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3. A National audit of the care of patients with acute kidney injury in England and Wales in 2019 and the association with patient outcomes

Author

Lee, Dr Keegan, Dan Cooper, Carr, Dr Edward, Marthi, Dr Amar, Swift, Dr Oscar, Hull, Dr Katherine, Nimmo, Dr Ailish, Liewm, Dr Hui, Tariq, Dr Behram, Whitehead, Dr Jenny, Edney, Dr Naomi, Whitbread, Dr Daniel, Mohamed, Dr Maha, Duffy, Dr Sam, Edwards, Dr Gwenno, Czajka, Dr Rachael, Ahmad, Dr Syed Hasan, Joslin, Dr Jennifer, Yong, Dr Esther Siaw Tsin, Chaudry, Dr Saurabh, McGuinness, Dr Daniel, Defreitas, Dr Sarah, Nosseir, Dr Heba, Seal, Dr Katherine, Amaran, Dr Mo, Gulati, Dr Kavita, Azam, Dr Muhammad J, Williams, Dr Jennifer, Smith-Jackson, Yin, Dr Bo-song, Shuaib, Dr Rishana, Akter, Dr Mosammat, Arimoto, Dr Ryoki, Oluyombo, Dr Rotimi, Davies, Dr Mark, Patel, Dr Purvi, Best-Trent, Tony, Handra, Dr Heidy, Mackie, Sarah, Wright, Kelly, Rahman, Dr Manzur, Cheema, Dr Hashem, Sardar, Dr Abbas, Harvard, Dr Lucy, Brook, Dr Matthew, Elphic, Dr Emma, Ahmed, Dr Mawahib, Ammar, Dr Kanbar, Harbe, Dr Madi, Corke, Dr Emma, Stacey, Dr Hannah, Yousif, Dr Mosab, Mohamed, Dr Dalal, Soe, Dr Lae Thandar, Sherna, Dr Adenwalla, Soutter, Dr Lauren, Davari, Dr Maria, Abburu, Dr Sneha, Wells, Dr James, Winterbottom, Dr Claire, Bottomley, Dr Matt, Morris, Dr Holly, Sadiq, Dr Anavami, Youssouf, Dr Sajeda, Graham-Brown, M.P.M., Casula, A., Savino, M., Humphrey, T., Pyart, R., Amaran, M., Williams, J., Crowe, K., and Medcalf, J.F.

Published
2024
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4. Prognostic Impact of Prostate-Specific Antigen at 6 Months After Radiotherapy in Localized Prostate Cancer: An Individual Patient Data Analysis of Randomized Trials

Author

Kwak, Lucia, primary, Ravi, Praful, additional, Armstrong, John G., additional, Beckendorf, Veronique, additional, Chin, Joseph L., additional, D'Amico, Anthony V., additional, Dearnaley, David P., additional, Di Stasi, Savino M., additional, Gillessen, Silke, additional, Lukka, Himanshu, additional, Mottet, Nicolas, additional, Pommier, Pascal, additional, Seiferheld, Wendy, additional, Sydes, Matthew R., additional, Tombal, Bertrand, additional, Zapatero, Almudena, additional, Regan, Meredith M., additional, Xie, Wanling, additional, and Sweeney, Christopher J., additional

Published
2024
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5. Clinical presentation and prognosis of COVID-19 in older adults with hypothyroidism: data from the GeroCovid observational study

Author

Bagala, V, Sala, A, Trevisan, C, Okoye, C, Incalzi, R, Monzani, F, Volpato, S, Antognoli, R, Antonietti, M, Bandini, G, Bellelli, G, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bignamini, S, Blandini, D, Boffelli, S, Bugada, M, Calsolaro, V, Calvani, D, Carpagnano, E, Carrieri, B, Castaldo, V, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Coin, A, Corsi, A, Custodero, C, D'Agostino, F, D'Errico, M, De Iorio, A, De Marchi, A, Desideri, G, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Filippini, C, Fiore, L, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Fumagalli, S, Gareri, P, Giordano, A, Giuliani, E, Greco, A, Herbst, A, Ielo, G, La Marca, A, Porta, U, Lazzari, I, Lelli, D, Longobucco, Y, Lucchini, F, Lucente, D, Maestri, L, Maggio, M, Mainqua, P, Marengoni, A, Martin, B, Massa, V, Mazza, L, Mazzoccoli, C, Mossello, E, Morellini, F, Mussi, C, Orio, G, Paglia, A, Pelagalli, G, Pelizzoni, L, Picci, A, Ranhoff, A, Remelli, F, Resta, O, Riccardi, A, Rinaldi, D, Rozzini, R, Sabba, C, Sacco, L, Santoliquido, M, Savino, M, Scarso, F, Sergi, G, Serviddio, G, Sidoli, C, Solfrizzi, V, Soli, B, Tafaro, L, Tedde, A, Testa, G, Tinti, M, Tonarelli, F, Tonon, E, Vitali, A, Zoccarato, F, Zotti, S, Bagala V., Sala A., Trevisan C., Okoye C., Incalzi R. A., Monzani F., Volpato S., Antognoli R., Antonietti M. P., Bandini G., Bellelli G., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bignamini S., Blandini D., Boffelli S., Bugada M., Calsolaro V., Calvani D., Carpagnano E., Carrieri B., Castaldo V., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Coin A., Corsi A., Custodero C., D'Agostino F., D'Errico M. M., De Iorio A., De Marchi A., Desideri G., Di Matteo E., Espinosa E., Esposito L., Fazio C., Filippini C., Fiore L., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Fumagalli S., Gareri P., Giordano A., Giuliani E., Greco A., Herbst A., Ielo G., La Marca A., Porta U., Lazzari I., Lelli D., Longobucco Y., Lucchini F., Lucente D., Maestri L., Maggio M., Mainqua P., Marengoni A., Martin B., Massa V., Mazza L., Mazzoccoli C., Mossello E., Morellini F., Mussi C., Orio G., Paglia A., Pelagalli G., Pelizzoni L., Picci A., Ranhoff A. H., Remelli F., Resta O., Riccardi A., Rinaldi D., Rozzini R., Sabba C., Sacco L., Santoliquido M., Savino M., Scarso F., Sergi G., Serviddio G., Sidoli C., Solfrizzi V., Soli B., Tafaro L., Tedde A., Testa G. D., Tinti M. G., Tonarelli F., Tonon E., Vitali A., Zoccarato F., Zotti S., Bagala, V, Sala, A, Trevisan, C, Okoye, C, Incalzi, R, Monzani, F, Volpato, S, Antognoli, R, Antonietti, M, Bandini, G, Bellelli, G, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bignamini, S, Blandini, D, Boffelli, S, Bugada, M, Calsolaro, V, Calvani, D, Carpagnano, E, Carrieri, B, Castaldo, V, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Coin, A, Corsi, A, Custodero, C, D'Agostino, F, D'Errico, M, De Iorio, A, De Marchi, A, Desideri, G, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Filippini, C, Fiore, L, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Fumagalli, S, Gareri, P, Giordano, A, Giuliani, E, Greco, A, Herbst, A, Ielo, G, La Marca, A, Porta, U, Lazzari, I, Lelli, D, Longobucco, Y, Lucchini, F, Lucente, D, Maestri, L, Maggio, M, Mainqua, P, Marengoni, A, Martin, B, Massa, V, Mazza, L, Mazzoccoli, C, Mossello, E, Morellini, F, Mussi, C, Orio, G, Paglia, A, Pelagalli, G, Pelizzoni, L, Picci, A, Ranhoff, A, Remelli, F, Resta, O, Riccardi, A, Rinaldi, D, Rozzini, R, Sabba, C, Sacco, L, Santoliquido, M, Savino, M, Scarso, F, Sergi, G, Serviddio, G, Sidoli, C, Solfrizzi, V, Soli, B, Tafaro, L, Tedde, A, Testa, G, Tinti, M, Tonarelli, F, Tonon, E, Vitali, A, Zoccarato, F, Zotti, S, Bagala V., Sala A., Trevisan C., Okoye C., Incalzi R. A., Monzani F., Volpato S., Antognoli R., Antonietti M. P., Bandini G., Bellelli G., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bignamini S., Blandini D., Boffelli S., Bugada M., Calsolaro V., Calvani D., Carpagnano E., Carrieri B., Castaldo V., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Coin A., Corsi A., Custodero C., D'Agostino F., D'Errico M. M., De Iorio A., De Marchi A., Desideri G., Di Matteo E., Espinosa E., Esposito L., Fazio C., Filippini C., Fiore L., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Fumagalli S., Gareri P., Giordano A., Giuliani E., Greco A., Herbst A., Ielo G., La Marca A., Porta U., Lazzari I., Lelli D., Longobucco Y., Lucchini F., Lucente D., Maestri L., Maggio M., Mainqua P., Marengoni A., Martin B., Massa V., Mazza L., Mazzoccoli C., Mossello E., Morellini F., Mussi C., Orio G., Paglia A., Pelagalli G., Pelizzoni L., Picci A., Ranhoff A. H., Remelli F., Resta O., Riccardi A., Rinaldi D., Rozzini R., Sabba C., Sacco L., Santoliquido M., Savino M., Scarso F., Sergi G., Serviddio G., Sidoli C., Solfrizzi V., Soli B., Tafaro L., Tedde A., Testa G. D., Tinti M. G., Tonarelli F., Tonon E., Vitali A., Zoccarato F., and Zotti S.

Abstract

Background: The prevalence of hypothyroidism among older patients hospitalized for COVID-19 and its association with mortality is unclear. This study aims to investigate the prevalence of hypothyroidism in older COVID-19 inpatients and verify if this comorbidity is associated with a specific pattern of onset symptoms and a worse prognosis. Methods: COVID-19 inpatients aged ≥ 60 years, participating in the GeroCovid acute wards cohort, were included. The history of hypothyroidism was derived from medical records and the use of thyroid hormones. Sociodemographic data, comorbidities, symptoms/signs at the disease onset and inflammatory markers at ward admission were compared between people with vs without history of hypothyroidism. The association between hypothyroidism and in-hospital mortality was tested through Cox regression. Results: Of the 1245 patients included, 8.5% had a history of hypothyroidism. These patients were more likely to present arterial hypertension and obesity compared with those without an history of hypothyroidism. Concerning COVID-19 clinical presentation, patients with hypothyroidism had less frequently low oxygen saturation and anorexia but reported muscle pain and loss of smell more commonly than those without hypothyroidism. Among the inflammatory markers, patients with hypothyroidism had higher lymphocytes values. At Cox regression, hypothyroidism was associated with reduced in-hospital mortality only in the univariable model (HR = 0.66, 95% CI 0.45–0.96, p = 0.03); conversely, no significant result were observed after adjusting for potential confounders (HR = 0.69, 95% CI 0.47–1.03, p = 0.07). Conclusions: Hypothyroidism does not seem to substantially influence the prognosis of COVID-19 in older people, although it may be associated with peculiar clinical and biochemical features at the disease onset.

Published
2023

6. Systemic Inflammatory Markers and Oncologic Outcomes in Patients with High-risk Non–muscle-invasive Urothelial Bladder Cancer

Author

Cantiello, Francesco, Russo, Giorgio I., Vartolomei, Mihai Dorin, Farhan, Abdal Rahman Abu, Terracciano, Daniela, Musi, Gennaro, Lucarelli, Giuseppe, Di Stasi, Savino M., Hurle, Rodolfo, Serretta, Vincenzo, Busetto, Gian Maria, Scafuro, Chiara, Perdonà, Sisto, Borghesi, Marco, Schiavina, Riccardo, Cioffi, Antonio, De Berardinis, Ettore, Almeida, Gilberto L., Bove, Pierluigi, Lima, Estevao, Ucciero, Giuseppe, Matei, Deliu Victor, Crisan, Nicolae, Verze, Paolo, Battaglia, Michele, Guazzoni, Giorgio, Autorino, Riccardo, Morgia, Giuseppe, Damiano, Rocco, de Cobelli, Ottavio, Mirone, Vincenzo, Shariat, Shahrokh F., and Ferro, Matteo

Published
2018
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9. Long-term outcome of COVID-19 patients treated with helmet noninvasive ventilation vs. high-flow nasal oxygen: a randomized trial

Author

Michi T., Mattana C., Menga L. S., Bocci M. G., Cesarano M., Rosa T., Gualano M. R., Montomoli J., Spadaro S., Tosato M., Rota E., Landi F., Cutuli S. L., Tanzarella E. S., Pintaudi G., Piervincenzi E., Bello G., Tonetti T., Rucci P., De Pascale G., Maggiore S. M., Grieco D. L., Conti G., Antonelli M., Maviglia R., Mercurio G., De Santis P., Pennisi M. A., Anzellotti G. M., Torrini F., Rubino C., Morena T. C., Gennenzi V., Postorino S., Vargas J., Filetici N., Settanni D., Durante M., Cascarano L., Di Muro M., Scarascia R., Bitondo M. M., Murdolo M., Mele A., Silva S., Zaccone C., Pozzana F., Maccaglia A., Savino M., Potalivo A., Ceccaroni F., Scavone A., Lombardi G., Montini L., Dell'Anna A. M., Volta C. A., Ranieri V. M., Falo G., Carelli S., Natalini D., Berardi C., Delle Cese L., Vetrugno L., Balzani E., Michi T., Mattana C., Menga L.S., Bocci M.G., Cesarano M., Rosa T., Gualano M.R., Montomoli J., Spadaro S., Tosato M., Rota E., Landi F., Cutuli S.L., Tanzarella E.S., Pintaudi G., Piervincenzi E., Bello G., Tonetti T., Rucci P., De Pascale G., Maggiore S.M., Grieco D.L., Conti G., Antonelli M., Maviglia R., Mercurio G., De Santis P., Pennisi M.A., Anzellotti G.M., Torrini F., Rubino C., Morena T.C., Gennenzi V., Postorino S., Vargas J., Filetici N., Settanni D., Durante M., Cascarano L., Di Muro M., Scarascia R., Bitondo M.M., Murdolo M., Mele A., Silva S., Zaccone C., Pozzana F., Maccaglia A., Savino M., Potalivo A., Ceccaroni F., Scavone A., Lombardi G., Montini L., Dell'Anna A.M., Volta C.A., Ranieri V.M., Falo G., Carelli S., Natalini D., Berardi C., Delle Cese L., Vetrugno L., and Balzani E.

Subjects
Helmet, COVID-19, Acute respiratory failure, High-flow nasal oxygen, Noninvasive ventilation, Patient self-inflicted lung injury (P-SILI)
Abstract

Background: Long-term outcomes of patients treated with helmet noninvasive ventilation (NIV) are unknown: safety concerns regarding the risk of patient self-inflicted lung injury and delayed intubation exist when NIV is applied in hypoxemic patients. We assessed the 6-month outcome of patients who received helmet NIV or high-flow nasal oxygen for COVID-19 hypoxemic respiratory failure. Methods: In this prespecified analysis of a randomized trial of helmet NIV versus high-flow nasal oxygen (HENIVOT), clinical status, physical performance (6-min-walking-test and 30-s chair stand test), respiratory function and quality of life (EuroQoL five dimensions five levels questionnaire, EuroQoL VAS, SF36 and Post-Traumatic Stress Disorder Checklist for the DSM) were evaluated 6months after the enrollment. Results: Among 80 patients who were alive, 71 (89%) completed the follow-up: 35 had received helmet NIV, 36 high-flow oxygen. There was no inter-group difference in any item concerning vital signs (N = 4), physical performance (N = 18), respiratory function (N = 27), quality of life (N = 21) and laboratory tests (N = 15). Arthralgia was significantly lower in the helmet group (16% vs. 55%, p = 0.002). Fifty-two percent of patients in helmet group vs. 63% of patients in high-flow group had diffusing capacity of the lungs for carbon monoxide < 80% of predicted (p = 0.44); 13% vs. 22% had forced vital capacity < 80% of predicted (p = 0.51). Both groups reported similar degree of pain (p = 0.81) and anxiety (p = 0.81) at the EQ-5D-5L test; the EQ-VAS score was similar in the two groups (p = 0.27). Compared to patients who successfully avoided invasive mechanical ventilation (54/71, 76%), intubated patients (17/71, 24%) had significantly worse pulmonary function (median diffusing capacity of the lungs for carbon monoxide 66% [Interquartile range: 47–77] of predicted vs. 80% [71–88], p = 0.005) and decreased quality of life (EQ-VAS: 70 [53–70] vs. 80 [70–83], p = 0.01). Conclusions: In patients with COVID-19 hypoxemic respiratory failure, treatment with helmet NIV or high-flow oxygen yielded similar quality of life and functional outcome at 6months. The need for invasive mechanical ventilation was associated with worse outcomes. These data indicate that helmet NIV, as applied in the HENIVOT trial, can be safely used in hypoxemic patients. Trial registration Registered on clinicaltrials.gov NCT04502576 on August 6, 2020

Published
2023

10. Data from The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non–muscle-Invasive Bladder Cancer

Author

Bielli, Pamela, primary, Panzeri, Valentina, primary, Lattanzio, Rossano, primary, Mutascio, Simona, primary, Pieraccioli, Marco, primary, Volpe, Elisabetta, primary, Pagliarulo, Vincenzo, primary, Piantelli, Mauro, primary, Giannantoni, Antonella, primary, Di Stasi, Savino M., primary, and Sette, Claudio, primary

Published
2023
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11. Supplementary Data from The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non–muscle-Invasive Bladder Cancer

Author

Bielli, Pamela, primary, Panzeri, Valentina, primary, Lattanzio, Rossano, primary, Mutascio, Simona, primary, Pieraccioli, Marco, primary, Volpe, Elisabetta, primary, Pagliarulo, Vincenzo, primary, Piantelli, Mauro, primary, Giannantoni, Antonella, primary, Di Stasi, Savino M., primary, and Sette, Claudio, primary

Published
2023
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12. Impact of COVID-19 pandemic on patients affected by peripheral arterial disease: an Italian single-center study

Author

Rando, Maria Margherita, Biscetti, Federico, Masciocchi, Carlotta, Savino, Mariachiara, Nicolazzi, Maria Anna, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Rossini, E, Massetti, Massimo, Gasbarrini, Antonio, Flex, Andrea, Rando, M M, Biscetti, F (ORCID:0000-0001-7449-657X), Masciocchi, C, Savino, M, Nicolazzi, M A, Nardella, E, Cecchini, A L, Massetti, M (ORCID:0000-0002-7100-8478), Gasbarrini, A (ORCID:0000-0002-7278-4823), Flex, A (ORCID:0000-0003-2664-4165), Rando, Maria Margherita, Biscetti, Federico, Masciocchi, Carlotta, Savino, Mariachiara, Nicolazzi, Maria Anna, Nardella, Elisabetta, Cecchini, Andrea Leonardo, Rossini, E, Massetti, Massimo, Gasbarrini, Antonio, Flex, Andrea, Rando, M M, Biscetti, F (ORCID:0000-0001-7449-657X), Masciocchi, C, Savino, M, Nicolazzi, M A, Nardella, E, Cecchini, A L, Massetti, M (ORCID:0000-0002-7100-8478), Gasbarrini, A (ORCID:0000-0002-7278-4823), and Flex, A (ORCID:0000-0003-2664-4165)

Abstract

Objective: Coronavirus disease 2019 (COVID-19) has evolved into a global pandemic, affecting a wide range of medical and surgical specialties. During COVID-19, we assisted in the reallocation of medical resources and services, as well as social distancing measures, and many patients with chronic diseases and comorbidities may have experienced difficulties in obtaining the correct medical care. The aim of the study was to investigate the impact of the COVID-19 pandemic on major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with peripheral arterial disease (PAD) and chronic limb-threatening ischemia (CLTI), compared to previous years. Patients and methods: We evaluated 1,335 hospital admissions of 877 patients with PAD admitted to Policlinico A. Gemelli Hospital between January 2017 and February 2020 and 368 hospital admissions of 272 patients with PAD admitted to the Policlinico A. Gemelli Hospital between March 2020 and March 2021. Data on demographic characteristics, comorbidities, symptoms, physical and radiological findings, laboratory tests, and routine visits before or after discharge were collected from electronic medical records. Results: Emergency room (ER) admissions among PAD patients during COVID-19 were higher than before the pandemic [190 (51.63%) vs. 579 (43.37%), p = 0.01]. A MACE was found in 78 (5.84%) pre-pandemic hospitalizations and 126 (34.24%) pandemic hospitalizations (p < 0.01). A MALE was identified in 942 (70.56%) pre-pandemic hospitalizations and 331 (89.95%) pandemic hospitalizations (p < 0.01). Amputation rates during the pandemic were higher than before the pandemic [80 (21.74%) vs. 191 (14.31%), p < 0.01]. The number of in-hospital deaths did not differ between the pandemic and pre-pandemic periods [11 (2.99%) vs. 51 (3.82%), p = 0.55]. Conclusions: In patients with PAD and CLTI, the number of MACE, MALE, and amputations was higher during the COVID-19 period compared to the thr

Published
2023

13. Feasibility of mirabegron in the treatment of overactive bladder in patients affected by Parkinson’s disease: A pilot study

Author

Marilena Gubbiotti, Antonella Conte, Savino M. Di Stasi, Nicola Tambasco, and Antonella Giannantoni

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Background: We investigated the effectiveness and safety of mirabegron oral treatment in a group of patients with Parkinson’s disease (PD) and overactive bladder (OAB), refractory to antimuscarinics. Materials and methods: Thirty patients with PD and refractory OAB were prospectively included in the study. At baseline, motor symptoms, severity of disease and cognitive status were assessed with the Hoehn–Yahr Scale, the Unified Parkinson’s disease Rating Scale, the Mini Mental State examination and the Montreal Cognitive Assessment. At baseline, urinary symptoms, satisfaction with treatment and the impact of urinary incontinence on quality of life (QoL) were assessed with the 3-day voiding diary, the Visual Analogue Scale (VAS), the Incontinence–QoL questionnaire and urodynamics. Patients started assuming mirabegron 50 mg tablets once daily. Evaluation of urinary symptoms and related questionnaires, motor symptoms, severity of PD and uroflowmetry with postvoid residual volume measurement were then repeated at the 3- and 6-month follow up. Side effects were also noted. Results: At baseline, the most frequently reported urinary symptoms were: urinary urgency (present in all the patients), urge urinary incontinence in 28/30 (93.3%) and increased daytime urinary frequency in 25 (83.3%) patients. At the 3-month follow up, 7 out of the 30 patients achieved a complete urinary continence. Significant improvements in VAS and Incontinence–QoL scores were observed in 24 patients. These benefits were maintained for the whole observation period. Four patients discontinued treatment due to poor efficacy, and two due to the cost of the drug. Conclusions: Mirabegron is a safe and effective treatment in patients with PD and OAB refractory to anticholinergics in the short-term follow up.

Published
2019
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15. Data from The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non–muscle-Invasive Bladder Cancer

Author

Claudio Sette, Savino M. Di Stasi, Antonella Giannantoni, Mauro Piantelli, Vincenzo Pagliarulo, Elisabetta Volpe, Marco Pieraccioli, Simona Mutascio, Rossano Lattanzio, Valentina Panzeri, and Pamela Bielli

Abstract

Purpose: Non–muscle-invasive bladder cancer (NMIBC) is a malignant disease characterized by high heterogeneity, which corresponds to dysregulated gene expression and alternative splicing (AS) profiles. Bioinformatics analyses of splicing factors potentially linked to bladder cancer progression identified the heterogeneous nuclear ribonucleoprotein I (i.e., PTBP1) as candidate. This study aimed at investigating whether PTBP1 expression associates with clinical outcome in patients with NMIBC.Experimental Design: A cohort of 152 patients presenting with primary NMIBC (pTa-pT1) was enrolled. Primary NMIBCs were assessed for PTBP1 expression by IHC, and the results were correlated with clinical data using Kaplan–Meier curves and Cox regression analyses. Cell proliferation and survival assays were performed to assess the function of PTBP1. Furthermore, the impact of PTBP1 on the AS pattern of specific bladder cancer–related genes was investigated in cancer cell lines and in patients' specimens.Results: Public datasets querying highlighted a positive correlation between PTBP1 expression and NMIBC progression, which was then confirmed by IHC analysis. High PTBP1 expression was associated with worse clinical outcome in terms of incidence of tumor relapse and survival in patients with NMIBC. Interestingly, downregulation of PTBP1 in bladder cancer cell lines affected prosurvival features. Accordingly, PTBP1 modulated AS of bladder cancer–related genes in cell lines and patient's specimens.Conclusions: PTBP1 expression correlates with disease progression, poor prognosis, and worse survival in patients with NMIBC. Downregulation of PTBP1 expression affects prosurvival features of bladder cancer cells and modulates AS of genes with relevance for bladder cancer, suggesting its role as an outcome-predictor in this disease. Clin Cancer Res; 24(21); 5422–32. ©2018 AACR.

Published
2023

16. Impact of COVID-19 pandemic on patients affected by peripheral arterial disease: an Italian single-center study.

Author

RANDO, M. M., BISCETTI, F., MASCIOCCHI, C., SAVINO, M., NICOLAZZI, M. A., NARDELLA, E., CECCHINI, A. L., ROSSINI, E., MASSETTI, M., GASBARRINI, A., and FLEX, A.

Abstract

OBJECTIVE: Coronavirus disease 2019 (COVID-19) has evolved into a global pandemic, affecting a wide range of medical and surgical specialties. During COVID-19, we assisted in the reallocation of medical resources and services, as well as social distancing measures, and many patients with chronic diseases and comorbidities may have experienced difficulties in obtaining the correct medical care. The aim of the study was to investigate the impact of the COVID-19 pandemic on major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with peripheral arterial disease (PAD) and chronic limb-threatening ischemia (CLTI), compared to previous years. PATIENTS AND METHODS: We evaluated 1,335 hospital admissions of 877 patients with PAD admitted to Policlinico A. Gemelli Hospital between January 2017 and February 2020 and 368 hospital admissions of 272 patients with PAD admitted to the Policlinico A. Gemelli Hospital between March 2020 and March 2021. Data on demographic characteristics, comorbidities, symptoms, physical and radiological findings, laboratory tests, and routine visits before or after discharge were collected from electronic medical records. RESULTS: Emergency room (ER) admissions among PAD patients during COVID-19 were higher than before the pandemic [190 (51.63%) vs. 579 (43.37%), p = 0.01]. A MACE was found in 78 (5.84%) pre-pandemic hospitalizations and 126 (34.24%) pandemic hospitalizations (p < 0.01). A MALE was identified in 942 (70.56%) pre-pandemic hospitalizations and 331 (89.95%) pandemic hospitalizations (p < 0.01). Amputation rates during the pandemic were higher than before the pandemic [80 (21.74%) vs. 191 (14.31%), p < 0.01]. The number of in-hospital deaths did not differ between the pandemic and pre-pandemic periods [11 (2.99%) vs. 51 (3.82%), p = 0.55]. CONCLUSIONS: In patients with PAD and CLTI, the number of MACE, MALE, and amputations was higher during the COVID-19 period compared to the three years before the pandemic. [ABSTRACT FROM AUTHOR]

Published
2023

17. Il divenire della disciplina urbanistica: il contributo di Michelangelo Savino

Author

Savino, M.

Subjects
Governo dei sistemi insediativi, Tecnica e Pianificazione urbanistica, Tecnica e Pianificazione urbanistica, disci0line territoriali, discipline urbanistiche, Governo dei sistemi insediativi, discipline urbanistiche, disci0line territoriali
Abstract

With this volume - Conversations with TeMA - the Journal opens a new editorial line specifically dedicated to promoting and disseminating the discussion between worldwide researchers on specific issues concerning the contents, methods and timing of our work. This first experience is dedicated to a deepening, in an interview formula, on the future of spatial planning in Italy both from a regulatory and technical-disciplinary perspective, also concerning what is happening in other countries. In line with the aims we had set, we decided to involve, in this first phase, both colleagues working in Italian universities and those working in foreign universities and research centres. This contribution is by Michelangelo Savino, Full Professor in Urban Planning, University of Padua, TeMA - Journal of Land Use, Mobility and Environment, No 1 (2023): Conversations with TeMA. For the evolution of spatial planning

Published
2023
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19. PNRR e la grande trasformazione del Paese. Introduzione

Author

Savino, M. and Fregolent, L.

Subjects
PNRR, Squilibri territoriali, Governo del territorio, Sviluppo economico, Politiche territoriali, PNRR, Sviluppo economico, Squilibri territoriali, Politiche territoriali, Governo del territorio
Published
2023

24. Introduzione

Author

Bonetti, P, D’Onghia, M, Morozzo della Rocca, P, Savino, M, Bonetti, P, Morozzo della Rocca, P, Savino, M, De Petris, A, Benvenuti, S, Chiaromonte, W, Baraggia, A, Celoria, E, Vanoni, L. P., Strazzari, D, Busata, L, De Oliveira, E, Di Maio, C, Iossa, A, Pietrogiovanni, V, Lazzaro, A, Corsi, C, Dall'Oglio, S, Interlandi, M, Nunin, R, Riccardi, L, Rondine, F, Panna, P, MCBritton, M, and D’Onghia, M

Subjects
lavoro, IUS/08 - DIRITTO COSTITUZIONALE, IUS/14 - DIRITTO DELL'UNIONE EUROPEA, Immigrazione, IUS/09 - ISTITUZIONI DI DIRITTO PUBBLICO, stranieri, IUS/21 - DIRITTO PUBBLICO COMPARATO, IUS/01 - DIRITTO PRIVATO, IUS/07 - DIRITTO DEL LAVORO
Published
2022

27. OC-0260 Predictive value of inflammatory markers in LARC patients undergoing neoadjuvant chemoradiotherapy

Author

Mariani, S., primary, Chiloiro, V., additional, Capocchiano, N.D., additional, Savino, M., additional, Reina, S., additional, Meldolesi, E., additional, Coco, C., additional, Corvari, B., additional, Damiani, A., additional, De Luca, V., additional, Manfrida, S., additional, Persiani, R., additional, Alfieri, S., additional, Valentini, V., additional, and Gambacorta, M.A., additional

Published
2022
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30. Immigrazione e lavoro: quali regole? Modelli, problemi e tendenze

Author

Bonetti, P, D’Onghia, M, Morozzo della Rocca, P, Savino, M, Bonetti, P, D’Onghia, M, Morozzo della Rocca, P, and Savino, M

Abstract

La disciplina italiana sull’immigrazione economica, ormai risalente, non consente di selezionare i lavoratori stranieri necessari. Non consente, perciò, di gestire entro la legalità un processo strutturale, indispensabile per lo sviluppo della società di destinazione. Movendo da queste premesse, l’Accademia di diritto e migrazioni (ADiM) ha avviato nel 2020 una ricerca volta a individuare, attraverso la comparazione con altri ordinamenti, i modelli e le soluzioni utili. Il volume raccoglie studi che esaminano non solo il caso italiano e i vincoli europei e internazionali sulle migrazioni economiche, ma anche il contesto storico e geopolitico, la legislazione e i problemi applicativi in altri Paesi occidentali di destinazione dei flussi migratori (Germania, Francia, Regno Unito, Stati Uniti, Canada, Irlanda, Portogallo, Spagna, Svezia e Svizzera). L’obiettivo è contribuire ad alimentare un dibattito costruttivo tra studiosi e policy-makers.

Published
2022

36. Hexaminolevulinate hydrochloride in the detection of nonmuscle invasive cancer of the bladder

Author

Savino M. Di Stasi, Francesco De Carlo, Vincenzo Pagliarulo, Francesco Masedu, Cristian Verri, Francesco Celestino, and Claus Riedl

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Clinical trials have shown that hexaminolevulinate (HAL) fluorescence cystoscopy improves the detection of bladder tumors compared with standard white-light cystoscopy, resulting in more efficacious treatment. However, some recent meta-analyses report controversially on recurrence-free rates with this procedure. A systematic review of literature was performed from December 2014 to January 2015 using the PubMed, Embase and Cochrane databases for controlled trials on photodynamic diagnosis (PDD) with HAL. A total of 154 publications were found up to January 2015. Three of the authors separately reviewed the records to evaluate eligibility and methodological quality of clinical trials. A total of 16 publications were considered eligible for analysis. HAL–PDD-guided cystoscopy increased overall tumor detection rate (proportion difference 19%, 95% confidence interval [CI] 0.152–0.236) although the benefit was particularly significant in patients with carcinoma in situ (CIS) lesion (proportion difference 15.7%, 95% CI 0.069–0.245) and was reduced in papillary lesions (Ta proportion difference 5.9%, 95% CI 0.014–0.103 and T1 proportion difference 1.2%, 95% CI 0.033–0.057). Moreover, there were 15% of patients (95% CI 0.098–0.211) with at least one additional tumor seen with PDD. With regard to recurrence rates, the data sample was insufficient for a statistical analysis, although the evaluation of raw data showed a trend in favor of HAL–PDD. This meta-analysis confirms the increased tumor detection rate by HAL–PDD with a most pronounced benefit for CIS lesion.

Published
2015
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40. T1 bladder cancer: comparison of the prognostic impact of two substaging systems on disease recurrence and progression and suggestion of a novel nomogram

Author

Roberto Miano, Savino M. Di Stasi, Rossana Telesca, Antonio Luigi Pastore, Alessandro Mauriello, Gaia Colalillo, Vincenzo Petrozza, Enrico Finazzi Agrò, Anastasios D. Asimakopoulos, Stefano Germani, Antonio Carbone, Gianluca Caruso, and Andrea Fuschi

Subjects
Oncology, Multivariate statistics, medicine.medical_specialty, RD1-811, genetic structures, Disease, urologic and male genital diseases, Internal medicine, Medicine, lamina propria, Prospective cohort study, skin and connective tissue diseases, urothelial carcinoma, Original Research, Bladder cancer, business.industry, Proportional hazards model, Significant difference, Univariate, staging, Nomogram, medicine.disease, bladder cancer, prognosis, urinary bladder neoplasms, Settore MED/24, Surgery, business, bladder cancer, urothelial carcinoma, staging, lamina propria, prognosis, urinary bladder neoplasms
Abstract

Background: The T1 substaging of bladder cancer (BCa) potentially impacts disease progression. The objective of the study was to compare the prognostic accuracy of two substaging systems on the recurrence and progression of primary pathologic T1 (pT1) BCa and to test a nomogram based on pT1 substaging for predicting recurrence-free survival (RFS) and progression-free survival (PFS).Methods: The medical records of 204 patients affected by pT1 BCa were retrospectively reviewed. Substaging was defined according to the depth of lamina propria invasion in T1a−c and the extension of the lamina propria invasion to T1-microinvasive (T1m) or T1-extensive (T1e). Uni- and multivariable Cox regression models evaluated the independent variables correlated with recurrence and progression. The predictive accuracies of the two substaging systems were compared by Harrell's C index. Multivariate Cox regression models for the RFS and PFS were also depicted by a nomogram.Results: The 5-year RFS was 47.5% with a significant difference between T1c and T1a (p = 0.02) and between T1e and T1m (p < 0.001). The 5-year PFS was 75.9% with a significant difference between T1c and T1a (p = 0.011) and between T1e and T1m (p < 0.001). Model T1m−e showed a higher predictive power than T1a−c for predicting RFS and PFS. In the univariate and multivariate model subcategory T1e, the diameter, location, and number of tumors were confirmed as factors influencing recurrence and progression after adjusting for the other variables. The nomogram incorporating the T1m−e model showed a satisfactory agreement between model predictions at 5 years and actual observations.Conclusions: Substaging is significantly associated with RFS and PFS for patients affected by T1 BCa and should be included in innovative prognostic nomograms.

Published
2021

42. The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis

Author

Ferro, Matteo, primary, Del Giudice, Francesco, additional, Carrieri, Giuseppe, additional, Busetto, Gian Maria, additional, Cormio, Luigi, additional, Hurle, Rodolfo, additional, Contieri, Roberto, additional, Arcaniolo, Davide, additional, Sciarra, Alessandro, additional, Maggi, Martina, additional, Porpiglia, Francesco, additional, Manfredi, Matteo, additional, Fiori, Cristian, additional, Antonelli, Alessandro, additional, Tafuri, Alessandro, additional, Bove, Pierluigi, additional, Terrone, Carlo, additional, Borghesi, Marco, additional, Costantini, Elisabetta, additional, Iliano, Ester, additional, Montanari, Emanuele, additional, Boeri, Luca, additional, Russo, Giorgio Ivan, additional, Madonia, Massimo, additional, Tedde, Alessandro, additional, Veccia, Alessandro, additional, Simeone, Claudio, additional, Liguori, Giovanni, additional, Trombetta, Carlo, additional, Brunocilla, Eugenio, additional, Schiavina, Riccardo, additional, Dal Moro, Fabrizio, additional, Racioppi, Marco, additional, Vartolomei, Mihai Dorin, additional, Longo, Nicola, additional, Spirito, Lorenzo, additional, Crocetto, Felice, additional, Cantiello, Francesco, additional, Damiano, Rocco, additional, Di Stasi, Savino M., additional, Marchioni, Michele, additional, Schips, Luigi, additional, Parma, Paolo, additional, Carmignani, Luca, additional, Conti, Andrea, additional, Soria, Francesco, additional, Gontero, Paolo, additional, Barone, Biagio, additional, Deho, Federico, additional, Zaffuto, Emanuele, additional, Papalia, Rocco, additional, Scarpa, Roberto M., additional, Pagliarulo, Vincenzo, additional, Lucarelli, Giuseppe, additional, Ditonno, Pasquale, additional, Botticelli, Francesco Maria Gerardo, additional, Musi, Gennaro, additional, Catellani, Michele, additional, and de Cobelli, Ottavio, additional

Published
2021
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43. Validation of Neutrophil-to-lymphocyte Ratio in a Multi-institutional Cohort of Patients With T1G3 Non–muscle-invasive Bladder Cancer

Author

Marco Borghesi, Gian Maria Busetto, Giorgio Guazzoni, Gilberto L. Almeida, Shahrokh F. Shariat, Rocco Damiano, Roberto La Rocca, Riccardo Autorino, Rodolfo Hurle, Giovanni Grimaldi, Vincenzo Mirone, Pierluigi Bove, Giuseppe Lucarelli, Paolo Verze, Mihai Dorin Vartolomei, Francesco Cantiello, Sisto Perdonà, Savino M. Di Stasi, Matteo Ferro, Eugenio Brunocilla, Ettore De Berardinis, Ottavio De Cobelli, Giorgio Ivan Russo, Abdal Rahman Abu Farhan, Estevão Lima, Nicolae Crisan, Riccardo Schiavina, Giuseppe Morgia, Daniela Terracciano, Vincenzo Serretta, Michele Battaglia, Gennaro Musi, Vartolomei, Mihai Dorin, Ferro, Matteo, Cantiello, Francesco, Lucarelli, Giuseppe, Di Stasi, Savino, Hurle, Rodolfo, Guazzoni, Giorgio, Busetto, Gian Maria, De Berardinis, Ettore, Damiano, Rocco, Perdona, Sisto, Verze, Paolo, La Rocca, Roberto, Borghesi, Marco, Schiavina, Riccardo, Brunocilla, Eugenio, Almeida, Gilberto L., Bove, Pierluigi, Lima, Estevao, Grimaldi, Giovanni, Autorino, Riccardo, Crisan, Nicolae, Abu Farhan, Abdal Rahman, Battaglia, Michele, Serretta, Vincenzo, Russo, Giorgio Ivan, Morgia, Giuseppe, Terracciano, Daniela, Musi, Gennaro, de Cobelli, Ottavio, Mirone, Vincenzo, Shariat, Shahrokh F., Almeida, Gilberto L, Shariat, Shahrokh F, Universidade do Minho, and Vartolomei MD, Ferro M, Cantiello F, Lucarelli G, Di Stasi S, Hurle R, Guazzoni G, Busetto GM, De Berardinis E, Damiano R, Perdona S, Verze P, La Rocca R, Borghesi M, Schiavina R, Brunocilla E, Almeida GL, Bove P, Lima E, Grimaldi G, Autorino R, Crisan N, Abu Farhan AR, Battaglia M, Serretta V, Russo GI, Morgia G, Terracciano D, Musi G, de Cobelli O, Mirone V, Shariat SF

Subjects
High risk, High-grade, NLR, Progression, Recurrence, Male, Neutrophils, medicine.medical_treatment, 030232 urology & nephrology, Settore MED/24 - Urologia, 0302 clinical medicine, Lymphocytes, Oncology, Urology, Aged, 80 and over, Middle Aged, Prognosis, 3. Good health, Administration, Intravesical, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Cohort, BCG Vaccine, Disease Progression, Female, Non muscle invasive, Adjuvant, Adult, medicine.medical_specialty, Cystectomy, Disease-Free Survival, Resection, 03 medical and health sciences, medicine, Humans, Lymphocyte Count, Neutrophil to lymphocyte ratio, Aged, Retrospective Studies, Science & Technology, Bladder cancer, business.industry, fungi, medicine.disease, Confidence interval, Urinary Bladder Neoplasms, Multicenter study, Neoplasm Recurrence, Local, business
Abstract

The aim of this multicenter study was to investigate the prognostic role of neutrophil-to-lymphocyte ratio (NLR) and to validate the NLR cutoff of 3 in a large multi-institutional cohort of patients with primary T1 HG/G3 non-muscle-invasive bladder cancer (NMIBC)., M.D.V. is supported by the Scholarship Foundation of the Republic of Austria - OeAD and by the EUSP Scholarship - European Association of Urology.

Published
2018

47. Association of patients' sex with treatment outcomes after intravesical bacillus Calmette-Guerin immunotherapy for T1G3/HG bladder cancer

Author

Per-Uno Malmström, Núria Malats, Vincenzo Serretta, Renzo Colombo, Richard Sylvester, Savino M. Di Stasi, Bas W.G. van Rhijn, Shahrokh F. Shariat, Paolo Gontero, Anne J. Grotenhuis, Marek Babjuk, Riccardo Bartoletti, Steven Joniau, Jack Baniel, T. Tony Cai, Jeffrey Karnes, Martin Spahn, Joan Palou, J. Varkarakis, Francesco Soria, J. Irani, Peter U. Ardelt, David D'Andrea, Guido Dalbagni, Eugene K. Cha, and Stéphane Larré

Subjects
Nephrology, Male, medicine.medical_treatment, Treatment outcome, 030232 urology & nephrology, Gastroenterology, 0302 clinical medicine, Immunologic, Recurrence, Urologi och njurmedicin, BCG, Progression, Intravesical, Hazard ratio, Bladder cancer, Response, Urology & Nephrology, Middle Aged, Administration, Intravesical, Treatment Outcome, 030220 oncology & carcinogenesis, Administration, BCG Vaccine, Female, Original Article, Immunotherapy, Adjuvant, Life Sciences & Biomedicine, Age, medicine.medical_specialty, Urology, 03 medical and health sciences, Sex Factors, Adjuvants, Immunologic, Internal medicine, medicine, Humans, Urology and Nephrology, Adjuvants, Aged, Retrospective Studies, Neoplasm Grading, Urinary Bladder Neoplasms, Science & Technology, Proportional hazards model, business.industry, medicine.disease, Confidence interval, Settore MED/24, business
Abstract

Purpose To investigate the association of patients’ sex with recurrence and disease progression in patients treated with intravesical bacillus Calmette–Guérin (BCG) for T1G3/HG urinary bladder cancer (UBC). Materials and methods We analyzed the data of 2635 patients treated with adjuvant intravesical BCG for T1 UBC between 1984 and 2019. We accounted for missing data using multiple imputations and adjusted for covariate imbalance between males and females using inverse probability weighting (IPW). Crude and IPW-adjusted Cox regression analyses were used to estimate the hazard ratios (HR) with their 95% confidence intervals (CI) for the association of patients’ sex with HG-recurrence and disease progression. Results A total of 2170 (82%) males and 465 (18%) females were available for analysis. Overall, 1090 (50%) males and 244 (52%) females experienced recurrence, and 391 (18%) males and 104 (22%) females experienced disease progression. On IPW-adjusted Cox regression analyses, female sex was associated with disease progression (HR 1.25, 95%CI 1.01–1.56, p = 0.04) but not with recurrence (HR 1.06, 95%CI 0.92–1.22, p = 0.41). A total of 1056 patients were treated with adequate BCG. In these patients, on IPW-adjusted Cox regression analyses, patients’ sex was not associated with recurrence (HR 0.99, 95%CI 0.80–1.24, p = 0.96), HG-recurrence (HR 1.00, 95%CI 0.78–1.29, p = 0.99) or disease progression (HR 1.12, 95%CI 0.78–1.60, p = 0.55). Conclusion Our analysis generates the hypothesis of a differential response to BCG between males and females if not adequately treated. Further studies should focus on sex-based differences in innate and adaptive immune system and their association with BCG response.

Published
2021

48. The impact of sars-cov-2 pandemic on time to primary, secondary resection and adjuvant intravesical therapy in patients with high-risk non-muscle invasive bladder cancer: A retrospective multi-institutional cohort analysis

Author

Giovanni Liguori, F. Botticelli, Pierluigi Bove, Francesco Del Giudice, Michele Catellani, Savino M. Di Stasi, Alessandro Sciarra, Paolo Parma, Emanuele Montanari, Francesco Porpiglia, Luca Boeri, Davide Arcaniolo, Rodolfo Hurle, Felice Crocetto, Massimo Madonia, Gennaro Musi, Marco Borghesi, Matteo Manfredi, Luigi Cormio, Vincenzo Pagliarulo, Luca Carmignani, Mihai Dorin Vartolomei, Matteo Ferro, Giorgio Ivan Russo, Carlo Terrone, Riccardo Schiavina, Giuseppe Carrieri, Paolo Gontero, Michele Marchioni, Federico Deho, Eugenio Brunocilla, Giuseppe Lucarelli, Alessandro Antonelli, Marco Racioppi, Roberto Contieri, Pasquale Ditonno, A. Conti, Claudio Simeone, Alessandro Tedde, Alessandro Veccia, Roberto M Scarpa, Nicola Longo, Alessandro Tafuri, Elisabetta Costantini, Ester Iliano, Francesco Soria, Martina Maggi, Luigi Schips, Carlo Trombetta, Gian Maria Busetto, Lorenzo Spirito, Emanuele Zaffuto, Biagio Barone, Francesco Cantiello, Cristian Fiori, Rocco Papalia, Fabrizio Dal Moro, Rocco Damiano, Ottavio De Cobelli, Ferro, M., Del Giudice, F., Carrieri, G., Busetto, G. M., Cormio, L., Hurle, R., Contieri, R., Arcaniolo, D., Sciarra, A., Maggi, M., Porpiglia, F., Manfredi, M., Fiori, C., Antonelli, A., Tafuri, A., Bove, P., Terrone, C., Borghesi, M., Costantini, E., Iliano, E., Montanari, E., Boeri, L., Russo, G. I., Madonia, M., Tedde, A., Veccia, A., Simeone, C., Liguori, G., Trombetta, C., Brunocilla, E., Schiavina, R., Dal Moro, F., Racioppi, M., Vartolomei, M. D., Longo, N., Spirito, L., Crocetto, F., Cantiello, F., Damiano, R., Di Stasi, S. M., Marchioni, M., Schips, L., Parma, P., Carmignani, L., Conti, A., Soria, F., Gontero, P., Barone, B., Deho, F., Zaffuto, E., Papalia, R., Scarpa, R. M., Pagliarulo, V., Lucarelli, G., Ditonno, P., Botticelli, F. M. G., Musi, G., Catellani, M., de Cobelli, O., Ferro M., Del Giudice F., Carrieri G., Busetto G.M., Cormio L., Hurle R., Contieri R., Arcaniolo D., Sciarra A., Maggi M., Porpiglia F., Manfredi M., Fiori C., Antonelli A., Tafuri A., Bove P., Terrone C., Borghesi M., Costantini E., Iliano E., Montanari E., Boeri L., Russo G.I., Madonia M., Tedde A., Veccia A., Simeone C., Liguori G., Trombetta C., Brunocilla E., Schiavina R., Dal Moro F., Racioppi M., Vartolomei M.D., Longo N., Spirito L., Crocetto F., Cantiello F., Damiano R., Di Stasi S.M., Marchioni M., Schips L., Parma P., Carmignani L., Conti A., Soria F., Gontero P., Barone B., Deho F., Zaffuto E., Papalia R., Scarpa R.M., Pagliarulo V., Lucarelli G., Ditonno P., Botticelli F.M.G., Musi G., Catellani M., and de Cobelli O.

Subjects
Cancer Research, medicine.medical_specialty, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, Article, Resection, Bladder cancer, Intravesical BCG, Re-TURBT, SARS-CoV-2, Trans-urethral resection of bladder tumor, COVID-19, pandemic, residency, residents, urology, Internal medicine, Pandemic, medicine, RC254-282, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Outbreak, bladder cancer, intravesical BCG, trans-urethral resection of bladder tumor, medicine.disease, Settore MED/24, Oncology, Intravesical bcg, business, Adjuvant, Cohort study
Abstract

Background: To investigate the impact of COVID-19 outbreak on the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). Methods: A retrospective analysis was performed using an Italian multi-institutional database of TURBT patients with high-risk urothelial NMIBC between January 2019 and February 2021, followed by Re-TURBT and/or adjuvant intravesical BCG. Results: A total of 2591 patients from 27 institutions with primary TURBT were included. Of these, 1534 (59.2%) and 1056 (40.8%) underwent TURBT before and during the COVID-19 outbreak, respectively. Time between diagnosis and TURBT was significantly longer during the COVID-19 period (65 vs. 52 days, p = 0.002). One thousand and sixty-six patients (41.1%) received Re-TURBT, 604 (56.7%) during the pre-COVID-19. The median time to secondary resection was significantly longer during the COVID-19 period (55 vs. 48 days, p &lt, 0.0001). A total of 977 patients underwent adjuvant intravesical therapy after primary or secondary resection, with a similar distribution across the two groups (n = 453, 86% vs. n = 388, 86.2%). However, the proportion of the patients who underwent maintenance significantly differed (79.5% vs. 60.4%, p &lt, 0.0001). Conclusions: The COVID-19 pandemic represented an unprecedented challenge to our health system. Our study did not show significant differences in TURBT quality. However, a delay in treatment schedule and disease management was observed. Investigation of the oncological impacts of those differences should be advocated.

Published
2021

50. Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis

Author

Sicignano, Ludovico Luca, Massaro, Maria Grazia, Savino, Marinica, Rigante, Donato, Gerardino, Laura, Manna, Raffaele, Sicignano LL, Massaro MG, Savino M, Rigante D (ORCID:0000-0001-7032-7779), Gerardino L (ORCID:0000-0002-3806-5788), Manna R (ORCID:0000-0003-1560-3907), Sicignano, Ludovico Luca, Massaro, Maria Grazia, Savino, Marinica, Rigante, Donato, Gerardino, Laura, Manna, Raffaele, Sicignano LL, Massaro MG, Savino M, Rigante D (ORCID:0000-0001-7032-7779), Gerardino L (ORCID:0000-0002-3806-5788), and Manna R (ORCID:0000-0003-1560-3907)

Abstract

The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.

Published
2021

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