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1. Treatment of Ulcerative Colitis: Impact on Platelet Aggregation

Author

Sasa Peric, Zeljko Todorovic, Nebojsa Zdravkovic, Andjela Gogic, Stefan Simovic, Vesna Grbovic, Mladen Maksic, Stefan Jakovljevic, Olivera Milovanovic, and Natasa Zdravkovic

Subjects
ulcerative colitis, platelet aggregation, infliximab, adalimumab, vedolizumab, azathioprine, Medicine (General), R5-920
Abstract

Background and Objectives: Ulcerative colitis is chronic and/or progressive inflammation of the colorectal mucosa and submucosa and represents one of two major inflammatory bowel diseases. Ulcerative colitis has been associated with increased risk of arteriosus and venous thrombosis. There are numerous factors responsible for this; one of them is platelet activation and aggregation. The objective of our study was to determine if different treatment options for ulcerative colitis have an impact on platelet aggregation. Materials and Methods: This research was a prospective, observational study and included 94 newly diagnosed patients with UC divided into four treatment groups. For all patients, we measured platelet aggregability by using an impedance aggregometry method with a multiplate analyzer before and after treatment with infliximab, adalimumab, vedolizumab and azathioprine. A Paired Samples t test was performed in order to determine the difference in platelet aggregability before and after a certain therapy, since the data followed a normal distribution. Taking into account the impact of some clinical characteristics, multiple linear regression was conducted for the purpose of estimating the effect of therapy on the level of reduction in platelet aggregability. Results: All four drugs significantly reduced platelet aggregability. After we excluded the influence of clinical and endoscopic scores and disease localization on the results, we found that infliximab had the greatest anti-platelet activity. Conclusions: In addition to the well-known traditional risk factors for atherosclerosis, activation and aggregation of platelets play a significant role in the development of arterial thrombosis, and our results suggested that therapy use for the treatment of UC, especially infliximab, can have a great impact on cardiovascular morbidity and mortality by decreasing platelet aggregability.

Published
2023
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2. Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials

Author

Rustem, Abdulkhakov, Norasiah, Abu Bakar, Humberto, Aguilar, Diego, Aizenberg, Hale, Akpinar, Evangelos, Akriviadis, Olga, Alexeeva, Bagdadi, Alikhanov, Andres, Alvarisqueta, Ashwin, Ananthakrishnan, Jane, Andrews, Tomasz, Arlukowicz, Nathan, Atkinson, Ozlen, Atug, Mauro, Bafutto, Jozef, Balaz, George, Bamias, Marko, Banic, Andrey, Baranovsky, Guerino, Barbalaco Neto, Metin, Basaranoglu, Curtis, Baum, Stefan, Baydanov, William, Bennetts, Fatih, Besisik, Sudhir, Bhaskar, Andrzej, Bielasik, Leonid, Bilianskyi, Bahri, Bilir, Pavol, Blaha, Verle, Bohman, Julia, Borissova, Vladimir, Borzan, Francisco, Bosques-Padilla, Yoram, Bouhnik, James, Brooker, Tetiana, Budko, Igor, Budzak, Ivan, Bunganic, Jonathon, Chapman, Azlida, Che' Aun, Tatiana, Chernykh, Michael, Chiorean, Ivan, Chopey, Dimitrios, Christodoulou, Pui Shan, Chu, Galina, Chumakova, Andrew, Cummins, Robert, Cunliffe, Mirjana, Cvetkovic, Ulku, Dagli, Wit Cezary, Danilkiewicz, Olena, Datsenko, Carlos Fernando, de Magalhães Francesconi, Henry, Debinski, Elena, Deminova, Jelena, Derova, John Nik, Ding, Julia, Dmitrieva, Oleg, Dolgikh, Tomas, Douda, Piotr, Drobinski, Gerald, Dryden, Pedro, Duarte Gaburri, George Aaron, DuVall, Mikhail, Dvorkin, Craig, Ennis, Yusuf, Erzin, Galyna, Fadieienko, Oleksandr, Fediv, Olga, Fedorishina, Miroslav, Fedurco, Roland, Fejes, Jorge, Fernandez, Monica Lorena, Fernandez, Lucky, Flores, Bradley, Freilich, Keith, Friedenberg, Sergio, Fuster, Beata, Gawdis-Wojnarska, Fabio Leonel, Gil Parada, Edgardo Daniel, Gimenez, Nataliia, Golovchenko, Oleksandr, Golovchenko, Maciej, Gonciarz, Can, Gonen, Glenn, Gordon, Milos, Gregus, Vladimir, Grinevich, Rogelio, Guajardo Rodriguez, Stephen, Hall, John, Hanson, Marek, Hartleb, Xavier, Hebuterne, Peter, Hendy, Robert, Herring, David, Hetzel, Peter, Higgins, Raouf, Hilal, Ida Normiha, Hilmi, Tibor, Hlavaty, Richard, Holman, Gerald, Holtmann, John, Hong, Frantisek, Horvath, Ihor, Hospodarskyy, Irena, Hrstic, Sadettin, Hulagu, Luis Alberto, Ibarra Verdugo, Ikechukwu, Ibegbu, Stephen, Inns, Vladimir, Ivashkin, James, Izanec, Rajesh, Jain, Zofia, Jamrozik-Kruk, Victor, Kamburov, John, Karagiannis, Tarkan, Karakan, Marek, Karczewski, Irina, Kasherininova, Seymour, Katz, Barry, Kaufman, Edita, Kazenaite, Irina, Kholina, Sunil, Khurana, Jaroslaw, Kierkus, Anzela, Kiselevska, Dariusz, Kleczkowski, Volodymyr, Klymenko, Slavko, Knezevic, Malgorzata, Kondusz-Szklarz, Natalya, Korablina, Bartosz, Korczowski, Lyubomir, Kosturkov, Iskren, Kotzev, Georgios, Kouklakis, Ioannis, Koutroubakis, Richard, Krause, Ian, Kronborg, Miodrag, Krstic, Zeljko, Krznaric, Mikolaj, Krzyzanowski, Grazyna, Kulig, Karin, Kull, Limas, Kupcinskas, Mark, Lamet, Tatjana, Latinovic Radakovic, Rupert, Leong, Wai Keung, Leung, Henry, Levine, Michael Kin Kong, Li, Lúcia, Libanez Bessa Campelo Braga, Maria, Livzan, Tetiana, Lohdanidi, Maria Helena, Louzada Pereira, John, Lowe, Kresimir, Luetic, Milan, Lukas, Yurii, Lymar, Finlay, Macrae, Anu, Mäelt, Igor, Maev, Arkadiusz, Mamos, Gerasimos, Mantzaris, Benno, Margus, Ivanka, Marinova, Inna, Markevych, Mario, Markov, Srdjan, Markovic, Juan Ricardo, Marquez Velasquez, Felipe, Mazzoleni, Konstantinos, Mimidis, Brent, Mitchell, Gregory, Moore, Luis Alonso, Morales Garza, Salvatore, Moscatello, Yuriy, Mostovoy, Reme, Mountifield, Aleksandar, Nagorni, Viacheslav, Neshta, Andrey, Obrezan, Oleksandr, Oliinyk, Genoile, Oliveira Santana Silva, Maria, Orzeszko, Vladimir, Pavlenko, Dimitar, Pavlov, Mariana, Penkova, Sasa, Peric, Plamen, Petkov, Asen, Petrov, Plamen, Petrov, Michaela, Petrova, Raymond, Phillips, Sergio, Pintor Chacon, Igor, Polianskyi, Ludmyla, Prystupa, Mykhailo, Pugach, Ana Teresa, Pugas Carvalho, Aldis, Pukitis, Jiri, Pumprla, Volodymyr, Pyrogovskyy, Istvan, Racz, Graham, Radford-Smith, Raja Affendi, Raja Ali, Daniel, Ramos Castañeda, Odery, Ramos Júnior, David, Rausher, Andrey, Rebrov, Jaroslaw, Regula, Amir, Rezk, Viktoriia, Reznikova, Iaroslava, Rishko, Xavier, Roblin, Grigory, Rodoman, Carlos Arturo, Rojas Rodriguez, Jerzy, Rozciecha, David, Rubin, Maciej, Rupinski, Jacek, Rzucidlo, Oleg, Sablin, Halil, Sahin, Rosemi, Salleh, Douglas, Samuel, Antonio, Scafuto Scotton, Robert, Schnabel, Michael, Schulman, Michael, Schultz, John, Scott, Shahriar, Sedghi, Ahmad, Shaban, Marina, Shapina, Natalia, Shaposhnikova, Oksana, Shchukina, Alex, Sherman, Irina, Shumikhina, Vladimir, Simanenkov, Vladislav, Simonov, Giedrius, Simulionis, Igor, Skrypnyk, Zbigniew, Sliwowski, Jan, Smid, Mahmood, Solaiman, Najm, Soofi, Konstantinos, Soufleris, Zoia, Spassova, Mykola, Stanislavchuk, Krystyna, Stec-Michalska, Jonathas, Stifft, Simeon, Stoinov, Girgina, Stoyanova, Keith, Sultan, Lindsey, Surace, Dimitar, Takov, Jaak, Tälli, Ludmila, Tankova, Hugo, Tanno, Dino, Tarabar, Elias, Tarakji, Konstantin, Tchernev, Hoi Poh, Tee, Lena, Thin, Carlton, Thomas, Irina, Tishaeva, Tsveta, Todorova, Oleksandr, Tokarenko, Ivars, Tolmanis, Ratko, Tomasevic, Vasiliy, Trofimov, Zsolt, Tulassay, Belkis, Unsal, Alma, Uzunova-Genova, John, Valentine, Ekaterina, Valuyskikh, Eduardo, Vasconcellos, Galina, Vasileva, Sergiy, Vasylyuk, Byron, Vaughn, Francisco, Velazquez, Vadym, Vizir, Borislav, Vladimirov, Miroslava, Volfova, Petr, Vyhnalek, Ian, Wallace, Marek, Waluga, William, Watkins, John, Weber, Anna, Wiechowska-Kozlowska, Nathaniel, Winstead, Pawel, Wojtkiewicz, Barbara, Wozniak-Stolarska, Bruce, Yacyshyn, Alexey, Yakovlev, Ziad, Younes, Lígia, Yukie Sassaki, Ilhami, Yuksel, Jan, Zachar, Cyrla, Zaltman, Natasa, Zdravkovic Petrovic, Vyacheslav, Zhdan, Maryna, Zinchenko, Maciej, Zymla, Rubin, David T, Dotan, Iris, DuVall, Aaron, Bouhnik, Yoram, Radford-Smith, Graham, Higgins, Peter D R, Mishkin, Daniel S, Arrisi, Pablo, Scalori, Astrid, Oh, Young S, Tole, Swati, Chai, Akiko, Chamberlain-James, Kirsten, Lacey, Stuart, McBride, Jacqueline, and Panés, Julian

Published
2022
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3. Risk factors for malnutrition among hospitalized gastroenterological patients

Author

Sasa Peric, Stanko Petrovic, Andrija Roganović, Ana Roganović, and Branka Roganovic

Subjects
Medicine (General), medicine.medical_specialty, business.industry, Severe disease, malnutrition, Disease, medicine.disease, Malignancy, Logistic regression, nutritional status, Malnutrition, R5-920, Weight loss, gastrointestinal diseases, Internal medicine, treatment outcome, medicine, risk factors, Pharmacology (medical), Risk factor, medicine.symptom, business, Body mass index, hospitalization
Abstract

Background / Aims. Risk factors for malnutrition of patients during hospitalization have not been precisely determined. The aim of the study was to determine these factors in hospitalized gastroenterological patients. Methods. Nutritional status (NS) of 650 gastroenterological patients was assessed on admission and at discharge by the six parameters: unintentional weight loss, lymphocyte counts, serum albumin concentration, body mass index, triceps skinfold thickness and mid-upper arm muscle circumference. The influence on NS at discharge was tested for ten factors: gender, age, affected organ, the nature, severity and complications of the disease, the lenght of hospitalization, mobility worsening during hospitalization, Karnofsky score and NS on admission. Primary and secondary risk factors were defined among the factors influencing significantly the malnutrition. Results. Seven factors were found to be the independent predictors for malnutrition in hospitalized gastroenterological patients. NS on admission was considered as primary risk factor (Forwald: Wald multivariate logistic regression analysis, p14 days, and mobility worsening during the hospitalization (Forwald:Wald multivariate logistic regression analysis, p from 0.001 to 0.027). Conclusion. There are seven risk factors for malnutrition among gastroenterological patients during hospitalization. Timely nutritional support in these patients can prevent the development of intrahospital malnutrition and its negative influence on clinical outcome.

Published
2022
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4. Immunization in inflammatory bowel diseases: Recommendations on vaccines administration

Author

Zoran Milenkovic, Branka Roganovic, and Sasa Peric

Subjects
lcsh:R5-920, immunosuppression, business.industry, medicine.medical_treatment, Inflammatory Bowel Diseases, Immunosuppression, immunization, vaccination, inflammatory bowel diseases, Vaccination, Immunization, Immunology, medicine, Pharmacology (medical), business, lcsh:Medicine (General), Administration (government)
Abstract

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Published
2021

5. Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials

Author

Rubin, David T, primary, Dotan, Iris, additional, DuVall, Aaron, additional, Bouhnik, Yoram, additional, Radford-Smith, Graham, additional, Higgins, Peter D R, additional, Mishkin, Daniel S, additional, Arrisi, Pablo, additional, Scalori, Astrid, additional, Oh, Young S, additional, Tole, Swati, additional, Chai, Akiko, additional, Chamberlain-James, Kirsten, additional, Lacey, Stuart, additional, McBride, Jacqueline, additional, Panés, Julian, additional, Rustem, Abdulkhakov, additional, Norasiah, Abu Bakar, additional, Humberto, Aguilar, additional, Diego, Aizenberg, additional, Hale, Akpinar, additional, Evangelos, Akriviadis, additional, Olga, Alexeeva, additional, Bagdadi, Alikhanov, additional, Andres, Alvarisqueta, additional, Ashwin, Ananthakrishnan, additional, Jane, Andrews, additional, Tomasz, Arlukowicz, additional, Nathan, Atkinson, additional, Ozlen, Atug, additional, Mauro, Bafutto, additional, Jozef, Balaz, additional, George, Bamias, additional, Marko, Banic, additional, Andrey, Baranovsky, additional, Guerino, Barbalaco Neto, additional, Metin, Basaranoglu, additional, Curtis, Baum, additional, Stefan, Baydanov, additional, William, Bennetts, additional, Fatih, Besisik, additional, Sudhir, Bhaskar, additional, Andrzej, Bielasik, additional, Leonid, Bilianskyi, additional, Bahri, Bilir, additional, Pavol, Blaha, additional, Verle, Bohman, additional, Julia, Borissova, additional, Vladimir, Borzan, additional, Francisco, Bosques-Padilla, additional, Yoram, Bouhnik, additional, James, Brooker, additional, Tetiana, Budko, additional, Igor, Budzak, additional, Ivan, Bunganic, additional, Jonathon, Chapman, additional, Azlida, Che' Aun, additional, Tatiana, Chernykh, additional, Michael, Chiorean, additional, Ivan, Chopey, additional, Dimitrios, Christodoulou, additional, Pui Shan, Chu, additional, Galina, Chumakova, additional, Andrew, Cummins, additional, Robert, Cunliffe, additional, Mirjana, Cvetkovic, additional, Ulku, Dagli, additional, Wit Cezary, Danilkiewicz, additional, Olena, Datsenko, additional, Carlos Fernando, de Magalhães Francesconi, additional, Henry, Debinski, additional, Elena, Deminova, additional, Jelena, Derova, additional, John Nik, Ding, additional, Julia, Dmitrieva, additional, Oleg, Dolgikh, additional, Tomas, Douda, additional, Piotr, Drobinski, additional, Gerald, Dryden, additional, Pedro, Duarte Gaburri, additional, George Aaron, DuVall, additional, Mikhail, Dvorkin, additional, Craig, Ennis, additional, Yusuf, Erzin, additional, Galyna, Fadieienko, additional, Oleksandr, Fediv, additional, Olga, Fedorishina, additional, Miroslav, Fedurco, additional, Roland, Fejes, additional, Jorge, Fernandez, additional, Monica Lorena, Fernandez, additional, Lucky, Flores, additional, Bradley, Freilich, additional, Keith, Friedenberg, additional, Sergio, Fuster, additional, Beata, Gawdis-Wojnarska, additional, Fabio Leonel, Gil Parada, additional, Edgardo Daniel, Gimenez, additional, Nataliia, Golovchenko, additional, Oleksandr, Golovchenko, additional, Maciej, Gonciarz, additional, Can, Gonen, additional, Glenn, Gordon, additional, Milos, Gregus, additional, Vladimir, Grinevich, additional, Rogelio, Guajardo Rodriguez, additional, Stephen, Hall, additional, John, Hanson, additional, Marek, Hartleb, additional, Xavier, Hebuterne, additional, Peter, Hendy, additional, Robert, Herring, additional, David, Hetzel, additional, Peter, Higgins, additional, Raouf, Hilal, additional, Ida Normiha, Hilmi, additional, Tibor, Hlavaty, additional, Richard, Holman, additional, Gerald, Holtmann, additional, John, Hong, additional, Frantisek, Horvath, additional, Ihor, Hospodarskyy, additional, Irena, Hrstic, additional, Sadettin, Hulagu, additional, Luis Alberto, Ibarra Verdugo, additional, Ikechukwu, Ibegbu, additional, Stephen, Inns, additional, Vladimir, Ivashkin, additional, James, Izanec, additional, Rajesh, Jain, additional, Zofia, Jamrozik-Kruk, additional, Victor, Kamburov, additional, John, Karagiannis, additional, Tarkan, Karakan, additional, Marek, Karczewski, additional, Irina, Kasherininova, additional, Seymour, Katz, additional, Barry, Kaufman, additional, Edita, Kazenaite, additional, Irina, Kholina, additional, Sunil, Khurana, additional, Jaroslaw, Kierkus, additional, Anzela, Kiselevska, additional, Dariusz, Kleczkowski, additional, Volodymyr, Klymenko, additional, Slavko, Knezevic, additional, Malgorzata, Kondusz-Szklarz, additional, Natalya, Korablina, additional, Bartosz, Korczowski, additional, Lyubomir, Kosturkov, additional, Iskren, Kotzev, additional, Georgios, Kouklakis, additional, Ioannis, Koutroubakis, additional, Richard, Krause, additional, Ian, Kronborg, additional, Miodrag, Krstic, additional, Zeljko, Krznaric, additional, Mikolaj, Krzyzanowski, additional, Grazyna, Kulig, additional, Karin, Kull, additional, Limas, Kupcinskas, additional, Mark, Lamet, additional, Tatjana, Latinovic Radakovic, additional, Rupert, Leong, additional, Wai Keung, Leung, additional, Henry, Levine, additional, Michael Kin Kong, Li, additional, Lúcia, Libanez Bessa Campelo Braga, additional, Maria, Livzan, additional, Tetiana, Lohdanidi, additional, Maria Helena, Louzada Pereira, additional, John, Lowe, additional, Kresimir, Luetic, additional, Milan, Lukas, additional, Yurii, Lymar, additional, Finlay, Macrae, additional, Anu, Mäelt, additional, Igor, Maev, additional, Arkadiusz, Mamos, additional, Gerasimos, Mantzaris, additional, Benno, Margus, additional, Ivanka, Marinova, additional, Inna, Markevych, additional, Mario, Markov, additional, Srdjan, Markovic, additional, Juan Ricardo, Marquez Velasquez, additional, Felipe, Mazzoleni, additional, Konstantinos, Mimidis, additional, Brent, Mitchell, additional, Gregory, Moore, additional, Luis Alonso, Morales Garza, additional, Salvatore, Moscatello, additional, Yuriy, Mostovoy, additional, Reme, Mountifield, additional, Aleksandar, Nagorni, additional, Viacheslav, Neshta, additional, Andrey, Obrezan, additional, Oleksandr, Oliinyk, additional, Genoile, Oliveira Santana Silva, additional, Maria, Orzeszko, additional, Vladimir, Pavlenko, additional, Dimitar, Pavlov, additional, Mariana, Penkova, additional, Sasa, Peric, additional, Plamen, Petkov, additional, Asen, Petrov, additional, Plamen, Petrov, additional, Michaela, Petrova, additional, Raymond, Phillips, additional, Sergio, Pintor Chacon, additional, Igor, Polianskyi, additional, Ludmyla, Prystupa, additional, Mykhailo, Pugach, additional, Ana Teresa, Pugas Carvalho, additional, Aldis, Pukitis, additional, Jiri, Pumprla, additional, Volodymyr, Pyrogovskyy, additional, Istvan, Racz, additional, Graham, Radford-Smith, additional, Raja Affendi, Raja Ali, additional, Daniel, Ramos Castañeda, additional, Odery, Ramos Júnior, additional, David, Rausher, additional, Andrey, Rebrov, additional, Jaroslaw, Regula, additional, Amir, Rezk, additional, Viktoriia, Reznikova, additional, Iaroslava, Rishko, additional, Xavier, Roblin, additional, Grigory, Rodoman, additional, Carlos Arturo, Rojas Rodriguez, additional, Jerzy, Rozciecha, additional, David, Rubin, additional, Maciej, Rupinski, additional, Jacek, Rzucidlo, additional, Oleg, Sablin, additional, Halil, Sahin, additional, Rosemi, Salleh, additional, Douglas, Samuel, additional, Antonio, Scafuto Scotton, additional, Robert, Schnabel, additional, Michael, Schulman, additional, Michael, Schultz, additional, John, Scott, additional, Shahriar, Sedghi, additional, Ahmad, Shaban, additional, Marina, Shapina, additional, Natalia, Shaposhnikova, additional, Oksana, Shchukina, additional, Alex, Sherman, additional, Irina, Shumikhina, additional, Vladimir, Simanenkov, additional, Vladislav, Simonov, additional, Giedrius, Simulionis, additional, Igor, Skrypnyk, additional, Zbigniew, Sliwowski, additional, Jan, Smid, additional, Mahmood, Solaiman, additional, Najm, Soofi, additional, Konstantinos, Soufleris, additional, Zoia, Spassova, additional, Mykola, Stanislavchuk, additional, Krystyna, Stec-Michalska, additional, Jonathas, Stifft, additional, Simeon, Stoinov, additional, Girgina, Stoyanova, additional, Keith, Sultan, additional, Lindsey, Surace, additional, Dimitar, Takov, additional, Jaak, Tälli, additional, Ludmila, Tankova, additional, Hugo, Tanno, additional, Dino, Tarabar, additional, Elias, Tarakji, additional, Konstantin, Tchernev, additional, Hoi Poh, Tee, additional, Lena, Thin, additional, Carlton, Thomas, additional, Irina, Tishaeva, additional, Tsveta, Todorova, additional, Oleksandr, Tokarenko, additional, Ivars, Tolmanis, additional, Ratko, Tomasevic, additional, Vasiliy, Trofimov, additional, Zsolt, Tulassay, additional, Belkis, Unsal, additional, Alma, Uzunova-Genova, additional, John, Valentine, additional, Ekaterina, Valuyskikh, additional, Eduardo, Vasconcellos, additional, Galina, Vasileva, additional, Sergiy, Vasylyuk, additional, Byron, Vaughn, additional, Francisco, Velazquez, additional, Vadym, Vizir, additional, Borislav, Vladimirov, additional, Miroslava, Volfova, additional, Petr, Vyhnalek, additional, Ian, Wallace, additional, Marek, Waluga, additional, William, Watkins, additional, John, Weber, additional, Anna, Wiechowska-Kozlowska, additional, Nathaniel, Winstead, additional, Pawel, Wojtkiewicz, additional, Barbara, Wozniak-Stolarska, additional, Bruce, Yacyshyn, additional, Alexey, Yakovlev, additional, Ziad, Younes, additional, Lígia, Yukie Sassaki, additional, Ilhami, Yuksel, additional, Jan, Zachar, additional, Cyrla, Zaltman, additional, Natasa, Zdravkovic Petrovic, additional, Vyacheslav, Zhdan, additional, Maryna, Zinchenko, additional, and Maciej, Zymla, additional

Published
2022
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6. The Usefulness of Prognostic Nutritional Index in Predicting Infection in Patients with Newly Diagnosed Pancreatic Cancer

Author

Sasa Peric, Branka Roganovic, Sanja Tripković, Ana Roganović Sarić, and Nebojsa Manojlovic

Subjects
Oncology, medicine.medical_specialty, Chemotherapy, Index (economics), biology, business.industry, medicine.medical_treatment, General Medicine, Newly diagnosed, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Serum albumin level, Carcinoembryonic antigen, 030220 oncology & carcinogenesis, Internal medicine, Pancreatic cancer, medicine, biology.protein, 030211 gastroenterology & hepatology, In patient, business
Abstract

Suicide is a very complex phenomenon with psychological, social, biological, cultural and environmental factors involved...

Published
2021
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7. The impact of in-hospital nutritional status deterioration on treatment outcome of adult gastroenterological patients

Author

Snežana R. Janković, Sasa Peric, and Branka Roganovic

Subjects
Male, medicine.medical_specialty, Multivariate analysis, Gastrointestinal Diseases, Treatment outcome, Nutritional Status, Weight loss, Internal medicine, adults, Medicine, Humans, Pharmacology (medical), Aged, lcsh:R5-920, business.industry, Incidence (epidemiology), Nutritional status, Middle Aged, Confidence interval, Hospitalization, Nutrition Assessment, Treatment Outcome, Relative risk, Physical therapy, Female, medicine.symptom, business, lcsh:Medicine (General), Body mass index, Serbia
Abstract

Background/Aim. In the current literature, data on impact of intrahospital changes in patients’ nutritional status on the treatment outcome are limited. The aim of this study was to investigate the relationship between nutritional status deterioration and the treatment outcome among hospitalized gastroenterological patients. Methods. In 650 adult gastroenterological patients nutritional status on admission and at discharge was evaluated using the 6 nutritional status assessment parameters: body mass index, triceps skinfold thickness, mid-upper arm muscle circumference, serum albumin concentration, lymphocyte count and unintentional weight loss. The influence on treatment outcome was tested for the nutritional status on admission, nutritional status at discharge and intrahospital nutritional status deterioration. Results. The incidence of favorable outcome in the non-undernourished and undernourished patients on admission was in the range 93.4-97.3% and 81.2- 91.2%, respectively. The incidence of favorable outcome in the non-undernourished and undernourished patients at discharge was in the range 94-97.4% and 80.8-88.1%, respectively. Favorable outcomes were obtained in 95.6-98.9% of the patients without nutritional status deterioration and in 87.1-90.3% of the patients with nutritional status deterioration. Intrahospital nutritional status deterioration significantly influenced the outcome, no matter what assessment parameter had been used (p < 0.001 for all the applied parameters). Furthermore, only the deterioration of nutritional status was found to be an independent predictor of treatment outcome (multivariate analysis Forwald Wald, p £ 0.001; relative risk (RR) = 0.104-0.350; confidence intervals (CI) = 0.037-0.186/0.297-0.657). Conclusion. Deterioration of nutritional status is an independent predictor of adverse outcome.

Published
2018

9. Risk factors for nutritional status determination and indications for preventive nutrition therapy in hospitalized gastroenterological patients

Author

Sasa Peric, Dino Tarabar, and Branka Roganovic

Subjects
Adult, Male, nutritional requirements, medicine.medical_specialty, Adolescent, Nutritional Status, Disease, Body weight, body weight, Preventive nutrition, Internal medicine, medicine, Humans, risk factors, Pharmacology (medical), Medical nutrition therapy, Risk factor, Aged, Aged, 80 and over, lcsh:R5-920, Nutritional Support, business.industry, Incidence (epidemiology), Nutritional status, Middle Aged, gastrointestinal diseases, Physical therapy, Female, lcsh:Medicine (General), business, Body mass index, hospitalization
Abstract

Background/Aim. Risk factors for the intrahospital nutritional status worsening (NSW) have not been precisely defined in the literature. The objective was defining thoese factors among gastroenterological patients and defining the risk patients requiring a preventive nutritional therapy. Methods. In 650 gastroenterological patients, NSW was evaluated on the basis of reducing of the six parameters: body weight, body mass index (BMI), triceps skinfold thickness (TSF), midupper arm muscle circumference (MAMC), serum albumin level (ALB), and lymphocyte count (LYM). The influence on NSW was tested for 13 factors concerning characteristics of the patient, disease, and diagnostic procedures. Among the factors influencing significantly the NSW, primary and secondary risk factors were selected. After scoring of risk factors had been performed, the risk-score for NSW (RSNSW) was defined. The critical value of RSNSW which required preventive nutritional therapy was also calculated. Results. The incidence of NSW was in the range 29.2%?57.9%. The presence of general complications and severe disease activity were considered as primary risk factors, whereas malignant disease, age above 71, hepato-billiary tract involvement, hospitalization longer than 14 days, and mobility worsening were considered as secondary risk factors. The best predictive value for the NSW was proved for the RSNSW ? 6. Because of that, preventive nutritional therapy should be indicated in patients presenting with both primary risk factors or in patients presenting with one primary factor combined with three secondary risk factors at least. Conclusion. There are 7 risk factors for NSW in gastroenterological patients, but they are not of the same importance - two primary and five secondary risk factors can be differentiated. Preventive nutritional therapy is indicated only in patients having both primary risk factors or in those presenting with one primary risk factor combined with three secondary risk factors at least.

Published
2007
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10. Optimal nutritional status assessment parameters in gastroenterological patients on hospital admission

Author

Dino Tarabar, Sasa Peric, and Branka Roganovic

Subjects
Pediatrics, medicine.medical_specialty, Nutritional Status, Body Mass Index, Weight loss, Weight Loss, Arm muscle, medicine, Humans, Pharmacology (medical), nutrition assessment, Lymphocyte Count, Serum Albumin, lcsh:R5-920, Anthropometry, Triceps Skinfold Thickness, business.industry, patient admission, Incidence (epidemiology), Malnutrition, nutritional and metabolic diseases, Nutritional status, medicine.disease, gastrointestinal diseases, Hospital admission, medicine.symptom, business, lcsh:Medicine (General), Body mass index, hospitalization
Abstract

Background/Aim. There are no recommendations for the optimal nutritional status assessment parameters (NSAPs) in the current literature. The aim of this study was to define the optimal NSAPs for nutritional status assessing in gastroenterological patients on hospital admission. Methods. Nutritional status of 612 gastroenterological patients was evaluated at the admission using 6 NSAPs: unintentional weight loss (WL), body mass index (BMI), triceps skinfold thickness (TSF), mid-upper arm muscle circumference (MAMC), serum albumin concentration (ALB), and lymphocyte counts (LYM). According to their nutritive status, the patients were classified as well nourished (normally nourished and obese), moderately undernourished and severely undernourished. Based on the similarities and differences in the assessment results, obtained according to each of 6 parameters, the optimal nutritional assessment parameters were defined, separately for the well-nourished / undernourished patients and for moderately / severely undernourished patients. Results. The incidence of malnutrition was in the range 5.9-29.7%. The results based on MAMC, ALB, and LYM were similar (25.2- 29.7%; p > 0.05), while the results based on WL, BMI, and TSF differed significantly (5.9-19.9%; p = 0.001-0.015). The assessment based on BMI was the most severe criterion, while the assessment according to MAMC was the mildest criterion in selection of malnourished patients. The assessment according to MAMC was the mildest criterion for the selection of severe malnourished patients (severely malnouorished patients accounted for 70.l%), while BMI and LYM were the most severe criteria (severely malnouorished patients accounted for 22.2% and 27.3%, respectively). The results based on BMI and LYM were similar (Wilcoxon test; p > 0.05). Conclusion. Combining BMI with MAMC is sufficient for the assessment of the nutritional status of gastroenterological patients on admission, as well as for differentiation between severely malnourished and moderately malnourished patients. .

Published
2007

11. Prolonged three year survival after adjuvant chemotherapy with UFT/leukovorin for II, IIIA and IIIB diffuse gastric cancer

Author

Sasa Peric, Dino Tarabar, Zoran Petrovic, Nenad Perisic, Branka Roganovic, Jasna Jovic, Radoje Doder, Stojan Lukacevic, Violeta Ristic, and Tanja P. Brocic

Subjects
Oncology, medicine.medical_specialty, Hepatology, Adjuvant chemotherapy, business.industry, Internal medicine, medicine, Gastroenterology, Cancer, business, medicine.disease
Published
2001
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