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Background: This was a prospective case control study conducted in the department of obstetrics and gynecology, Era’s Lucknow Medical College and Hospital from November 2018 to March 2020. Aim was to find whether there was a link between serum 25-OH vitamin D levels, and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods: 30 newly diagnosed cases of PCOS and 30 women without PCOS were enrolled. Their clinical details as well as BMI and waist hip ratio were noted. The biochemical parameters which were measured included fasting glucose, fasting insulin, serum 25-OH vitamin D. The insulin resistance was calculated. Results: 50% of the PCOS had insulin resistance and also deficient /or insufficient vitamin D levels, versus 16.7% in the control group. This association was statistically highly significant with p value as 0.00016. No statistical significance was found with regard to the mean serum 25-OH vitamin D level. 53.4%, of the PCOS women had hirsutism versus 3.3% in the control group and was statistically significant, p value

Background: The prevalence of incisional surgical site infections varies widely over the world. In affluent European countries, the overall SSI rate is 3/100 surgical procedures, while in the United States, it is 2.6/100 surgical procedures. Aim: The goal of this study was to determine the incidence of incisional surgical site infection (ISSI) in obstetric and gynaecological surgeries, as well as the risk factors, microbiological spectrum, antibiotic sensitivity, and hospital stay impact. Methods: A prospective observational study was done under the Department of Obstetrics and Gynecology, Era’s Lucknow medical college and hospital. All consecutive patients who underwent caesarean section, vaginal delivery with episiotomy, laparotomy, and hysterectomy were included in this study. Laparoscopic surgeries were excluded. Results; In this series of 646 surgeries, 6.18% developed ISSI. In the category of major surgeries, the ISSI rate was 8.89%. Amongst the 185 episiotomies 1.6% gaped. Anemia, diabetes mellitus, excess body weight, emergency or elective surgery, rapid built up of hemoglobin with blood transfusion, previous caesarean scar and tobacco intake were the risk factors identified. Coagulase negative staphylococcus was the dominant microbe. Antibiotic sensitivity to linezolid was found in 50% of the ISSI cases followed by amikacin, clindamycin and some others. The mean hospital stay was 13 days while the maximum was 26 days. Conclusion: The study established the current status of incisional surgical site infections, identified the risk factors, the microbial spectrum, the antibiotic sensitivity and the need for further studies using a preventive approach.

During the two years study period, 8557 deliveries took place, of which 114 were pregnancies with myoma giving the incidence as 1.33%. 12 of the 114 pregnancies ended in abortion, i.e.10.5%. The myoma placenta relationship and the obstetric outcome was analyzed in the remaining 102 pregnancies which continued beyond 22 weeks. Of these, 41.2% had complications. Premature rupture of membranes was the commonest complication seen in 22.5%. No case of preeclampsia or antepartum haemorrhage occurred in the 'no contact' category. Amongst the cases where the placenta was either in contact or superimposed on the broid, 85.5% -87.5% developed one or more complication. The myoma placenta relationship was found to be statistically signicant, p value

Background: A prospective randomized control trial (RCT) was conducted in the department of obstetrics and gynecology. The aim of the study was to evaluate the effect of pre-operative vaginal preparation with 1% povidone iodine solution on the post-operative caesarean infectious morbidity.Methods: 72 women were enrolled in the experimental group who received 1% povidone iodine vaginal wash and 72 in the control group who did not receive any vaginal wash. The investigators were blinded to the computer-generated random number table and to the allocation group. The clinical data was recorded and after its completion, the allocation group was revealed to the investigator. The data was tabulated and statistically analyzed using SPSS 21.Results: Age, parity, BMI, gestational age, blood loss, and operative time between the two groups was comparable. Pre-operative povidone iodine vaginal wash was more effective when membranes were intact versus ruptured. With intact membranes, statistical significance was reached for postoperative fever, seroma, endometritis, gaped incisional site, and foul discharge with p value 0.012, 0.012, 0.013, 0.027 and 0.012 respectively, between group A and B. The overall infectious morbidity in the 144 subjects showed statistical significance for endometritis, and foul-smelling lochia with p value 0.049 and 0.024 respectively; urinary tract infection, hospital stay duration, and incisional wound dehiscence were higher in group B versus group A, the difference in these parameters did not reach statistical significance.Conclusions: Pre-operative vaginal cleansing with 1% povidone iodine reduced post-operative infectious morbidity more effectively in those with intact membranes than ruptured membranes.

Background: To find the incidence of incisional surgical site infection (ISSI) in obstetric and gynecological procedures, the risk factors, the microbial spectrum, the antibiotic sensitivity and the impact on the hospital stay. Methods: A prospective observational study was done under the department of obstetrics and gynecology, Era’s Lucknow medical college and hospital. All consecutive patients who underwent caesarean section, vaginal delivery with episiotomy, laparotomy, and hysterectomy were included in this study. Laparoscopic surgeries were excluded. Results; In this series of 646 surgeries, 6.18% developed ISSI. In the category of major surgeries, the ISSI rate was 8.89%. Amongst the 185 episiotomies 1.6% gaped. Anemia, diabetes mellitus, excess body weight, emergency or elective surgery, rapid built up of hemoglobin with blood transfusion, previous caesarean scar and tobacco intake were the risk factors identified. Coagulase negative staphylococcus was the dominant microbe. Antibiotic sensitivity to linezolid was found in 50% of the ISSI cases followed by amikacin, clindamycin and some others. The mean hospital stay was 13 days while the maximum was 26 days.Conclusions: The study established the current status of incisional surgical site infections, identified the risk factors, the microbial spectrum, the antibiotic sensitivity and the need for further studies using a preventive approach.

Background: Preterm births continue to be the leading cause of perinatal and neonatal morbidity; representing one of the principal targets for obstetric health care and challenging the obstetrician to tackle this problem by focussing on the preventive approach. Methods: This study was conducted in the department of Obstetrics and Gynaecology of a tertiary centre during the period from 1 st October 2010 to 29 th February 2012. Patients presenting between 28 and 37 weeks in preterm labour were included in this study. Patients enrolled into the study were subjected to a detailed history with respect to age, parity, previous pregnancy outcomes and to identify the presence of any risk factors in this pregnancy including presence of GDM, PIH, anemia or any other medical disease. A thorough obstetric and systemic examination was done for the presence of hydramnios and multiple gestation. Data was analysed using Pearson’s Chi square test. Results: The study showed the incidence of preterm births to be 7.81%. The maximum number of cases belonged to the age group 20-29 years. 15.8% belonged to the extremes of reproductive age group. 12.11% had a history of previous preterm births. However, 35% of patients in the study who presented in preterm labour had a previous history of abortions. The significant risk factors found to be associated with preterm labour were hypertensive disorders, antepartum haemorrhage, malpresentations, multiple gestation, UTI and presence of vaginal infections. Conclusions: If we take into account the increase in multiple pregnancies and induced preterm birth, spontaneous preterm birth in singleton pregnancies has probably decreased. This decrease in preterm birth is undoubtedly related to better prenatal care for all pregnant women. The recognition of risk factors for preterm labour constitutes a part of basic prenatal care. Most etiological factors are modifiable, and preconception counselling should emphasize and address these issues.

Amoebiasis of the uterine cervix is an extremely rare entity, and presentation as fibroid uterus has not been reported, to the best of our knowledge in our extensive search of the English literature. It can clinically simulate cervical malignancy by virtue of surface papillomatous and overall ulcerated and necrotic appearance. We present a case of amoebic infection of the cervix in a 45-year-old female which was suspected to be a posterior wall fibroid with degeneration until a histopathological examination of the surgical specimen revealed the presence of Entamoeba histolytica trophozoites. The patient recovered after surgery and antiamoebic therapy.