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159 results on '"Satturwar, Swati"'

4. Comparing Accuracy of Helicobacter pylori Identification Using Traditional Hematoxylin and Eosin–Stained Glass Slides With Digital Whole Slide Imaging

Author

Chen, Wei, Ziebell, Jennifer, Arole, Vidya, Parkinson, Bryce, Yu, Lianbo, Dai, Harrison, Frankel, Wendy L., Yearsley, Martha, Esnakula, Ashwini, Sun, Shaoli, Gamble, Denise, Vazzano, Jennifer, Mishra, Manisha, Schoenfield, Lynn, Kneile, Jeffrey, Reuss, Sarah, Schumacher, Melinda, Satturwar, Swati, Li, Zaibo, Parwani, Anil, and Lujan, Giovanni

Published
2024
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12. Pulmonary Histoplasmosis Complicated by Nonvalvular Right Ventricular Wall Histoplasma capsulatum Endocarditis.

Author

Shaker, Nada, Amadi, Chiemezie C., Ganapathi, Asvin M., Satturwar, Swati, and Shilo, Konstantin

Subjects
HISTOPLASMOSIS, ENDOCARDITIS, NEEDLE biopsy, RETICULO-endothelial system, SUPRAVENTRICULAR tachycardia, LUNGS
Abstract

Histoplasmosis is commonly a self-limited fungal disease that primarily affects the lung and reticuloendothelial system. Cardiac involvement by histoplasmosis is uncommon. In this report, we provide a detailed description of severe pulmonary histoplasmosis complicated by the disease involvement of the free wall of the right ventricle. A 55-year-old female presented with cough, fevers, dyspnea, and 30-pound unintentional weight loss in 6 months. Her past medical history was significant for supraventricular tachycardia with permanent pacemaker implantation. Imaging studies revealed an intracardiac mass accompanied by mediastinal lymphadenopathy and bilateral lung nodules. Endobronchial ultrasound-guided transbronchial needle aspiration of station 4R lymph nodes revealed numerous yeast forms, morphologically consistent with Histoplasma capsulatum. The diagnosis was further corroborated by the elevated titers of serum antibodies against Histoplasma capsulatum. The right ventricular mass debulking with biopsy showed necrotizing granulomatous inflammation involving nonvalvular endocardium and myocardium of the free wall of the right ventricle. The report documents an unusual presentation of pulmonary histoplasmosis accompanied by nonvalvular endocarditis and suggests a possible association between the site of the cardiac infection and the presence of a permanent intravascular pacer device. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Comparing Accuracy of Helicobacter pylori Identification Using Traditional Hematoxylin and Eosin (H&E)-stained Glass Slides with Digital Whole Slide Imaging

Author

Chen, Wei, primary, Ziebell, Jennifer, additional, Arole, Vidya, additional, Parkinson, Bryce, additional, Yu, Lianbo, additional, Dai, Harrison, additional, Frankel, Wendy L., additional, Yearsley, Martha, additional, Esnakula, Ashwini, additional, Sun, Shaoli, additional, Gamble, Denise, additional, Vazzano, Jennifer, additional, Mishra, Manisha, additional, Schoenfield, Lynn, additional, Kneile, Jeffrey, additional, Reuss, Sarah, additional, Schumacher, Melinda, additional, Satturwar, Swati, additional, Li, Zaibo, additional, Parwani, Anil, additional, and Lujan, Giovanni, additional

Published
2023
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25. Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies

Author

Rizzo, Paola Chiara, primary, Girolami, Ilaria, additional, Marletta, Stefano, additional, Pantanowitz, Liron, additional, Antonini, Pietro, additional, Brunelli, Matteo, additional, Santonicco, Nicola, additional, Vacca, Paola, additional, Tumino, Nicola, additional, Moretta, Lorenzo, additional, Parwani, Anil, additional, Satturwar, Swati, additional, Eccher, Albino, additional, and Munari, Enrico, additional

Published
2022
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34. Postmortem Findings Associated With SARS-CoV-2

Author

Satturwar, Swati, Fowkes, Mary, Farver, Carol, Wilson, Allecia M., Eccher, Albino, Girolami, Ilaria, Pujadas, Elisabet, Bryce, Clare, Salem, Fadi, El Jamal, Siraj M., Paniz-Mondolfi, Alberto, Petersen, Bruce, Gordon, Ronald E., Reidy, Jason, Fraggetta, Filippo, Marshall, Desiree A., and Pantanowitz, Liron

Subjects
Myocardium, coronavirus, SARS-CoV-1, COVID-19, Brain, Original Articles, Global Health, Kidney, Severe Acute Respiratory Syndrome, Pathology and Forensic Medicine, autopsy, Case-Control Studies, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, pathology, Surgery, Anatomy, Lung, Spleen
Abstract

Supplemental Digital Content is available in the text., Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome–associated Coronavirus 2 (SARS-CoV-2), has become a global threat to public health. COVID-19 is more pathogenic and infectious than the prior 2002 pandemic caused by SARS-CoV-1. The pathogenesis of certain disease manifestations in COVID-19 such as diffuse alveolar damage (DAD) are thought to be similar to SARS-CoV-1. However, the exact pathogenesis of COVID-19 related deaths remains poorly understood. The aim of this article was to systematically summarize the rapidly emerging literature regarding COVID-19 autopsies. A meta-analysis was also conducted based on data accrued from preprint and published articles on COVID-19 (n=241 patients) and the results compared with postmortem findings associated with SARS-CoV-1 deaths (n=91 patients). Both autopsy groups included mostly adults of median age 70 years with COVID-19 and 50 years with SARS-CoV-1. Overall, prevalence of DAD was more common in SARS-CoV-1 (100.0%) than COVID-19 (80.9%) autopsies (P=0.001). Extrapulmonary findings among both groups were not statistically significant except for hepatic necrosis (P

Published
2021
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46. Thyroid paraganglioma: A diagnostic pitfall in thyroid FNA.

Author

Satturwar, Swati P., Rossi, Esther D., Maleki, Zahra, Cantley, Richard L., Faquin, William C., and Pantanowitz, Liron

Abstract

Background: Thyroid paragangliomas are extremely rare and often are misdiagnosed by preoperative fine‐needle aspiration (FNA) because their cytologic features overlap with those of other thyroid neoplasms. The objective of this study was to review the cytomorphology in a series of thyroid paragangliomas and correlate the findings with histopathology. Methods: Five thyroid paraganglioma cases that underwent FNA were reviewed. Their clinical presentation, radiology features, cytomorphology, ancillary tests, and histopathology were analyzed. Results: All patients were women with an average age of 49 years (age range, 35‐61 years) and presented with an asymptomatic, solitary thyroid nodule. Radiologically, these nodules (size range, 1.8‐3.0 cm) were well circumscribed, hypoechoic, and hypervascular. FNA smears showed clusters of loosely cohesive, medium‐to‐large epithelioid cells with clear‐to‐eosinophilic and occasionally foamy cytoplasm that had indistinct cytoplasmic borders. The nuclei were round to oval with focal nuclear membrane irregularities, inconspicuous nucleoli, focal marked anisonucleosis, and occasional intranuclear pseudoinclusions. Naked nuclei, variable numbers of plasmacytoid cells, multinucleated giant cells, and sustentacular cells were present in the background along with blood vessels and lymphocytes. Cytology diagnoses were incorrect and included follicular neoplasm (n = 4) and follicular lesion of undetermined significance (n = 1). Final histopathology with immunohistochemistry revealed conventional paraganglioma (n = 3) or sclerosing paraganglioma with invasive features (n = 2). Conclusions: All thyroid paragangliomas were misdiagnosed on FNA as follicular neoplasms, in part because of the rarity of these tumors in this location and cytomorphology mimicking follicles. The absence of colloid, the presence of naked nuclei, focal marked anisonucleosis, and the presence of sustentacular cells are important cytology clues. Thyroid paragangliomas are extremely rare and often are misdiagnosed by preoperative fine‐needle aspiration cytology. The presence of naked nuclei, focal marked anisonucleosis, and sustentacular cells and the absence of colloid are important cytologic clues that may help to triage fine‐needle aspiration samples for ancillary testing to confirm the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Sarcomas Harboring EWSR1::PATZ1Fusions: A Clinicopathologic Study of 17 Cases

Author

Dehner, Carina A., Torres-Mora, Jorge, Gupta, Sounak, Kipp, Benjamin R., Halling, Kevin C., Chen, Shaoxiong, Warmke, Laura M., Michal, Michael, Alani, Ali, Yu, Wendong, Kovacs, Krisztian, Obeidin, Farres, Iwenofu, Obiajulu Hans, Satturwar, Swati, Meis, Jeanne M., and Folpe, Andrew L.

Abstract

Soft tissue sarcomas harboring EWSR1::PATZ1are a recently recognized entity with variable morphology and a heterogeneous immunohistochemical profile. We studied 17 such tumors. The tumors occurred in 12 men and 5 women (median age, 50 years; range, 15-71 years), involved the thoracoabdominal soft tissues (14 cases; 82%), lower extremities (2 cases; 12%), and tongue (1 case; 6%), and ranged from 0.7 to 11.3 cm (median, 4.7 cm). All but 1 patient received complete surgical resection; 7 were also treated with neoadjuvant chemo/radiotherapy. All cases showed typical features of EWSR1::PATZ1sarcoma, including uniform round to spindled cells, fibromyxoid matrix, fibrous bands, hyalinized vessels, and pseudoalveolar/microcystic spaces. Unusual features, seen in a subset of cases, included degenerative-appearing nuclear atypia, epithelioid cytomorphology, mature fat, abundant rhabdomyoblasts, high mitotic activity, and foci with increased cellularity and nuclear atypia. Positive immunohistochemical results were desmin (16/17, 94%), MyoD1 (13/14, 93%), myogenin (6/14, 43%), GFAP (10/10, 100%), S100 protein (15/17, 88%), SOX10 (7/13, 54%), keratin (10/17, 59%), CD99 (4/11, 36%), H3K27me3 (retained expression 9/9, 100%), p16 (absent expression 1/4, 25%), and p53 (wild type 3/3, 100%). Fusion events included EWSR1exon 8::PATZ1exon 1 (14/17, 82%), EWSR1exon 9::PATZ1exon 1 (2/17, 12%), and EWSR1exon 7::PATZ1exon 1 (1/17, 6%). No evaluated tumor had alterations of CDKN2A/Band/or TP53, or MDM2amplification. Clinical follow-up (16 patients: median, 13.5 months; range, 1-77 months) showed distant metastases in 3 patients (1/3 at time of presentation) and no local recurrences. At the time of last follow-up, 14 patients were disease free, 1 was alive with disease, 1 was dead of disease (at 13 months), and 1 had an indeterminant pulmonary nodule. We conclude that the morphologic spectrum of EWSR1::PATZ1is broader than has been previously appreciated. Although more long-term follow-up is needed, the prognosis of these very rare sarcomas may be more favorable than previously reported.

Published
2024
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