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6. Sensitive detection and quantification of SARS-CoV-2 in saliva

Author

Abasiyanik, Mustafa Fatih, Flood, Blake, Lin, Jing, Ozcan, Sefika, Rouhani, Sherin J., Pyzer, Athalia, Trujillo, Jonathan, Zhen, Chaojie, Wu, Ping, Jumic, Stephen, Wang, Andrew, Gajewski, Thomas F., Wang, Peng, Hartley, Madeline, Ameti, Bekim, Niemiec, Rachael, Fernando, Marian, Mishra, Vasudha, Savage, Peter, Aydogan, Bulent, Bethel, Cindy, Matushek, Scott, Beavis, Kathleen G., Agrawal, Nishant, Segal, Jeremy, Tay, Savaş, and Izumchenko, Evgeny

Published
2021
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7. Immune profiles in primary squamous cell carcinoma of the head and neck

Author

Saloura, Vassiliki, Izumchenko, Evgeny, Zuo, Zhixiang, Bao, Riyue, Korzinkin, Michael, Ozerov, Ivan, Zhavoronkov, Alex, Sidransky, David, Bedi, Atul, Hoque, Mohammad O., Koeppen, Hartmut, Keck, Michaela K., Khattri, Arun, London, Nyall, Kotlov, Nikita, Fatima, Aiman, Vougiouklakis, Theodore, Nakamura, Yusuke, Lingen, Mark, Agrawal, Nishant, Savage, Peter A., Kron, Stephen, Kline, Justin, Kowanetz, Marcin, and Seiwert, Tanguy Y.

Published
2019
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8. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

Author

Nalle, Sam C., Zuo, Li, Ong, Ma. Lora Drizella M., Singh, Gurminder, Worthylake, Alicia M., Choi, Wangsun, Manresa, Mario Cabrero, Southworth, Anna P., Edelblum, Karen L., Baker, Gregory J., Joseph, Nora E., Savage, Peter A., and Turner, Jerrold R.

Subjects
Apoptosis -- Research, Graft vs. host disease -- Care and treatment -- Prevention, Hematopoietic stem cell transplantation -- Usage, T cells -- Research, Enzymes, Histochemistry, Permeability, Stem cells, Surgery, Stem cell transplantation, Health care industry
Abstract

Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation (HSCT) that affects multiple organs. GVHD-associated intestinal damage can be separated into two distinct phases, initiation and propagation, which correspond to conditioning-induced damage and effector T cell activation and infiltration, respectively. Substantial evidence indicates that intestinal damage induced by pretransplant conditioning is a key driver of GVHD initiation. Here, we aimed to determine the impact of dysregulated intestinal permeability on the subsequent GVHD propagation phase. The initiation phase of GVHD was unchanged in mice lacking long MLCK (MLCK210), an established regulator of epithelial tight junction permeability. However, MLCK210-deficient mice were protected from sustained barrier loss and exhibited limited GVHD propagation, as indicated by reduced histopathology, fewer [CD8.sup.+] effector T cells in the gut, and improved overall survival. Consistent with these findings, intestinal epithelial MLCK210 expression and enzymatic activity were similarly increased in human and mouse GVHD biopsies. Intestinal epithelial barrier loss mediated by MLCK210 is therefore a key driver of the GVHD propagation. These data suggest that inhibition of MLCK210-dependent barrier regulation may be an effective approach to limiting GVHD progression., Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) is used in the treatment of neoplastic and immune disorders. Graft-versus-host disease (GVHD), in which donor-derived T cells target recipient alloantigens to cause [...]

Published
2019
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19. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study

Author

Bonds, Denise E, Miller, Michael E, Bergenstal, Richard M, Buse, John B, Byington, Robert P, Cutler, Jeff A, Dudl, Rjames, Ismail-Beigi, Faramarz, Kimel, Angela R, Hoogwerf, Byron, Horowitz, Karen R, Savage, Peter J, Seaquist, Elizabeth R, Simmons, Debra L, Sivitz, William I, Speril-Hillen, Joann M, and Sweeney, Mary Ellen

Published
2010

20. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study

Author

Miller, Michael E, Bonds, Denise E, Gerstein, Hertzel C, Seaquist, Elizabeth R, Bergenstal, Richard M, Calles-Escandon, Jorge, Childress, R Dale, Craven, Timothy E, Cuddihy, Robert M, Dailey, George, Feinglos, Mark N, Ismail-Beigi, Farmarz, Largay, Joe F, O'Connor, Patrick J, Paul, Terri, Savage, Peter J, Schubart, Ulrich K, Sood, Ajay, and Genuth, Saul

Published
2010

23. A robust and interpretable gene signature for predicting the lymph node status of primary T1 / T2 oral cavity squamous cell carcinoma

Author

Ghantous, Yasmin, primary, Omar, Mohamed, additional, Broner, Esther Channah, additional, Agrawal, Nishant, additional, Pearson, Alexander T., additional, Rosenberg, Ari J., additional, Mishra, Vasudha, additional, Singh, Alka, additional, El‐naaj, Imad Abu, additional, Savage, Peter A., additional, Sidransky, David, additional, Marchionni, Luigi, additional, and Izumchenko, Evgeny, additional

Published
2021
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28. Skin stem cells orchestrate de novo generation of extrathymic regulatory T cells to establish a temporary protective niche during wound healing

Author

Truong, Cynthia, primary, Guo, Weijie, additional, Woodside, Liberty, additional, Gang, Audrey, additional, Savage, Peter, additional, Infarinato, Nicole, additional, Stewart, Katherine, additional, Polak, Lisa, additional, Levorse, John, additional, Pasolli, Amalia, additional, Dikiy, Stanislav, additional, Rudensky, Alexander, additional, Fuchs, Elaine, additional, and Miao, Yuxuan, additional

Published
2021
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29. Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma

Author

Broner, Esther C., primary, Trujillo, Jonathan A., additional, Korzinkin, Michael, additional, Subbannayya, Tejaswini, additional, Agrawal, Nishant, additional, Ozerov, Ivan V., additional, Zhavoronkov, Alex, additional, Rooper, Lisa, additional, Kotlov, Nikita, additional, Shen, Le, additional, Pearson, Alexander T., additional, Rosenberg, Ari J., additional, Savage, Peter A., additional, Mishra, Vasudha, additional, Chatterjee, Aditi, additional, Sidransky, David, additional, and Izumchenko, Evgeny, additional

Published
2021
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31. The endogenous repertoire harbors self-reactive CD4+T cell clones that adopt a follicular helper T cell-like phenotype at steady state

Author

Lee, Victoria, Rodriguez, Donald M., Ganci, Nicole K., Zeng, Sharon, Ai, Junting, Chao, Jaime L., Walker, Matthew T., Miller, Christine H., Klawon, David E. J., Schoenbach, Mary H., Kennedy, Domenick E., Maienschein-Cline, Mark, Socci, Nicholas D., Clark, Marcus R., and Savage, Peter A.

Abstract

The T cell repertoire of healthy mice and humans harbors self-reactive CD4+conventional T (Tconv) cells capable of inducing autoimmunity. Using T cell receptor profiling paired with in vivo clonal analysis of T cell differentiation, we identified Tconvcell clones that are recurrently enriched in non-lymphoid organs following ablation of Foxp3+regulatory T (Treg) cells. A subset of these clones was highly proliferative in the lymphoid organs at steady state and exhibited overt reactivity to self-ligands displayed by dendritic cells, yet were not purged by clonal deletion. These clones spontaneously adopted numerous hallmarks of follicular helper T (TFH) cells, including expression of Bcl6 and PD-1, exhibited an elevated propensity to localize within B cell follicles at steady state, and produced interferon-γ in non-lymphoid organs following sustained Tregcell depletion. Our work identifies a naturally occurring population of self-reactive TFH-like cells and delineates a previously unappreciated fate for self-specific Tconvcells.

Published
2023
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39. Trends in cardiovascular complications of diabetes

Author

Fox, Caroline S., Coady, Sean, Sorlie, Paul D., Levy, Daniel, Meigs, James B., D'Agostino, Ralph B., Sr., Wilson, W.F. Peter, and Savage, Peter J.

Subjects
Cardiovascular diseases -- Surveys, Cardiovascular diseases -- Diagnosis, Diabetes -- Surveys
Abstract

A study was conducted to determine whether adults with and without diabetes experienced similar declines in incident cardiovascular disease (CVD) in 1950-1995.The results reported a 50% reduction in the rate of incident CVD events among adults with diabetes, although the absolute risk of CVD is 2-fold greater than among persons without diabetes.

Published
2004

41. A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma.

Author

Ghantous, Yasmin, Omar, Mohamed, Broner, Esther Channah, Agrawal, Nishant, Pearson, Alexander T., Rosenberg, Ari J., Mishra, Vasudha, Singh, Alka, El‐naaj, Imad Abu, Savage, Peter A., Sidransky, David, Marchionni, Luigi, and Izumchenko, Evgeny

Subjects
NECK dissection, SQUAMOUS cell carcinoma, LYMPH nodes, GENE expression profiling, RECEIVER operating characteristic curves, METASTASIS
Abstract

Oral cavity squamous cell carcinoma (OSCC) affects more than 30 000 individuals in the United States annually, with smoking and alcohol consumption being the main risk factors. Management of early‐stage tumors usually includes surgical resection followed by postoperative radiotherapy in certain cases. The cervical lymph nodes (LNs) are the most common site for local metastasis, and elective neck dissection is usually performed if the primary tumor thickness is greater than 3.5 mm. However, postoperative histological examination often reveals that many patients with early‐stage disease are negative for neck nodal metastasis, posing a pressing need for improved risk stratification to either avoid overtreatment or prevent the disease progression. To this end, we aimed to identify a primary tumor gene signature that can accurately predict cervical LN metastasis in patients with early‐stage OSCC. Using gene expression profiles from 189 samples, we trained K‐top scoring pairs models and identified six gene pairs that can distinguish primary tumors with nodal metastasis from those without metastasis. The signature was further validated on an independent cohort of 35 patients using real‐time polymerase chain reaction (PCR) in which it achieved an area under the receiver operating characteristic (ROC) curve and accuracy of 90% and 91%, respectively. These results indicate that such signature holds promise as a quick and cost effective method for detecting patients at high risk of developing cervical LN metastasis, and may be potentially used to guide the neck treatment regimen in early‐stage OSCC. What's new? In oral squamous cell carcinoma (OSCC), early diagnosis of lymph‐node metastasis is essential for successful treatment. However, there is a pressing need for techniques that can improve risk stratification, in order to spare patients without metastases from further invasive surgery. In this study, the authors used a computer model to identify a simple, clinic‐friendly gene panel that can predict which OSCC tumors will likely spread to the lymph nodes. The reliability of this panel underscores the importance of embedding biological knowledge in the training process of cancer predictive models. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study

Author

Schmidt, Maria Inaas, Duncan, Bruce B, Sharrett, A Richey, Lindberg, Gunnar, Savage, Peter J, Offenbacher, Steven, Azambuja, Maria Inaas, Tracy, Russell P, and Heiss, Gerardo

Subjects
Type 2 diabetes -- Complications and side effects, Coronary heart disease -- Risk factors, Coronary heart disease -- Diagnosis, Biological markers -- Health aspects
Published
1999

48. An examination of the work of Sir Robert Lorimer

Author

Savage, Peter D.

Subjects
720, Scottish architect
Abstract

This thesis provides a chronological account of Lorimer's career and his work in eight chapters. The aim is to show how his work developed during his lifetime. The opportunities he was able to grasp, and his achievements in building design and landscaping are discussed. The second, allied, aim of this thesis is to show how Lorimer's abilities developed within the three different roles which he assumed at the professional level. The first two chapters discuss his development in early years; chapters 3, 4 and 5 discuss his middle years as a private architect, mainly for domestic buildings; chapter 6 discusses his role as a principal architect for the Imperial War Graves Commission, for which he acted in a public role; chapter 7 discusses the Scottish National War Memorial, for which he acted as National Architect. Lorimer's work is appraised at each stage in his career, and the fact that he enjoyed several different reputations in his own lifetime is discussed. Whereas he was seen as a pioneer at the end of the last century, by the end of the first decade of this century he was widely known as a Gothicist. His country houses then gained him the reputation of being the Scottish Lutyens, and finally in the thirties, the Scottish National War Memorial evoked a national pride so intense that it confirmed Lorimer more as a patriot than as any particular caste of architect.

Published
1973

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