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618 results on '"Sato, Fuminori"'

6. Sensitive and selective quantification of mid-regional proadrenomedullin in human plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry

Author

Iwao, Motoshi, Suzuki, Yosuke, Tanaka, Ryota, Koyama, Teruhide, Ozaki, Etsuko, Nakata, Takeshi, Aoki, Kohei, Fukuda, Akihiro, Sato, Yuhki, Kuriyama, Nagato, Fukunaga, Naoya, Sato, Fuminori, Katagiri, Fumihiko, Ohno, Keiko, Shibata, Hirotaka, Mimata, Hiromitsu, and Itoh, Hiroki

Published
2020
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12. A phase III multicenter, randomized, controlled study of combined androgen blockade with versus without zoledronic acid in prostate cancer patients with metastatic bone disease: results of the ZAPCA trial

Author

Kamba, Tomomi, Kamoto, Toshiyuki, Maruo, Shinichiro, Kikuchi, Takashi, Shimizu, Yosuke, Namiki, Shunichi, Fujimoto, Kiyohide, Kawanishi, Hiroaki, Sato, Fuminori, Narita, Shintaro, Satoh, Takefumi, Saito, Hideo, Sugimoto, Mikio, Teishima, Jun, Masumori, Naoya, Egawa, Shin, Sakai, Hideki, Okada, Yusaku, Terachi, Toshiro, Ogawa, Osamu, and ZAPCA Study Group

Published
2017
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19. Effect of Renal Impairment on the Pharmacokinetics of Memantine

Author

Moritoyo, Takashi, Hasunuma, Tomoko, Harada, Kazuhiro, Tateishi, Tomonori, Watanabe, Makoto, Kotegawa, Tsutomu, Nagai, Masahiro, Kumagai, Yuji, Fujitani, Tomomichi, Okura, Takahumi, Fukuoka, Tomikazu, Miyoshi, Kenichi, Matsuura, Bunzo, Furukawa, Shinya, Kobori, Tomoe, Moritoyo, Hiroyoko, Nishikawa, Noriko, Tsujii, Tomoaki, Iwaki, Hirotaka, Nakamura, Masahiko, Makino, Satoshi, Ohnuma, Kei, Yuji, Koichiro, Hashimoto, Megumi, Takasu, Masaru, Hashizume, Yutaka, You, Koji, Matsumura, Tomoko, Tanaka, Yuji, Matsumoto, Nahoko, Nakamura, Junichi, Miura, Jun, Akizawa, Tadao, Kitazawa, Kozo, Shibata, Takanori, Kuroki, Aki, Honda, Hirokazu, Mukai, Masanori, Ohashi, Kyoichi, Morimoto, Takuya, Imai, Hiromitsu, Okudaira, Toshiaki, Sato, Fuminori, Imanaga, Junko, Tanaka, Katsuhiro, and Nomoto, Masahiro

Published
2012
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20. A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery

Author

Hayashida, Ryosuke, primary, Tsuchiya, Kyoichiro, additional, Sekine, Tetsuo, additional, Momose, Takashi, additional, Sato, Fuminori, additional, Sakurada, Maya, additional, Nishida, Kenji, additional, Hayashi, Tatsuya, additional, Morita, Yasuhiro, additional, Okada, Haruka, additional, Fukushima, Noriyoshi, additional, Yamada, Tetsuya, additional, and Tsujino, Motoyoshi, additional

Published
2022
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29. CLP1 links tRNA metabolism to progressive motor-neuron loss

Author

Hanada, Toshikatsu, Weitzer, Stefan, Mair, Barbara, Bernreuther, Christian, Wainger, Brian J., Ichida, Justin, Hanada, Reiko, Orthofer, Michael, Cronin, Shane J., Komnenovic, Vukoslav, Minis, Adi, Sato, Fuminori, Mimata, Hiromitsu, Yoshimura, Akihiko, Tamir, Ido, Rainer, Johannes, Kofler, Reinhard, Yaron, Avraham, Eggan, Kevin C., Woolf, Clifford J., Glatze, Markus, Herbst, Ruth, Martinez, Javier, and Penninger, Josef M.

Subjects
Neuromuscular diseases -- Research, Motor neurons -- Observations, Phosphotransferases -- Properties, Transfer RNA -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clpl ([Clp1.sup.K/K]) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of neuromuscular junctions, resulting in impaired motor function, muscle weakness, paralysis and fatal respiratory failure. Transgenic rescue experiments show that CLP1 functions in motor neurons. Mechanistically, loss of CLP1 activity results in accumulation of a novel set of small RNA fragments, derived from aberrant processing of tyrosine pre-transfer RNA. These tRNA fragments sensitize cells to oxidative-stress-induced p53 (also known as TRP53) activation and p53-dependent cell death. Genetic inactivation of p53 rescues [Clp1.sup.K/K] mice from the motor neuron loss, muscle denervation and respiratory failure. Our experiments uncover a mechanistic link between tRNA processing, formation of a new RNA species and progressive loss of lower motor neurons regulated by p53., RNA molecules undergo co- and post-transcriptional processing, leading to mature, functional RNAs. In mammals and archaea CLP1 proteins are kinases that phosphorylate the 5' hydroxyl ends of RNA (1-3). Human [...]

Published
2013
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32. Computational prediction of the effect of microcavitation on an atomization mechanism in a gasoline injector nozzle

Author

Ishimoto, Jun, Sato, Fuminori, and Sato, Gaku

Subjects
Cavitation -- Research, Atomization -- Research, Nozzles -- Mechanical properties, Nozzles -- Maintenance and repair, Internal combustion engines -- Equipment and supplies, Engineering and manufacturing industries, Science and technology
Abstract

The effect of microcavitation on the 3D structure of the liquid atomization process in a gasoline injector nozzle was numerically investigated and visualized by a new integrated computational fluid dynamics (CFD) technique for application in the automobile industry. The present CFD analysis focused on the primary breakup phenomenon of liquid atomization which is closely related to microcavitation, the consecutive formation of liquid film, and the generation of droplets by a lateral flow in the outlet section of the nozzle. Governing equations for a high-speed lateral atomizing injector nozzle flow taking into account the microcavitation generation based on the barotropic large eddy simulation-volume of fluid model in conjunction with the continuum surface force model were developed, and then an integrated parallel computation was performed to clarify the detailed atomization process coincident with the microcavitation of a high-speed nozzle flow. Furthermore, data on such factors as the volume fraction of microcavities, atomization length, liquid core shapes, droplet-size distribution, spray angle, and droplet velocity profiles, which are difficult to confirm by experiment, were acquired. According to the present analysis, the atomization rate and the droplets-gas atomizing flow characteristics were found to be controlled by the generation of microcavitation coincident with the primary breakup caused by the turbulence perturbation upstream of the injector nozzle, hydrodynamic instabilities at the gas-liquid interface, and shear stresses between the liquid core and periphery of the jet. Furthermore, it was found that the energy of vorticity, close to the gas-liquid interface was converted to energy for microcavity generation or droplet atomization. [DOI: 10.1115/1.4000264]

Published
2010

42. Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA

Author

Sato, Fuminori, Kurokawa, Masatoshi, Yamauchi, Nobuhiko, and Hattori, Masa-aki

Subjects
Chick embryo -- Research, Chick embryo -- Genetic aspects, Gene silencing -- Research, Biological sciences
Abstract

Myostatin (GDF-8) is known to negatively regulate skeletal muscle mass in myogenesis, but few studies have been conducted on the function of endogenous GDF-8 in primary myoblasts. The present study was performed to assess the function of GDF-8 by RNA interference using primary culture of chicken embryonic myoblasts in which myoblasts were differentiated into myotubes. An active form of small interfering RNA (siRNA-1) targeting GDF-8 mRNA was introduced into myoblasts, and an inactive form of siRNA (siRNA-2) was used as a negative control. GDF-8 transcript level was significantly reduced 24 h after the introduction of siRNA-1 to 25% of the control, whereas a 52-kDa GDF-8 precursor was reduced to 45% of the control at 48 h. However, siRNA-2 did not decrease GDF-8 transcript level. When GDF-8-mediated promoter activity was measured chronologically by means of a pGL(CAGA)w-constructed luciferase reporter assay, a concomitant change in activity was initiated after 24 h. The activity rapidly decreased 30 h after siRNA-1 introduction, whereas high activity was maintained at 30-42 h in the control and siRNA-2-treated myoblasts. Myogenic factors such as MyoD and p21, but not myogenin, were altered after 72 h. Cell fusion of the multinucleated myotubes was delayed by the siRNA-1 introduction, and myotubes with aggregated nuclei were shorter and wider. These results strongly suggest that deficiency of GDF-8 delays cell differentiation and causes great alterations in the cellular morphology of chicken embryonic myotubes. GDF-8; GDF-8-mediated promoter activity; multinucleated myotubes doi:10.1152/ajpcell.00543.2005

Published
2006

47. Genomic profiling of renal cell carcinoma in patients with end-stage renal disease

Author

Inoue, Toru, Matsuura, Keiko, Yoshimoto, Taichiro, Nguyen, Lam Tung, Tsukamoto, Yoshiyuki, Nakada, Chisato, Hijiya, Naoki, Narimatsu, Takahiro, Nomura, Takeo, Sato, Fuminori, Nagashima, Yoji, Kashima, Kenji, Hatakeyama, Shingo, Ohyama, Chikara, Numakura, Kazuyuki, Habuchi, Tomonori, Nakagawa, Masayuki, Seto, Masao, Mimata, Hiromitsu, and Moriyama, Masatsugu

Published
2012
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