Search

Your search keyword '"Sasayama, Shigetake"' showing total 1,207 results
Start Over Author "Sasayama, Shigetake"
1,207 results on '"Sasayama, Shigetake"'

3. Long QT Syndrome as a Cause of Cardiac Sudden Death

Author

Horie, Minoru, Yoshida, Hidetada, Otani, Hideo, Ai, Tomohiko, Nishimoto, Toshihisa, Haruna, Tetsuya, Kono, Yutaka, Sasayama, Shigetake, Kitabatake, Akira, editor, Sasayama, Shigetake, editor, Francis, Gary S., editor, and Okamoto, Hiroshi, editor

Published
2000
Full Text
View/download PDF

47. Increased expression of cardiotrophin-1 during ventricular remodeling in hypertensive rats

Author

Takimoto, Yoshihito, Aoyama, Takeshi, Iwanaga, Yoshitaka, Izumi, Toshiaki, Kihara, Yasuki, Pennica, Diane, and Sasayama, Shigetake

Subjects
Physiology -- Research, Hypertension -- Research, Congestive heart failure -- Research, Biological sciences
Abstract

Cardiotrophin-1 (CT-1) stimulates longitudinal myocardial cell hypertrophy. We examined the expression of CT-1, leukemia inhibitory factor (LIF), and gp130 by competitive RT-PCR and Western blotting in Dahl salt-sensitive (DS) rats with a high-salt diet, which showed a distinct transition from left ventricular hypertrophy (LVH) to congestive heart failure (CHF). The expression levels of CT-1 mRNA and protein were significantly increased at the CHF stage compared with the LVH stage and age-matched Dahl salt-resistant (DR) rats (n = 6 for each group), mRNA expression of LIF was not changed in the left ventricle at any stage by RT-PCR. gp130 mRNA and protein levels of DS rats at 11 and 17 wk were significantly increased compared with age-matched DR rats. The isolated myocyte length of DS rats at 17 wk was the longest among the four groups of rats. The LV end-diastolic dimension (LVDd) of DS rats, determined by echocardiography, was significantly increased at the CHF stage. There was a significant correlation between the CT-1 protein level and LVDd. CT-1 may play a role in ventricular remodeling during transition from LVH to CHF in the rat hypertensive model. gp130; hypertension; left ventricular remodeling; congestive heart failure

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results