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Poster with SOT on March 19-23, 2023 in Nashville, TN Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Poster for SOT in March 19-23, 2023 in Nashville, TN Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Poster for SOT on 3/15 - 3/19/2020 in Anaheim, CA Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Poster for SOT on March 19-23, 2023 in Nashville, TN Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to ISES on Sept. 25-29, 2022 in Lisbon, Portugal Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to the Water Resources Research Institute Virtual Annual Conference at NCSU March 2021Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to the North American Lake Management Society (NALMS) Conference April 2021Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Poster presented to the American Chemical Society Fall meeting August 2020Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to RISK-HUNT3R Face-to-Face Kickoff Meeting on July 5-7, 2022 in the Netherlands Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to the EPA Environmental Modeling Public Meeting August 2020.Search for CCTE records in EPA���s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to the UNC Dept. of Environmental Sciences and Engineering In-House Seminar February 2021February 17, 2021Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Poster for NCSOT on 1/19/2022 and for SOT on 3/31/2022.Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to NTA for Environmental Risk Assessment Meeting on 5/22/2022 in Durham, NC Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Presentation to the International Society of Exposure Science (ISES) Virtual Conference September 2021Search for CCTE records in EPA’s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

The inhalation route is important for both occupational and general population chemical exposures. Unfortunately, in vivo data describing chemical toxicokinetics (that is, absorption, distribution, metabolism, and excretion) are typically unavailable for the chemicals in commerce and the environment. “High throughput toxicokinetic methods” (HTTK) combine relatively rapid in vitro measurements of toxicokinetics with generic mathematical models that make use of the in vitro data and physico-chemical properties. We present “httk”, our HTTK software tool that includes and integrates both in vitro data and toxicokinetic models. We have recently added models for inhalation of both gases and aerosols. The structures of these inhalation models are refactored from previous models to allow for parameterization with in vitro toxicokinetic data. Because the models are generic, their expected performance for chemicals lacking in vivo data can be estimated based on chemicals that have in vivo data available. The inhalation models have been statistically evaluated using EPA’s Concentration vs. Time toxicokinetics database (CvTdb). For the gas model, resulting blood and/or plasma concentrations of 41 volatile organic chemicals were modeled across 142 exposure scenarios and compared to published data. The slope of the regression line of best fit between log-transformed simulated and observed measured plasma and/or blood concentrations was 0.47 with an r2= 0.45 and a log-scale Root Mean Square Error (RMSE) of 1.10. Additionally, log-transformed maximum concentration (Cmax) and area under the curve (AUC) values were compared, resulting in direct comparison RMSEs of 0.47 and 0.49 respectively. HTTK inhalation models allow for in vitro-in vivo extrapolation of volatile compounds, enabling comparison of estimates of bioactive in vivo doses with estimates of chemical exposures. These approaches have the potential to integrate in vitro toxicity data for air pollutants into chemical risk evaluations.Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Poster presented to the International Society of Exposure Science (ISES) Annual Meeting September 2020EPA Science Inventory Link - https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=351815&Lab=CCTE&simplesearch=0&showcriteria=2&sortby=pubDate&searchall=351815&timstype=&datebeginpublishedpresented=06/17/2019

Presentation to the Society of Toxicology 2021 annual meeting March 12-26, 2021

Supplemental Material, sj-pdf-1-atl-10.1177_02611929211060264 for A Systematic Review of Published Physiologically based Kinetic Models and an Assessment of their Chemical Space Coverage by Courtney V Thompson, James W Firman, Michael R Goldsmith, Christopher M Grulke, Yu-Mei Tan, Alicia Paini, Peter E Penson, Risa R Sayre, Steven Webb and Judith C Madden in Alternatives to Laboratory Animals

Supplemental Material, sj-pdf-2-atl-10.1177_02611929211060264 for A Systematic Review of Published Physiologically based Kinetic Models and an Assessment of their Chemical Space Coverage by Courtney V Thompson, James W Firman, Michael R Goldsmith, Christopher M Grulke, Yu-Mei Tan, Alicia Paini, Peter E Penson, Risa R Sayre, Steven Webb and Judith C Madden in Alternatives to Laboratory Animals

Presentation to the American Society for Mass Spectrometry Conference January 2020

and poster for presentation at the American Chemical Society Spring Meeting in April 2019

Poster presented to the American Chemical Society fall meeting in August 2019

Presentation to the Society of Toxicology annual meeting March 2019

Poster presented to the Society of Toxicology annual meeting in Baltimore, MD in March of 2019

Poster presented at the American Chemical Society Fall 2019 National Meeting

Poster presented at Society of Toxicology annual meeting March 2019

Poster for presentation at 2018 SOT.

Poster presented at North Carolina Society of Toxicology Meeting Oct 2017

Presentation at ISES-ISEE Joint Annual Meeting Aug 2018

Poster presented at EPA's Non-Targeted Analysis Collaborative Research Trial (ENTACT) Workshop Aug 2018

Poster presented at Society of Toxicology Annual meeting in March 2018

Presentation for American Industrial Hygiene Association Webinar June 2018

Poster presented at ICCVAM Workshop: Predictive Models for Acute Oral Systemic Toxicity, Bethesda, MD April 2018

BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management. However, it is cost- and time-prohibitive to evaluate all new and existing chemicals using traditional rodent acute toxicity tests. In silico models built using existing data facilitate rapid acute toxicity predictions without using animals. OBJECTIVES: The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Acute Toxicity Workgroup organized an international collaboration to develop in silico models for predicting acute oral toxicity based on five different end points: Lethal Dose 50 (LD50 value, U.S. Environmental Protection Agency hazard (four) categories, Globally Harmonized System for Classification and Labeling hazard (five) categories, very toxic chemicals [LD50 (LD50≤50mg/kg)], and nontoxic chemicals (LD50>2,000mg/kg). METHODS: An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches. RESULTS: The resulting consensus predictions, which leverage the collective strengths of each individual model, form the Collaborative Acute Toxicity Modeling Suite (CATMoS). CATMoS demonstrated high performance in terms of accuracy and robustness when compared with in vivo results. DISCUSSION: CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for in vivo rat acute oral toxicity studies. CATMoS predictions for more than 800,000 chemicals have been made available via the National Toxicology Program's Integrated Chemical Environment tools and data sets (ice.ntp.niehs.nih.gov). The models are also implemented in a free, standalone, open-source tool, OPERA, which allows predictions of new and untested chemicals to be made. https://doi.org/10.1289/EHP8495.