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6 results on '"Santos, Magnun N.N."'

1. Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020

Author

Amorim, Mariene R., Souza, William M., Barros, Antonio C.G., Jr., Toledo-Teixeira, Daniel A., Bispo-dos-Santos, Karina, Simeoni, Camila L., Parise, Pierina L., Vieira, Aline, Forato, Julia, Claro, Ingra M., Mofatto, Luciana S., Barbosa, Priscila P., Brunetti, Natalia S., Franca, Emerson S.S., Pedroso, Gisele A., Carvalho, Barbara F.N., Zaccariotto, Tania R., Krywacz, Kamila C.S., Vieira, Andre S., Mori, Marcelo A., Farias, Alessandro S., Pavan, Maria H.P., Bachur, Luis Felipe, Cardoso, Luis G.O., Spilki, Fernando R., Sabino, Ester C., Faria, Nuno R., Santos, Magnun N.N., Angerami, Rodrigo, Leme, Patricia A.F., Schreiber, Angelica, Moretti, Maria L., Granja, Fabiana, and Proenca-Modena, Jose Luiz

Subjects
Diagnosis, Development and progression, Case studies, Risk factors, Health aspects, Respiratory tract infections -- Diagnosis -- Development and progression, Recurrence (Disease) -- Risk factors, Medical personnel -- Case studies -- Health aspects, COVID-19 -- Diagnosis -- Development and progression, Diseases -- Relapse
Abstract

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, in late 2019. As of April 8, 2021, COVID-19 has affected >132 [...]

Published
2021
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2. Levels of SARS-CoV-2 Lineage P.1 Neutralization by Antibodies Elicited after Natural Infection and Vaccination

Author

de Souza, William M., primary, Amorim, Mariene R., additional, Sesti-Costa, Renata, additional, Coimbra, Lais D., additional, Toledo-Teixeira, Daniel Augusto de, additional, Parise, Pierina L., additional, Barbosa, Priscilla P., additional, Bispo-dos-Santos, Karina, additional, Mofatto, Luciana S., additional, Simeoni, Camila L., additional, Brunetti, Natalia S., additional, Claro, Ingra M., additional, Duarte, Adriana S. S., additional, Coletti, Thais M., additional, Zangirolami, Audrey B., additional, Costa-Lima, Carolina, additional, Gomes, Arilson Bernardo S. P., additional, Buscaratti, Lucas I., additional, Sales, Flavia C., additional, Costa, Vitor A., additional, Franco, Lucas A.M., additional, Candido, Darlan S., additional, Pybus, Oliver G., additional, de Jesus, Jaqueline G., additional, Silva, Camila A. M., additional, Ramundo, Mariana S., additional, Ferreira, Giulia M., additional, Pinho, Mariana C., additional, Souza, Leandro M., additional, Rocha, Esmenia C., additional, Andrade, Pamela S., additional, Crispim, Myuki A.E., additional, Maktura, Grazielle C., additional, Manuli, Erika R., additional, Santos, Magnun N.N., additional, Camilo, Cecilia C., additional, Angerami, Rodrigo N., additional, Moretti, Maria L., additional, Spilki, Fernando R., additional, Arns, Clarice W., additional, Addas-Carvalho, Marcelo, additional, Benites, Bruno D., additional, Mori, Marcelo A., additional, Gaburo, Nelson, additional, Dye, Christopher, additional, Wu, Chieh-Hsi, additional, Marques-Souza, Henrique, additional, Marques, Rafael E., additional, Farias, Alessandro, additional, Diamond, Michael S., additional, Faria, Nuno R., additional, Sabino, Ester C., additional, Granja, Fabiana, additional, and Proenca-Modena, Jose Luiz, additional

Published
2021
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3. Endothelial Barrier Integrity Is Disrupted In Vitro by Heme and by Serum From Sickle Cell Disease Patients

Author

Sao Paulo Research Foundation, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Santaterra, Vanessa A.G., Luz Fiusa, Maiara M., Hounkpe, Bidossessi W., Chenou, Francine, Tonasse, Wouitchekpo V., Da Costa, Loredana N.G., García-Weber, Diego, Domingos, Igor de Farias, Lima, Franciele de, Borba-Junior, Ivanio T., Araújo, Aderson da Silva, Lucena-Araujo, Antonio R., Bezerra, Marcos A.C., Dos Santos, Magnun N.N., Coasta, Fernando F., Millán, Jaime, De Paula, Erich V., Sao Paulo Research Foundation, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Santaterra, Vanessa A.G., Luz Fiusa, Maiara M., Hounkpe, Bidossessi W., Chenou, Francine, Tonasse, Wouitchekpo V., Da Costa, Loredana N.G., García-Weber, Diego, Domingos, Igor de Farias, Lima, Franciele de, Borba-Junior, Ivanio T., Araújo, Aderson da Silva, Lucena-Araujo, Antonio R., Bezerra, Marcos A.C., Dos Santos, Magnun N.N., Coasta, Fernando F., Millán, Jaime, and De Paula, Erich V.

Abstract

Free extracellular heme has been shown to activate several compartments of innate immunity, acting as a danger-associated molecular pattern (DAMP) in hemolytic diseases. Although localized endothelial barrier (EB) disruption is an important part of inflammation that allows circulating leukocytes to reach inflamed tissues, non-localized/deregulated disruption of the EB can lead to widespread microvascular hyperpermeability and secondary tissue damage. In mouse models of sickle cell disease (SCD), EB disruption has been associated with the development of a form of acute lung injury that closely resembles acute chest syndrome (ACS), and that can be elicited by acute heme infusion. Here we explored the effect of heme on EB integrity using human endothelial cell monolayers, in experimental conditions that include elements that more closely resemble in vivo conditions. EB integrity was assessed by electric cell-substrate impedance sensing in the presence of varying concentrations of heme and sera from SCD patients or healthy volunteers. Heme caused a dose-dependent decrease of the electrical resistance of cell monolayers, consistent with EB disruption, which was confirmed by staining of junction protein VE-cadherin. In addition, sera from SCD patients, but not from healthy volunteers, were also capable to induce EB disruption. Interestingly, these effects were not associated with total heme levels in serum. However, when heme was added to sera from SCD patients, but not from healthy volunteers, EB disruption could be elicited, and this effect was associated with hemopexin serum levels. Together our in vitro studies provide additional support to the concept of heme as a DAMP in hemolytic conditions.

Published
2020

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