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Your search keyword '"Sarraf-Yazdi, Shiva"' showing total 32 results
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32 results on '"Sarraf-Yazdi, Shiva"'

4. A Scoping Review of Professional Identity Formation in Undergraduate Medical Education

Author

Sarraf-Yazdi, Shiva, Teo, Yao Neng, How, Ashley Ern Hui, Teo, Yao Hao, Goh, Sherill, Kow, Cheryl Shumin, Lam, Wei Yi, Wong, Ruth Si Man, Ghazali, Haziratul Zakirah Binte, Lauw, Sarah-Kei, Tan, Javier Rui Ming, Lee, Ryan Bing Qian, Ong, Yun Ting, Chan, Natalie Pei Xin, Cheong, Clarissa Wei Shuen, Kamal, Nur Haidah Ahmad, Lee, Alexia Sze Inn, Tan, Lorraine Hui En, Chin, Annelissa Mien Chew, Chiam, Min, and Krishna, Lalit Kumar Radha

Published
2021
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16. The toll of staying dry in a sea of context.

Author

Sarraf‐Yazdi, Shiva and Compton, Scott

Subjects
*SCHOOL environment, *COURSE evaluation (Education), *MEDICAL education, *EDUCATIONAL outcomes, *MEDICAL logic, *PATIENT safety
Abstract

Compton and Sarraf‐Yazdi explore the role of context, drawing Connections across articles focused on the concept of Situation to advocate for collaborative communities with multidisciplinary expertise to improve scholarship in the field. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival.

Author

Mi J, Zhang X, Giangrande PH, McNamara JO 2nd, Nimjee SM, Sarraf-Yazdi S, Sullenger BA, and Clary BM

Subjects
Cell Proliferation, Cell Survival drug effects, Cells, Cultured drug effects, Dose-Response Relationship, Drug, Drug Delivery Systems methods, Endothelial Cells drug effects, Humans, Aptamers, Nucleotide administration & dosage, Endothelial Cells cytology, Endothelial Cells physiology, Integrin alphaVbeta3 metabolism, RNA administration & dosage
Abstract

Alphavbeta3 integrin is a crucial factor involved in a variety of physiological processes, such as cell growth and migration, tumor invasion and metastasis, angiogenesis, and wound healing. Alphavbeta3 integrin exerts its effect by regulating endothelial cell (EC) migration, proliferation, and survival. Inhibiting the function of alphavbeta3 integrin, therefore, represents a potential anti-cancer, anti-thrombotic, and anti-inflammatory strategy. In this study, we tested an RNA aptamer, Apt-alphavbeta3 that binds recombinant alphavbeta3 integrin, for its ability to bind endogenous alphavbeta3 integrin on the surface of cells in culture and to subsequently affect cellular response. Our data illustrate that Apt-alphavbeta3 binds alphavbeta3 integrin expressed on the surface of live HUVECs. This interaction significantly decreases both basal and PDGF-induced cell proliferation as well as inhibition of cell adhesion. Apt-alphavbeta3 can also reduce PDGF-stimulated tube formation and increase HUVEC apoptosis through inhibition of FAK phosphorylation pathway. Our results demonstrate that by binding to its target, Apt-alphavbeta3 can efficiently inhibit human EC proliferation and survival, resulting in reduced angiogenesis. It predicts that Apt-alphavbeta3 could become useful in both tumor imaging and the treatment of tumor growth, atherosclerosis, thrombosis, and inflammation.

Published
2005
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