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34. Development of the Organizational Mental Health Support Scale for Nurses working in hospital

Author

Sasaki, Seiko and Sasaki, Makiko

Subjects
看護師, 尺度, メンタルへルス, 組織的支援
Abstract

病院に勤務する「看護師の組織的メンタルへルス支援尺度（Organizational Mental Health Support Scale for Nurse:以下OMSSN）」を開発し，その信頼性と妥当性の検証を目的とした．文献から看護師のメンタルヘルスに対する組織的支援の記述内容を抽出した．意味内容の吟味，項目の適切性，表現妥当性を検討しOMSSN 原案22項目を作成した．その後，尺度の信頼性，妥当性を検討するため全国の一般病院で看護師のメンタルヘルス支援を担当している看護職各1名を対象にOMSSN 原案と組織属性等の調査を行った．分析対象は140名であった．項目分析，探索的因子分析と確認的因子分析を行った結果，15項目3因子『院内連携の活用』『組織の支援体制』『看護師長の直接的関わり』が抽出され，クロンバックα係数はそれぞれ0.90，0.78，0.68で尺度全体では0.89であった．確認的因子分析のモデル適合度はGFI =0.83，AGFI =0.81であった．組織属性では病院機能評価の受審，安全衛生委員会設置の設置，メンタルヘルス指針がある病院では，これらがない病院に比べてOMSSN の平均得点が高かった．本尺度は，確認的モデル適合度はやや低い結果であったが，尺度の信頼性，構成概念の一定の妥当性が確認できたことから，看護師の組織的メンタルへルス支援の実施状況の測定に役立てられると考える．The purpose of this study was to develop the Organizational Mental Health Support Scale for Nurses (OMSSN) and test the scale’s reliability and validity. We extracted description contents of the organized support for the mental health of the nurse from documents. We examined the examination of meaning contents, the adequacy of the item, expression validity and made OMSSN original bill 22 items. We investigated OMSSN original bill and the organization attribute targeting at for each one nursing nurse's post in charge of mental health support afterwards in the public Hospital of the whole country to examine reliability, the validity of the standard. For each of the 140 subjects in the survey, an item, exploratory factor, and confirmatory factor analysis was performed. As a result, 15 items and three factors, Use of In-Hospital Collaboration, Organization Support System, and Direct Relationship of Nurses, were extracted. The Cronbach's alpha coefficients were 0.90, 0.78, and 0.68, respectively 0.89 for the entire scale. The model fit of the confirmatory factor analysis was GFI = 0.83 and AGFI = 0.81. In terms of organizational attributes, hospitals with mental health guidelines that were subject to hospital function evaluations and established health and safety committees showed higher average OMSSN scores than hospitals without these attributes. Although the OMSSN showed a slightly low result in terms of confirming a model fit, our study did confirm that the scale was reliable and the constructs valid. Therefore, we suggest it can be useful for measuring the implementation status of nurses' systematic mental health support.

Published
2020

42. Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study

Author

1000010733371, Kobayashi, Sumitaka, Sata, Fumihiro, Goudarzi, Houman, Araki, Atsuko, Miyashita, Chihiro, Sasaki, Seiko, Okada, Emiko, Iwasaki, Yusuke, Nakajima, Tamie, 1000080112449, Kishi, Reiko, 1000010733371, Kobayashi, Sumitaka, Sata, Fumihiro, Goudarzi, Houman, Araki, Atsuko, Miyashita, Chihiro, Sasaki, Seiko, Okada, Emiko, Iwasaki, Yusuke, Nakajima, Tamie, 1000080112449, and Kishi, Reiko

Abstract

The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log(10) scale) decreased palmitic, palmitoleic, and oleic acid levels (log(10) scale), with the observed beta in the range of - 0.452 to - 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed beta in the range of - 0.266 to - 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid (P-int=0.004 to 0.017). In conclusion, the interactions between maternal PFOS levels and PPARGC1A or PPARD may modify maternal FA levels.

Published
2021

45. The association of prenatal exposure to perfluorinated chemicals with glucocorticoid and androgenic hormones in cord blood samples: the Hokkaido study

Author

Goudarzi, Houman, Araki, Atsuko, Itoh, Sachiko, Sasaki, Seiko, Miyashita, Chihiro, Mitsui, Takahiko, Nakazawa, Hiroyuki, Nonomura, Katsuya, and Kishi, Reiko

Subjects
Organofluorine compounds -- Health aspects, Maternal-fetal exchange -- Health aspects, Corticosteroids -- Properties, Fetal blood -- Testing, Androgens -- Properties, Environmental issues, Health
Abstract

BACKGROUND: Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and steroid hormones such as glucocorticoids and androgenic hormones mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on the homeostasis of these steroid hormones are not well understood in humans. OBJECTIVES: We examined the relationship between prenatal exposure to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) and cord blood levels of glucocorticoid and androgenic hormones. METHODS: We conducted a hospital-based birth cohort study between July 2002 and October 2005 in Sapporo, Japan (n = 514). In total, 185 mother-infant pairs were included in the present study. Prenatal PFOS and PFOA levels in maternal serum samples were measured using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Cord blood levels of glucocorticoid (cortisol and cortisone) and androgenic hormones [dehydroepiandrosterone (DHEA) and androstenedione] were also measured in the same way. RESULTS: We found a dose-response relationship of prenatal PFOS, but not PFOA, exposure with glucocorticoid levels after adjusting for potential confounders. Cortisol and cortisone concentrations were -23.98-ng/mL (95% CI: -0.47.12, -11.99; p for trend = 0.006) and -63.21-ng/mL (95% CI: -132.56, -26.72; p for trend < 0.001) lower, respectively, in infants with prenatal PFOS exposure in the fourth quartile compared with those in the first quartile. The highest quartile of prenatal PFOS exposure was positively associated with a 1.33-ng/mL higher DHEA level compared with the lowest quartile (95% CI: 0.17, 1.82; p for trend = 0.017), whereas PFOA showed a negative association with DHEA levels (quartile 4 vs. quartile 1: -1.23 ng/mL, 95% CI: -1.72, -0.25; p for trend = 0.004). We observed no significant association between PFCs and androstenedione levels. CONCLUSIONS: Our results indicate that prenatal exposure to PFCs is significantly associated with glucocorticoid and DHEA levels in cord blood. http://dx.doi.org/10.1289/EHP142, Introduction Perfluorinated chemicals (PFCs) are human-made chemicals that have been widely used in different types of industry for the past 60 years. They are ubiquitous and widely detected in the [...]

Published
2017
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50. MOESM1 of Prenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children’s Health

Author

Minatoya, Machiko, Araki, Atsuko, Itoh, Sachiko, Yamazaki, Keiko, Sumitaka Kobayashi, Miyashita, Chihiro, Sasaki, Seiko, and Kishi, Reiko

Abstract

Additional file 1: Table S1. Comparison of characteristics in this study population (n=3,216) and in the whole follow-up population (n=6,804). Table S2. Correlation coefficients between characteristics of participants and SDQ scores. Table S3. Cotinine levels and rate of children with ADHD symptoms. Figure S1 DAG for selecting covariates.

Published
2019
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