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25 results on '"Satake, Nobuo"'

6. Coexistent poorly-differentiated neuroendocrine cell carcinoma and non-invasive well- differentiated adenocarcinoma in tubulovillous adenoma of the rectum : report of a casel

Author

Kuratate, Shinji, Inoue, Seiya, Chikakiyo, Motoya, Kaneda, Yuji, Harino, Yukari, Hirose, Toshiyuki, Yagi, Toshiyuki, Saitoh, Seiya, Sumitomo, Masayuki, Fujino, Ryozo, and Satake, Nobuo

Subjects
adenoendocrine cell carcinoma, neuroendocrine cell carcinoma, rectum, small cell carcinoma, digestive system diseases
Abstract

A 74-years old man was referred to our hospital for treatment of a rectal mass. Colonoscopy revealed villous tumor covering all the lower rectal lumen. Biopsy yielded a diagnosis of adenoma. CT examination showed tumor shadows of the rectum and the liver. Pelvic MRI examination showed a 10.5 8 7 cm tumor with high signal intensity on the T2 weighted images in the rectum. Rectosigmoidectomy with lymph node dissection was performed with the diagnosis of rectal cancer that metastasized to the liver. Histological and immuno- histochemical features showed coexistent poorly-differentiated small cell neuroendocrine cell (NEC) carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma. However the chemotherapy with FOLFOX and Bevacizumab was performed postoperatively, the patient died in cancer 3 months after surgery. Rectal poorly-differentiated NEC carcinomas are thought to be a tumor with a high malignant potential. Recently, the UICC TNM classifications of malignant tumors, 7th edition and the Guidelines for colorectal NEC tumors of European Neuroendocrine Tumor Society have been published. They would be evaluated, and effective multimodal therapy for NEC carcinomas should be established.

Published
2010

8. Cytological analysis of glycogen-rich carcinoma of the breast : report of two cases

Author

Satake, Nobuo, Uehara, Hisanori, Sano, Nobuya, Kubo, Takayuki, Sasa, Mitsunori, and Izumi, Keisuke

Subjects
fine-needle aspiration biopsy cytology, cytology, glycogen-rich carcinoma, breast, c-erbB-2
Abstract

Background : Glycogen-rich carcinoma is a rare special histologic subtype of breast cancer and its incidence is estimated to be 1.4% in breast malignancies. However, its precise characteristics in cytological specimens have not yet been fully clarified. Case : Fifty-nine-year-old and 53-year-old women underwent fine-needle aspiration biopsy cytology (FNABC) of a breast tumor, confirming malignancy. A mastectomy with axillary dissection was performed. Cytologically, a moderate amount of eosinophilic, finely granular cytoplasm was seen in the majority of the tumor cells, however, foamy and vacuolated cytoplasm was noted in some tumor cells. Histologically, the tumor cells of both cases had clear and granular cytoplasm, which showed a positive reaction with periodic acid-Schiff, eliminated by diastase. Conclusion : While clear cytoplasm in the tumor cells in the FNABC seemed to be a pivotal cytological characteristic of glycogen-rich carcinoma, it may not be a major component of cytological specimens. Routine periodic acid-Schiff staining may be required to diagnose glycogen-rich carcinoma in cytological methods.

Published
2002

10. A case of perinephric liposarcoma which recurred ten years later from the initial operation

Author

Kuratate, Shinji, Chikakiyo, Motoya, Kaneda, Yuji, Harino, Yukari, Hirose, Toshiyuki, Yagi, Toshiyuki, Saitoh, Seiya, Sumitomo, Masayuki, Fujino, Ryozo, Satake, Nobuo, Hirose, Takahiro, Kuratate, Shinji, Chikakiyo, Motoya, Kaneda, Yuji, Harino, Yukari, Hirose, Toshiyuki, Yagi, Toshiyuki, Saitoh, Seiya, Sumitomo, Masayuki, Fujino, Ryozo, Satake, Nobuo, and Hirose, Takahiro

Abstract

A 58-year old man was referred to our hospital for treatment of an abdominal mass. As for him, tumor resection with right nephrectomy had been performed ten years ago for a giant well-differentiated perinephric liposarcoma. CT examination showed a huge tumor shadow in the abdominal cavity. Abdominal MRI examination showed a 15 8 cm tumor with almost high signal intensity on the T2 weighted images. At lapalotomy, a large bulky retroperitoneal tumor pointed out before an operation was found. Surgical extirpation of the tumor was performed. Besides, several tumors of the thumb head size were detected into right retroperitoneal fatty tissue. The right side mesocolon and the tumors were not able to exfoliate, therefore right hemicolectomy was performed. Histological features showed dedifferentiated liposarcoma. The postoperative course was uneventful. But eight months after surgery, he was admitted again for treatment of a 4 3 cm retroperitoneal tumor. Extirpation of the tumor was performed. Histological finding of this tumor also showed dedifferentiated liposarcoma. Dedifferentiation, occurring in 15% of the well-differentiated liposarcomas, sometimes may develop later. Long-term detailed follow-up is necessary for well-differentiated liposarcoma.

Published
2011

11. Prevention of lethal hepatic injury in Long-Evans Cinnamon (LEC) rats by D-galactosamine hydrochloride

Author

Otsuka, Toshihiro, Izumi, Keisuke, Tokunaga, Itsuo, Gotohda, Takako, Ipposhi, Kaneshige, Takiguchi, Yoshiharu, Kaneda, Shinya, Satake, Nobuo, Ohnishi, Takamasa, Tashiro, Seiki, Shimada, Mitsuo, Otsuka, Toshihiro, Izumi, Keisuke, Tokunaga, Itsuo, Gotohda, Takako, Ipposhi, Kaneshige, Takiguchi, Yoshiharu, Kaneda, Shinya, Satake, Nobuo, Ohnishi, Takamasa, Tashiro, Seiki, and Shimada, Mitsuo

Abstract

Repeated injections of D-galactosamine hydrochloride (GalN) increase the survival rate of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson’s disease. The aim of the present study was to investigate the mechanism of GalN for prevention of spontaneous lethal hepatic injury in LEC rats. MaleLEC rats were given a single subcutaneous injection of 300mg/kg of GalN or vehicle (0.9%NaCl) at 14weeks, and killed at 28 weeks of age. Next, 6-week-old male LEC rats were given weekly subcutaneous injections of 300 mg/kg of GalN or vehicle for 3 or 12 weeks, and their hepatic 8-hydroxydeoxy-2’-guanosine (8-OHdG), glutathione peroxidase (GPX), and catalase activities were measured. None of GalN-treated rats died of hepatic injury (0/12), whereas the mortality rate of control rats given 0.9% NaCl was 17% (2/12). GalN administration for 12 weeks decreased the hepatic 8-OHdG, and GalN administration for either 3 or 12weeks increased the glutathione peroxidase activity. GalN administration increased the serum level of alanine aminotransferase, and accelerated megalocytic degeneration of the hepatocytes. GalN treatment is effective in preventing lethal hepatitis in LEC rats and decrease of oxidative DNA damage by GalN plays an important role in increase of the survival rate.

Published
2006

14. Complicated paraneoplastic neurological syndromes: a report of two patients with small cell or non-small cell lung cancer

Author

Hiasa, Yukiko, primary, Kunishige, Makoto, additional, Mitsui, Takao, additional, Kondo, Shunsuke, additional, Kuriwaka, Rika, additional, Shigekiyo, Shizuka, additional, Kanematsu, Takanori, additional, Satake, Nobuo, additional, Bando, Yoshimi, additional, Kondo, Akira, additional, Endo, Itsuro, additional, Oshima, Yasushi, additional, and Matsumoto, Toshio, additional

Published
2003
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16. Nihon Shoni Jinzobyo Gakkai Zasshi

Author

Kondo, Shuji, primary, Kagami, Shoji, additional, Urushihara, Maki, additional, Kitamura, Akiko, additional, Satake, Nobuo, additional, Izumi, Keisuke, additional, and Kuroda, Yasuhiro, additional

Published
2002
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19. Cancer Genetics of the Tuberous Schlerosis (TSC2) Gene Mutant.

Author

Hino, Okio, Kobayshi, Toshiyuki, Orimoto, Kenji, Urakami, Shinji, Fukuda, Tomokazu, Satake, Nobuo, and Yamashita, Yokihiko

Abstract

Human tuberous sclerosis is an autosomal dominant multisystem disorder characterized by phakomatosis with manifestations that include mental retardation and seizures, although abortive types are frequent. Recently, we identified a germline mutation in the rat homologous of the human tuberous sclerosis gene (TSC2) as the predisposing Eker gene (Kobayashi T, et al. Nature Genet 1995;9:70–74). The phenotype in human differs from that in the Eker rat, except for the occurrence of renal carcinomas (in humans, angiomyolipomas are more common). It is well known that tuberous sclerosis shows a variety of phenotypes, even within the same family; thus, the Eker rat may provide insights into phenotype-specific mutations. Because nothing is known about the molecular mechanism of human tuberous sclerosis, the Eker rat has great potential for elucidating the TSC2 gene role in renal carcinogenesis, as well as studying species-specific differences in tumorigenesis or cell-type specific carcinogenesis, or both. [ABSTRACT FROM AUTHOR]

Published
1999

23. Biallelic mutations of the <TOGGLE>Tsc2</TOGGLE> gene in chemically induced rat renal cell carcinoma

Author

Satake, Nobuo, Urakami, Shinji, Hirayama, Youko, Izumi, Keisuke, and Hino, Okio

Abstract

A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched for mutations of the Tsc2 gene in chemically induced non-Eker rat renal cell carcinomas (RCs). N-ethyl-N-hydroxyethylnitrosamine (EHEN)- and diethylnitrosamine (DEN)-induced non-Eker rat primary RCs were subjected to polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis using specific primers covering all exons of the Tsc2 gene (41 coding exons and 1 non-coding exon). We simultaneously searched for mutations in the Vhl gene, a rat homologue of von Hippel-Lindau disease (VHL) gene, as well as the Tsc2 gene. Mutations in the Vhl gene were not detected in any rat RCs (0/8). In contrast, Tsc2 gene mutations were detected at a high frequency in EHEN-induced RCs (2/3) and DEN-induced RCs (3/5) (total 5/8) (p &lt; 0.05). By a direct cloning approach utilizing PCR analysis in 2 applicable cases, we could demonstrate the presence of intragenic somatic mutations in both alleles of the Tsc2 gene. Our results suggest that Tsc2 gene inactivation plays an important role in EHEN- and DEN-induced RCs as well as in Eker rat RCs. Int. J. Cancer 77:895–900, 1998.© 1998 Wiley-Liss, Inc.

Published
1998
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24. Two Ectopic Liver Lobes Discovered Incidentally at an Autopsy: A Case Report.

Author

Sumida S, Satake N, and Tsuneyama K

Abstract

The ectopic liver lobe is a rare anomaly and is most frequently reported as a solitary mass. Herein, we report a case of multiple (two) ectopic liver lobes detected at an autopsy. A Japanese man in his 70s died of an infectious disease associated with acquired immunodeficiency syndrome (AIDS). Autopsy revealed the incidental finding of two 1-cm masses, located anterior to the inferior vena cava. Both masses were composed of liver tissue and had internal microscopic structures resembling the porta hepatis, consisting of an outflow bile duct and blood vessels. The outflow bile duct appeared to be continuous with the common bile duct, but the connection point of the outflow vessel was unclear. The liver tissue showed fibrous thickening of the central veins and portal venopathy, including fibrosis in the portal area as well as narrowing and loss of the portal veins. There was no evidence of congestion, fibrosis, biliary stasis, or neoplasm. The incidence of hepatocellular carcinoma is higher in the ectopic liver lobe than in the proper liver, presumably due to the abnormal circulation and bile excretion pathways. The patient also presented with portal venopathy; this suggests the presence of abnormal circulatory dynamics., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Sumida et al.)

Published
2024
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25. [Rapidly progressive AL amyloidosis in a patient with relapsed multiple myeloma after achieving a complete response to tandem autologous PBSCT].

Author

Yagi H, Ozaki S, Sekimoto E, Shibata H, Shigekiyo T, and Satake N

Subjects
Amyloidosis etiology, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Disease Progression, Doxorubicin administration & dosage, Doxorubicin therapeutic use, Fatal Outcome, Hematopoietic Stem Cell Transplantation methods, Humans, Male, Middle Aged, Multiple Myeloma complications, Multiple Myeloma pathology, Neoplasm Recurrence, Local complications, Neoplasm Recurrence, Local pathology, Recurrence, Transplantation, Autologous methods, Vincristine administration & dosage, Vincristine therapeutic use, Amyloidosis therapy, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Multiple Myeloma therapy, Neoplasm Recurrence, Local therapy
Abstract

A 56-year-old male presented with pathological rib fracture and lumbago in 2006. He was diagnosed with multiple myeloma (IgG-lambda type, D&S stage IIIA, ISS 2). He was treated with VAD therapy and tandem auto-PBSCT, and achieved CR in 2007. He was followed without chemotherapy, but relapsed in 2009. He received lenalidomide plus dexamethasone and bortezomib plus dexamethasone and achieved PR which was sustained for 25 months. In 2012, he developed edema of the lower legs and pleural effusion, and was diagnosed as having nephrotic syndrome and heart failure due to AL amyloidosis. He died of renal failure and heart failure 3 months after this diagnosis. Autopsy findings showed amyloid deposition in many organs including the heart, kidneys, liver, spleen, and intestines. Development of rapidly progressive AL amyloidosis is a rare complication of relapse after the achievement of CR, but careful monitoring is needed in patients with multiple myeloma.

Published
2013

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