122 results on '"Sardas S"'
Search Results
2. The role of antioxidant supplementation in occupational exposure to waste anaesthetic gases
- Author
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Sardas, S., Izdes, S., Ozcagli, E., Kanbak, O., and Kadioglu, E.
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- 2006
- Full Text
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3. Menopause
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Tutuncu L., Arslanhan N., Ergur A. R., Mungen E., Yergok Y. Z., An E. S., Uner M., Eryilmaz M., Akar M. E., Inan I., Kelekci S., Yilmaz B., Kart C., Günaydin A. S., Cakir A., Yilmaz B., Oguz S., Gunyeli I., Kelekci S., Kalyoncu S., Ertas I. E., Kahyaoglu S., Gokturk U., Mollamahmutoglu L., Elter K., Yildizhan B., Basgul A., Pekin T., Gokaslan H., Kavak Z. N., Karas C., Gol M., Guclu S., Dogan E., Saygili U., Onvural A., Gol M., Akan P., Dogan E., Karas C., Saygili U., Posaci C., Biri A., Yurtcu E., Ciftci B., Ergun M. A., Gursoy R., Biberoglu K., Ozcagli E., Sardas S., Erkan A., Ergun M. A., Yilmaz A., Tiras B., Guner H., Yalcin R., Bozkurt N., Gursoy R., Yildirim M., Karabacak O., Himmetoglu O., Gulbahar O., Gursoy R., Nas T., Eskioglu A., Kumru S., Yildiz M. F., Godekmerdan A., Gürates B., Kiran H., Kiran G., Ekerbicer H. C., Guven A. M., Ürünsak I. F., Güzel A. B., Demir S. C., Kadayifci O., Dursun P., Gultekin M., Bozdag G., Aksan G., Aksu T., Bayrak A., Esinler D., Oguz S., Tapisiz O. L., Aytan H., Gunyeli I., Erdem S., Tuncay G., Mollamahmutoglu L., Aksakal O., Aytan H., Cavkaytar S., Tapisiz O. L., Gungor T., Ozdal B., Akhan S. E., Hanli U., Kalayci R., Kaya M., Ahisali B., Turfanda A., Hassa H., Tanir H. M., Tekin B., Oge T., Kahraman S., Yildirim A., Ürünasak I. F., Güzel A. B., Demir S. C., Özbilen N., Kadayifci O., Dane C., Cetin A., Dane B., Kiray M., Erginbas M., Döventas Y., Karabeyoglu N., Dursun P., Gultekin M., Aksu T., Kalli E., Kiran H., Kiran G., Guven A. M., Karakus S., Sapmaz K., Cetin T. M., Canda M. T., Bagriyanik H. A., Kaplan P. B., Yilmaz O., Gucer F., Yuce M. A., Tugyan K., Yoldemir T., Davas I., Tanrikulu A., Yazgan A., and Varolan A.
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- 2005
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4. Mitochondrial DNA and Y-Chromosome Variation in the Caucasus
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Nasidze, I., Ling, E. Y. S., Quinque, D., Dupanloup, I., Cordaux, R., Rychkov, S., Naumova, O., Zhukova, O., Sarraf-Zadegan, N., Naderi, G. A., Asgary, S., Sardas, S., Farhud, D. D., Sarkisian, T., Asadov, C., Kerimov, A., and Stoneking, M.
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- 2004
5. Comparison of genotoxicity of sevoflurane and isoflurane in human lymphocytes studied in vivo using the comet assay
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Karabıyık, L, Şardaş, S, Polat, U, KocabaŞ, N.A, and Karakaya, A.E
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- 2001
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6. DNA repair capacity of the colorectal cancer patients and the correlation between the pathological parameters
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Tolan, HK, primary, Tozan-Beceren, A, additional, Sardas, S, additional, Senkesen, Ö, additional, Çelikel, Ç, additional, Gençosmanoglu, R, additional, and Yegen, C, additional
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- 2019
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7. Significance of Serum Ferritin Concentrations in Lung Cancer and it’s Relation with Cellular Immunity
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Sardas, O. S., Sancaktar, O., Sardas, S., Koc, H., Chambers, Philip L., editor, Chambers, Claire M., editor, and Greim, Helmut, editor
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- 1989
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8. Genetic association (PON1 activity, MDR 1 gene) and adverse effects on infant growth/neurodevelopment
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Sardas, S., primary
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- 2016
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9. The wound healing effects of Nerium oleander extract against burn-induced oxidative injury
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Akgün, S.G., primary, Aydemir, S., additional, Özkan, N., additional, Beceren, A., additional, and Sardas, S., additional
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- 2016
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10. Importance of pharmacogenetics in adverse drug reactions
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Sardas, S., primary
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- 2015
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11. Personalized and predictive medicine in Turkey: A symposium report of the Istanbul Working Group on Personalized Medicine, Istanbul, Turkey, September 10-12, 2009
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Sardas S., Maugard C., Genc E., Gok S., Hyzel C., Bernard-Gallon D., Hizel, C., Gök, S., Sardaş, S., Bernard-Gallon, D., Maugard, C., Genç, E., and Yeditepe Üniversitesi
- Subjects
Pharmacology ,medicine.medical_specialty ,Traditional medicine ,business.industry ,Istanbul turkey ,Pharmacogenomics-guided pharmacovigilance ,Personalized medicine ,LMICs ,Predictive medicine ,Regional capacity building ,Family medicine ,Genetics ,medicine ,Molecular Medicine ,Lower and middle income countries ,business ,Molecular Biology ,Genetics (clinical) - Abstract
Pharmacogenetics has its roots in the 1950s with pioneering studies of monogenic variations in drug metabolism and pharmacokinetics. With the availability of high-throughput genomics technologies and the completion of the Human Genome Project in 2003, we are now in the postgenomics era. This transition is increasingly marked with study of polygenic and multifactorial traits such as common complex human diseases as well as pharmacodynamic differences among populations. Changes that emerge from postgenomics medicine are not, however, limited to seismic shifts in scale and scope of pharmacogenetics research. Importantly, many low- and middle-income countries (LMICs) of the South, Asia-Pacific, Eastern Mediterranean and the Middle-East are becoming notable contributors with rapid globalization of science and increasing access to genomics technologies. This brings about, in parallel, an acute demand for regional capacity building in LMICs so that the future evaluation and implementation of postgenomics technologies in personalized medicine take place in an integrated, sustainable and equitable manner. With this overarching vision, we herein report the founding of the Istanbul Working Group in Personalized Medicine (IWG-PM, represented by the authors of this report) that was inaugurated as a component of the 2nd Symposium on Personalized and Predictive Medicine held in Istanbul, sponsored by the Yeditepe University, and the Turkish Scientific and Technological Research Council (TUB?TAK) (10-12 September, 2009). While highlighting the applications of personalized medicine in oncology, psychiatry, nutrition, infectious diseases, occupational health, genetic testing and systems biology, the symposium also raised challenging questions in the context of LMICs. How can we best evaluate the promises, intended and unintended impacts of personalized medicine and enabling technologies in the context of Turkey, and the LMICs more generally? IWG-PM is a small but significant and necessary step to initiate regional capacity building in Turkey. We trust that the IWG-PM initiative may also provide a constructive example to further develop capacity in other LMICs in the Eastern Mediterranean region. © 2009 Bentham Science Publishers Ltd.
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- 2009
12. Relationship between debrisoquine oxidation phenotype and susceptibility to lung cancer
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Sardas, S and Cok, İSMET
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- 2001
13. The role of oxidative DNA damage, DNA repair, GSTM1, SOD2 and OGG1 polymorphisms in individual susceptibility to Barrett's esophagus
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Kadioglu, E., primary, Sardas, S., additional, Ergun, M., additional, Unal, S., additional, and Karakaya, A.E., additional
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- 2010
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14. Editorial [Pharmacogenovigilance – An Idea whose Time has Come]
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Sardas, S., primary
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- 2010
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15. Personalized and Predictive Medicine in Turkey: A Symposium Report of the Istanbul Working Group on Personalized Medicine, Istanbul, Turkey, September 10-12, 2009
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Hyzel, C., primary, Gok, S., additional, Sardas, S., additional, Bernard-Gallon, D., additional, Maugard, C., additional, and Genc, E., additional
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- 2009
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16. Determination of DNA damage by alkaline halo and comet assay in patients under sevoflurane anesthesia
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Kadioglu, E, primary, Sardas, S, additional, Erturk, S, additional, Ozatamer, O, additional, and Karakaya, AE, additional
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- 2009
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17. Comparison of genotoxic effect between smokeless tobacco (Maras powder) users and cigarette smokers by the alkaline comet assay
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Sardas, S, primary, Cimen, B, additional, Karsli, S, additional, Yurdun, T, additional, and Donbak, L, additional
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- 2009
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18. Vth International Conference on Environmental Mutagens in Human Populations: Introduction
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AU, W, primary, SARDAS, S, additional, KARAKAYA, A, additional, and KARAHALIL, B, additional
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- 2008
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19. Dedication
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MEHLMAN, M, primary, AU, W, additional, SARDAS, S, additional, and KARAKAYA, A, additional
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- 2008
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20. Oxidative DNA damage and total antioxidant status in rats during experimental gram-negative sepsis
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Kaymak, C, primary, Kadioglu, E, additional, Ozcagli, E, additional, Osmanoglu, G, additional, Izdes, S, additional, Agalar, C, additional, Basar, H, additional, and Sardas, S, additional
- Published
- 2008
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21. SISTER CHROMATID EXCHANGE IN PATIENTS TREATED WITH NONSTEROIDAL ANTIINFLAMMATORY DRUGS
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CENGEL, M, SARDAS, S, KARAKAYA, AE, UGUR, N, and METIN, A
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- 1991
22. Mercury Exposure in Dental Practice
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Atesagaoglu, A., primary, Omurlu, H., primary, Ozcagli, E., primary, Sardas, S., primary, and Ertas, N., primary
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- 2006
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23. The Role of Triple Therapy, Age, Gender and Smoking on the Genotoxic Effects of Helicobacter Pylori Infection
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Gulten, T, primary, Tokyay, N, additional, Demiray, M, additional, Gulten, M, additional, Ercan, I, additional, Evke, E, additional, Sardas, S, additional, and Karakaya, AE, additional
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- 2002
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24. Risk assessment in the operating room
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Karabiyik, L., primary, Sardas, S., additional, Özdemir, S., additional, Öztok, U., additional, and Karadenizli, Y., additional
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- 2000
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25. Diazepam and propofol used as anesthetics during open-heart surgery do not cause chromosomal aberrations in peripheral blood lymphocytes
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Karahalil, B., Yağar, S., Bahadır, G., Durak, P., and Şardaş, S.
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- 2005
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26. Individual Variation in the Activation and Inactivation of Metabolic Pathways of Cyclophosphamide
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Boddy, A. V., primary, Furtun, Y., additional, Sardas, S., additional, Sardas, O., additional, and Idle, J. R., additional
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- 1992
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27. Polymorphic 4-hydroxylation of debrisoquine in a Turkish population
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Sardas, S, primary, Pontin, J, additional, and Idle, J R, additional
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- 1991
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28. Analysis of the serum paraoxonase/arylesterase polymorphism in a Turkish population
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Karakaya, A, primary, Suzen, S, additional, Sardas, S, additional, Karakaya, A E, additional, and Vural, N, additional
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- 1991
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29. N-Acetyltransferase Phenotype of Patients with Bladder Cancer.
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Karakaya, A.E., Cok, I., Sardas, S., Gögüs, O., and Sardas, O.S.
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- 1986
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30. A look at the Past: History of Rimonabant
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Aydinkarahaliloglu, D. N., Aykac, E., Kasap, Y., Sagis, G., Babacanoglu, C., Ilbars, H., Bulent Yildiz, Sardas, S., Ozbek, H., and Kerman, S.
31. POLYMORPHIC URINARY METABOLITE PROFILE OF CYCLOPHOSPHAMIDE IN TURKISH PATIENTS
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FURTUN, Y, SARDAS, S, SARDAS, O, BODDY, AV, and IDLE, JR
32. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H-H, Genediab, Study Group, Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabak, A. Gy, Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Canton, A., Burgos, R., Hernandez, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simo, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., Mcdermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y-S, Sternesjo, J., Sandler, S., Chen, M-C, Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Breant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessieres-Lacombe, S., Gedec, Study Group, Tauber, J-P, Home, P. D., Lindholm, A., Riis, A., European Insulin Aspart Study Group, Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Us Dm, Study Group Of Insulin Glargine In Type, Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Hvidore Study group on Childhood Diabetes, Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Ukpds, Group, Steiner, G., Dais, Project Group, Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Verges, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph, Benko, B., Ljubic, S., Turk, Z., Granic, M., Marz, W., Wollschlager, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O Rahilly, S., Hattersley, A. T., Mccarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Siman, C., Wisse, Bert, Gittenberger-De Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ozegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rosc, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Skrha, J., Kvasnicka, J., Kalvodova, B., Hilgertova, J., Schatteman, K., Goossens, F., Scharpe, S., Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Haring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., Mckinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnas, A. M., Andersen, N. Aa, Osterhoff, M., Mohlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Furnsinn, C., Nowotny, P., Waldhausl, W., Roden, M., Neeft, M., Meijer, A. J., Bavenholm, P., Pigon, J., Efendic, S., Kastenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovska, A., Kasalicky, P., Hosova, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefebvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valero, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., Galan, B., Netea, M. G., Hancu, N., Smits, P., Meer, J. W. M., Osterbye, T., Jorgensen, K. H., Tranum-Jensen, J., Fredman, P., Hoy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patane, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., Vos, P., Visser, L., Haan, B. J., Klok, P., Schilfgaarde, R., Poppema, S., Juang, J-H, Kuo, C-H, Hsu, B. R-S, Nacher, V., Perez, M., Biarnes, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Busing, M., Becker, T., Klempnauer, J., Hucking, K., Schmiegel, W. H., Nauck, M. A., Boucek, P., Saudek, F., Adamec, M., Kozitarova, R., Jedinakova, T., Vlasakova, Z., Bartos, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J-C, Gillespie, J. S., Mcmaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Vericel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P-O, Msengul, A., Salman, F., Sargrn, M., Ozer, E., Karsidaǧ, K., Salman, S., Gedik, S., Satman, I., Dinccaǧ, N., Yilmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. 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V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Hoffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grubetaer, M., Hartmann, P., Hoffstadt, K., Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, S., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemandez, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch, Hammes, H-P, Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G. Rd, Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. D., Darts Memo, Collaboration, Ioannidis, G., Peppa, M., Rontogianni, E., Kallifronas, M., Lekatsas, I., Chrysanthopoulou, G., Anthopoulos, L., Kesse, M., Thalassinos, N., Neves, C., Medina, J. L., Lopes, F., Guvener, N., Guvener, M., Kocagoz, T., Boke, E., Pasaoglu, I., Bascil Tutuncu, N., Oto, A., Karvonen, M. K., Koulu, M., Pesonen, U., Mercuri, M., Rauramaa, R., Pittsburgh Epidemiology of Diabetes Complications (EDC) Study, Rutter, M. K., Kestevan, P., Mccomb, J. M., Marshall, S. M., Sobieska, M., Wiktorowicz, K., Kanters, S. D. J. M., Banga, J. D., Algra, A., Frijns, C. J. M., Beutler, J. J., Fijnheer, R., Nicoloff, G., Baydanoff, S., Stanimirova, N., Petrova, Ch, Lario, S., Campistol, J. M., Cases, A., Claria, J., Inigo, P., Esmatjcs, E., Sarman, B., Toth, M., Kocsis, I., Somogyi, A., Bumbure, A., Jachimowicz, K., Samson, J., Tomasiak, M., Sobol, A., Stanczyk, L., Watala, C., Stradina, P., Wisniewska-Jarosinska, M., Marciniak, D., Wieclawska, B., Golanski, J., Zinnat, R., Mahmud, I., Buyukasik, Yahya, Demiroglu, H., Szczepanik, A., Skowronski, M., Murawska, A., Meeking, D. R., Allard, S., Munday, J., Chowienczyk, P., Shaw, K. M., Cummings, M. H., Simkova, R., Jirsa, M., Hadoke, P. W. F., Mcintyre, C. A., Jones, G. C., Williams, B. C., Elliott, A. I., Mcknight, J. A., Pernow, J., Bombonato, G. C., Finucci, G. F., Zotta, L., Senses, V., Ozyazgan, S., Ince, E., Tuncdemir, M., Sultuybek, G., Akkan, A. G., Unlucerci, Y., Bekpinar, S., Meyer, M. F., Lee, B. C., Shore, A. C., Humphreys, J. M., Tooke, J. E., Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Pfohl, M., Mcinerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvari, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Poto, L., Wagner, L., Mazak, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A-S, Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M.
33. An Appeal to the Global Health Community for a Tripartite Innovation: An 'essential Diagnostics List,' 'health in All Policies,' and 'see-Through 21st Century Science and Ethics'
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Dove, E.S., Barlas, O., Birch, K., Boehme, C., Borda-Rodriguez, A., Byne, W.M., Chaverneff, F., Coskun, Y., Dahl, M.-L., Dereli, T., Diwakar, S., Elbeyli, L., Endrenyi, L., Eroʇlu-Kesim, B., Ferguson, L.R., Gungor, K., Gursoy, U., Hekim, F., Huzair, F., Kaushik, K., Kickbusch, I., Klroʇlu, O., Kolker, E., Kononen, E., Lin, B., Llerena, A., Malhan, F., Nair, B., Patrinos, G.P., Sardas, S., Sert, O., Srivastava, S., Steuten, L.M.G., Toraman, C., Vayena, E., Wang, Wei, Warnich, L., Ozdemir, V., Dove, E.S., Barlas, O., Birch, K., Boehme, C., Borda-Rodriguez, A., Byne, W.M., Chaverneff, F., Coskun, Y., Dahl, M.-L., Dereli, T., Diwakar, S., Elbeyli, L., Endrenyi, L., Eroʇlu-Kesim, B., Ferguson, L.R., Gungor, K., Gursoy, U., Hekim, F., Huzair, F., Kaushik, K., Kickbusch, I., Klroʇlu, O., Kolker, E., Kononen, E., Lin, B., Llerena, A., Malhan, F., Nair, B., Patrinos, G.P., Sardas, S., Sert, O., Srivastava, S., Steuten, L.M.G., Toraman, C., Vayena, E., Wang, Wei, Warnich, L., and Ozdemir, V.
- Abstract
Dove, E.S., Barlas, Ö., Birch, K., Boehme, C., Borda-Rodriguez, A., Byne, W.M., Chaverneff, F., Coşkun, Y., Dahl, M.-L., Dereli, T., Diwakar, S., Elbeyli, L., Endrenyi, L., Eroʇlu-Kesim, B., Ferguson, L.R., Güngör, K., Gürsoy, U., Hekim, N., Huzair, F., Kaushik, K., Kickbusch, I., Klroʇlu, O., Kolker, E., Könönen, E., Lin, B., Llerena, A., Malhan, F., Nair, B., Patrinos, G.P., Sardaş, S., Sert, O., Srivastava, S., Steuten, L.M.G., Toraman, C., Vayena, E., Wang, W., Warnich, L., Özdemir, V. (2015). An Appeal to the Global Health Community for a Tripartite Innovation: An "essential Diagnostics List," "health in All Policies," and "see-Through 21st Century Science and Ethics". In OMICS A Journal of Integrative Biology, 19(8), 435-442. Available here.
34. The Effect of Smoking on Serum Lactate Dehydrogenase Levels and its Isoenzymes after an Ingestion of Paracetamol
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Sardas, S., primary, Sardas, O.S., additional, Karakaya, A., additional, Karakaya, A.E., additional, and Ugur, N., additional
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- 1988
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35. N-Acetyltransferase Phenotype of Patients with Bladder Cancer
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Karakaya, A.E., primary, Cok, I., additional, Sardas, S., additional, Gögüs, O., additional, and Sardas, O.S., additional
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- 1986
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36. The Effect of Smoking on Serum Lactate Dehydrogenase Levels and its Isoenzymes after an Ingestion of Paracetamol.
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Sardas, S., Sardas, O.S., Karakaya, A., Karakaya, A.E., and Ugur, N.
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- 1988
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37. Use of alkaline Comet assay (single cell gel electrophoresis technique) to detect DNA damages in lymphocytes of operating room personnel occupationally exposed to anaesthetic gases
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Şardaş, S, Aygün, N, Gamli, M, Ünal, Y, Ünal, N, Berk, N, and Karakaya, A.E
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- 1998
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38. DNA damage evaluated by the alkaline comet assay in lymphocytes of humans anaesthetized with isoflurane
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Şardaş, S, Karabıyık, L, Aygün, N, and Karakaya, A.E
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- 1998
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39. Genotoxicity studies on professional hair colorists exposed to oxidation hair dyes
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Şardaş, S, Aygün, N, and Karakaya, A.E
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- 1997
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40. Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation
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Şardaş, S., Karahalil, B., Karakaya, A.E., and Şaşmaz, R.
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- 1994
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41. Sister-chromatid exchanges in operating room personnel
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Şardaş, S., Cuhruk, H., Karakaya, A.E., and Atakurt, Y.
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- 1992
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42. The effect of smoking on sister chromatid exchange rate of newborn infants born to smoking mothers
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Şardaş, S., Karahalil, B., Akyol, D., Kükner, S., and Karakaya, A.E.
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- 1995
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43. Assessment of smoking-induced DNA damage in lymphocytes of smoking mothers of newborn infants using the alkaline single-cell gel electrophoresis technique
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Şardaş, S., Walker, D., Akyol, D., and Karakaya, A.E.
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- 1995
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44. Sister-chromatid exchanges in epileptic patients on anticonvulsant therapy
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Şardaş, S., Ada, M., Karakaya, A.E., and Aydin, N.
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- 1994
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45. Increased frequency of sister chromatid exchanges in the peripheral lymphocytes of cigarette smokers
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Şardaş, S., Gök, S., and Karakaya, A.E.
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- 1991
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46. Melatonin ameliorates oxidative DNA damage and protects against formaldehyde-induced oxidative stress in rats
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Aydemir, Sezgin, Akgun, Sevcan Gul, Beceren, Ayfer, Yuksel, Meral, Kumas, Meltem, Erdogan, Nusret, Semra Sardas, Omurtag, Gulden Zehra, Aydemir, S., Department of Toxicology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey, Departments of Pathology Laboratory Technicianship, Marmara University, Haydarpasa, Istanbul, Turkey, Akgun, S.G., Department of Toxicology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey, Beceren, A., Department of Toxicology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey, Yuksel, M., Departments of Medical Laboratory Technicianship, Marmara University, Haydarpasa, Istanbul, Turkey, Kumas, M., Medical Laboratory Techniques, Vocational School of Health Related Services, Marmara University, Haydarpasa, Istanbul, Turkey, Erdogan, N., Departments of Pathology Laboratory Technicianship, Marmara University, Haydarpasa, Istanbul, Turkey, Sardas, S., Department of Toxicology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey, Omurtag, G.Z., Department of Toxicology, School of Pharmacy, Istanbul Medipol University, Kavacık-Beykoz, Istanbul, Turkey, and KUMAŞ, Meltem
- Subjects
Chemiluminescence ,Oxidative stress ,Aydemir S., Akgün S. G. , BECEREN A., YÜKSEL M., KUMAŞ M., Erdogan N., Sardas S., Omurtag G. Z. , -Melatonin ameliorates oxidative DNA damage and protects against formaldehyde-induced oxidative stress in rats-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.10, ss.6250-6261, 2017 ,Formaldehyde ,Histopathology ,DNA damage ,Histopa-thology ,Comet assay ,Melatonin - Abstract
WOS: 000400553200039 Formaldehyde (FA) is an organic chemical which is widely used all over the world and has hazardous effects for the environment. FA can react with many biomolecules in the biological systems and lead to toxic effects on humans. Melatonin (MEL), a neurohormone produced by pineal gland, has been shown to be an effective antioxidant with free radical scavenging properties. The present study aimed to evaluate the ameliorative effects of MEL on FA-induced toxicity by monitoring oxidant/antioxidant and histopathological changes in the lung, liver and kidney tissues of rats as well as DNA damage in the blood samples. FA was administered through inhalation at a rate of 6 ppm for 6 weeks and intraperitoneal injection at a rate of 10 mg/kg/day for 14 days. MEL was administered in related groups at a rate of 10 mg/kg/day. Upon the completion of the experimental protocol, tissues were dissected for processing biochemical assays and routine histological staining. Blood samples were collected to investigate DNA damage with the comet assay and ELISA kit for 8-hydroxydeoxyguanosine (8-OHdG). FA exposures increased the levels of DNA damage, malondialdehyde and myeloperoxidase activity and reduced glutathione levels. FA also significantly raised the level of tissue reactive oxygen species. FA-induced morphological changes in the tissues were also observed with the light microscope. These alterations were reversed by MEL treatment. In conclusion, the present study suggests that oxidative mechanisms play an important role in FA toxicity. MEL ameliorates oxidative tissue and DNA damage resulting from FA-induced toxicity by balancing oxidant-antioxidant status, inhibiting neutrophil infiltration and reducing 8-OHdG level, and might be beneficial in reducing FA-induced oxidative tissue and DNA damage. Commission of Scientific Investigations Projects (BAPKO) of Marmara University [SAG-C-DRP-110915-0414] This study was financially supported by Grant Project No: SAG-C-DRP-110915-0414 from the Commission of Scientific Investigations Projects (BAPKO) of Marmara University.
- Published
- 2017
47. Biological Evaluation and Computational Modelling Studies on N-acyl Hydrazone and 2,5-Substituted 1,3,4-Oxadiazole Derivatives as Non-toxic Antimicrobial Agents.
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Giray B, Kaya N, Fiabane M, Buyuk AS, Küçük HB, Sardas S, and Mori M
- Abstract
Introduction: The increasing use of antibiotics coupled with the lack of innovative and effective antimicrobial agents has increased the development of antimicrobial resistance (AMR) worldwide. To overcome the AMR-associated prolonged disease duration and increased mortality rates, new antimicrobial agents are in high demand. In this context, hydrazone and oxadiazole derivatives are endowed with remarkable biocidal activity, becoming profitable scaffolds in the design of antimicrobial candidates., Method: In this study, the antimicrobial effects of N-acyl hydrazones 1-15 and 2,5-substituted 1,3,4- oxadiazoles 16-27 against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, and clinically isolated Shigella sonnei, Klebsiella pneumoniae, and Candida albicans were evaluated. For this purpose, Kirby-Bauer disc diffusion and MIC tests were carried out, indicating that most of these compounds were active against tested microorganisms. Particularly, several compounds proved active against E. coli, whereas S. aureus showed higher resistance. The genotoxic potential of most active compounds was determined by in vitro alkaline comet assay, and they were found to be non-toxic at studied concentrations., Results: Finally, molecular docking and dynamics (MD) studies identified four compounds as potential inhibitors of bacterial DNA gyrase B (GyrB)., Conclusion: Further exploration of molecular determinants revealed favourable drug-like properties, highlighting the potential of these molecules for subsequent hit-to-lead optimization studies., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2025
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48. Considerations into pharmacogenomics of COVID-19 pharmacotherapy: Hope, hype and reality.
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Al-Taie A, Büyük AŞ, and Sardas S
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- Humans, Precision Medicine, Pandemics, Pharmacogenetics, COVID-19 Drug Treatment
- Abstract
COVID-19 medicines, such as molnupiravir are beginning to emerge for public health and clinical practice. On the other hand, drugs display marked variability in their efficacy and safety. Hence, COVID-19 medicines, as with all drugs, will be subject to the age-old maxim "one size prescription does not fit all". In this context, pharmacogenomics is the study of genome-by-drug interactions and offers insights on mechanisms of patient-to-patient and between-population variations in drug efficacy and safety. Pharmacogenomics information is crucial to tailoring the patients' prescriptions to achieve COVID-19 preventive and therapeutic interventions that take into account the host biology, patients' genome, and variable environmental exposures that collectively influence drug efficacy and safety. This expert review critically evaluates and summarizes the pharmacogenomics and personalized medicine aspects of the emerging COVID-19 drugs, and other selected drug interventions deployed to date. Here, we aim to sort out the hope, hype, and reality and suggest that there are veritable prospects to advance COVID-19 medicines for public health benefits, provided that pharmacogenomics is considered and implemented adequately. Pharmacogenomics is an integral part of rational and evidence-based medical practice. Scientists, health care professionals, pharmacists, pharmacovigilance practitioners, and importantly, patients stand to benefit by expanding the current pandemic response toolbox by the science of pharmacogenomics, and its applications in COVID-19 medicines and clinical trials., Competing Interests: Declaration of competing interest Not applicable., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
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- 2022
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49. Biomonitoring of Heavy Metal(oid)s in the Residents of Abandoned Mining District in Northern Cyprus.
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Kocadal K, Alkas FB, Ulutas OK, Kurt MA, Battal D, Sardas S, Etikan I, and Saygi S
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- Biological Monitoring, Cyprus, Environmental Monitoring, Mining, Metals, Heavy analysis, Metals, Heavy toxicity, Soil Pollutants analysis
- Abstract
Several heavy metal(oid)s are known mutagens and/or carcinogens. Exposure to these elements can lead to the development of malignancies. Gemikonagi, which is in the western part of Cyprus, was the hometown of mining operations. It is believed that the mining site is a significant heavy metal(oid) source for the environment and residents. In this biomonitoring study, a total of 60 blood samples from Gemikonagi region (n = 30) and from a control region located 40 km northeast from the mining site, Tepebasi (n = 30), and 5 soil samples from each region were collected to conduct heavy metal analysis using ICP-MS. To conduct genotoxicity analysis, alkaline comet assay and in vivo micronucleus assays were used. t test for independent samples and Mann-Whitney U tests were applied. Copper and iron were found to be enriched in Gemikonagi, while arsenic was found to be enriched in Tepebasi. Genotoxicity analyses demonstrated a statistically significant increase in parameters of micronuclei frequency (p value = 0.0001) and Comet Assay statistics upon exposure to some elements, such as arsenic (p value = 0.04) and copper (p value = 0.012). The results indicate that a general enrichment in heavy elements is not endemic to Gemikonagi, but a problem that might be generalized to the entirety of Cyprus. Graphical abstract., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.)
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- 2021
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50. The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders.
- Author
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Milić M, Ceppi M, Bruzzone M, Azqueta A, Brunborg G, Godschalk R, Koppen G, Langie S, Møller P, Teixeira JP, Alija A, Anderson D, Andrade V, Andreoli C, Asllani F, Bangkoglu EE, Barančoková M, Basaran N, Boutet-Robinet E, Buschini A, Cavallo D, Costa Pereira C, Costa C, Costa S, Da Silva J, Del Boˊ C, Dimitrijević Srećković V, Djelić N, Dobrzyńska M, Duračková Z, Dvořáková M, Gajski G, Galati S, García Lima O, Giovannelli L, Goroshinskaya IA, Grindel A, Gutzkow KB, Hernández A, Hernández C, Holven KB, Ibero-Baraibar I, Ottestad I, Kadioglu E, Kažimirová A, Kuznetsova E, Ladeira C, Laffon B, Lamonaca P, Lebailly P, Louro H, Mandina Cardoso T, Marcon F, Marcos R, Moretti M, Moretti S, Najafzadeh M, Nemeth Z, Neri M, Novotna B, Orlow I, Paduchova Z, Pastor S, Perdry H, Spremo-Potparević B, Ramadhani D, Riso P, Rohr P, Rojas E, Rossner P, Safar A, Sardas S, Silva MJ, Sirota N, Smolkova B, Staruchova M, Stetina R, Stopper H, Surikova EI, Ulven SM, Ursini CL, Valdiglesias V, Valverde M, Vodicka P, Volkovova K, Wagner KH, Živković L, Dušinská M, Collins AR, and Bonassi S
- Subjects
- Biomarkers blood, DNA Damage genetics, DNA Damage physiology, Humans, Comet Assay methods
- Abstract
The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those factors that can explain the large inter-individual and inter-laboratory variation. International collaborative initiatives such as the hCOMET project - a COST Action launched in 2016 - represent a valuable tool to meet this challenge. The aims of hCOMET were to establish reference values for the level of DNA damage in humans, to investigate the effect of host factors, lifestyle and exposure to genotoxic agents, and to compare different sources of assay variability. A database of 19,320 subjects was generated, pooling data from 105 studies run by 44 laboratories in 26 countries between 1999 and 2019. A mixed random effect log-linear model, in parallel with a classic meta-analysis, was applied to take into account the extensive heterogeneity of data, due to descriptor, specimen and protocol variability. As a result of this analysis interquartile intervals of DNA strand breaks (which includes alkali-labile sites) were reported for tail intensity, tail length, and tail moment (comet assay descriptors). A small variation by age was reported in some datasets, suggesting higher DNA damage in oldest age-classes, while no effect could be shown for sex or smoking habit, although the lack of data on heavy smokers has still to be considered. Finally, highly significant differences in DNA damage were found for most exposures investigated in specific studies. In conclusion, these data, which confirm that DNA damage measured by the comet assay is an excellent biomarker of exposure in several conditions, may contribute to improving the quality of study design and to the standardization of results of the comet assay in human populations., Competing Interests: Declaration of Competing Interest The authors report no declarations of interest., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
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