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2 results on '"Sara Würbel"'

1. ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock

Author

Clemens Scherer, Enzo Lüsebrink, Danny Kupka, Thomas J. Stocker, Konstantin Stark, Jan Kleeberger, Mathias Orban, Antonia Kellnar, Tobias Petzold, Simon Deseive, Kathrin Krieg, Sara Würbel, Sara Kika, Mario Istrefi, Stefan Brunner, Daniel Braun, Christian Hagl, Jörg Hausleiter, Steffen Massberg, Dirk Sibbing, and Martin Orban

Subjects
platelet reactivity, cardiogenic shock, bleeding, acute myocardial infarction, va-ecmo, impella, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

While previous reports showed ADP-induced platelet reactivity to be an independent predictor of bleeding after PCI in stable patients, this has never been investigated in patients with cardiogenic shock. The association of bleeding events with respect to ADP-induced platelet aggregation was investigated in patients undergoing primary PCI for acute myocardial infarction complicated by cardiogenic shock and with available on-treatment ADP-induced platelet aggregation measurements. Out of 233 patients, 74 suffered from a severe BARC3 or higher bleed. ADP-induced platelet aggregation was significantly lower in patients with BARC≥3 bleedings (p

Published
2022
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2. ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock

Author

Mario Istrefi, Antonia Kellnar, Jan Kleeberger, Sara Würbel, Christian Hagl, Clemens Scherer, Danny Kupka, Daniel Braun, Simon Deseive, Kathrin Krieg, Sara Kika, Tobias Petzold, Stefan Brunner, Dirk Sibbing, Martin Orban, Konstantin Stark, Thomas J. Stocker, Enzo Lüsebrink, Jörg Hausleiter, Mathias Orban, Steffen Massberg, University of Zurich, Orban, Mathias, and Orban, Martin

Subjects
Blood Platelets, Male, medicine.medical_specialty, 2720 Hematology, Myocardial Infarction, Shock, Cardiogenic, 610 Medicine & health, Hemorrhage, Platelet reactivity, Internal medicine, medicine, Humans, Platelet, Myocardial infarction, Risk factor, Impella, Aged, business.industry, Cardiogenic shock, Hematology, General Medicine, Bleed, medicine.disease, Adenosine Diphosphate, 10032 Clinic for Oncology and Hematology, Conventional PCI, Acute Disease, Cardiology, Female, business
Abstract

While previous reports showed ADP-induced platelet reactivity to be an independent predictor of bleeding after PCI in stable patients, this has never been investigated in patients with cardiogenic shock. The association of bleeding events with respect to ADP-induced platelet aggregation was investigated in patients undergoing primary PCI for acute myocardial infarction complicated by cardiogenic shock and with available on-treatment ADP-induced platelet aggregation measurements. Out of 233 patients, 74 suffered from a severe BARC3 or higher bleed. ADP-induced platelet aggregation was significantly lower in patients with BARC≥3 bleedings (p < .001). Multivariate analysis identified on-treatment ADP-induced platelet aggregation as an independent risk factor for bleeding (HR = 0.968 per AU). An optimal cutoff value of

Published
2021

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