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AbstractCommunity-led housing initiatives address housing challenges through citizen participation and collective action. Despite increasing interest, their impact remains limited in scale. In England, community-led housing enabler hubs were established with government and charitable funding to support sector growth through professional support for volunteer groups. This study examines the implementation of these regional intermediary organisations using qualitative data from three case study regions and the national context. Findings suggest that whilst the intervention was welcomed as a route to increased access and scale within the sector, tensions were apparent between the development of a professionalised intermediary service and the grassroots nature of community-led housing development. The findings show enabler hubs declined after the discontinuation of core funding. This reflects the challenges of short-termism and projectification found throughout the third sector. [ABSTRACT FROM AUTHOR]

Introduction: As in other countries worldwide, Diabetes mellitus type 2 (T2D) and hypertension (HTN) prevalence is increasing in Cambodia. The country is examining models to scale-up integrated T2D and HTN care. However, costs of integrated care in this setting are not yet well-understood. Thus, we modelled the cost of an "Ideal Minimum Integrated Care" (IMIC) package (detection, diagnosis, treatment + health education, self-management and follow-up) for T2D and HTN in Cambodia. Description: We visualised a package – IMIC – of effective interventions for T2D and HTN inspired by SCUBY-ICP and PEN. WHO NCD and HEART Costing Tools were adapted to estimate annual total IMIC intervention cost per health centre, cost per case and cost per capita. Discussion: Cost of the IMIC provides information on costs to aid decision-making on implementation. The Excel-based costing tool is easy to accomplish and can be replicated to provide more accurate results by using more precise actual input data, once these are available in the country. Conclusion: The projected costs of IMIC for T2D and HTN in Cambodia provides evidence to informed decision-making of relevant actors in implementing scale-up of IMIC for T2D and HTN. The model can be used in countries with similar context to calculate costs of integrated care. [ABSTRACT FROM AUTHOR]

Background: A dramatic decline in mental health of people worldwide in the early COVID-19 pandemic years has not recovered. In rural and remote Australia, access to appropriate and timely mental health services has been identified as a major barrier to people seeking help for mental ill-health. From 2020 to 2021 a care navigation model, Navicare, was co-designed with rural and remote communities in the Greater Whitsunday Region of Central Queensland in Australia. The Exploration, Preparation, Implementation and Sustainment (EPIS) framework was used to design and guide multiple aspects of a multisite study, The Bridging Study, to evaluate the implementation of Navicare in Australia. Methods: A community-engaged hybrid effectiveness-implementation study design will focus on the tailored implementation of Navicare at three new sites as well as monitoring implementation at an existing site established since 2021. Study outcomes assessed will include sustained access as the co-primary outcome (measured using access to Navicare mental health referral services) and Proctor's Implementation Outcomes of feasibility, acceptability, appropriateness, adoption, fidelity, implementation cost, and sustainability. Data collection for the implementation evaluation will include service usage data, community consultations, interviews, and workshops; analysed using mixed methods and guided by EPIS and other implementation frameworks. Pre-post effectiveness and cost-consequence study components are embedded in the implementation and sustainment phases, with comparison to pre-implementation data and value assessed for each EPIS phase using hospital, service, and resource allocation data. A scaling up strategy will be co-developed using a national roundtable forum in the final year of the study. Qualitative exploration of other aspects of the study (e.g., mechanisms of action and stakeholder engagement) will be conducted. Discussion: Our study will use tailoring to local sites and a community-engaged approach to drive implementation of a mental health care navigation service in rural and remote Australia, with expected benefits to mental healthcare access. This approach is consistent with policy recommendations nationally and internationally as building blocks for rural health including the World Health Organization Framework for Action on Strengthening Health Systems to Improve Health Outcomes. Trial registration: Prospectively registered on April 2, 2024, on the Australian New Zealand Clinical Trials Registry, no. ACTRN12624000382572. https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386665&isReview=true. [ABSTRACT FROM AUTHOR]

The nutraceutical beverages market has increased in recent years, motivated by the increasing trend of con - sumers choosing food and beverages beneficial to health, mostly after the COVID-19 pandemic. Several researchers have proposed different formulations, where the combination of plants has been tested at the laboratory and pilot scales to maximize the desirable features of the beverages, including antioxidant capacity, anticarcinogens, and anti-inflammatory properties. Developing these products requires scaling-up from these scales to the industry one and, hence, identifying the criteria and/or parameters affecting process yield due to the transport phenomena associated with the scale increment. This work proposes a framework for scaling up solidliquid extraction in a nutraceutical beverage process using available pilot plant data, combining brute-force and empirical scaling approaches. This framework provides an alternative for industries that have acquired equipment without considering the principles of similarity between the larger scale and the laboratory stage. Operating conditions are tuned to reach the product quality at the pilot level and the maximum beverage's antioxidant capacity. A techno-economic analysis of the production process and an environmental evaluation were performed, providing the basis for an effective scaling-up to the industry level. The scaling-up proved to be feasible, as the net present value of the process is $2018,000 with a payback time of 4.83 years; the major source of solid waste is the raw materials with a carbon footprint less than 0.205 MT e(:02 due this process operates with temperatures lower than 100 °C. The circular economy indicators in this project were circular material usage rate and Waste Stream Recycling Rate. The Circular Material Usage Rate ranged from 16.7 % to 66.7 % depending on the composition of the cocoa husk in the raw material, and the Waste Stream Recycling Rate (96) ranged from 4.4 % to 5 % destined for composting development. The framework is designed to be applicable to other food production processes that encounter equipment constraints. It facilitates the evaluation of process yield and enables the simulation and analysis of economic profitability and environmental impact using circular economy indicators at an industrial/commercial scale. [ABSTRACT FROM AUTHOR]

Abstract Wellbore stability analysis is a critical component of petroleum engineering, evaluating the risks of sanding, reservoir compaction, and casing failures. Laboratory rock mechanical measurements must be scaled up to reservoir scales to achieve accurate results. One challenge lies in upscaling dynamic measurements from petrophysical logs to pseudo-static elastic properties, which has significant implications for oil and gas operations. We present a novel approach that combines laboratory rock mechanical measurements with well-log data to develop a mechanical earth model (MEM) for an Iranian oilfield with over 350 wells. We conducted static elastic property measurements on 40 core samples from various layers and depths of carbonate and sandstone rocks, demonstrating the practical application of our approach. By integrating these measurements with dynamic log data and static-dynamic correlations, we established a framework for evaluating the mechanical properties of different layers. Our findings indicate that the safe mud weight window ranges from 41.5 to 118.59 pcf, while the stable mud weight window ranges from 41.5 to 156 pcf. We demonstrate the importance of conducting parallel rock mechanical studies on cores and logs to reduce uncertainties, costs, and risks during oil and gas operations. We also propose a novel methodology combining lithological characteristics, abnormally high pressure, and borehole instability mechanisms to evaluate the stability of borehole walls. This framework provides a fresh perspective on wellbore stability analysis and offers practical solutions for the industry. Essential novel techniques include developing a geomechanical model that integrates laboratory rock mechanical measurements with well-log data to evaluate mechanical properties and calculate safe and stable mud-weight windows. Our study advances wellbore stability analysis by providing a new method for addressing this long-standing challenge. It offers valuable insights for petroleum engineers working in the oil and gas industry.

Photocatalytic synthesis of value‐added chemicals has gained increasing attention in recent years owing to its versatility in driving many important reactions under ambient conditions. Selective hydrogenation, oxidation, coupling, and halogenation with a high conversion of the reactants have been realized using designed photocatalysts in batch reactors with small volumes at a laboratory scale; however, scaling‐up remains a critical challenge due to inefficient utilization of incident light and active sites of the photocatalysts, resulting in poor catalytic performance that hinders its practical applications. Flow systems are considered one of the solutions for practical applications of light‐driven reactions and have experienced great success in photolytic and homogeneous photocatalysis, yet their applications in heterogeneous photocatalysis are still under development. In this perspective, we have summarized recent progress in photolytic and photocatalytic synthetic chemistry performed in flow systems from the view of reactor design with a special focus on heterogeneous photocatalysis. The advantages and limitations of different flow systems, as well as some practical considerations of design strategies are discussed. [ABSTRACT FROM AUTHOR]

Wellbore stability analysis is a critical component of petroleum engineering, evaluating the risks of sanding, reservoir compaction, and casing failures. Laboratory rock mechanical measurements must be scaled up to reservoir scales to achieve accurate results. One challenge lies in upscaling dynamic measurements from petrophysical logs to pseudo-static elastic properties, which has significant implications for oil and gas operations. We present a novel approach that combines laboratory rock mechanical measurements with well-log data to develop a mechanical earth model (MEM) for an Iranian oilfield with over 350 wells. We conducted static elastic property measurements on 40 core samples from various layers and depths of carbonate and sandstone rocks, demonstrating the practical application of our approach. By integrating these measurements with dynamic log data and static-dynamic correlations, we established a framework for evaluating the mechanical properties of different layers. Our findings indicate that the safe mud weight window ranges from 41.5 to 118.59 pcf, while the stable mud weight window ranges from 41.5 to 156 pcf. We demonstrate the importance of conducting parallel rock mechanical studies on cores and logs to reduce uncertainties, costs, and risks during oil and gas operations. We also propose a novel methodology combining lithological characteristics, abnormally high pressure, and borehole instability mechanisms to evaluate the stability of borehole walls. This framework provides a fresh perspective on wellbore stability analysis and offers practical solutions for the industry. Essential novel techniques include developing a geomechanical model that integrates laboratory rock mechanical measurements with well-log data to evaluate mechanical properties and calculate safe and stable mud-weight windows. Our study advances wellbore stability analysis by providing a new method for addressing this long-standing challenge. It offers valuable insights for petroleum engineers working in the oil and gas industry. [ABSTRACT FROM AUTHOR]

The use of native plants for arid land restoration requires the application of pre‐germination treatments to alleviate seed dormancy mechanisms. As it is known, scarification allows several valuable species to overcome the primary forms of dormancy. However, supplying large quantities of scarified seeds at a low cost represents a significant challenge. In this context, our objective was to evaluate locally constructed machines accessible to people of degraded lands in a state of poverty. The effectiveness was evaluated by comparing two native shrubs from South American arid lands, Larrea divaricata and L. cuneifolia. Four treatments were applied: control (T0), mechanical scarification with a hand drill equipped with sandpaper on its head (T1), and mechanical scarification for 15 seconds (T2) and 30 seconds (T3) with a self‐constructed machine, capable of regulating pressure and speed. For both species, the germination probability was higher with T2 (0.82 ± 0.02) compared to T0 (0.28 ± 0.03) and T1 (0.65 ± 0.03). T3 presented intermediate values (0.75 ± 0.03) but did not differ significantly from T1 and T2. Our results show the effectiveness of a locally constructed seed scarification tool to upscale seed‐based restoration in arid lands. [ABSTRACT FROM AUTHOR]

Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium‐ion battery (LIB) recycling processes and has gained considerable attention from the academic and industrial sectors in recent years. The primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical performance. This technology's advantages over traditional pyrometallurgy and hydrometallurgy are cost‐effectiveness, energy efficiency, and sustainability, and it preserves the material structure and morphology and can shorten the overall recycling path. This review extensively discusses the advancements in the direct recycling of LIBs, including battery sorting, pretreatment processes, separation of cathode and anode materials, and regeneration and quality enhancement of electrode materials. It encompasses various approaches to successfully regenerate high‐value electrode materials and streamlining the recovery process without compromising their electrochemical properties. Furthermore, we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives: (1) battery design, (2) disassembling, (3) electrode delamination, and (4) commercialization and sustainability. Based on these challenges and changing market trends, a few strategies are discussed to aid direct recycling efforts, such as binders, electrolyte selection, and alternative battery designs; and recent transitions and technological advancements in the battery industry are presented. [ABSTRACT FROM AUTHOR]

Supercritical fluid technology is an advanced field that offers remarkable versatility and it applies to a broad range of processes. However, the scaling-up of the supercritical fluid impregnation process is still scarcely explored. This research investigates the technical analysis of the supercritical fluid impregnation scaling-up of olive (Olea europaea L.) leaf extract into polypropylene (PP) films. The impregnation scale was increased up to 20-fold while maintaining constant ratios among the extract volume, film area, CO2 amount, and vessel geometry. The study compares homogeneity, total extract loading, and ABTS antioxidant activity of impregnated films at both scales. Homogeneity was assessed using CIELAB coordinates and desorption electrospray ionization mass spectroscopy (DESI-MS) imaging. Films impregnated at 250 bar and 55 °C for 1 h in 100 ml and 500 ml vessels were uniform in colour, whereas those from the larger vessel were less homogeneous. To evaluate the effect of time on impregnation at the largest scale, impregnation was conducted for 1, 6, 24, and 48 h. Homogeneity and ABTS antioxidant activity improved over time, and DESI-MS images showed a gradual decrease in oleuropein signal intensity over time. After 6 h, PP films achieved a total extract loading of 14.02 mg g−1 of polymer, 23 % ABTS antioxidant activity, with a global diffusion coefficient of the extract compounds in PP films of 3.42 × 10−13 m2 s−1. While this study offers valuable insights into scaling up the supercritical fluid impregnation of olive leaf extract into PP films, several limitations remain. Future research is required for a more comprehensive understanding and practical application of the process.

The incorporation of biological control agents (BCAs) such as Trichoderma spp. in agricultural systems favors the transition towards sustainable practices of plant nutrition and diseases control. Novel bioproducts for crop management are called to guarantee sustainable antagonism activity of BCAs and increase the acceptance of the farmers. The encapsulation in polymeric matrices play a prominent role for providing an effective carrier/protector and long-lasting bioproduct. This research aimed to study the influence of biopolymer in hydrogel capsules on survival and shelf-life of T. koningiopsis. Thus, two hydrogel capsules prototypes based on alginate (P1) and amidated pectin (P2), containing conidia of T. koningiopsis Th003 were formulated. Capsules were prepared by the ionic gelation method and calcium gluconate as crosslinker. Conidia releasing under different pH values of the medium, survival of conidia in drying capsules, storage stability, and biocontrol activity against rice sheath blight (Rhizoctonia solani) were studied. P2 prototype provided up to 98% survival to Th003 in fluid bed drying, faster conidia releasing at pH 5.8, storage stability greater than 6 months at 18 °C, and up to 67% of disease reduction. However, both biopolymers facilitate the antagonistic activity against R. solani, and therefore can be incorporated in novel hydrogel capsules-based biopreparations. This work incites to develop novel biopesticides-based formulations with potential to improve the delivery process in the target site and the protection of the active ingredient from the environmental factors. [ABSTRACT FROM AUTHOR]

Abstract Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium‐ion battery (LIB) recycling processes and has gained considerable attention from the academic and industrial sectors in recent years. The primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical performance. This technology's advantages over traditional pyrometallurgy and hydrometallurgy are cost‐effectiveness, energy efficiency, and sustainability, and it preserves the material structure and morphology and can shorten the overall recycling path. This review extensively discusses the advancements in the direct recycling of LIBs, including battery sorting, pretreatment processes, separation of cathode and anode materials, and regeneration and quality enhancement of electrode materials. It encompasses various approaches to successfully regenerate high‐value electrode materials and streamlining the recovery process without compromising their electrochemical properties. Furthermore, we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives: (1) battery design, (2) disassembling, (3) electrode delamination, and (4) commercialization and sustainability. Based on these challenges and changing market trends, a few strategies are discussed to aid direct recycling efforts, such as binders, electrolyte selection, and alternative battery designs; and recent transitions and technological advancements in the battery industry are presented.

Abstract Comprehensive sexuality education (CSE) can substantially contribute to the health and well-being of young people. Yet, most CSE interventions remain limited to the small piloting or research phase and scale-up is often an afterthought at the end of a project. Because of the specificities of CSE, including it being a controversial topic in many contexts and a topic on the fringe between health, education and youth, a specific scaling approach to CSE is needed. The commentary presents a practical framework to support civil society organisations (CSOs), to address barriers to scaling up CSE in their contexts. The utilization and relevance of the framework is demonstrated in this article, by featuring examples from the scale up process of CSE in Indonesia. The framework identifies key principles for scaling up, including: taking a scaling mindset from the start, government ownership and political commitment for scale-up, and identifying the added value of CSOs. The framework starts with a self-assessment by the CSO and then follows four phases: making the case, engaging in dialogue, establishing building blocks and implementation and scale-up. Each of these phases are illustrated with examples from Indonesia. This framework is a call to action with practical guidelines to support CSOs to take on this role, because with the right scaling strategies, the largest generation of young people ever alive can become healthy, empowered and productive adults.

Background Effective healthcare innovations are often not scaled up beyond their initial local context. Lack of practical knowledge on how to move from local innovations to large-system improvement hinders innovation and learning capacity in health systems. Studying scale-up processes can lead to a better understanding of how to facilitate the scale-up of interventions. eConsult is a digital health innovation that aims to connect primary care professionals with specialists through an asynchronous electronic consultation. The recent implementation of eConsult in the public health systems of four Canadian jurisdictions provides a unique opportunity to identify different enabling strategies and related factors that promote the scaling up of eConsult across jurisdictions.Methods We conducted a narrative case study in four Canadian provinces, Quebec, Ontario, Manitoba, and Newfoundland & Labrador, over a 3-year period (2018–2021). We observed provincial eConsult committee meetings (n = 65) and national eConsult forums (n = 3), and we reviewed internal documents (n = 93). We conducted semistructured interviews with key actors in each jurisdiction (eg, researchers, primary care professionals, specialists, policy-makers, and patient partners) (n = 40). We conducted thematic analysis guided by the literature on factors and strategies used to scale up innovations.Results We identified a total of 31 strategies related to six key enabling factors to scaling up eConsult, including: (1) multi-actor engagement; (2) relative advantage; (3) knowledge transfer; (4) strong evidence base; (5) physician leadership; and (6) resource acquisition (eg, human, material, and financial resources). More commonly used strategies, such as leveraging research infrastructure and bringing together various actors, were used to address multiple enabling factors.Conclusion Actors used various strategies to scale up eConsult within their respective contexts, and these helped address six key factors that seemed to be essential to the scale-up of eConsult.

Abstract Background Demand generation aims to increase clients’ desire to use family planning. The aim of this work was to systematically summarize strategies, facilitators, and barriers to scaling up and sustaining demand generation in family planning. Methods We searched electronic bibliographic databases from inception to October 2022. We included quantitative, qualitative, and mixed methods reports on demand generation strategies in family planning, regardless of country, language, publication status, or methodological limitations. We assessed abstracts, titles and full-text papers according to the inclusion criteria, extracted data, and assessed methodological quality of included reports. We used the convergent integrated approach and a deductive thematic synthesis to summarize demand generation themes and subthemes. We used the health system building blocks to synthesize the factors affecting implementation (barriers and facilitators). We used GRADE-CERQual to assess our confidence in the findings. Results Forty-six studies (published 1990–2022) were included: forty-one quantitative, one qualitative, and four mixed methods). Three were from one high-income country, and forty three from LMIC settings. Half of reports were judged to be of unclear risk of bias. There were unique yet interrelated strategies of scaling-up demand generation for family planning. Interpersonal communication strategies increase adoption and coverage of modern contraceptive methods, but the effect on sustainability is uncertain. Mass media exposure increases knowledge and positive attitudes and may increase the intention to use modern contraceptive methods. Demand-side financing approaches probably increase awareness of contraceptives and the use of modern contraceptive methods among poor clients. Multifaceted Demand generation approaches probably improve adoption, coverage and sustainability of modern methods use. Factors that influence the success of implementing these strategies include users knowledge about family planning methods, the availability of modern methods, and the accessibility to services. Conclusions Demand generation strategies may function independently or supplement each other. The myriad of techniques of the different demand generation strategies, the complexities of family planning services, and human interactions defy simplistic conclusions on how a specific strategy or a bundle of strategies may succeed in increasing and sustaining family planning utilization. Trial Registration Systematic review registration: Center for Open Science, osf.io/286j5

Nature-based solutions (NBS) are considered as means to tackle climate change and biodiversity loss while simultaneously enhancing human well-being. Yet, it is still poorly understood how NBS could be mainstreamed. We address this gap by proposing a framework on NBS and employing it in Finland's Kiiminkijoki River basin through participatory workshops and a questionnaire. We examine socio-environmental challenges and visions, existing and emerging NBS to reach the visions, and ways to scale-up NBS to a river basin level. In the river basin, water quality is the priority challenge, due to its relationships with local culture, climate change, and biodiversity. Our results consider how (1) to ensure the relevance of NBS for local actors, (2) instrumental, intrinsic, and relational value perspectives can be enhanced simultaneously by NBS, and (3) site specific NBS can be mainstreamed (i.e., by scaling up, down, out, in, deep) to the river basin level and beyond. [ABSTRACT FROM AUTHOR]

This work presents a pH control approach, robust to model uncertainties including the scaling-up process. The algorithm is based on a master-slave synchronization, where the real process is taken as the slave, and the master is generated by the real-time simulation of the closed-loop mathematical model of the process. In that sense, the objective is to control the pH value, under minimal process information and subject to perturbations and time-varying references ranging between the basic and acid regions, at laboratory and industrial scales. [ABSTRACT FROM AUTHOR]

Objectives: The STrAtegies for RelaTives (START) intervention is effective and cost‐effective in supporting family carers of people with dementia. It is currently not available to all eligible carers in England. What would be the impacts on service costs and carer health‐related quality of life if START was provided to all eligible carers in England, currently and in future? Methods: Effectiveness and cost‐effectiveness data from a previously conducted randomised controlled trial were combined with current and future projections of numbers of people with newly diagnosed dementia to estimate overall and component costs and health‐related quality of life outcomes between 2015 (base year for projections) and 2040. Results: Scaling‐up START requires investments increasing annually but would lead to significant savings in health and social care costs. Family carers of people with dementia would experience improvements in mental health and quality of life, with clinical effects lasting at least 6 years. Scaling up the START intervention to eligible carers was estimated to cost £9.4 million in 2020, but these costs would lead to annual savings of £68 million, and total annual quality‐adjusted life year (QALY) gains of 1247. Although the costs of START would increase to £19.8 million in 2040, savings would rise to £142.7 million and Quality adjusted life years gained to 1883. Conclusions: Scaling‐up START for family carers of people with dementia in England would improve the lives of family carers and reduce public sector costs. Family carers play a vital part in dementia care; evidence‐based interventions that help them to maintain this role, such as START, should be available across the country. Key points: Family carers are the mainstay of dementia support across the world.The STrAtegies for RelaTives (START) intervention has previously been shown to be clinically and cost‐effective.Making START available to all eligible family carers in England, both currently and projected to 2040, would lead to significant savings in health and social care service costs, amounting to £143 million in 2040.Improvements in the mental health and quality of life of carers would also be substantial. [ABSTRACT FROM AUTHOR]

This paper presents the analysis of a pilot anaerobic digestion plant that operates with organic fraction of municipal solid waste (OFMSW) from a wholesale market and can treat up to 500 kg d−1. The process was monitored for a period of 524 days during which the residue was characterized and the biogas production and methane content were recorded. The organic load rate (OLR) of volatile solids (VS) was 0.89 kg m−3 d−1 and the Hydraulic Retention Time (HRT) was 25 d during the process. The yield was 82 Nm3 tons OFMSW−1 biogas, equivalent to 586 Nm3 tons CH4 VS−1. The results obtained in the pilot plant were used to carry out a technical–economic evaluation of a plant that treats 50 tons of OFMSW from wholesale markets. A production of 3769 Nm3 d−1 of biogas and 2080 Nm3 d−1 of methane is estimated, generating 35.1 MWh d−1 when converted to electricity. [ABSTRACT FROM AUTHOR]

Under the umbrella concepts of upscaling and emerging technology, a wide variety of phenomena related to technology development and deployment in society are examined to meet societal imperatives (e.g., environment, safety, social justice). The design literature does not provide an explicit common theoretical and practical framework to clarify the assessment method to handle "an" upscaling. In this nebulous context, designers are struggling to identify the characteristics to anticipate the consequences of emerging technology upscaling. This article therefore first proposes a structuring framework to analyze the literature in a wide range of industrial sectors (energy, chemistry, building, etc.). This characterization brought to light five prevalent archetypes clarifying the concepts of upscaling and emerging technology. Then, a synthesis of invariants and methodological requirements for designers is proposed to deal with upscaling assessment according to each archetype, based on a literature review of existing design methods. This literature review process showed a disparity in treatment for some archetypes, regarding the industrial sector. A discussion is consequently proposed in the conclusion to guide design practices. [ABSTRACT FROM AUTHOR]

Comprehensive sexuality education (CSE) can substantially contribute to the health and well-being of young people. Yet, most CSE interventions remain limited to the small piloting or research phase and scale-up is often an afterthought at the end of a project. Because of the specificities of CSE, including it being a controversial topic in many contexts and a topic on the fringe between health, education and youth, a specific scaling approach to CSE is needed. The commentary presents a practical framework to support civil society organisations (CSOs), to address barriers to scaling up CSE in their contexts. The utilization and relevance of the framework is demonstrated in this article, by featuring examples from the scale up process of CSE in Indonesia. The framework identifies key principles for scaling up, including: taking a scaling mindset from the start, government ownership and political commitment for scale-up, and identifying the added value of CSOs. The framework starts with a self-assessment by the CSO and then follows four phases: making the case, engaging in dialogue, establishing building blocks and implementation and scale-up. Each of these phases are illustrated with examples from Indonesia. This framework is a call to action with practical guidelines to support CSOs to take on this role, because with the right scaling strategies, the largest generation of young people ever alive can become healthy, empowered and productive adults. [ABSTRACT FROM AUTHOR]

Abstract Background Post pregnancy family planning includes both postpartum and post-abortion periods. Post pregnancy women remain one of the most vulnerable groups with high unmet need for family planning. This review aimed to describe and assess the quality of the evidence on implementation strategies, facilitators, and barriers to scaling up and sustaining post pregnancy family planning. Methods Electronic bibliographic databases (MEDLINE, PubMed, Scopus, the Cochrane Library, and Global Index Medicus) were searched from inception to October 2022 for primary quantitative, qualitative, and mixed method reports on scaling up post pregnancy family planning. Abstracts, titles, and full-text papers were assessed according to the inclusion criteria to select studies regardless of country, language, publication status, or methodological limitations. Data were extracted and methodological quality assessed using the Mixed Methods Appraisal Tool. The convergent integrated approach and a deductive thematic synthesis were used to identify themes and sub-themes of strategies to scale up post pregnancy family planning. The health system building blocks were used to summarize barriers and facilitators. GRADE-CERQual was used to assess our confidence in the findings. Results Twenty-nine reports (published 2005–2022) were included: 19 quantitative, 7 qualitative, and 3 mixed methods. Seven were from high-income countries, and twenty-two from LMIC settings. Sixty percent of studies had an unclear risk of bias. The included reports used either separate or bundled strategies for scaling-up post pregnancy family planning. These included strategies for healthcare infrastructure, policy and regulation, financing, human resource, and people at the point of care. Strategies that target the point of care (women and / or their partners) contributed to 89.66% (26/29) of the reports either independently or as part of a bundle. Point of care strategies increase adoption and coverage of post pregnancy contraceptive methods. Conclusion Post pregnancy family planning scaling up strategies, representing a range of styles and settings, were associated with improved post pregnancy contraceptive use. Factors that influence the success of implementing these strategies include issues related to counselling, integration in postnatal or post-abortion care, and religious and social norms. Trial registration Center for Open Science, OSF.IO/EDAKM

The voltage output of a single MFC is normally less than 0.8 V, often less than 0.3 V at maximum power output, which greatly limits the application of MFCs. When MFCs are scaled up, however, increasing reactor size has typically resulted in decreased power density. In this study, we developed a novel MFC configuration that contains multiple cloth electrode assemblies in which the MFCs were internally connected in series (iCiS-MFC). The iCiS-MFC, equivalent to 3 CEA-MFCs, produced a high voltage output over 1.8 V and a maximum power density of 3.5 W m-2 using carbon cloth cathodes containing activated carbon as the catalyst. This power density is 6% higher than that reported for a similar smaller CEA-MFC, indicating that power can be maintained during scale-up with a greater than 33-fold increase in total cathode surface area and greater than 20-fold increase in reactor volume. High stability was also demonstrated based on the performance of the iCiS-MFC over a period of one year of operation. The high power and stability is likely due, in part, to a more efficient means of current collection through the internal series connection, which also avoids the use of expensive current collectors. These results clearly demonstrate the great potential of this MFC design for further scaling-up.

Background: Demand generation aims to increase clients' desire to use family planning. The aim of this work was to systematically summarize strategies, facilitators, and barriers to scaling up and sustaining demand generation in family planning. Methods: We searched electronic bibliographic databases from inception to October 2022. We included quantitative, qualitative, and mixed methods reports on demand generation strategies in family planning, regardless of country, language, publication status, or methodological limitations. We assessed abstracts, titles and full-text papers according to the inclusion criteria, extracted data, and assessed methodological quality of included reports. We used the convergent integrated approach and a deductive thematic synthesis to summarize demand generation themes and subthemes. We used the health system building blocks to synthesize the factors affecting implementation (barriers and facilitators). We used GRADE-CERQual to assess our confidence in the findings. Results: Forty-six studies (published 1990–2022) were included: forty-one quantitative, one qualitative, and four mixed methods). Three were from one high-income country, and forty three from LMIC settings. Half of reports were judged to be of unclear risk of bias. There were unique yet interrelated strategies of scaling-up demand generation for family planning. Interpersonal communication strategies increase adoption and coverage of modern contraceptive methods, but the effect on sustainability is uncertain. Mass media exposure increases knowledge and positive attitudes and may increase the intention to use modern contraceptive methods. Demand-side financing approaches probably increase awareness of contraceptives and the use of modern contraceptive methods among poor clients. Multifaceted Demand generation approaches probably improve adoption, coverage and sustainability of modern methods use. Factors that influence the success of implementing these strategies include users knowledge about family planning methods, the availability of modern methods, and the accessibility to services. Conclusions: Demand generation strategies may function independently or supplement each other. The myriad of techniques of the different demand generation strategies, the complexities of family planning services, and human interactions defy simplistic conclusions on how a specific strategy or a bundle of strategies may succeed in increasing and sustaining family planning utilization. Trial Registration: Systematic review registration: Center for Open Science, osf.io/286j5 Plain English summary: Family planning could prevent one third of maternal deaths by allowing women to delay motherhood, avoid unintended pregnancies and subsequent abortions. Demand generation is one of the critical factors for increasing coverage and sustainability of family planning programs. Demand generation activities aim to increase clients' desire to use family planning by changing their attitudes or perceptions about FP or increasing their awareness or knowledge about FP methods and also by improving access to contraceptive services. Many demand generation activities also aim to shift social and cultural norms to affect individual behavior change. Scaling up demand generation and ensuring that demand for family planning is satisfied is essential for achieving universal access to reproductive health-care services. We systematically searched for and summarized reports of strategies to scale up demand generation for family planning. Available evidence shows that interpersonal communication strategies increase adoption and coverage of modern contraceptive methods, but the effect on sustainability is uncertain. Mass media exposure increases knowledge and positive attitudes and may increase the intention to use modern contraceptive methods. The effect of new media is uncertain. Demand-side financing approach probably increase awareness of contraceptives and the use of modern contraceptive methods among poor women. The most apparent factors influencing the success of implementing these strategies include knowledge about family planning methods, especially regarding side effects and health concerns, the availability of modern contraceptive methods, and the accessibility to family planning services. [ABSTRACT FROM AUTHOR]

Several plant growth–promoting bacteria (PGPB) are gram-negative, and their cell viability is affected during the bio-inoculant production. Hence, formulation-drying processes provide challenges that limit the adoption of these beneficial microorganisms in sustainable agricultural production. Among delivery system strategies for gram-negative PGPB, the encapsulating cells in biopolymeric materials are emerging as a promising alternative. This research aims to evaluate the effect of additives and crosslinking agents on the survival of the consortium of Herbaspirillum frisingense AP21, Azospirillum brasilense D7, and Rhizobium leguminosarum T88 in hydrogel capsules. Three crosslinkers and diverse potential drying protectors were tested. Calcium gluconate provides notable consortium survival advantages regarding colony-forming units (CFUs) (losses of up to 4 log CFU) compared to calcium lactate and calcium chloride (up to 6 log CFU). Additives such as skimmed milk, whey protein, and Gelita® EC improve the recovery of viable cells after the drying process, demonstrating an increase in cell survival of the three bacteria by up to 4 log CFU. The combination of these substances into a capsule prototype extends the storage stability of bacterial consortium up to 3 months at 18 ± 2 °C. This study expands the knowledge for formulating gram-negative PGPB consortium, regarding the crosslinker and drying protector relationship on encapsulation processes with drying survival and further storage stability performance. Key points: • Hydrogel immobilization formulation approach for PGPB consortium • Enhancing drying survival of gram-negative PGPB consortium • Increasing storage stability of PGPB consortium at 18 °C [ABSTRACT FROM AUTHOR]

Hollow fiber membranes demonstrate various advantages for high performance oxygen separation. However, the small diameters of hollow fibers and the brittleness of ceramics limit their mechanical strength, imposing great difficulties on stack and module development. Gas‐tight sealing is another challenge for upscaling of hollow fiber membrane technology. Low temperature sealant materials of epoxy resin or silicon are typically used for hollow fiber stacks, requiring that the sealing portions be located out of hot zone. Consequently, only partial length of hollow fibers participates in oxygen permeation. In this study, upscaling of our recently developed asymmetric hollow fiber‐supported thin film membranes is conducted, where individual hollow fibers are assembled in parallel to form a stack. A reliable gas‐tight sealing is obtained by combining ceramic paste with conductive adhesive ink cohesively. Comprehensive oxygen permeation test is conducted with the sealing portions being in hot zone and compared with a single hollow fiber membrane. Fundamental mechanism is discussed to understand the performances and their differences. An accelerated long‐term test (∼320 h, 16 thermal cycles) demonstrates excellent stability and robustness of the stack and sealing. The characterization of post‐test samples further confirms excellent stability and robustness of the phases and microstructures of the stack. [ABSTRACT FROM AUTHOR]

A description is made of the quality of Spanish family support programmes, based on their impact, dissemination, scaling up in communities, and sustainability; 57 implemented programmes with informed evidence were selected by EurofamNet. Most of the programmes were shown to make a positive impact, using quantitative methodologies, and they were manualized, while about half of them defined the core contents and included professional training. From a cluster analysis of programmes with scaling up, those with a high and moderate level of systematization were identified, based on the existence of defined core contents, implementation conditions, institutional support, professional training, and reports of findings. The highly systematized programmes were characterized by a greater use of mixed methodologies, their scientific dissemination through different means, and their inclusion in services. A programme quality analysis is proposed, taking an integrated approach that relates the programme’s impact with its design, implementation, and evaluation of sustainability.

Abstract Background The ATICA study was a Hybrid I type randomized effectiveness-implementation trial that demonstrated effectiveness of a multicomponent mHealth intervention (Up to four SMS messages sent to HPV-positive women, and one SMS message to CHWs to prompt a visit of women with no triage Pap 60 days after a positive-test), to increase adherence to triage of HPV positive women (ATICA Study). We report data on perceptions of health decision-makers and health-care providers regarding the intervention implementation and scaling-up. Methods A qualitative study was carried out based on individual, semi-structured interviews with health decision-makers (n = 10) and health-care providers (n = 10). The themes explored were selected and analyzed using domains and constructs of the Consolidated Framework for Implementation Research (CFIR) and the maintenance dimension of the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework. Results Both health-care providers and decision-makers had a positive assessment of the intervention through most included constructs: knowledge of the intervention, intervention source, design quality, adaptability, compatibility, access to knowledge and information, relative advantage, women’s needs, and relative priority. However, some potential barriers were also identified including: complexity, leadership engagement, external policies, economic cost, women needs and maintenance. Stakeholders conditioned the strategy’s sustainability to the political commitment of national and provincial health authorities to prioritize cervical cancer prevention, and to the establishment of the ATICA strategy as a programmatic line of work by health authorities. They also highlighted the need to ensure, above all, that there was staff to take Pap tests and carry out the HPV-lab work, and to guarantee a constant provision of HPV-tests. Conclusion Health decision-makers and health-care providers had a positive perception regarding implementation of the multicomponent mHealth intervention designed to increase adherence to triage among women with HPV self-collected tests. This increases the potential for a successful scaling-up of the intervention, with great implications not only for Argentina but also for middle and low-income countries considering using mHealth interventions to enhance the cervical screening/follow-up/treatment process.

Background: Post pregnancy family planning includes both postpartum and post-abortion periods. Post pregnancy women remain one of the most vulnerable groups with high unmet need for family planning. This review aimed to describe and assess the quality of the evidence on implementation strategies, facilitators, and barriers to scaling up and sustaining post pregnancy family planning. Methods: Electronic bibliographic databases (MEDLINE, PubMed, Scopus, the Cochrane Library, and Global Index Medicus) were searched from inception to October 2022 for primary quantitative, qualitative, and mixed method reports on scaling up post pregnancy family planning. Abstracts, titles, and full-text papers were assessed according to the inclusion criteria to select studies regardless of country, language, publication status, or methodological limitations. Data were extracted and methodological quality assessed using the Mixed Methods Appraisal Tool. The convergent integrated approach and a deductive thematic synthesis were used to identify themes and sub-themes of strategies to scale up post pregnancy family planning. The health system building blocks were used to summarize barriers and facilitators. GRADE-CERQual was used to assess our confidence in the findings. Results: Twenty-nine reports (published 2005–2022) were included: 19 quantitative, 7 qualitative, and 3 mixed methods. Seven were from high-income countries, and twenty-two from LMIC settings. Sixty percent of studies had an unclear risk of bias. The included reports used either separate or bundled strategies for scaling-up post pregnancy family planning. These included strategies for healthcare infrastructure, policy and regulation, financing, human resource, and people at the point of care. Strategies that target the point of care (women and / or their partners) contributed to 89.66% (26/29) of the reports either independently or as part of a bundle. Point of care strategies increase adoption and coverage of post pregnancy contraceptive methods. Conclusion: Post pregnancy family planning scaling up strategies, representing a range of styles and settings, were associated with improved post pregnancy contraceptive use. Factors that influence the success of implementing these strategies include issues related to counselling, integration in postnatal or post-abortion care, and religious and social norms. Trial registration: Center for Open Science, OSF.IO/EDAKM Plain English Summary: Family planning could prevent one third of maternal deaths by allowing women to delay motherhood, avoid unintended pregnancies and subsequent abortions. Post pregnancy family planning includes both postpartum and post-abortion periods. Post pregnancy women remain one of the most vulnerable groups with high unmet need for family planning. Scaling up post pregnancy family planning is essential for achieving universal access to reproductive health-care services. Reports of strategies to scale up post pregnancy family planning were systematically reviewed and summarized. These included strategies for healthcare infrastructure, policy and regulation, financing, human resource, and people at the point of care. Strategies that target the point of care (women and/or their partners) contributed to 89.66% (26/29) of the reports either independently or as part of a bundle. Point of care strategies increase adoption and coverage of post pregnancy contraceptive methods. Certain factors influence the success of implementing these strategies, including issues related to counselling, integration in postnatal or post-abortion care, and religious and social norms. [ABSTRACT FROM AUTHOR]

Nanoparticles (NPs) thanks to their unique features such as large surface area, high catalytic activity and intra-cellular electron transfer ability used as an enhancement additive in biohydrogen production. Up to date, inorganic, organic and their mixtures of various NPs were produced from different input sources and synthesis methodology. The NPs properties and cost minimization are the critical factors for the scale up studies of industrial applications. Nevertheless, there have not been any study on the determination of the most efficient and feasible NPs in biohydrogen production for the scaling up the process. In this study, the NPs used for biohydrogen production enhancement over Clostridium sp. by dark fermentation were examined and these studies were evaluated to determine the most effective and feasible NPs using the two-stage TOPSIS method. As a result, iron-containing NPs (hematite, magnetite) were determined as the most effective and economical NPs for increasing the yield. [Display omitted] • NPs addition to bio-H 2 reactors is limited to lab-scale studies. • To be able to use NPs in large-scale systems, a feasibility study is crucial. • The most feasible NPs was determined using the TOPSIS method. • Iron-containing NPs are the most effective and economical for yield improvement. [ABSTRACT FROM AUTHOR]

Multi-label classification has recently attracted research interest as a data mining task. Many current applications in data mining address problems that have instances belonging to more than one class. This requires the development of new efficient methods. Instance selection has been used in multi-label learning to improve the execution time and classification performance of many learning methods. Following the single-label approach, instance selection has been applied by selecting or unselecting the same instances for all labels. In this paper, we present a different and novel approach. An instance might be useful for some labels and harmful for others; therefore, our algorithm allows each instance to be discarded, selected, or only partially selected for use in the classification of certain labels. An extensive comparison using 45 datasets shows the usefulness of our approach in improving the current instance selection methods for multi-label problems, as well as the ability of our algorithm to compete with other more complex multi-label classification methods. • This paper presents a new framework for instance selection for multi-label datasets. • The method improves several state-of-the-art methods. • The method is scalable to large multi-label datasets. • Interesting new research lines are opened by the framework. [ABSTRACT FROM AUTHOR]

The development of alternative fuels has been promoted by the extreme fossil fuel consumption brought on by urbanisation and deteriorating pollution. Due to its high energy and combustible qualities, biohydrogen has been perceived as a potential fuel substitute in dealing with issues related to the rising emission of greenhouse gases and global warming. As a source of carbon sequestration and sustainable renewable energy, biohydrogen synthesis by algae species has been prevalent in research scale. This review focuses on the novel and recent metabolic approaches for enhanced algal based biohydrogen production. Pretreatment methods available and scaling techniques used for enhancing the biohydrogen productivity using algal species have been elaborated in the review. Algal characteristics that make them suitable alternative for biohydrogen production are discussed briefly. Various pretreatment methods such as physical, chemical, biological and thermal are elaborated. In addition, the factors involved in influencing the biohydrogen productivity and the metabolic engineering approaches for modifying the pathway in algae are highlighted. Scaling up of process using different types of photobioreactors such as tubular, flat panel, airlift and stirred tank are reported that briefs about merits and demerits of each photobioreactor. • Algal biohydrogen is considered as continuous renewable energy. • Algal characteristics, cultivation and harvesting methods are discussed. • Various pretreatment approaches for enhancing productivity are explained in detail. • Parameters that affect the rate of biohydrogen production is reviewed. • Scaling of biohydrogen production using photoreactors has been elaborated. [ABSTRACT FROM AUTHOR]