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8. Clinical Characteristics of Cough Frequency Patterns in Patients with and without Asthma

Author

Fukuhara, Atsuro, Saito, Junpei, Birring, Surinder S., Sato, Suguru, Uematsu, Manabu, Suzuki, Yasuhito, Rikimaru, Mami, Watanabe, Natsumi, Saito, Mikako, Kawamata, Takaya, Umeda, Takashi, Togawa, Ryuichi, Sato, Yuki, Koizumi, Tatsuhiko, Hirai, Kenichiro, Minemura, Hiroyuki, Nikaido, Takefumi, Kanazawa, Kenya, Tanino, Yoshinori, Munakata, Mitsuru, and Shibata, Yoko

Published
2020
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16. Sputum Neurturin Levels in Adult Asthmatic Subjects

Author

Sato,Suguru, Suzuki,Yasuhito, Kikuchi,Masami, Rikimaru,Mami, Saito,Junpei, Shibata,Yoko, Sato,Suguru, Suzuki,Yasuhito, Kikuchi,Masami, Rikimaru,Mami, Saito,Junpei, and Shibata,Yoko

Abstract

Suguru Sato, Yasuhito Suzuki, Masami Kikuchi, Mami Rikimaru, Junpei Saito, Yoko Shibata Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, JapanCorrespondence: Suguru Sato, Email suguru@fmu.ac.jpBackground: Neurturin (NRTN) is a neurotrophic factor that was originally identified in the development and maintenance of neural cells. Recent studies involving NRTN knockout mice have reported its anti-inflammatory effects in allergic airway conditions. However, the role of NRTN in human asthma has not yet been identified.Objective: The purposes of the present study were to confirm the presence of NRTN in the airways and to investigate the clinical and pathogenetic roles of NRTN in asthma.Methods: The NRTN levels in the induced sputum were measured by enzyme-linked immunosorbent assay (ELISA). Relationships between NRTN and clinical characteristics, asthma control status, and airway inflammation were assessed.Results: Sixty-four asthmatic subjects were enrolled in the study. All asthmatic subjects had detectable sputum NRTN levels, with a mean (SD) level of 2.03 (1.29) ng/mL. The sputum NRTN levels had significant positive correlations with sputum eosinophil and exhaled nitric oxide levels and were significantly higher in the atopic subjects than in the non-atopic subjects. No significant difference in sputum NRTN levels were observed for asthma control status and asthma exacerbation. In sputum inflammatory analyses, sputum NRTN level was positively correlated with interleukin (IL)-5 and IL-13 levels, and negatively correlated with matrix metalloproteinase (MMP)-9 level.Conclusion: It is plausible that sputum NRTN could serve as a new marker for Type 2 airway inflammation, implicating its role in the process of airway remodeling in asthma. Future studies should investigate the clinical relevance of sputum NRTN level in prospective analyses.Keywords: neurturin, asthma, sputum, airway inflammation, type 2 inflammation

Published
2023

22. Serum Syndecan-4 as a Possible Biomarker in Patients With Acute Pneumonia

Author

Nikaido, Takefumi, Tanino, Yoshinori, Wang, Xintao, Sato, Suguru, Misa, Kenichi, Fukuhara, Naoko, Sato, Yuki, Fukuhara, Atsuro, Uematsu, Manabu, Suzuki, Yasuhito, Kojima, Tetsuhito, Tanino, Mishie, Endo, Yuichi, Tsuchiya, Kohsuke, Kawamura, Ikuo, Frevert, Charles W., and Munakata, Mitsuru

Published
2015

23. Effect of Zr Addition on Magnetic Properties of TbCu7-Type Sm–Fe–N Powder Synthesized by Low-Temperature Ca Reduction Diffusion Process

Author

Sato, Suguru, Suzuki, Kazuyuki, and Okada, Shusuke

Abstract

The effect of the addition of Zr on the magnetic properties of anisotropic TbCu7-type Sm–Fe–N powders prepared by the low-temperature reduction-diffusion (LTRD) process was investigated. At the reduction diffusion temperature of 873 K, the TbCu7-type Sm–Fe phase ratio decreased with an increase in the Zr content. At a higher reduction diffusion temperature of 973 K, a TbCu7-type Sm–Fe phase was obtained regardless of the amount of Zr added. Furthermore, the Th2Zn17-type Sm–Fe phase was obtained without the addition of Zr. Therefore, it was indicated that the addition of Zr can stabilize the TbCu7-type Sm–Fe phase at high temperatures. By nitriding the obtained powder, a TbCu7-type Sm–Fe–N powder was obtained; however, its magnetic properties deteriorated as the amount of Zr increased. Microstructural analysis revealed that the element ratio Zr/Sm in the TbCu7-type Sm–Fe–N particles saturated at approximately 0.05, and the excess Zr was consumed to form the ZrFe2 phase on the outside of the particles. It was concluded that the ZrFe2 phase results in the deterioration of the magnetic properties of the powder.

Published
2023
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31. Guidelines for Reproductive Medicine in Japan

Author

Yamada, Mitsutoshi, primary, Ishikawa, Tomonori, additional, Iwasa, Takeshi, additional, Oishi, Hajime, additional, Osuka, Satoko, additional, Oka, Kenji, additional, Ono, Shuichi, additional, Ono, Masanori, additional, Orisaka, Makoto, additional, Kanasaki, Haruhiko, additional, Kawano, Yasushi, additional, Kawamura, Kazuhiro, additional, Kishi, Hiroshi, additional, Kimura, Fuminori, additional, Kuroda, Shinnosuke, additional, Kuwahara, Akira, additional, Kobayashi, Hideyuki, additional, Komiya, Akira, additional, Saito, Hidekazu, additional, Sato, Kenji, additional, Sato, Suguru, additional, Shiraishi, Koji, additional, Shirasawa, Hiromitsu, additional, Suzuki, Tatsuya, additional, Takai, Yasushi, additional, Takae, Seido, additional, Takahashi, Toshifumi, additional, Takiuchi, Tsuyoshi, additional, Tachibana, Masahito, additional, Tamura, Isao, additional, Tamura, Hiroshi, additional, Jwa, Seung Chik, additional, Baba, Tsuyoshi, additional, Harada, Miyuki, additional, Hirata, Tetsuya, additional, Fukui, Atsushi, additional, Fukuda, Yusuke, additional, Fukuhara, Shinichiro, additional, Maruyama, Tetsuo, additional, Yumura, Yasushi, additional, Yoshino, Osamu, additional, Hirota, Yasushi, additional, Tsujimura, Akira, additional, Kuji, Naoaki, additional, and Osuga, Yutaka, additional

Published
2022
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34. Usefulness of diurnal variation of fractional exhaled nitric oxide for predicting early therapeutic response to asthma treatment

Author

Uematsu,, Manabu, primary, Saito,, Junpei, additional, Sato,, Suguru, additional, Fukuhara,, Atsuro, additional, Suzuki,, Yasuhito, additional, Rikimaru,, Mami, additional, Onuma,, Takumi, additional, Tomita,, Hikaru, additional, Watanabe,, Natsumi, additional, Saito,, Mikako, additional, Morimoto,, Julia, additional, Kawamata,, Takaya, additional, Umeda,, Takashi, additional, Togawa,, Ryuichi, additional, Sato,, Yuki, additional, Koizumi,, Tatsuhiko, additional, Hirai,, Kenichiro, additional, Minemura,, Hiroyuki, additional, Nikaido,, Takefumi, additional, Kanazawa,, Kenya, additional, Tanino,, Yoshinori, additional, Munakata,, Mitsuru, additional, and Shibata,, Yoko, additional

Published
2021
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36. Usefulness of diurnal variation of fractional exhaled nitric oxide for predicting early therapeutic response to asthma treatment.

Author

Uematsu, Manabu, Saito, Junpei, Sato, Suguru, Fukuhara, Atsuro, Suzuki, Yasuhito, Rikimaru, Mami, Onuma, Takumi, Tomita, Hikaru, Watanabe, Natsumi, Saito, Mikako, Morimoto, Julia, Kawamata, Takaya, Umeda, Takashi, Togawa, Ryuichi, Sato, Yuki, Koizumi, Tatsuhiko, Hirai, Kenichiro, Minemura, Hiroyuki, Nikaido, Takefumi, and Kanazawa, Kenya

Subjects
NITRIC oxide, EXPIRATORY flow, ASTHMA
Abstract

Fractional exhaled nitric oxide (FeNO) is considered to be an adjunct for asthma management, although its usefulness remains controversial. Therefore, it may be necessary for new approaches to use FeNO for asthma management. We evaluated whether diurnal variations of FeNO can predict response to asthma treatment. This pilot study consisted of 22 uncontrolled asthmatics and 16 healthy subjects. FeNO and peak expiratory flow (PEF) were measured by themselves twice daily at home for three weeks (asthmatics) or two weeks (healthy subjects), and daily mean and diurnal variations of FeNO and PEF levels were calculated. In uncontrolled asthmatics, treatment was intensified a week after study entry, and then control status was reevaluated after three to four weeks. Asthmatics were then divided into two groups; good or poor responders. Diurnal variations of FeNO levels, as well as daily mean FeNO and PEF levels, in uncontrolled asthmatics before intensive treatment were significantly higher than those in healthy subjects, regardless of treatment response (p < 0.01). Furthermore, in the good responders, diurnal variations of FeNO levels were significantly decreased in the 1st week (p < 0.05) of intensive treatment, whereas the daily mean FeNO levels significantly dropped in the 2nd week (p < 0.05). In the poor responders, no such changes were observed in FeNO levels. In terms of PEF, only the daily mean levels were significantly elevated after the initiation of intensive treatment, regardless of treatment response. Diurnal variations of FeNO may contribute to predicting early therapeutic response to asthma treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Association Between Sleep Characteristics and Asthma Control in Middle-Aged and Older Adults: A Prospective Cohort Study

Author

Sato,Suguru, Saito,Junpei, Fukuhara,Atsuro, Uematsu,Manabu, Suzuki,Yasuhito, Rikimaru,Mami, Kawamata,Takaya, Umeda,Takashi, Koizumi,Tatsuhiko, Togawa,Ryuichi, Sato,Yuki, Nikaido,Takefumi, Minemura,Hiroyuki, Kanazawa,Kenya, Tanino,Yoshinori, Shibata,Yoko, Sato,Suguru, Saito,Junpei, Fukuhara,Atsuro, Uematsu,Manabu, Suzuki,Yasuhito, Rikimaru,Mami, Kawamata,Takaya, Umeda,Takashi, Koizumi,Tatsuhiko, Togawa,Ryuichi, Sato,Yuki, Nikaido,Takefumi, Minemura,Hiroyuki, Kanazawa,Kenya, Tanino,Yoshinori, and Shibata,Yoko

Abstract

Suguru Sato, Junpei Saito, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Mami Rikimaru, Takaya Kawamata, Takashi Umeda, Tatsuhiko Koizumi, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Hiroyuki Minemura, Kenya Kanazawa, Yoshinori Tanino, Yoko Shibata Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, 960-1295, JapanCorrespondence: Suguru SatoDepartment of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Hikarigaoka-1, Fukushima, 960-1295, JapanTel +81-24-547-1360Fax +81-24-548-9366Email suguru@fmu.ac.jpBackground: Nocturnal asthma symptoms are a well-known feature of sleep disturbance. However, there are few reports on the association between sleep-related characteristics and asthma exacerbation. The aim of the current prospective observational study was to explore the factors while sleeping associated with future asthma exacerbation.Materials and Methods: At baseline, adult asthmatics underwent home sleep monitoring by a Watch-PAT instrument and then they were prospectively followed-up for the occurrence of exacerbations. The number of asthma exacerbation was observed over a period of one year, and multivariable analyses of the factors associated with asthma exacerbation were performed.Results: A total of 62 asthmatic subjects were enrolled (mean age 62.1 years), 59 of whom were finally included in the prospective observational study. Obstructive sleep apnea (defined by an apnea-hypopnea index based on peripheral arterial tone more than 5 times/hour) were observed in 81% of the subjects. During the one-year monitoring period, 14 of the 59 subjects (24%) used occasional systemic corticosteroids for their exacerbation asthma (worsened group) while the other 45 subjects did not experience asthma exacerbation (stable group). A comparison of the baseline clinical characteristics and sleep-related data between the two groups, mean forced expiratory volume one second percent (FEV1/FVC), mean baseline Asth

Published
2021

41. Association Between Sleep Characteristics and Asthma Control in Middle-Aged and Older Adults: A Prospective Cohort Study

Author

Sato, Suguru, primary, Saito, Junpei, additional, Fukuhara, Atsuro, additional, Uematsu, Manabu, additional, Suzuki, Yasuhito, additional, Rikimaru, Mami, additional, Kawamata, Takaya, additional, Umeda, Takashi, additional, Koizumi, Tatsuhiko, additional, Togawa, Ryuichi, additional, Sato, Yuki, additional, Nikaido, Takefumi, additional, Minemura, Hiroyuki, additional, Kanazawa, Kenya, additional, Tanino, Yoshinori, additional, and Shibata, Yoko, additional

Published
2021
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49. Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Involving the Lung and Brain: A Rare Case Study

Author

Suzuki, Yasuhito, primary, Minemura, Hiroyuki, additional, Tomita, Hikaru, additional, Saito, Mikako, additional, Watanabe, Natsumi, additional, Umeda, Takashi, additional, Kawamata, Takaya, additional, Rikimaru, Mami, additional, Morimoto, Julia, additional, Koizumi, Tatsuhiko, additional, Togawa, Ryuichi, additional, Sato, Yuki, additional, Hirai, Kenichiro, additional, Uematsu, Manabu, additional, Nikaido, Takefumi, additional, Fukuhara, Naoko, additional, Fukuhara, Atsuro, additional, Sato, Suguru, additional, Saito, Junpei, additional, Kanazawa, Kenya, additional, Tanino, Yoshinori, additional, and Shibata, Yoko, additional

Published
2020
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50. Spontaneous Regression of Sarcoidosis with Panhypopituitarism

Author

Kawamata, Takaya, primary, Tanino, Yoshinori, additional, Nikaido, Takefumi, additional, Sato, Yuki, additional, Togawa, Ryuichi, additional, Suzuki, Yasuhito, additional, Watanabe, Natsumi, additional, Saito, Mikako, additional, Rikimaru, Mami, additional, Umeda, Takashi, additional, Koizumi, Tatsuhiko, additional, Hirai, Kenichiro, additional, Uematsu, Manabu, additional, Minemura, Hiroyuki, additional, Fukuhara, Atsuro, additional, Sato, Suguru, additional, Saito, Jumpei, additional, Kanazawa, Kenya, additional, Hebisawa, Akira, additional, and Shibata, Yoko, additional

Published
2020
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