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2. A systematic review for the evidence of recommendations and guidelines in hybrid nuclear cardiovascular imaging

Author

Besson, Florent L., Treglia, Giorgio, Bucerius, Jan, Anagnostopoulos, Constantinos, Buechel, Ronny R., Dweck, Marc R., Erba, Paula A., Gaemperli, Oliver, Gimelli, Alessia, Gheysens, Olivier, Glaudemans, Andor W. J. M., Habib, Gilbert, Hyafil, Fabian, Lubberink, Mark, Rischpler, Christopher, Saraste, Antti, and Slart, Riemer H. J. A.

Published
2024
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9. Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest—a substudy of the XeHypotheca trial

Author

Koskensalo, Kalle, Virtanen, Sami, Saunavaara, Jani, Parkkola, Riitta, Laitio, Ruut, Arola, Olli, Hynninen, Marja, Silvasti, Päivi, Nukarinen, Eija, Martola, Juha, Silvennoinen, Heli M, Tiainen, Marjaana, Roine, Risto O, Scheinin, Harry, Saraste, Antti, Maze, Mervyn, Vahlberg, Tero, and Laitio, Timo T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Cardiovascular, Biomedical Imaging, Clinical Research, Humans, Biomarkers, Coma, Diffusion Tensor Imaging, Out-of-Hospital Cardiac Arrest, Phosphopyruvate Hydratase, Prognosis, Proton Magnetic Resonance Spectroscopy, Seizures, Survivors, Diffusion tensor imaging, 1H-MRS, Neuron-specific enolase, Cardiac arrest, Brain hypoxia-ischemia, Prognostication, XeHYPOTHECA Research Group, Brain hypoxia–ischemia, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeWe compared the predictive accuracy of early-phase brain diffusion tensor imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS), and serum neuron-specific enolase (NSE) against the motor score and epileptic seizures (ES) for poor neurological outcome after out-of-hospital cardiac arrest (OHCA).MethodsThe predictive accuracy of DTI, 1H-MRS, and NSE along with motor score at 72 h and ES for the poor neurological outcome (modified Rankin Scale, mRS, 3 - 6) in 92 comatose OHCA patients at 6 months was assessed by area under the receiver operating characteristic curve (AUROC). Combined models of the variables were included as exploratory.ResultsThe predictive accuracy of fractional anisotropy (FA) of DTI (AUROC 0.73, 95% CI 0.62-0.84), total N-acetyl aspartate/total creatine (tNAA/tCr) of 1H-MRS (0.78 (0.68 - 0.88)), or NSE at 72 h (0.85 (0.76 - 0.93)) was not significantly better than motor score at 72 h (0.88 (95% CI 0.80-0.96)). The addition of FA and tNAA/tCr to a combination of NSE, motor score, and ES provided a small but statistically significant improvement in predictive accuracy (AUROC 0.92 (0.85-0.98) vs 0.98 (0.96-1.00), p = 0.037).ConclusionNone of the variables (FA, tNAA/tCr, ES, NSE at 72 h, and motor score at 72 h) differed significantly in predicting poor outcomes in this patient group. Early-phase quantitative neuroimaging provided a statistically significant improvement for the predictive value when combined with ES and motor score with or without NSE. However, in clinical practice, the additional value is small, and considering the costs and challenges of imaging in this patient group, early-phase DTI/MRS cannot be recommended for routine use.Trial registrationClinicalTrials.gov NCT00879892, April 13, 2009.

Published
2023

11. Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage—study protocol for a randomized clinical trial

Author

Laaksonen, Mikael, Rinne, Jaakko, Rahi, Melissa, Posti, Jussi P., Laitio, Ruut, Kivelev, Juri, Saarenpää, Ilkka, Laukka, Dan, Frösen, Juhana, Ronkainen, Antti, Bendel, Stepani, Långsjö, Jaakko, Ala-Peijari, Marika, Saunavaara, Jani, Parkkola, Riitta, Nyman, Mikko, Martikainen, Ilkka K., Dickens, Alex M., Rinne, Juha, Valtonen, Mika, Saari, Teijo I., Koivisto, Timo, Bendel, Paula, Roine, Timo, Saraste, Antti, Vahlberg, Tero, Tanttari, Juha, and Laitio, Timo

Published
2023
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15. Embolization of percutaneous left atrial appendage closure devices: Timing, management and clinical outcomes

Author

Eppinger, Sophie, Piayda, Kerstin, Galea, Roberto, Sandri, Marcus, Maarse, Moniek, Güner, Ahmet, Karabay, Can Y., Pershad, Ashish, Ding, Wern Y., Aminian, Adel, Akin, Ibrahim, Davtyan, Karapet V., Chugunov, Ivan A., Marijon, Eloi, Rosseel, Liesbeth, Schmidt, Thomas Robert, Amabile, Nicolas, Korsholm, Kasper, Lund, Juha, Guerios, Enio, Amat-Santos, Ignacio J., Boccuzzi, Giacomo, Ellis, Christopher R., Sabbag, Avi, Ebelt, Henning, Clapp, Brian, Assa, Hana Vaknin, Levi, Amos, Ledwoch, Jakob, Lehmann, Sonja, Lee, Oh-Hyun, Mark, George, Schell, Wendy, della Rocca, Domenico G., Natale, Andrea, de Backer, Ole, Kefer, Joelle, Esteban, Pablo P., Abelson, Mark, Ram, Pradhum, Moceri, Pamela, Galache Osuna, Jose G., Alvarez, Xavier Millán, Cruz-Gonzalez, Ignacio, de Potter, Tom, Ghassan, Moubarak, Osadchiy, Andrey, Chen, Weita, Goyal, Sandeep K., Giannini, Francesco, Rivero-Ayerza, Máximo, Afzal, Shazia, Jung, Christian, Skurk, Carsten, Langel, Martin, Spence, Mark, Merkulov, Evgeny, Lempereur, Mathieu, Shin, Seung Y., Mesnier, Jules, McKinney, Heather L., Schuler, Brian T., Armero, Sebastien, Gheorghe, Livia, Ancona, Marco B.M., Santos, Lino, Mansourati, Jacques, Nombela-Franco, Luis, Nappi, Francesco, Kühne, Michael, Gaspardone, Achille, van der Pals, Jesper, Montorfano, Matteo, Fernández-Armenta, Juan, Harvey, James E., Rodés-Cabau, Josep, Klein, Norbert, Sabir, Sajjad A., Kim, Jung-Sun, Cook, Stephane, Kornowski, Ran, Saraste, Antti, Nielsen-Kudsk, Jens E., Gupta, Dhiraj, Boersma, Lucas, Räber, Lorenz, Sievert, Kolja, Sievert, Horst, and Bertog, Stefan

Published
2024
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19. Nuclear medicine in the assessment and prevention of cancer therapy-related cardiotoxicity: prospects and proposal of use by the European Association of Nuclear Medicine (EANM)

Author

Totzeck, Matthias, Aide, Nicolas, Bauersachs, Johann, Bucerius, Jan, Georgoulias, Panagiotis, Herrmann, Ken, Hyafil, Fabien, Kunikowska, Jolanta, Lubberink, Mark, Nappi, Carmela, Rassaf, Tienush, Saraste, Antti, Sciagra, Roberto, Slart, Riemer H. J. A., Verberne, Hein, and Rischpler, Christoph

Published
2023
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20. Coronary computed tomography angiography-based endothelial wall shear stress in normal coronary arteries

Author

Schultz, Jussi, van den Hoogen, Inge J., Kuneman, Jurrien H., de Graaf, Michiel A., Kamperidis, Vasileios, Broersen, Alexander, Jukema, J. Wouter, Sakellarios, Antonis, Nikopoulos, Sotirios, Tsarapatsani, Konstantina, Naka, Katerina, Michalis, Lampros, Fotiadis, Dimitrios I., Maaniitty, Teemu, Saraste, Antti, Bax, Jeroen J., and Knuuti, Juhani

Published
2023
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25. Natural History of Myocardial αvβ3Integrin Expression After Acute Myocardial Infarction: Correlation with Changes in Myocardial Blood Flow

Author

Dietz, Matthieu, primary, Kamani, Christel H., additional, Bousige, Colin, additional, Dunet, Vincent, additional, Delage, Judith, additional, Rubimbura, Vladimir, additional, Nicod Lalonde, Marie, additional, Treglia, Giorgio, additional, Schaefer, Niklaus, additional, Nammas, Wail, additional, Saraste, Antti, additional, Knuuti, Juhani, additional, Mewton, Nathan, additional, and Prior, John O., additional

Published
2024
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26. Determining Hemodynamically Significant Coronary Artery Disease: Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [15O]H2O PET Imaging

Author

Hoek, Roel, primary, van Diemen, Pepijn A., additional, Raijmakers, Pieter G., additional, Driessen, Roel S., additional, Somsen, Yvemarie B.O., additional, de Winter, Ruben W., additional, Jukema, Ruurt A., additional, Twisk, Jos W.R., additional, Robbers, Lourens F.H.J., additional, van der Harst, Pim, additional, Saraste, Antti, additional, Lubberink, Mark, additional, Sörensen, Jens, additional, Knaapen, Paul, additional, Knuuti, Juhani, additional, and Danad, Ibrahim, additional

Published
2024
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27. Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial

Author

Saraste, Antti, Ballo, Haitham, Arola, Olli, Laitio, Ruut, Airaksinen, Juhani, Hynninen, Marja, Bäcklund, Minna, Ylikoski, Emmi, Wennervirta, Johanna, Pietilä, Mikko, Roine, Risto O, Harjola, Veli-Pekka, Niiranen, Jussi, Korpi, Kirsi, Varpula, Marjut, Scheinin, Harry, Maze, Mervyn, Vahlberg, Tero, Laitio, Timo, Virtanen, Sami, Parkkola, Riitta, Saunavaara, Jani, Martola, Juha, Silvennoinen, Heli, Tiainen, Marjaana, Grönlund, Juha, Inkinen, Outi, Silvasti, Päivi, Nukarinen, Eija, and Olkkola, Klaus T

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular, Clinical Research, Heart Disease, Clinical Trials and Supportive Activities, cardiac arrest, cardiac function, cardioprotection, echocardiography, ejection fraction, myocardial strain, Clinical sciences
Abstract

This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest.DesignA randomized two-group single-blinded phase 2 clinical drug trial.SettingA multipurpose ICU in two university hospitals.PatientsOf the 110 randomized comatose survivors after out-of-hospital cardiac arrest with a shockable rhythm in the xenon in combination with hypothermia after cardiac arrest trial, 38 patients (24-76 yr old) with complete echocardiography were included in this study.InterventionsPatients were randomized to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours or hypothermia treatment alone. Echocardiography was performed at hospital admission and 24 ± 4 hours after hypothermia.Measurements and main resultsLeft ventricular ejection fraction, myocardial longitudinal systolic strain, and diastolic function were analyzed blinded to treatment. There were 17 xenon and 21 control patients in whom echocardiography was completed. Clinical characteristics did not differ significantly between the groups. At admission, ejection fraction was similar in xenon and control patients (39% ± 10% vs 38% ± 11%; p = 0.711) but higher in xenon than control patients after hypothermia (50% ± 10% vs 42% ± 10%; p = 0.014). Global longitudinal systolic strain was similar in xenon and control patients at admission (-9.0% ± 3.8% vs -8.1% ± 3.6%; p = 0.555) but better in xenon than control patients after hypothermia (-14.4.0% ± 4.0% vs -10.5% ± 4.0%; p = 0.006). In patients with coronary artery disease, longitudinal strain improved in the nonischemic myocardial segments in xenon patients. There were no changes in diastolic function between the groups.ConclusionsAmong comatose survivors of a cardiac cause out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia was associated with greater recovery of left ventricular systolic function in comparison with hypothermia alone.

Published
2021

28. Coronary Volume to Left Ventricular Mass Ratio in Patients With Hypertension

Author

van Rosendael, Sophie E., van Rosendael, Alexander R., Kuneman, Jurrien H., Patel, Manesh R., Nørgaard, Bjarne Linde, Fairbairn, Timothy A., Nieman, Koen, Akasaka, Takashi, Berman, Daniel S., Koweek, Lynne M. Hurwitz, Pontone, Gianluca, Kawasaki, Tomohiro, Sand, Niels Peter Rønnow, Jensen, Jesper M., Amano, Tetsuya, Poon, Michael, Øvrehus, Kristian A., Sonck, Jeroen, Rabbat, Mark G., Rogers, Campbell, Matsuo, Hitoshi, Leipsic, Jonathon A., Marsan, Nina Ajmone, Jukema, J. Wouter, Bax, Jeroen J., Saraste, Antti, and Knuuti, Juhani

Published
2023
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38. Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial

Author

Smit, Jeff M, primary, Rocchiccioli, Silvia, additional, Signore, Giovanni, additional, Michelucci, Elena, additional, Di Giorgi, Nicoletta, additional, van Rosendael, Alexander R, additional, El Mahdiui, Mohammed, additional, Neglia, Danilo, additional, Knuuti, Juhani, additional, Saraste, Antti, additional, Buechel, Ronny R, additional, Teresinska, Anna, additional, Pizzi, Maria N, additional, Roque, Albert, additional, Poddighe, Rosa, additional, Mertens, Bart J, additional, Caselli, Chiara, additional, Parodi, Oberdan, additional, Pelosi, Gualtiero, additional, and Scholte, Arthur J, additional

Published
2024
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39. Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council

Author

Slart, Riemer H.J.A., primary, Bengel, Frank M., additional, Akincioglu, Cigdem, additional, Bourque, Jamieson M., additional, Chen, Wengen, additional, Dweck, Marc R., additional, Hacker, Marcus, additional, Malhotra, Saurabh, additional, Miller, Edward J., additional, Pelletier-Galarneau, Matthieu, additional, Packard, René R.S., additional, Schindler, Thomas H., additional, Weinberg, Richard L., additional, Saraste, Antti, additional, and Slomka, Piotr J., additional

Published
2024
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48. Myocardial Innervation

Author

Schwaiger, Markus, Jacobson, Arnold F., Saraste, Antti, Narula, Jagat, Bengel, Frank M., Dilsizian, Vasken, editor, and Narula, Jagat, editor

Published
2021
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49. Preliminary protocol for measuring the reproducibility and accuracy of flow values on digital PET/CT systems in [15O]H2O myocardial perfusion imaging using a flow phantom.

Author

Siekkinen, Reetta, Partanen, Heidi, Kukola, Linda, Tolvanen, Tuula, Fenwick, Andrew, Smith, Nadia A. S., Teräs, Mika, Saraste, Antti, and Teuho, Jarmo

Subjects
MYOCARDIAL perfusion imaging, UNITS of measurement, BLOOD flow
Abstract

Background: Several factors may decrease the accuracy of quantitative PET myocardial perfusion imaging (MPI). It is therefore essential to ensure that myocardial blood flow (MBF) values are reproducible and accurate, and to design systematic protocols to achieve this. Until now, no systematic phantom protocols have been available to assess the technical factors affecting measurement accuracy and reproducibility in MPI. Materials and methods: We implemented a standard measurement protocol, which applies a flow phantom in order to compare image-derived flow values with respect to a ground truth flow value with [15O]H2O MPI performed on both a Discovery MI (DMI-20, GE Healthcare) and a Biograph Vision 600 (Vision-600, Siemens Healthineers) system. Both systems have automatic [15O]H2O radio water generators (Hidex Oy) individually installed, allowing us to also study the differences occurring due to two different bolus delivery systems. To investigate the technical factors contributing to the modelled flow values, we extracted the [15O]H2O bolus profiles, the flow values from the kinetic modeling (Qin and Qout), and finally calculated their differences between test-retest measurements on both systems. Results: The measurements performed on the DMI-20 system produced Qin and Qout values corresponging to each other as well as to the reference flow value across all test-retest measurements. The repeatability differences on DMI-20 were 2.1% ± 2.6% and 3.3% ± 4.1% for Qin and Qout, respectively. On Vision-600 they were 10% ± 8.4% and 11% ± 10% for Qin and Qout, respectively. The measurements performed on the Vision-600 system showed more variation between Qin and Qout values across test-retest measurements and exceeded 15% difference in 7/24 of the measurements. Conclusions: A preliminary protocol for measuring the accuracy and reproducibility of flow values in [15O]H2O MPI between digital PET/CT systems was assessed. The test-retest reproducibility falls below 15% in majority of the measurements conducted between two individual injector systems and two digital PET/CT systems. This study highlights the importance of implementing a standardized bolus injection and delivery protocol and importance of assessing technical factors affecting flow value reproducibility, which should be carefully investigated in a multi-center setting. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Determining Hemodynamically Significant Coronary Artery Disease: Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [15O]H2O PET Imaging.

Author

Hoek, Roel, van Diemen, Pepijn A., Raijmakers, Pieter G., Driessen, Roel S., Somsen, Yvemarie B. O., de Winter, Ruben W., Jukema, Ruurt A., Twisk, Jos W. R., Robbers, Lourens F. H. J., van der Harst, Pim, Saraste, Antti, Lubberink, Mark, Sörensen, Jens, Knaapen, Paul, Knuuti, Juhani, and Danad, Ibrahim

Published
2024
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