Search

Ovotesticular disorder of sexual development (DSD), formerly known as true hermaphroditism, is a rare form of DSD in which both testicular and ovarian tissues are present in the same individual either in a single gonad (ovotestis) or in opposite gonads with a testis and an ovary on each side. The diagnosis of ovotesticular DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. Herein, we report two patients with ovotesticular DSD-one presenting with ambiguous genitalia on the third day after birth and the other with short stature and primary amenorrhea in adolescence. Clinical and histopathological investigation revealed a sex-determining region on the Y chromosome (SRY)-positive 46,XX karyotype and bilateral ovotestes in case 1 and a 46,XY karyotype with hypergonadotropic hypogonadism and a streak gonad in one ovotestis with dysgerminoma, gonadoblastoma, and papillary tubal hyperplasia in the contralateral ovotestis in case 2. Laparoscopic examination and gonadal biopsy for histopathological diagnosis remain the cornerstones for a diagnosis of ovotesticular DSD. Moreover, SRY positivity in a 46,XX patient, a 46,XY karyotype, an intra-abdominal gonad, and the age of patient at the time of diagnosis are predictive risk factors for the development of gonadoblastoma and/or dysgerminoma in ovotesticular DSD.

The melanocytic cells of the cervical epithelium are capable of forming the complete spectrum of melanocytic lesions, from benign lentigines to melanoma. Primary malignant melanoma of the uterine cervix is a rare neoplasm with aggressive behavior. The absence of melanin pigment can lead to misdiagnosis as carcinomas, sarcomas, or lymphoma. Immunohistochemical studies should be used for confirmation. In order to consent the cervix as a primary site, exclusion of any other probable primary sites of melanoma is needed. Here, we present a 61-year-old female patient with postmenopausal vaginal bleeding. After cervical smear, diagnosis was confirmed by cervical punch biopsy. Diagn. Cytopathol. 2016;44:535-537. © 2016 Wiley Periodicals, Inc.

Oz: Overin sklerozan stromal tumoru seks kord stromal tumorler kategorisinde yer alir ve bu gruptaki tumorlerin %2-6’sini olusturur. Bu tumor, histolojik olarak hyalinize veya odemli stromayla ayrilan hucreden zengin lobul benzeri yapilardan olusur. Bu alanlar, igsi hucreler ve oval-yuvarlak hucreler olmak uzere iki farkli hucre tipi icerir. Burada sklerozan stromal tumor tanisi almis uc olgu sunulmustur. Amacimiz overin sklerozan stromal tumorunu klinikopatolojik ozellikleri ile sunmak ve ayirici taniyi son literatur bilgilerini de gozden gecirerek tartismaktir. Anahtar Kelimeler: over, over tumorleri, seks kord stromal tumorleri, immunohistokimya Abstract: The sclerosing stromal tumor (SST) of the ovary belongs to sex cord-stromal tumors category and is accounted for 2-6 % of this group. Histologically, this tumor consists of cellular pseudolobules that were separated by hyalinized or oedematous stroma. These areas include two different cell types; spindle shaped and round to oval cells. Three cases diagnosed as sclerosing stromal tumor were presented in this article. Aim of this article is to present clinicopathologic features of SST and to discuss the differential diagnosis by reviewing the recent literature. Keywords: ovary, ovary neoplasms, sex cord-stromal tumor, immunohistochemistry

The melanocytic cells of the cervical epithelium are capable of forming the complete spectrum of melanocytic lesions, from benign lentigines to melanoma. Primary malignant melanoma of the uterine cervix is a rare neoplasm with aggressive behavior. The absence of melanin pigment can lead to misdiagnosis as carcinomas, sarcomas, or lymphoma. Immunohistochemical studies should be used for confirmation. In order to consent the cervix as a primary site, exclusion of any other probable primary sites of melanoma is needed. Here, we present a 61-year-old female patient with postmenopausal vaginal bleeding. After cervical smear, diagnosis was confirmed by cervical punch biopsy. Diagn. Cytopathol. 2016;44:535-537. © 2016 Wiley Periodicals, Inc.

Congenital hyperinsulinism (CHI) is a common cause of hypoglycemia in infants. We report three cases of CHI with differing clinical, biochemical, and molecular genetic spectra. One patient was unresponsive to medical treatment and died after subtotal pancreatectomy because of complications due to the surgery. Two patients have been followed successfully with medical treatment. Early diagnosis and appropriate treatment of CHI are essential to prevent morbidity and mortality.

Acquired toxoplasmosis is more frequently an unrecognized disease. Immunocompetent adults and adolescents with primary infection are generally asymptomatic, or symptoms observed may include malaise, fever, and lymphadenopathy. In contrast, immunocompromised patients may experience severe manifestation including encephalitis and multi system organ failure. We report a case of toxoplasmic hepatitis presenting with hepatomegaly in an immunocompetent patient.

Adenocarcinoma of the appendix is rarely encountered and is usually discovered at the pathology examination of the surgical specimen. Adenocarcinoma of the vermiform appendix is a rare neoplasm and constitutes