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7. Ecological Role of Widespread Bacteriocin Production among Bacillus cereus Contaminating Dairy Products and Characterization of Three Cereins.

Author

Chaabouni, I., Ouertani, A., Koubaa, N., Sassi, I., Barkallah, I., Saidi, M., and Cherif, A.

Subjects
BACILLUS cereus, DAIRY products, FOOD contamination, SPOREFORMING bacteria, GRAM-positive bacteria, BACTERIAL communities
Abstract

Bacillus cereus is a ubiquitous spore-forming gram-positive bacterium. The antibacterial molecules or bacteriocins provide an ecological advantage to B. cereus and promote its proliferation in the bacterial communities and food contamination. The goal of the present work was to detect and identify the antimicrobial activity potential of 114 B. cereus food strains. It aimed at accessing the ecological status of B. cereus variants and characterizing the bacteriocins. An inhibitory activity was detected in 61.4% of the collection. Three selected isolates were found to be bacteriocin (cerein) producers and were identified as B. cereus by 16S rRNA gene sequencing. The cerein activities were inhibited by at least one protease treatment. They were stable within a wide range of pH, sustained heat treatments (up to 96°C for 30 min) and treatment with organic solvents and detergents. These cereins showed bactericidal and bacteriolytic effects. They belonged to class II of bacteriocins. The three cereins were produced at the early stationary phase and remained stable until 50 h of cultivation. The preparation trough SDS PAGE gave an inhibitory zone with an apparent molecular weight of about 10 kDa to the three cereins. The three selected bacteriocins produced by B. cereus dairy strains deserve further research of their potential in pathogen control. Bacteriocin production may play a key role in the ubiquitous distribution of B. cereus and his persistency in dairy products. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Corrigendum to 'Sentinel node biopsy after primary systemic therapy in node positive breast cancer patients: Time trend, imaging staging power and nodal downstaging according to molecular subtype' (European Journal of Surgical Oncology (2019) 45(6) (969–975), (S0748798319302458), (10.1016/j.ejso.2019.01.219))

Author

Di Micco R., Zuber V., Fiacco E., Carriero F., Gattuso M. I., Nazzaro L., Panizza P., Gianolli L., Canevari C., Di Muzio N., Pasetti M., Sassi I., Zambetti M., Gentilini O. D., Di Micco, R., Zuber, V., Fiacco, E., Carriero, F., Gattuso, M. I., Nazzaro, L., Panizza, P., Gianolli, L., Canevari, C., Di Muzio, N., Pasetti, M., Sassi, I., Zambetti, M., and Gentilini, O. D.

Abstract

The authors regret that the author list in reference 27 was written incorrectly and should have been as follows: 27. M. Donker, M.E Straver, J. Wesseling, C.E. Loo, M. Schot, C.A Drukker et al. Marking axillary lymph nodes with radioactive iodine seeds for axillary staging after neoadjuvant systemic treatment in breast cancer patients: the MARI procedure. Ann Surg, 261 (2) (2015), pp. 378-382 The authors would like to apologise for any inconvenience caused.

Published
2019

16. Biopsia mammaria stereotassica RM-guidata mediante sistema coassiale misto ferromagnetico-amagnetico con aghi da 12-18 Gauge: esperienza clinica e risultati a lungo termine

Author

Belloni, E, Panizza, P, Ravelli, S, De Cobelli, F, Gusmini, S, Losio, C, Sassi, I, Del Maschio, A., PERSEGHIN, GIANLUCA, Belloni, E, Panizza, P, Ravelli, S, De Cobelli, F, Gusmini, S, Losio, C, Sassi, I, Perseghin, G, and Del Maschio, A

Subjects
Breast magnetic resonance, Radiology, Nuclear Medicine and Imaging, Follow-up, Medicine (all), Breast lesion, Breast biopsy, MED/13 - ENDOCRINOLOGIA, Coaxial needle
Abstract

Purpose: This study investigated the clinical application of a magnetic-resonance (MR)-guided breast biopsy (MRBB) system consisting of a nonmagnetic coaxial needle and a ferromagnetic core biopsy needle. Materials and methods: MRBB was performed on 70 breast lesions. The biopsy device consisted of a nonmagnetic 14- to 16-gauge coaxial needle and a ferromagnetic 16- to 18-gauge biopsy needle. Results: Of the 70 lesions, 29 were malignant and 41 nonmalignant. All 29 malignant lesions underwent surgery and were confirmed as malignant at final histology. Of the 41 nonmalignant lesions, 35 underwent follow-up breast MR imaging (mean, 26±19 months), which demonstrated no lesions changes; six lesions underwent surgery because of poor radiological-pathological correlation; of these 6 lesions, 3 were nonmalignant, one was borderline (lobular carcinoma in situ) and two were malignant (well-differentiated tubular carcinoma and infiltrating ductal carcinoma). Sensitivity, specificity, positive and negative predictive values and diagnostic accuracy were, respectively, 93.5%, 100%, 100%, 95.1% and 97.1% if the lobular carcinoma in situ was considered a nonmalignant histological result, and 90.6%, 100%, 100%, 92.7% and 95.7% if the lobular carcinoma in situ was considered malignant. Conclusions: MRBB with a ferromagnetic-nonmagnetic coaxial system represented an easy way to perform a biopsy procedure and was easily applicable in the routine clinical setting. © 2013 Springer-Verlag

Published
2013

17. Nonpalpable breast lesions: preoperative radiological guidance in radioguided occult lesion localisation (ROLL). Lesioni mammarie non palpabili: la guida radiologica preoperatoria nella ROLL (radioguided occult lesion localisation)

Author

Belloni, E, Canevari, C, Panizza, P, Marassi, A, Rodighiero, M, Tacchini, S, Zuber, V, Sassi, I, Gianolli, L, Del Maschio, A., FAZIO, FERRUCCIO, Belloni, E, Canevari, C, Panizza, P, Marassi, A, Rodighiero, M, Tacchini, S, Zuber, V, Sassi, I, Gianolli, L, Fazio, F, and Del Maschio, A

Subjects
Breast lesion, Radioguided localisation, Mammography, Ultrasonography
Abstract

PURPOSE: This study evaluated the methods, technical aspects and impact of preoperative radiological guidance in radioguided occult lesion localisation (ROLL) for single nonpalpable breast lesions. MATERIALS AND METHODS: A total of 288 patients underwent ROLL before surgery. Human serum albumin macroaggregates labelled with 3.7-7.4 MBq of technetium(99) were injected into the lesion. In the case of ultrasonographic guidance (221/288 patients), inoculum positioning resulted in a change of echogenicity at the lesion site. In the case of mammographic guidance (67/288 patients), iodinated contrast medium was injected following the radiotracer for subsequent mammographic evaluation. Patients underwent surgery within 24 h from ROLL. A gamma-detecting probe was used to locate the lesion during surgery and guide its removal. After excision, the specimen was examined by either ultrasonography or mammography to verify complete lesion removal before histological evaluation. RESULTS: The lesion was correctly localised in 281/288 patients (97.5%). One ROLL procedure failed because surgery could not be performed within 24 h and the radioactivity decayed. Of the six incorrect localisations, 2 were due to the radiological guidance and 4 to technetium(99) dispersion. CONCLUSIONS: Radiological guidance in ROLL ensured the outcome of the procedure of localisation and removal of single, nonpalpable breast lesions in the majority of cases.

Published
2011

21. Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer

Author

Gallivanone F. 1, Canevari C. 2, Sassi I. 3, Zuber V. 4, Marassi A. 4, Gianolli L. 2, Picchio M. 1, 2, Messa C. 1, 5, Gilardi M. C. 1, and Castiglioni I. 1

Subjects
breast cancer, 18F-FDG PET
Abstract

AIM: The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC). METHODS: Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC- SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated. RESULTS: Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean ?7.00 is associated to BC patients with moderately and poorly differentiated IDC, negative expression of ER and PgR and a positive expression of MiB-1. CONCLUSION: Pretherapy PVC 18F-FDG PET PVC-SUVBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.

Published
2014

25. A virtual lab of integrated molecular medicine

Author

Grosso E. 1, Gallivanone F. 2, Stefano A. 1, Canevari C. 3, Gelfi 4, 5, Marassi A. 3, Sassi I. 3, Messa C. 1, 2, 4, Gilardi M.C. 2, 3, and Castiglioni I. 4

Published
2011

30. Bleeding gastric polyposis-like metastases of hepatocellular carcinoma

Author

Denardi, P, Braga, M, Zerbi, A, Sassi, I, Mangili, F, Cristallo, M, Dicarlo, V, DENARDI P, BRAGA M, ZERBI A, SASSI I, MANGILI F, CRISTALLO M, DICARLO V, Denardi, P, Braga, M, Zerbi, A, Sassi, I, Mangili, F, Cristallo, M, Dicarlo, V, DENARDI P, BRAGA M, ZERBI A, SASSI I, MANGILI F, CRISTALLO M, and DICARLO V

Abstract

The first case ever described of symptomatic gastric polypoid metastases in a 62-year-old patient, who had undergone right hepatectomy for hepatocellular carcinoma (HCC) 2 years before, is reported. The patient presented recurrences of gastrointestinal bleeding. Barium meal and endoscopy showed multiple gastric polyps extending from the cardia to the pylorus. Histological examination of biopsies of these polyps resulted consistent with metastases of HCC. A total gastrectomy was performed for palliation of symptoms. Histo-pathological examination confirmed the presence of metastatic HCC: neoplastic nests implanted in the submucosa and extending towards the mucosa. The above observation supports that the possible route of spread in our patient could be hematogenous from reversed portal blood flow. The patient died 20 months after surgery, with liver recurrence of the tumor.

Published
1992

32. Valuable expression of MIB1 index in serous ovarian tumors

Author

Frigerio L, Agnello A, Sassi I, Bassan M, Dindelli M, Marelli G, Candotti G, Ferrari A., ORIGONI , MASSIMO, Frigerio, L, Agnello, A, Sassi, I, Bassan, M, Dindelli, M, Origoni, Massimo, Marelli, G, Candotti, G, and Ferrari, A.

Published
1997

33. Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer

Author

Gallivanone, F, Canevari, C, Sassi, I, Zuber, V, Marassi, A, Gianolli, L, Picchio, M, Messa, M, Gilardi, M, Castiglioni, I, Castiglioni, I., MESSA, MARIA CRISTINA, GILARDI, MARIA CARLA, Gallivanone, F, Canevari, C, Sassi, I, Zuber, V, Marassi, A, Gianolli, L, Picchio, M, Messa, M, Gilardi, M, Castiglioni, I, Castiglioni, I., MESSA, MARIA CRISTINA, and GILARDI, MARIA CARLA

Abstract

The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC)

Published
2014

35. [The new prospects for radioimmunoguided surgery: the avidin-biotin system]

Author

Stella, M, De Nardi, P, Paganelli, G, Sassi, I, Magnani, P, Baratti, D, Mangili, F, Spagnolo, W, Di Carlo, V., FAZIO, FERRUCCIO, Stella, M, De Nardi, P, Paganelli, G, Sassi, I, Magnani, P, Baratti, D, Mangili, F, Spagnolo, W, Fazio, F, and Di Carlo, V

Subjects
Intraoperative Care, Radioimmunodetection, Biotin, Neoplasm Recurrence, Local, False Negative Reaction, Avidin, Colorectal Neoplasms, Human
Published
1991

39. Indagine su maternità e gravidanza nella nazione italiana

Author

Pecorari, D., Padovani, Ezio Maria, La Mendola, S., Adelfio, N., Artuso, A., Bartolini, R., Bergamini, V., Carlomagno, G., Cisternino, A., Cucuzza, G., Delucca, A., Diani, Franco, Formica, Z., Giacalone, A., Marchese, C., Massacesi, L., Massacesi, M., Mazzucchelli, G., Meocci, S., Milkowsky, M., Morganti, P., Palmisano, A., Pellegrino, G., Ragonese, P., Recchia, E., Repetti, F., Sassi, I., Taddei, F., Tanganelli, E., Turinetto, A., Valentini, A., Verdi, F., Xibilia, C., and Zarro, M. C.

Published
1992

40. Avidin-biotin system in radioimmunoguided surgery for colorectal cancer. Advantages and limits

Author

Stella, M, De Nardi, P, Paganelli, G, Magnani, P, Mangili, F, Sassi, I, Baratti, D, Gini, P, Zito, F, Cristallo, M, Fazio, F, Di Carlo, V, Di Carlo, V., FAZIO, FERRUCCIO, Stella, M, De Nardi, P, Paganelli, G, Magnani, P, Mangili, F, Sassi, I, Baratti, D, Gini, P, Zito, F, Cristallo, M, Fazio, F, Di Carlo, V, Di Carlo, V., and FAZIO, FERRUCCIO

Abstract

Radiolabeled monoclonal antibodies (MAbs) have been reported to allow tumor intraoperative detection by means of a gamma-detecting probe. The technology is called the Radioimmunoguided Surgery (RIGS) system. The main inconveniences of the method are 1) the long interval needed for clearance of unattached MAbs from the patient's body, between the injection of the MAb and surgery, and 2) the low sensitivity of current MAbs used in detecting small tumors. We describe a new method to overcome these inconveniences using biotinylated MAbs and avidin in order to obtain a rapid blood clearance of the radiolabeled MAbs both anticarcinoembryonic antigen and antitumor-associated glycoprotein-72 MAbs.

Published
1994

41. Two-step tumour targetting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin

Author

Paganelli, G, Belloni, C, Magnani, P, Zito, F, Pasini, A, Sassi, I, Meroni, M, Mariani, M, Vignali, M, Siccardi, A, Fazio, F, MERONI, MICHELE, FAZIO, FERRUCCIO, Paganelli, G, Belloni, C, Magnani, P, Zito, F, Pasini, A, Sassi, I, Meroni, M, Mariani, M, Vignali, M, Siccardi, A, Fazio, F, MERONI, MICHELE, and FAZIO, FERRUCCIO

Abstract

A new method for intraperitoneal tumour targetting in ovarian cancer using biotinylated monoclonal antibodies (MoAb) and radioactive streptavidin is described. Fifteen patients with histologically documented ovarian carcinoma were injected intraperitoneally with 2 mg of biotinylated MoAb MOv18, followed 3-5 days later by 100-150 micrograms of indium-111 streptavidin, at the specific activity of 280-370 MBq/mg in 500 ml of normal saline. No toxicity was observed. Tumours were imaged from 2 to 48 h after radioactivity injection by recording both planar and single photon emission tomography (SPET) data. All patients underwent surgery 1-8 days later (mean 3 days) after scanning. The resected tumour and normal tissue radioactivity were measured. On the day of surgery, the tumour to normal tissue ratio was 9:1 (range 3:1-30:1) and 45:1 (range 12:1-120:1) for intra- and extraperitoneal samples, respectively. The mean tumor to blood ratio was 14:1 (range 4:1-30:1). The injected dose (i.d.) per gram of tumour was 0.112 (range 0.01-0.3) for recurrences and 0.05 for primary tumour (range 0.005-0.2). Over 24-48 h 14% i.d. (range 8-18% i.d.) was found in the urine, 14% i.d. (range 6-29% i.d.) in the blood and 63% i.d. (range 56-70% i.d.) was still in the peritoneal cavity. These preliminary clinical data suggest that this two-step strategy may be superior to the conventional approach (radiolabelled antibodies) for intraperitoneal radioimmunolocalization and radioimmunotherapy of ovarian cancer.

Published
1992

46. Directional hemispherical radiative properties of random dielectric rough surfaces.

Author

Ghmari, F., Sassi, I., and Sifaoui, M. S.

Subjects
*GEOMETRICAL optics, *OPTICS, *DIELECTRIC devices, *MULTIPLE scattering (Physics), *RADIATIVE transitions, *ELECTROMAGNETIC waves, *RADIO wave propagation
Abstract

In this paper the directional hemispherical reflectivity and transmissivity of one-dimensional, randomly rough, dielectric surfaces are determined by the use of the integral method. This method is derived from electromagnetic theory without any restrictive hypotheses. Since this exact approach is computationally very intensive, a geometric optics approximation method is also developed. Curves displaying radiative properties versus the correlation length for a constant mean square deviation of the surface from flatness are presented. In this respect, the influence on the validity of the approximate method of multiple scattering, the shadowing effect and the real index of refraction of the dielectric have been investigated. Transverse electric and transverse magnetic polarized incident plane waves are considered. For the latter, our interest is focused on the influence of roughness on the reflected and transmitted intensities for an angle of incidence close to the Brewster angle. [ABSTRACT FROM AUTHOR]

Published
2005
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47. Partial volume corrected 18F-FDG PET mean standardized uptake value correlates with prognostic factors in breast cancer

Author

Gallivanone F, Canevari C, Sassi I, Zuber V, Marassi A, Gianolli L, Picchio M, Messa C, Mc, Gilardi, Isabella Castiglioni, Gallivanone, F, Canevari, C, Sassi, I, Zuber, V, Marassi, A, Gianolli, L, Picchio, M, Messa, C, Gilardi, M C, Castiglioni, I, Messa, M, and Gilardi, M

Subjects
Adult, Prognosi, Breast Neoplasms, Multimodal Imaging, Regression Analysi, Fluorodeoxyglucose F18, Cluster Analysis, Humans, Multivariate Analysi, Aged, Aged, 80 and over, Cluster Analysi, Models, Statistical, Body Weight, Middle Aged, Prognosis, ROC Curve, Data Interpretation, Statistical, Positron-Emission Tomography, Multivariate Analysis, Radiographic Image Interpretation, Computer-Assisted, Regression Analysis, Female, Tomography, X-Ray Computed, Breast Neoplasm, 18F-FDG PET, Human, Mammography
Abstract

The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC).Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC- SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated.Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean≈4 g/cc was found correlated to BC patients with Invasive Lobular Carcinoma (ILC) or well differentiated Invasive Ductal Carcinoma (IDC), a positive expression of ER and PgR and a negative expression of MiB-1, while PVC-SUVBW-mean≈7.00 is associated to BC patients with moderately and poorly differentiated IDC, negative expression of ER and PgR and a positive expression of MiB-1.Pretherapy PVC 18F-FDG PET PVC-SUVBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.

49. Isolation of the elusive pig islet

Author

Camillo Ricordi, Socci, C., Davalli, A. M., Staudacher, C., Baro, P., Vertova, A., Sassi, I., Gavazzi, F., Pozza, G., and Di Carlo, V.

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