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Objective: Contrary to the adult population, cranioplasty after decompressive craniectomy in pediatric population is still carrying the weight of unsolved problems, mainly due to the obvious lack of alternative materials replacing the autologous bone, which high rate of resorption may sometimes turn[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Intraoperative magnet resonance imaging (MRI) has emerged as a powerful adjunct for resection of brain tumors. However, its exact role has not been firmly established. The purpose of our meta-analysis was to determine the impact of intraoperative MRI on surgical management of childhood CNS[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Contrary to the adult population, where high-level evidence-based treatment options analysed by recent trials such as STITCH make an impact on daily routine, the surgical treatment of the traumatic brain injury (TBI) in the pediatric population, especially the usage of decompressive craniectomy[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of dendritic cells. Literature is limited, especially on LCH in adults. As the disease is more common in children, guidelines were established in pediatric oncology. In contrast, there is no comprehensive analysis of differences[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Intraventricular hemorrhage (IVH) is a common complication of premature neonates with small birth weight, which often leads to hydrocephalus and treatment with ventriculoperitoneal (VP) shunting procedures. Trapped fourth ventricle (TFV) can be a devastating consequence of the subsequent [for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: Brain tumors in infants are rare and form a distinct subgroup of pediatric brain tumors. These tumors differ from tumors in older children with respect to histology and management and tend to have a poorer outcome. Malignant histology is common, with persistently poor outcomes evolving adjuvant[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: Misplacement of ventricular catheter in shunt surgery occurs in 40% with freehand technique and is a risk for early shunt failure resulting in additional morbidity. The goal of this retrospective, single center study was to analyze the impact of using real-time ultrasound guidance on[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Objective: Chordoma is a rare, potentially malignant neoplasm, believed to derive from the fetal notochord affecting adults primarily. It occurs in the whole neuroaxis, but is mainly seen in the clival or sacral area. For poorly differentiated chordoma, loss of expression of SMARCB1/INI1, a possible[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Hemangiomas are very frequent benign spinal tumors (9–12 %). However, epidural location is extremely rare. At present, only 50 cases were reported in the literature during the last ten years. We proposed to analyze clinical and radiological features of this rare entity treated[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

El objetivo del presente estudio fue analizar. La epidemiología y los factores de riesgo específicos de la lesión cerebral traumática (TBI) en los cómics ilustrados de Asterix. Entre la literatura ilustrada, el TBI es un patrón de lesión predominante. Métodos Se realizó un análisis retrospectivo de TBI en los 34 cómics de Asterix mediante el examen del estado neurológico inicial y los signos de TBI. Los datos clínicos se correlacionaron con la información sobre el mecanismo de trauma, los antecedentes socioculturales de las víctimas y los agresores y las circunstancias de los traumas, para identificar factores de riesgo específicos. Resultados Se identificaron setecientas cuatro TBIs. La mayoría de las personas involucradas eran adultos y hombres. La principal causa de trauma fue el asalto (98.8%). Los traumas se clasificaron como graves en más del 50% (GCS 3–8). Se identificaron diferentes déficits neurológicos y signos de fracturas basales del cráneo. Aunque más de la mitad de las víctimas de lesiones en la cabeza tenían un deterioro inicial grave de la conciencia, no se encontró ningún caso de muerte o déficit neurológico permanente. El grupo más grande de personajes con lesiones en la cabeza estaba constituido por romanos (63.9%), mientras que los galos causaron casi el 90% de las TBI. El 70,5% de las víctimas había usado un casco, pero se había perdido en la gran mayoría de los casos (87,7%). En el 83% de los casos, las TBI fueron causadas bajo la influencia de un agente de dopaje llamado "la poción mágica"., The goal of the present study was to analyze the epidemiology and specific risk factors of traumatic brain injury (TBI) in the Asterix illustrated comic books. Among the illustrated literature, TBI is a predominating injury pattern. Methods A retrospective analysis of TBI in all 34 Asterix comic books was performed by examining the initial neurological status and signs of TBI. Clinical data were correlated to information regarding the trauma mechanism, the sociocultural background of victims and offenders, and the circumstances of the traumata, to identify specific risk factors. Results Seven hundred and four TBIs were identified. The majority of persons involved were adult and male. The major cause of trauma was assault (98.8%). Traumata were classified to be severe in over 50% (GCS 3–8). Different neurological deficits and signs of basal skull fractures were identified. Although over half of head-injury victims had a severe initial impairment of consciousness, no case of death or permanent neurological deficit was found. The largest group of head-injured characters was constituted by Romans (63.9%), while Gauls caused nearly 90% of the TBIs. A helmet had been worn by 70.5% of victims but had been lost in the vast majority of cases (87.7%). In 83% of cases, TBIs were caused under the influence of a doping agent called “the magic potion”.

Background The goal of the present study was to analyze the epidemiology and specific risk factors of traumatic brain injury (TBI) in the Asterix illustrated comic books. Among the illustrated literature, TBI is a predominating injury pattern. Methods A retrospective analysis of TBI in all 34 Asterix comic books was performed by examining the initial neurological status and signs of TBI. Clinical data were correlated to information regarding the trauma mechanism, the sociocultural background of victims and offenders, and the circumstances of the traumata, to identify specific risk factors. Results Seven hundred and four TBIs were identified. The majority of persons involved were adult and male. The major cause of trauma was assault (98.8%). Traumata were classified to be severe in over 50% (GCS 3–8). Different neurological deficits and signs of basal skull fractures were identified. Although over half of head-injury victims had a severe initial impairment of consciousness, no case of death or permanent neurological deficit was found. The largest group of head-injured characters was constituted by Romans (63.9%), while Gauls caused nearly 90% of the TBIs. A helmet had been worn by 70.5% of victims but had been lost in the vast majority of cases (87.7%). In 83% of cases, TBIs were caused under the influence of a doping agent called “the magic potion”. Conclusions Although over half of patients had an initially severe impairment of consciousness after TBI, no permanent deficit could be found. Roman nationality, hypoglossal paresis, lost helmet, and ingestion of the magic potion were significantly correlated with severe initial impairment of consciousness (p≤0.05).

Background The goal of the present study was to analyze the epidemiology and specific risk factors of traumatic brain injury (TBI) in the Asterix illustrated comic books. Among the illustrated literature, TBI is a predominating injury pattern. Methods A retrospective analysis of TBI in all 34 Asterix comic books was performed by examining the initial neurological status and signs of TBI. Clinical data were correlated to information regarding the trauma mechanism, the sociocultural background of victims and offenders, and the circumstances of the traumata, to identify specific risk factors. Results Seven hundred and four TBIs were identified. The majority of persons involved were adult and male. The major cause of trauma was assault (98.8%). Traumata were classified to be severe in over 50% (GCS 3–8). Different neurological deficits and signs of basal skull fractures were identified. Although over half of head-injury victims had a severe initial impairment of consciousness, no case of death or permanent neurological deficit was found. The largest group of head-injured characters was constituted by Romans (63.9%), while Gauls caused nearly 90% of the TBIs. A helmet had been worn by 70.5% of victims but had been lost in the vast majority of cases (87.7%). In 83% of cases, TBIs were caused under the influence of a doping agent called “the magic potion”., 5 páginas

Background: The goal of the present study was to analyze the epidemiology and specific risk factors of traumatic brain injury (TBI) in the Asterix illustrated comic books. Among the illustrated literature, TBI is a predominating injury pattern. Methods: A retrospective analysis of TBI in all 34 Asterix comic books was performed by examining the initial neurological status and signs of TBI. Clinical data were correlated to information regarding the trauma mechanism, the sociocultural background of victims and offenders, and the circumstances of the traumata, to identify specific risk factors. Results: Seven hundred and four TBIs were identified. The majority of persons involved were adult and male. The major cause of trauma was assault (98.8%). Traumata were classified to be severe in over 50% (GCS 3–8). Different neurological deficits and signs of basal skull fractures were identified. Although over half of head-injury victims had a severe initial impairment of consciousness, no case of death or permanent neurological deficit was found. The largest group of head-injured characters was constituted by Romans (63.9%), while Gauls caused nearly 90% of the TBIs. A helmet had been worn by 70.5% of victims but had been lost in the vast majority of cases (87.7%). In 83% of cases, TBIs were caused under the influence of a doping agent called “the magic potion”. Conclusions: Although over half of patients had an initially severe impairment of consciousness after TBI, no permanent deficit could be found. Roman nationality, hypoglossal paresis, lost helmet, and ingestion of the magic potion were significantly correlated with severe initial impairment of consciousness (p≤0.05).

Objective: Treatment and prognosis of pediatric brain tumours depend mainly on the histological diagnosis including the tumour grade according to WHO classification. Therefore, it would be ideal to achieve further information regarding the grading of childhood brain tumours preoperatively. The aim of[for full text, please go to the a.m. URL], 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010

Die konventionelle Therapie von malignen Gliomen (operative Entfernung, Bestrahlung, Chemotherapie) erzielt keine nachhaltigen Erfolge. Die Prognose von Patienten mit malignen Gliomen richtet sich nach wie vor nach der histologischen Wertigkeit des Tumors und dem Karnowski-Index des Patienten. Um die Ergebnisse der Therapie von malignen Gliomen zu verbessern, werden zusätzliche therapeutische Möglichkeiten benötigt. In früheren klinischen Studien konnte gezeigt werden, dass sich unter der Therapie mit H15® die perifokalen Ödeme bei Patienten mit malignen Gliomen signifikant zurückbilden und sich zudem ihre klinischen Symptome verbessern. Es war darüber hinaus eine Abnahme der Ausscheidung von LTE4, einem Metaboliten der Leukotriensynthese in Hirntumoren, zu beobachten. Zudem wurde in Zellkulturen eine proliferationshemmende Aktivität von H15® festgestellt. Mit der vorliegenden tierexperimentellen Studie wurden Einflüsse von H15® auf das Tumorwachstum untersucht. 40 weiblichen Wistar-Ratten mit einem Gewicht von 220g bis 250g wurden C6-Gliomzellen in den rechten Nucleus caudatus injiziert. Die Tiere wurden randomisiert und in vier Gruppen zu jeweils 10 Tieren unterteilt. Drei dieser Gruppen wurden mit verschiedenen Dosen von H15® behandelt; die vierte Gruppe diente als Kontrollgruppe. Nach 14 tägiger Verabreichung von H15® (3mal täglich) vom Tag nach der Tumorzellimplantation an wurden die Gehirne entnommen und mikroskopisch untersucht. Es wurde eine signifikante Stabilisierung des Vitalitätsindex in der Behandlungsgruppe mit der höchsten Medikamentendosis im Vergleich zur Kontrollgruppe aufgezeigt. Abhängig von der Dosierung wurde weiterhin ein signifikanter Unterschied im Tumorvolumen festgestellt. Der Anteil induzierter, apoptotischer Zellen war in Tieren, die mit hohen Dosen behandelt wurden, signifikant größer, als bei Tieren mit niedriger Dosierung. Bei den Tieren wurden keine bzw. geringe Nebenwirkungen auf das verabreichte Medikament beobachtet. Diese Daten belegen einen hemmenden Einfluss von H15® auf das Wachstum von C6-Gliomzellen in Rattenhirnen., The conventional malignant glioma therapy (surgery, radiation therapy and chemotherapy) does not yield satisfying results. The prognosis of the glioma patient depends more on the histological grading of the tumor and the patient s age than on the therapy. Especially the adjuvant chemotherapy does not influence survival time in glioma patients significantly. To improve results in malignant glioma therapy additional therapeutic regimes are necessary. An earlier study showed a significant reduction of perifocal edema in patients with malignant glioma under therapy with H15®, accompanied with a clinical improvement. Also a decrease of urinary LTE4-excretion as a metabolite of leukotriene synthesis in brain tumors was observed. Furthermore a proliferation inhibiting activity of H15® was found in cell cultures. The purpose of this experimental study was to examine the effects of the boswellic acids, which are constituents of an extract from gum resin, on tumor growth in vivo. Fourty female wistar rats weighing 220 250 g were inoculated C6 tumor cells into the right caudate nucleus and randomization into 4 groups each with 10 rats. The treatment groups received different dosages and were compared to a control group without any additional treatment. Drug treatment (3 times per day) was started immediately after implantation and stopped after 14 days. The animals were sacrificed and the brains were examined microscopically. Comparing low and high dosage of H15® treatment a significant difference in tumor volume was detected. The vitality index in animals with high dose treatment was significantly better than in the low dose treatment group. The proportion of apoptotic tumor cells in animals with high dose treatment was significantly larger than in the low dose treatment group. Only milde side effects were observed by the animal during the therapy with H15®. These data demonstrate an antiproliferative influence of H15® in rat glioma growth.