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5 results on '"Sara, Savola"'

1. Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study

Author

Anna Raunio, Ville Kivistö, Mia Kero, Jarno Tuimala, Sara Savola, Minna Oinas, Eloise Kok, Kia Colangelo, Anders Paetau, Tuomo Polvikoski, Pentti J. Tienari, Henri Puttonen, and Liisa Myllykangas

Subjects
Neuropathology, Aged, 80 and over, Lewy body disease, Alpha-Synuclein, Spinal cord, Dorsal root ganglion, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation of spinal cord and peripheral LRP can elucidate mechanisms of Lewy body disorders and origins of synuclein accumulation. Still, very few unselected studies have focused on LRP in these regions. Here we analysed LRP in spinal cord, dorsal root ganglion, and adrenal gland in the population-based Vantaa 85 + study, including every ≥ 85 years old citizen living in the city of Vantaa in 1991 (n = 601). Samples from spinal cord (C6-7, TH3-4, L3-4, S1-2) were available from 303, lumbar dorsal root ganglion from 219, and adrenal gland from 164 subjects. Semiquantitative scores of LRP were determined from immunohistochemically stained sections (anti-alpha-synuclein antibody 5G4). LRP in the ventral and dorsal horns of spinal cord, thoracic intermediolateral column, dorsal root ganglion and adrenal gland were compared with brain LRP, previously determined according to DLB Consortium criteria and by caudo-rostral versus amygdala-based LRP classification. Spinal LRP was found in 28% of the total population and in 61% of those who had LRP in the brain. Spinal cord LRP was found only in those subjects with LRP in the brain, and the quantity of spinal cord LRP was associated with the severity of brain LRP (p

Published
2022
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2. A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease

Author

Per Borghammer, Mie Kristine Just, Jacob Horsager, Casper Skjærbæk, Anna Raunio, Eloise H. Kok, Sara Savola, Shigeo Murayama, Yuko Saito, Liisa Myllykangas, and Nathalie Van Den Berge

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract The dual-hit hypothesis of Parkinson’s disease (PD) originally postulated that a neurotropic pathogen leads to formation of α-synuclein pathology in the olfactory bulb (OB) and dorsal motor nucleus of the vagus (DMV) and then invades the brain from these two entry points. Little work has been conducted to validate an important underlying premise for the dual-hit hypothesis, namely that the initial Lewy pathology does arise simultaneously in the OB and the enteric nervous system (ENS) plexuses and DMV at the earliest disease stage. We conducted a focused re-analysis of two postmortem datasets, which included large numbers of mild Lewy body disease (LBD) cases. We found that cases with α-synuclein pathology restricted to the peripheral autonomic nervous system and/or lower brainstem (early body-first LBD cases) very rarely had any OB pathology, suggesting that Lewy pathology commonly arises in the ENS without concomitant involvement of the OB. In contrast, cases with mild amygdala-predominant Lewy pathology (early brain-first LBD cases) nearly always showed OB pathology. This is compatible with the first pathology being triggered in the OB or amygdala followed by secondary spreading to connected structures, but without early involvement of the ENS or lower brainstem. These observations support that the pathologic process starts in either the olfactory bulb or the ENS, but rarely in the olfactory bulb and gut simultaneously. More studies on neuropathological datasets are warranted to reproduce these findings. The agreement between the revised single-hit hypothesis and the recently proposed brain-first vs. body-first model of LBD is discussed.

Published
2022
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3. Alpha-synuclein pathology of olfactory bulbs/peduncles in the Vantaa85+ cohort exhibit two divergent patterns: a population-based study

Author

Anna Raunio, Eloise H. Kok, Mia Kero, Karri Kaivola, Minna Oinas, Anders Paetau, Pentti J. Tienari, Liisa Myllykangas, Jarno Tuimala, Sara Savola, Tuomo Polvikoski, Department of Pathology, HUSLAB, HUS Diagnostic Center, Clinicum, Neurokirurgian yksikkö, HUS Neurocenter, Korva-, nenä- ja kurkkutautien klinikka, Silmäklinikka, TRIMM - Translational Immunology Research Program, and Department of Neurosciences

Subjects
Male, Pathology, medicine.medical_specialty, Synucleinopathies, education, Biology, DIAGNOSIS, 3124 Neurology and psychiatry, Pathology and Forensic Medicine, Cohort Studies, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Correspondence, MANAGEMENT, medicine, Humans, 030304 developmental biology, Aged, 80 and over, Alpha-synuclein, 0303 health sciences, DEMENTIA, 3112 Neurosciences, LEWY BODIES, Olfactory Bulb, Population based study, chemistry, Cohort, alpha-Synuclein, Female, 3111 Biomedicine, Neurology (clinical), 030217 neurology & neurosurgery
Published
2021
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4. Primary age-related tauopathy in a Finnish population-based study of the oldest old (Vantaa 85+)

Author

Sara, Savola, Karri, Kaivola, Anna, Raunio, Mia, Kero, Mira, Mäkelä, Kalle, Pärn, Priit, Palta, Maarit, Tanskanen, Jarno, Tuimala, Tuomo, Polvikoski, Pentti J, Tienari, Anders, Paetau, and Liisa, Myllykangas

Subjects
Aged, 80 and over, Genotype, Tauopathies, Alzheimer Disease, Apolipoprotein E4, Humans, Cognitive Dysfunction, Finland, Aged
Abstract

Few studies have investigated primary age-related tauopathy (PART) in a population-based setting. Here, we assessed its prevalence, genetic background, comorbidities and features of cognitive decline in an unselected elderly population.The population-based Vantaa 85+ study includes all 601 inhabitants of Vantaa aged ≥ 85 years in 1991. Neuropathological assessment was possible in 301. Dementia (DSM IIIR criteria) and Mini-Mental State Examination (MMSE) scores were assessed at the baseline of the study and follow-ups. PART subjects were identified according to the criteria by Crary et al and were compared with subjects with mild and severe Alzheimer's disease (AD) neuropathological changes. The effects of other neuropathologies were taken into account using multivariate and sensitivity assays. Genetic analyses included APOE genotypes and 29 polymorphisms of the MAPT 3' untranslated region (3'UTR region).The frequency of PART was 20% (n = 61/301, definite PART 5%). When PART subjects were compared with those with severe AD pathology, dementia was less common, its age at onset was higher and duration shorter. No such differences were seen when compared with those with milder AD pathology. However, both AD groups showed a steeper decline in MMSE scores in follow-ups compared with PART. APOE ε4 frequency was lower, and APOE ε2 frequency higher in the PART group compared with each AD group. The detected nominally significant associations between PART and two MAPT 3'UTR polymorphisms and haplotypes did not survive Bonferroni correction.PART is common among very elderly. PART subjects differ from individuals with AD-type changes in the pattern of cognitive decline, associated genetic and neuropathological features.

Published
2021

5. Dog Ownership from a Life Course Perspective and Leisure-time Physical Activity in Late Adulthood: The Helsinki Birth Cohort Study

Author

Hannes Lohi, Johan G. Eriksson, Katriina Tiira, Niko Wasenius, Sara Savola, Minna K. Salonen, Mika Simonen, and Merja K. Laine

Subjects
0301 basic medicine, Adult, Male, Health (social science), Social Psychology, Adolescent, Leisure time, Physical activity, Walking, Age and sex, Metabolic equivalent, Healthy Aging, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Dogs, Leisure Activities, Medicine, Animals, Humans, Longitudinal Studies, Child, Generalized estimating equation, Exercise, health care economics and organizations, Finland, Aged, business.industry, Ownership, Public Health, Environmental and Occupational Health, Infant, Pets, Middle Aged, 030104 developmental biology, Child, Preschool, Life course approach, Female, business, Birth cohort, human activities, Dog owners, 030217 neurology & neurosurgery, Demography
Abstract

Objective We investigated the association between dog ownership during the life course and leisure-time PA (LTPA) in late adulthood. Methods We included 714 participants (mean age = 70.8 ± 2.6 years) from the Helsinki Birth Cohort Study (HBCS). Dog ownership for every decade of life, current dog ownership, and current LTPA in metabolic equivalents of task (MET) were assessed with questionnaires. Age and sex adjusted generalized estimating equation models and analysis of regression were applied for the analyses. Results No significant age by dog ownership interaction on total, conditioning or non-conditioning LTPA was found (p ≥ .68). However, after the age of 40 years, dog ownership was increasingly associated with greater total and non-conditioning LTPA in later life. The mean difference in total LTPA, which was mostly explained by non-conditioning LTPA, was largest between the current dog owners and non-owners (15.2 MET-hours/week, 95% CI: 5.5-24.8, p = .002). ConclusionsCurrent dog ownership is associated with 15.2 MET-hours/week greater total LTPA compared to the non-owners. The differences were already observable after the age of 40. Thus, dog ownership induced increase in LTPA can have a positive influence on the aging processes and consequently positively influence healthy active aging.

Published
2018

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