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2. Immunogenetics Problems in Cord Blood Transplantation

Author

Poli, Francesca, Diomelli, Barbara, Ghidoli, Nadia, Tettamanti, Cristina, Macchi, Barbara, Scalamogna, Mario, Sirchia, Girolamo, Abraham, Nader G., editor, Tabilio, Antonio, editor, Martelli, Massimo, editor, Asano, Shigetaka, editor, and Donfrancesco, Alberto, editor

Published
1999
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9. Long-term outcome of renal transplant from older donors

Author

Remuzzi, Giuseppe, Cravedi, Paolo, Perna, Annalisa, Dimitrov, Borislav D., Turturro, Mart, Locatelli, Giuseppe, Rigotti, Paolo, Baldan, Nichola, Beatini, Marco, Valente, Umberto, Scalamogna, Mario, and Ruggenenti, Piero

Subjects
Organ donors -- Health aspects, Kidneys -- Transplantation, Kidneys -- Health aspects
Abstract

A study to determine whether selecting older kidneys according to their histological characteristics before implantation would positively influence long-term outcome is presented. It is revealed that the long-term survival of the single or dual kidney from donors older than 60 years is excellent if the grafts are evaluated histologically before implantations.

Published
2006

20. Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor–human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation

Author

de Arias, Alejandro Espadas, Haworth, Simone Elizabeth, Belli, Luca Saverio, Burra, Patrizia, Pinzello, Giovambattista, Vangeli, Marcello, Minola, Ernesto, Guido, Maria, Boccagni, Patrizia, De Feo, Tullia Maria, Torelli, Rosanna, Cardillo, Massimo, Scalamogna, Mario, and Poli, Francesca

Published
2009
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21. Renal Transplantation

Author

Cardillo, Massimo, primary, Poli, Francesca, additional, Barraco, Fiorenza, additional, Fazio, Nicola De, additional, Rossini, Giuseppe, additional, Boschiero, Luigi, additional, Nocera, Arcangelo, additional, Rigotti, Paolo, additional, Marchini, Francesco, additional, Zacchello, Graziella, additional, Zanon, Gianfranco, additional, Sandrini, Silvio, additional, Chiaramonte, Stefano, additional, Maresca, Cristina, additional, Caldara, Rossana, additional, Messa, Piergiorgio, additional, Berardinelli, Luisa, additional, Ambrosini, Andrea, additional, Montanaro, Domenico, additional, Rampino, Teresa, additional, Minetti, Enrico, additional, Gotti, Eliana, additional, Ghio, Luciana, additional, Ginevri, Fabrizio, additional, Albertario, Fulvio, additional, and Scalamogna, Mario, additional

Published
2004
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24. Split and whole liver transplantation outcomes: A comparative cohort study

Author

Cardillo, Massimo, De Fazio, Nicola, Pedotti, Paola, De Feo, Tullia, Fassati, Luigi Rainero, Mazzaferro, Vincenzo, Colledan, Michele, Gridelli, Bruno, Caccamo, Lucio, DeCarlis, Luciano, Valente, Umberto, Andorno, Enzo, Cossolini, Mariangelo, Martini, Cristiano, Antonucci, Adelmo, Cillo, Umberto, Zanus, Giacomo, Baccarani, Umberto, and Scalamogna, Mario

Published
2006
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37. LIVER TRANSPLANTATION IN PATIENTS IN UNOS STATUS 1: OUTCOME OF 419 TRANSPLANTATIONS IN THE NORTH ITALY TRANSPLANT PROGRAM

Author

De Feo Tullia, M., De Fazio Nicola, Andorno, Enzo, Baccarani, Umberto, Cillo, Umberto, Colledan, Michele, De Carlis Luciano, Donataccio, Matteo, Regalia, Enrico, Risaliti, Andrea, Rossi, Giorgio, Procaccio, Francesco, Scalamogna, Mario, De Feo, T, De Fazio, N, Andorno, E, Baccarani, U, Cillo, U, Colledan, M, De Carlis, L, Donataccio, M, Regalia, E, Risaliti, A, Rossi, G, Procaccio, F, and Scalamogna, M

Subjects
Transplantation, Surgery
Published
2009

42. Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation:The Milan Experience

Author

Lanzetta, Marco, primary, Nolli, Roberta, additional, Radaelli, Ilaria, additional, Coletti, Rosella, additional, Paleari, Felice, additional, Cappellini, Anna, additional, Uggeri, Franco, additional, Scalamogna, Mario, additional, and Rampa, Alessandro, additional

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43. Influence of immunogenetic background on the outcome of recurrent hepatitis C after liver transplantation

Author

Belli, Luca Saverio, Zavaglia, Claudio, Alberti, Alberto Battista, Poli, Francesca, Rondinara, Gianfranco, Silini, Enrico, Taioli, Emanuela, De Carlis, Luciano, Scalamogna, Mario, Forti, Domenico, Pinzello, Giovambattista, Idèo, Gaetano, Belli, L, Zavaglia, C, Alberti, A, Poli, F, Rondinara, G, Silini, E, Taioli, E, De Carlis, L, Scalamogna, M, Forti, D, Pinzello, G, and Idèo, G

Subjects
Allele, Adult, Male, Hepatology, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Middle Aged, Hepatitis C, Liver Transplantation, Immunogenetic, Postoperative Complications, Gene Frequency, Recurrence, Multivariate Analysis, Disease Progression, Immunogenetics, Humans, Female, Postoperative Complication, Multivariate Analysi, Alleles, Human
Abstract

In immunocompetent patients, specific human leukocyte antigen (HLA) class II alleles have been associated with the severity of hepatitis C virus (HCV)-related disease, in particular, HLA-DRBI* 1 I has been found to exert a protective effect. The authors have analyzed the role of HLA class I and II alleles in determining the frequency, timing, and progression of histologically proven recurrent hepatitis C in 89 patients who underwent a liver transplant for HCV-related cirrhosis. In addition, the influence of HLA mismatch between donor and recipient, HCV genotype, and use of steroid pulses was also evaluated. Median patient follow up was 35 months (range 4-119). HLA-DRBI typing was performed by genomic analysis in all cases. Liver biopsies were obtained routinely and at least at yearly intervals. Histologically proven recurrent hepatitis was observed in 46 patients (52%), 10 patients progressing to stage 5-6 fibrosis in most cases within 2 years after transplant. By univariate analysis, 3 variables, HLA-B14, HLA-DRB1*04, and HLA-DRB1 donor/recipient mismatch, showed a significant effect on time to recurrent hepatitis C disease. These parameters were included in a multivariate regression model along with HCV genotype, treatment with steroid pulses and DRB1*11. HLA-B14, HLA-DRBI*04, and HLA-DRBI donor/recipient mismatch were confirmed to provide a significant and independent contribution to the risk of hepatitic disease recurrence. As for the severity of the disease, none of the 10 patients with stage 5-6 hepatitis carried the HLA- DRBI*11 allele, in line with what was observed in nontransplant subjects. Our results suggest that in posttransplant recurrent hepatitis C, immunogenetic factors are relevant in determining HCV infection outcome

Published
2000

44. HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation

Author

Belli, L, Burra, P, Poli, F, Alberti, A, Silini, E, Zavaglia, C, Fagiuoli, S, Prando, D, Espadas De Arias, A, Boninsegna, S, Tinelli, C, Scalamogna, M, De Carlis, L, Pinzello, G, Belli, Luca Saverio, Burra, Patrizia, Poli, Francesca, Alberti, Alberto Battista, Silini, Enrico, Zavaglia, Claudio, Fagiuoli, Stefano, Prando, Daniela, Espadas De Arias, Alejandro, Boninsegna, Sara, Tinelli, Carmine, Scalamogna, Mario, De Carlis, Luciano, Pinzello, Giovambattista, Belli, L, Burra, P, Poli, F, Alberti, A, Silini, E, Zavaglia, C, Fagiuoli, S, Prando, D, Espadas De Arias, A, Boninsegna, S, Tinelli, C, Scalamogna, M, De Carlis, L, Pinzello, G, Belli, Luca Saverio, Burra, Patrizia, Poli, Francesca, Alberti, Alberto Battista, Silini, Enrico, Zavaglia, Claudio, Fagiuoli, Stefano, Prando, Daniela, Espadas De Arias, Alejandro, Boninsegna, Sara, Tinelli, Carmine, Scalamogna, Mario, De Carlis, Luciano, and Pinzello, Giovambattista

Abstract

Background & Aims: This study extends our previously reported observations that various immunological factors are associated with the occurrence of histologically proven recurrent hepatitis C. The two specific issues investigated were to confirm the associations of MHC alleles and donor/recipient mismatch with the occurrence of recurrent hepatitis C in an independent cohort of newly transplanted patients and to look for immunologic and nonimmunologic variables affecting the severity of the recurrent disease. Methods: Two separate cohorts of consecutive patients were studied: a look-back cohort (LC) of 120 patients and a cohort for studying the disease progression (CSDP) of 190 patients. Protocol liver biopsies were obtained at least 1, 3, 5, 7, and 10 years after liver transplantation (LT). Results: A fully mismatched donor/recipient pair at the DRB1 locus was confirmed to be associated with both the recurrence of histologic hepatitis in the LC (59% vs 23%, P = .0002) and its progression beyond stage 3 in the CSPD (71.4% vs 39.3%, P = .0003). Relevant immunologic and nonimmunologic variables were included into a multivariate Cox proportional model and three variables, namely, donor age, full HLA-DRB1 donor-recipient mismatch, and HLA B14, resulted in independent risk factors for the development of severe fibrosis. Conclusion: This study provides evidence that DRB1 donor-recipient mismatch affects both the occurrence and progression of recurrent hepatitis C disease. This information is clinically relevant as it may help to better allocate organs and to recognize patients at risk for progression so that specific interventions can be implemented. © 2006 by the American Gastroenterological Association Institute

Published
2006

45. Liver Retransplantation in Adults: The Largest Multicenter Italian Study

Author

Maggi, Umberto, primary, Andorno, Enzo, additional, Rossi, Giorgio, additional, De Carlis, Luciano, additional, Cillo, Umberto, additional, Bresadola, Fabrizio, additional, Mazzaferro, Vincenzo, additional, Risaliti, Andrea, additional, Bertoli, Paolo, additional, Consonni, Dario, additional, Barretta, Francesco, additional, De Feo, Tullia, additional, and Scalamogna, Mario, additional

Published
2012
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49. Influence of immunogenetic background on the outcome of recurrent hepatitis C after liver transplantation

Author

Belli, L, Zavaglia, C, Alberti, A, Poli, F, Rondinara, G, Silini, E, Taioli, E, De Carlis, L, Scalamogna, M, Forti, D, Pinzello, G, Idèo, G, Belli, Luca Saverio, Zavaglia, Claudio, Alberti, Alberto Battista, Poli, Francesca, Rondinara, Gianfranco, Silini, Enrico, Taioli, Emanuela, De Carlis, Luciano, Scalamogna, Mario, Forti, Domenico, Pinzello, Giovambattista, Idèo, Gaetano, Belli, L, Zavaglia, C, Alberti, A, Poli, F, Rondinara, G, Silini, E, Taioli, E, De Carlis, L, Scalamogna, M, Forti, D, Pinzello, G, Idèo, G, Belli, Luca Saverio, Zavaglia, Claudio, Alberti, Alberto Battista, Poli, Francesca, Rondinara, Gianfranco, Silini, Enrico, Taioli, Emanuela, De Carlis, Luciano, Scalamogna, Mario, Forti, Domenico, Pinzello, Giovambattista, and Idèo, Gaetano

Abstract

In immunocompetent patients, specific human leukocyte antigen (HLA) class II alleles have been associated with the severity of hepatitis C virus (HCV)-related disease, in particular, HLA-DRBI* 1 I has been found to exert a protective effect. The authors have analyzed the role of HLA class I and II alleles in determining the frequency, timing, and progression of histologically proven recurrent hepatitis C in 89 patients who underwent a liver transplant for HCV-related cirrhosis. In addition, the influence of HLA mismatch between donor and recipient, HCV genotype, and use of steroid pulses was also evaluated. Median patient follow up was 35 months (range 4-119). HLA-DRBI typing was performed by genomic analysis in all cases. Liver biopsies were obtained routinely and at least at yearly intervals. Histologically proven recurrent hepatitis was observed in 46 patients (52%), 10 patients progressing to stage 5-6 fibrosis in most cases within 2 years after transplant. By univariate analysis, 3 variables, HLA-B14, HLA-DRB1*04, and HLA-DRB1 donor/recipient mismatch, showed a significant effect on time to recurrent hepatitis C disease. These parameters were included in a multivariate regression model along with HCV genotype, treatment with steroid pulses and DRB1*11. HLA-B14, HLA-DRBI*04, and HLA-DRBI donor/recipient mismatch were confirmed to provide a significant and independent contribution to the risk of hepatitic disease recurrence. As for the severity of the disease, none of the 10 patients with stage 5-6 hepatitis carried the HLA- DRBI*11 allele, in line with what was observed in nontransplant subjects. Our results suggest that in posttransplant recurrent hepatitis C, immunogenetic factors are relevant in determining HCV infection outcome

Published
2000

50. Hand Transplantation: The Milan Experience

Author

Lanzetta, Marco, primary, Nolli, Roberta, additional, Vitale, Giovannni, additional, Magni, Francesca, additional, Radaelli, Ilaria, additional, Stroppa, Luisa, additional, Urso, Graziella, additional, Martinez, Ettore, additional, Lucchini, Giovanna, additional, Pioltelli, Pietro, additional, Carta, Italo, additional, Convertino, Ornella, additional, Petruzzo, Palmina, additional, Cappellini, Anna, additional, Coletti, Rosella, additional, Dezza, Clara, additional, Lucchina, Stefano, additional, Rampa, Alessandro, additional, Rovati, Luca, additional, Paleari, Felice, additional, Uggeri, Franco, additional, and Scalamogna, Mario, additional

Published
2007
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