres-Vallinoto, Izaura Maria Vieira, Brasil-Costa, Igor, Quaresma, Juarez Antônio Simões, Falcão, Luiz Fábio Magno, Santos, Eduardo José Melo dos, and Vallinoto, Antonio Carlos Rosário

Published
2024
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2. Genetic, Clinical, Epidemiological, and Immunological Profiling of IgG Response Duration after SARS-CoV-2 Infection.

Author

Póvoa da Costa, Flávia, Sarges, Kevin Matheus Lima de, Silva, Rosilene da, Santos, Erika Ferreira dos, Nascimento, Matheus Holanda do, Rodrigues, Alice Maciel, Cantanhede, Marcos Henrique Damasceno, Rodrigues, Fabíola Brasil Barbosa, Viana, Maria de Nazaré do Socorro de Almeida, Leite, Mauro de Meira, Oliveira, Camille Ferreira de, Neves, Pablo Fabiano Moura das, Pereira Neto, Gabriel dos Santos, Brito, Mioni Thieli Figueiredo Magalhães de, Silva, Andréa Luciana Soares da, Henriques, Daniele Freitas, Quaresma, Juarez Antônio Simões, Falcão, Luiz Fábio Magno, Queiroz, Maria Alice Freitas, and Vallinoto, Izaura Maria Vieira Cayres

Subjects
GENETIC profile, RANK correlation (Statistics), GENE expression, COVID-19 pandemic, GENETICS
Abstract

The IgG response against SARS-CoV-2 infection can persist for over six months (long response; LR). However, among 30% of those infected, the duration can be as short as three months or less (short response; SR). The present study assembled serological data on the anti-SARS-CoV-2 IgG response duration of two previous studies and integrated these results with the plasmatic cytokine levels and genetic profile of 10 immune-relevant SNPs that were also previously published, along with the plasmatic total IgG, IgA, and IgM levels, allowing for the genetic, clinical, immunological, and epidemiological aspects of the post-COVID-19 IgG response duration to be understood. The SR was associated with previous mild acute COVID-19 and with an SNP (rs2228145) in IL6R related to low gene expression. Additionally, among the SR subgroup, no statistically significant Spearman correlations were observed between the plasma levels of IL-17A and the Th17 regulatory cytokines IFN-γ (rs = 0.2399; p = 0.1043), IL-4 (rs = 0.0273; p = 0.8554), and IL-2 (rs = 0.2204; p = 0.1365), while among the LR subgroup, weaker but statistically significant Spearman correlations were observed between the plasma levels of IL-17A and IFN-γ (rs = 0.3873; p = 0.0016), IL-4 (rs = 0.2671; p = 0.0328), and IL-2 (rs = 0.3959; p = 0.0012). These results suggest that the Th17 response mediated by the IL-6 pathway has a role in the prolonged IgG response to SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

Author

Sarges, Kevin Matheus Lima de, Póvoa da Costa, Flávia, Santos, Erika Ferreira dos, Cantanhede, Marcos Henrique Damasceno, da Silva, Rosilene, Veríssimo, Adriana de Oliveira Lameira, Viana, Maria de Nazaré do Socorro de Almeida, Rodrigues, Fabíola Brasil Barbosa, Leite, Mauro de Meira, Torres, Maria Karoliny da Silva, Bentes da Silva, Christiane, Brito, Mioni Thieli Figueiredo Magalhães de, Silva, Andréa Luciana Soares da, Henriques, Daniele Freitas, Vallinoto, Izaura Maria Vieira Cayres, Viana, Giselle Maria Rachid, Queiroz, Maria Alice Freitas, Vallinoto, Antonio Carlos Rosário, and Santos, Eduardo José Melo dos

Subjects
TUMOR necrosis factors, CYTOKINE release syndrome, COVID-19, SINGLE nucleotide polymorphisms, INFLAMMATORY mediators
Abstract

Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Author

Rodrigues, Fabíola Brasil Barbosa, primary, da Silva, Rosilene, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, de Meira Leite, Mauro, additional, Póvoa da Costa, Flávia, additional, de Nazaré do Socorro de Almeida Viana, Maria, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Silva, Carla Pinheiro da, additional, Costa, Igor Brasil, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Viana, Giselle Maria Rachid, additional, Queiroz, Maria Alice Freitas, additional, Lima, Sandra Souza, additional, Lopes, Jeferson da Costa, additional, Torres, Maria Karoliny da Silva, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Bichara, Carlos David Araújo, additional, Vallinoto, Antonio Carlos Rosário, additional, and Santos, Eduardo José Melo dos, additional

Published
2023
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6. Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

Author

Queiroz, Maria Alice Freitas, primary, Santiago, Angélica Menezes, additional, Brito, Wandrey Roberto dos Santos, additional, Pereira, Keise Adrielle Santos, additional, de Brito, William Botelho, additional, Torres, Maria Karoliny da Silva, additional, Lopes, Jeferson da Costa, additional, Santos, Erika Ferreira dos, additional, da Costa, Flávia Póvoa, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, Leite, Mauro de Meira, additional, Viana, Maria de Nazaré do Socorro de Almeida, additional, Rodrigues, Fabíola Brasil Barbosa, additional, da Silva, Rosilene, additional, Viana, Giselle Maria Rachid, additional, Chaves, Tânia do Socorro Souza, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Santos, Carla Pinheiro dos, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Amoras, Ednelza da Silva Graça, additional, Lima, Sandra Souza, additional, Cayres-Vallinoto, Izaura Maria Vieira, additional, Brasil-Costa, Igor, additional, Quaresma, Juarez Antônio Simões, additional, Falcão, Luiz Fábio Magno, additional, Santos, Eduardo José Melo dos, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2023
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7. Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles

Author

Soares, Sinei Ramos, primary, da Silva Torres, Maria Karoliny, additional, Lima, Sandra Souza, additional, de Sarges, Kevin Matheus Lima, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, de Meira Leite, Mauro, additional, da Costa, Flávia Póvoa, additional, Cantanhede, Marcos Henrique Damasceno, additional, da Silva, Rosilene, additional, de Oliveira Lameira Veríssimo, Adriana, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Feitosa, Rosimar Neris Martins, additional, Quaresma, Juarez Antônio Simões, additional, Chaves, Tânia do Socorro Souza, additional, Viana, Giselle Maria Rachid, additional, Falcão, Luiz Fábio Magno, additional, Santos, Eduardo José Melo dos, additional, Vallinoto, Antonio Carlos Rosário, additional, and da Silva, Andréa Nazaré Monteiro Rangel, additional

Published
2023
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8. Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome

Author

Queiroz, Maria Alice Freitas, primary, Neves, Pablo Fabiano Moura das, additional, Lima, Sandra Souza, additional, Lopes, Jeferson da Costa, additional, Torres, Maria Karoliny da Silva, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Bichara, Carlos David Araújo, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, Leite, Mauro de Meira, additional, da Costa, Flávia Póvoa, additional, Viana, Maria de Nazaré do Socorro de Almeida, additional, Rodrigues, Fabíola Brasil Barbosa, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, da Silva, Rosilene, additional, Bichara, Clea Nazaré Carneiro, additional, Berg, Ana Virgínia Soares van den, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Santos, Carla Pinheiro dos, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Viana, Giselle Maria Rachid, additional, Carneiro, Francisca Regina Oliveira, additional, Palacios, Vera Regina da Cunha Menezes, additional, Quaresma, Juarez Antonio Simões, additional, Brasil-Costa, Igor, additional, Santos, Eduardo José Melo dos, additional, Falcão, Luiz Fábio Magno, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2022
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