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9 results on '"Sapienza, M R"'

2. Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition

Author

Sapienza, M R, Fuligni, F, Agostinelli, C, Tripodo, C, Righi, S, Laginestra, M A, Pileri, Jr, A, Mancini, M, Rossi, M, Ricci, F, Gazzola, A, Melle, F, Mannu, C, Ulbar, F, Arpinati, M, Paulli, M, Maeda, T, Gibellini, D, Pagano, L, Pimpinelli, N, Santucci, M, Cerroni, L, Croce, C M, Facchetti, F, Piccaluga, P P, and Pileri, S A

Published
2014
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4. Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified

Author

Laginestra, M A, primary, Piccaluga, P P, additional, Fuligni, F, additional, Rossi, M, additional, Agostinelli, C, additional, Righi, S, additional, Sapienza, M R, additional, Motta, G, additional, Gazzola, A, additional, Mannu, C, additional, Sabattini, E, additional, Bacci, F, additional, Tabanelli, V, additional, Sacchetti, C A S, additional, Barrese, T Z, additional, Etebari, M, additional, Melle, F, additional, Clò, A, additional, Gibellini, D, additional, Tripodo, C, additional, Inghirami, G, additional, Croce, C M, additional, and Pileri, S A, additional

Published
2014
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6. Glutathione transferase-A2 S112T polymorphism predicts survival, transplant-related mortality, busulfan and bilirubin blood levels after allogeneic stem cell transplantation

Author

Bonifazi, F., primary, Storci, G., additional, Bandini, G., additional, Marasco, E., additional, Dan, E., additional, Zani, E., additional, Albani, F., additional, Bertoni, S., additional, Bontadini, A., additional, De Carolis, S., additional, Sapienza, M. R., additional, Rizzi, S., additional, Motta, M. R., additional, Ferioli, M., additional, Garagnani, P., additional, Cavo, M., additional, Mantovani, V., additional, and Bonafe, M., additional

Published
2013
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7. CDKN1B/p27 expression in peripheral T cell lymphoma not otherwise specified

Author

Gazzola, A., primary, Sista, M. T., additional, Agostinelli, C., additional, Righi, S., additional, Sapienza, M. R., additional, Mannu, C., additional, Rossi, M., additional, Bacci, F., additional, Sabattini, E., additional, Went, P., additional, Zinzani, P. L., additional, Pileri, S. A., additional, and Piccaluga, P. P., additional

Published
2010
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9. Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

Author

Fabio Facchetti, Emilio Berti, Claudio Tripodo, Maryam Etebari, Giovanna Motta, Nicola Pimpinelli, Fabio Fuligni, Stefano Pileri, Gaetano Ivan Dellino, Alessandro Pileri, Claudio Agostinelli, Valentina Indio, Marco Paulli, Stefania Orecchioni, Stefano Amente, Federica Melle, Giovanna Talarico, Maria Antonella Laginestra, Giuseppe Tarantino, Francesco Bertolini, Maura Rossi, Elena Sabattini, Francesco Abate, Raul Rabadan, Valentina Tabanelli, Lorenzo Cerroni, Francesco Gavino Brundu, Mauro Truni, Rossana Piccioni, Maria Rosaria Sapienza, Brunangelo Falini, Sapienza M.R., Abate F., Melle F., Orecchioni S., Fuligni F., Etebari M., Tabanelli V., Laginestra M.A., Pileri A., Motta G., Rossi M., Agostinelli C., Sabattini E., Pimpinelli N., Truni M., Falini B., Cerroni L., Talarico G., Piccioni R., Amente S., Indio V., Tarantino G., Brundu F., Paulli M., Berti E., Facchetti F., Dellino G.I., Bertolini F., Tripodo C., Rabadan R., Pileri S.A., Sapienza, M. R., Abate, F., Melle, F., Orecchioni, S., Fuligni, F., Etebari, M., Tabanelli, V., Laginestra, M. A., Pileri, A., Motta, G., Rossi, M., Agostinelli, C., Sabattini, E., Pimpinelli, N., Truni, M., Falini, B., Cerroni, L., Talarico, G., Piccioni, R., Amente, S., Indio, V., Tarantino, G., Brundu, F., Paulli, M., Berti, E., Facchetti, F., Dellino, G. I., Bertolini, F., Tripodo, C., Rabadan, R., Pileri, S. A., Sapienza, Maria Rosaria, Abate, Francesco, Melle, Federica, Orecchioni, Stefania, Fuligni, Fabio, Etebari, Maryam, Tabanelli, Valentina, Laginestra, Maria Antonella, Pileri, Alessandro, Motta, Giovanna, Rossi, Maura, Agostinelli, Claudio, Sabattini, Elena, Pimpinelli, Nicola, Truni, Mauro, Falini, Brunangelo, Cerroni, Lorenzo, Talarico, Giovanna, Piccioni, Rossana, Amente, Stefano, Indio, Valentina, Tarantino, Giuseppe, Brundu, Francesco, Paulli, Marco, Berti, Emilio, Facchetti, Fabio, Dellino, Gaetano Ivan, Bertolini, Francesco, Tripodo, Claudio, Rabadan, Raul, and Pileri, Stefano A

Subjects
Acute Myeloid Leukemia, Blastic plasmacytoid dendritic cell neoplasm, epigenetic mutations, Skin Neoplasms, Azacitidine, Decitabine, Plasmacytoid dendritic cell, Gene mutation, Biology, BPDCN, Article, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Histone methylation, 5’-Azacytidine, WES, medicine, Humans, Epigenetics, Exome sequencing, Regulation of gene expression, Myeloproliferative Disorders, Dendritic Cells, Genomics, Hematology, 5 -Azacytidine, Myeloid Neoplasms, Cancer research, 030215 immunology, medicine.drug
Abstract

Blastic Plasmacytoid Dendritic Cell Neoplasm is a rare and aggressive hematological malignancy currently lacking an effective therapy. To possibly identify genetic alterations useful for a new treatment design, we analyzed by whole-exome sequencing fourteen Blastic Plasmacytoid Dendritic Cell Neoplasm patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program as the most significantly undermined (P

Published
2018

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