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6 results on '"Saroj, Jyotshana"'

1. Generating a Peptide Library Using the Repeats of Amino Acid Scaffolds Created by Sliding the Framework of a 7-mer Human Chemerin Segment and Discovery of Potent Antibacterial and Antimycobacterial Peptides

Author

Akhtar, Sariyah, Ansari, Mohd Mustkim, Verma, Rahul Dev, Sharma, Juhi, Gupta, Arvind, Dhuriya, Rajendra Kumar, Verma, Devesh Pratap, Saroj, Jyotshana, Ali, Mehmood, Verma, Neeraj Kumar, Mitra, Kalyan, Singh, Bhupendra Narain, and Ghosh, Jimut Kanti

Abstract

The quest for new approaches for generating novel bioactive designer proteins/peptides has continued with their success in various biomedical applications. Previously, we designed a 14-mer α-helical peptide with antimicrobial and antimycobacterial activities by employing a tandem repeat of the 7-mer, “KVLGRLV” human chemerin segment. Herein, we devised a new method of “sliding framework” with this segment to create amino acid scaffolds of varying sizes and sequences and explored the design of a peptide library with antibacterial and antimycobacterial activities. By utilizing 2 to 7 repeats of these 2 to 6-residue scaffolds, we designed and synthesized 30 peptides of 10–16 residue lengths. Thus, we identified novel AMPs with α-helical, β-sheet, and random coil structures, membrane-destabilizing, and intracellular modes of action, and 9 of them showed therapeutic indices between 100 and 750. Three and two of these nine peptides showed in vivoantibacterial and antitubercular efficacies against Escherichia coliATCC 25922 and Mycobacterium bovisBCG infections, respectively, in a mouse model.

Published
2025
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2. Characterization of a Myeloid Differentiation Factor 2-Derived Peptide that Facilitates THP-1 Macrophage-Mediated Phagocytosis of Gram-Negative Bacteria

Author

Tandon, Anshika, primary, Harioudh, Munesh Kumar, additional, Verma, Neeraj Kumar, additional, Saroj, Jyotshana, additional, Gupta, Arvind, additional, Pant, Garima, additional, Tripathi, Jitendra Kumar, additional, Kumar, Amit, additional, Kumari, Tripti, additional, Tripathi, Amit Kumar, additional, Mitra, Kalyan, additional, and Ghosh, Jimut Kanti, additional

Published
2024
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4. 10-Residue MyD88-Peptide Adopts β-Sheet Structure, Self-Assembles, Binds to Lipopolysaccharides, and Rescues Mice from Endotoxin-Mediated Lung-Infection and Death

Author

Kumari, Tripti, primary, Verma, Devesh Pratap, additional, Kuldeep, Jitendra, additional, Dhanabal, Vidhya Bharathi, additional, Verma, Neeraj Kumar, additional, Sahai, Rohit, additional, Tripathi, Amit Kumar, additional, Saroj, Jyotshana, additional, Ali, Mehmood, additional, Mitra, Kalyan, additional, Siddiqi, Mohammad Imran, additional, Bhattacharjya, Surajit, additional, and Ghosh, Jimut Kanti, additional

Published
2022
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5. Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities

Author

Pratap Verma, Devesh, primary, Ansari, Mohd Mustkim, additional, Verma, Neeraj Kumar, additional, Saroj, Jyotshana, additional, Akhtar, Sariyah, additional, Pant, Garima, additional, Mitra, Kalyan, additional, Singh, Bhupendra Narain, additional, and Ghosh, Jimut Kanti, additional

Published
2021
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