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22 results on '"Sartori, Marina R."'

7. Cholinergic regulation along the pulmonary arterial tree of the South American rattlesnake: vascular reactivity, muscarinic receptors, and vagal innervation

Author

Filogonio, Renato, primary, Sartori, Marina R., additional, Morgensen, Susie, additional, Tavares, Driele, additional, Campos, Rafael, additional, Abe, Augusto S., additional, Taylor, Edwin W., additional, Rodrigues, Gerson J., additional, De Nucci, Gilberto, additional, Simonsen, Ulf, additional, Leite, Cléo A. C., additional, and Wang, Tobias, additional

Published
2020
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10. The electrocardiogram of vertebrates: Evolutionary changes from ectothermy to endothermy

Author

Boukens, Bastiaan J.D., primary, Kristensen, Ditte L., additional, Filogonio, Renato, additional, Carreira, Laura B.T., additional, Sartori, Marina R., additional, Abe, Augusto S., additional, Currie, Shannon, additional, Joyce, William, additional, Conner, Justin, additional, Opthof, Tobias, additional, Crossley, Dane A., additional, Wang, Tobias, additional, and Jensen, Bjarke, additional

Published
2019
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11. Developmental staging table of the green iguana

Author

Lima, Fabiano C., primary, Py‐Daniel, Tainã R., additional, Sartori, Marina R., additional, Abe, Augusto S., additional, Santos, Odeony Paulo dos, additional, Freitas, Letícia M., additional, Pereira, Kleber F., additional, and Sebben, Antonio, additional

Published
2018
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16. Developmental staging table of the green iguana.

Author

Lima, Fabiano C., Py‐Daniel, Tainã R., Sartori, Marina R., Abe, Augusto S., Santos, Odeony Paulo dos, Freitas, Letícia M., Pereira, Kleber F., and Sebben, Antonio

Subjects
IGUANAS, LIZARDS, CLAWS, EMBRYOS, FEMALE reproductive organs
Abstract

Embryonic staging tables provide information to standardize embryological investigations and to subsidize discussions about evolution. We have established a developmental staging table for Iguana iguana iguana. The sample was composed of 142 embryos, incubated at a constant temperature and collected at regular intervals. Morphological features as pharyngeal arches, craniofacial structures, eyes, limbs, claws, pigmentation, scales and egg tooth were evaluated to determine development stages. The normal staging table includes 17 stages from oviposition to hatching, based on chronology and morphological external features. Stages from 1 to 27 occur before oviposition. Stage 28 was the first described, because all embryos presented limb bud anlage, key feature of the previous stage. We used pharyngeal arches and limb buds to describe the first stages; claws, genital papilla and scales to describe the middle stages; and pigmentation, size and egg tooth to describe the last stages. Incubation lasted approximately 2 months in a controlled environment. The results were similar to the data from other lizards, confirming the embryonic conservative pattern of the group. [ABSTRACT FROM AUTHOR]

Published
2019
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21. Enhanced resistance to Ca2+-induced mitochondrial permeability transition in the long-lived red-footed tortoise Chelonoidis carbonaria

Author

Sartori, Marina R., Navarro, Claudia D. C., Castilho, Roger F., and Vercesi, Anibal E.

Abstract

The interaction between supraphysiological cytosolic Ca2+ levels and mitochondrial redox imbalance mediates the mitochondrial permeability transition (MPT). The MPT is involved in cell death, diseases and aging. This study compared the liver mitochondrial Ca2+ retention capacity and oxygen consumption in the long-lived red-footed tortoise (Chelonoidis carbonaria) with those in the rat as a reference standard. Mitochondrial Ca2+ retention capacity, a quantitative measure of MPT sensitivity, was remarkably higher in tortoises than in rats. This difference was minimized in the presence of the MPT inhibitors ADP and cyclosporine A. However, the Ca2+ retention capacities of tortoise and rat liver mitochondria were similar when both MPT inhibitors were present simultaneously. NADH-linked phosphorylating respiration rates of tortoise liver mitochondria represented only 30% of the maximal electron transport system capacity, indicating a limitation imposed by the phosphorylation system. These results suggested underlying differences in putative MPT structural components [e.g. ATP synthase, adenine nucleotide translocase (ANT) and cyclophilin D] between tortoises and rats. Indeed, in tortoise mitochondria, titrations of inhibitors of the oxidative phosphorylation components revealed a higher limitation of ANT. Furthermore, cyclophilin D activity was approximately 70% lower in tortoises than in rats. Investigation of critical properties of mitochondrial redox control that affect MPT demonstrated that tortoise and rat liver mitochondria exhibited similar rates of H2O2 release and glutathione redox status. Overall, our findings suggest that constraints imposed by ANT and cyclophilin D, putative components or regulators of the MPT pore, are associated with the enhanced resistance to Ca2+-induced MPT in tortoises.

Published
2022
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22. Cholinergic regulation along the pulmonary arterial tree of the South American rattlesnake: vascular reactivity, muscarinic receptors, and vagal innervation.

Author

Filogonio R, Sartori MR, Morgensen S, Tavares D, Campos R, Abe AS, Taylor EW, Rodrigues GJ, De Nucci G, Simonsen U, Leite CAC, and Wang T

Subjects
Acetylcholine pharmacology, Animals, Cholinergic Agonists pharmacology, Crotalus, Electric Stimulation, Pulmonary Artery drug effects, Pulmonary Artery innervation, Pulmonary Artery metabolism, Receptors, Muscarinic metabolism, Respiratory Sinus Arrhythmia physiology, Vagus Nerve physiology
Abstract

Vascular tone in the reptilian pulmonary vasculature is primarily under cholinergic, muscarinic control exerted via the vagus nerve. This control has been ascribed to a sphincter located at the arterial outflow, but we speculated whether the vascular control in the pulmonary artery is more widespread, such that responses to acetylcholine and electrical stimulation, as well as the expression of muscarinic receptors, are prevalent along its length. Working on the South American rattlesnake ( Crotalus durissus ), we studied four different portions of the pulmonary artery (truncus, proximal, distal, and branches). Acetylcholine elicited robust vasoconstriction in the proximal, distal, and branch portions, but the truncus vasodilated. Electrical field stimulation (EFS) caused contractions in all segments, an effect partially blocked by atropine. We identified all five subtypes of muscarinic receptors (M 1 -M 5 ). The expression of the M 1 receptor was largest in the distal end and branches of the pulmonary artery, whereas expression of the muscarinic M 3 receptor was markedly larger in the truncus of the pulmonary artery. Application of the neural tracer 1,1'-dioctadecyl-3,3,3',3'-tetramethylindo-carbocyanine perchlorate (DiI) revealed widespread innervation along the whole pulmonary artery, and retrograde transport of the same tracer indicated two separate locations in the brainstem providing vagal innervation of the pulmonary artery, the medial dorsal motor nucleus of the vagus and a ventro-lateral location, possibly constituting a nucleus ambiguus. These results revealed parasympathetic innervation of a large portion of the pulmonary artery, which is responsible for regulation of vascular conductance in C. durissus , and implied its integration with cardiorespiratory control.

Published
2020
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