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12 results on '"Scalise, Luca"'

1. The role of ponatinib in adult BCR-ABL1 positive acute lymphoblastic leukemia after allogeneic transplantation: a real-life retrospective multicenter study

Author

Leotta, Salvatore, Markovic, Uros, Pirosa, Maria Cristina, Stella, Stefania, Tringali, Stefania, Martino, Massimo, Specchia, Giorgina, Carluccio, Paola, Risitano, Antonio M., Grimaldi, Francesco, Vigna, Ernesto, Palmieri, Fausto, Palmieri, Raffaele, Annunziata, Mario, Pisapia, Giovanni, Palazzo, Giulia, Milone, Giulio Antonio, Pelle, Angelo Curto, Scalise, Luca, Di Giorgio, Mary Ann, Bulla, Anna, Leotta, Valerio, Di Raimondo, Francesco, and Milone, Giuseppe

Published
2021
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5. Pomalidomide-Responsive Extramedullary Myeloma Relapsed after Allogeneic Hematopoietic Transplant and Refractory to Multiple Lines of Chemotherapy

Author

Leotta, Salvatore, primary, Pirosa, Maria Cristina, additional, Markovic, Uros, additional, Scalise, Luca, additional, Bulla, Anna, additional, Sapienza, Giuseppe, additional, Di Giorgio, Mary Ann, additional, Martino, Enrica Antonia, additional, Curto Pelle, Angelo, additional, Leotta, Valerio, additional, Milone, Giulio, additional, Cupri, Alessandra, additional, Vaddinelli, Doriana, additional, Villari, Loredana, additional, Conticello, Concetta, additional, and Milone, Giuseppe, additional

Published
2019
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6. B-ALL Relapses After Autologous Stem Cell Transplantation Associated With a Shift from e1a2 to e14a2 BCR-ABL Transcripts: A Case Report

Author

STELLA, STEFANIA, primary, MASSIMINO, MICHELE, additional, TIRRÒ, ELENA, additional, VITALE, SILVIA RITA, additional, SCALISE, LUCA, additional, LEOTTA, SALVATORE, additional, PENNISI, MARIA STELLA, additional, PUMA, ADRIANA, additional, ROMANO, CHIARA, additional, STAGNO, FABIO, additional, SAPIENZA, GIUSEPPE, additional, MILONE, GIUSEPPE, additional, and MANZELLA, LIVIA, additional

Published
2018
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7. Prognostic Role of Neutrophil to Lymphocyte Ratio (NLR) in Myelofibrosis Patients Treated with Ruxolitinib: A Multi-Center Experience

Author

Romano, Alessandra, primary, Palandri, Francesca, additional, Masarova, Lucia, additional, Bonifacio, Massimiliano, additional, Polverelli, Nicola, additional, Elli, Elena Maria, additional, Iurlo, Alessandra, additional, Bergamaschi, Micaela, additional, Benevolo, Giulia, additional, Tieghi, Alessia, additional, Sgherza, Nicola, additional, Cavazzini, Francesco, additional, Isidori, Alessandro, additional, Binotto, Gianni, additional, Bosi, Costanza, additional, Crugnola, Monica, additional, Catani, Lucia, additional, Scaffidi, Luigi, additional, Cattaneo, Daniele, additional, Vitolo, Umberto, additional, Cuneo, Antonio, additional, Semenzato, Gianpietro, additional, Aversa, Franco, additional, Cavo, Michele, additional, Vianelli, Nicola, additional, Bartoletti, Daniela, additional, Scalise, Luca, additional, Palumbo, Giuseppe A., additional, Di Raimondo, Francesco, additional, and Verstovsek, Srdan, additional

Published
2018
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8. Long-Term Molecular Remission Achieved by Antibody Anti-CD22 and Ponatinib in a Patient Affected by Ph’+ Acute Lymphoblastic Leukemia Relapsed after Second Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report

Author

Pirosa, Maria Cristina, primary, Leotta, Salvatore, additional, Cupri, Alessandra, additional, Stella, Stefania, additional, Martino, Enrica Antonia, additional, Scalise, Luca, additional, Sapienza, Giuseppe, additional, Calafiore, Valeria, additional, Mauro, Elisa, additional, Spadaro, Andrea, additional, Vigneri, Paolo, additional, Di Raimondo, Francesco, additional, and Milone, Giuseppe, additional

Published
2018
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12. B-ALL Relapses After Autologous Stem Cell Transplantation Associated With a Shift from e1a2 to e14a2 BCR-ABL Transcripts: A Case Report.

Author

Stella S, Massimino M, Tirrò E, Vitale SR, Scalise L, Leotta S, Pennisi MS, Puma A, Romano C, Stagno F, Sapienza G, Milone G, and Manzella L

Subjects
DNA Mutational Analysis, Gene Expression Regulation, Neoplastic drug effects, Humans, Imatinib Mesylate administration & dosage, Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology, Philadelphia Chromosome drug effects, Recurrence, Remission Induction, Transplantation, Autologous methods, Fusion Proteins, bcr-abl genetics, Hematopoietic Stem Cell Transplantation, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Abstract

Background/aim: The Philadelphia chromosome is found in 30% of acute lymphoblastic leukemia (ALL) patients, a distinct ALL subgroup where the BCR-ABL fusion gene is associated with poor prognosis. Treatment with tyrosine kinase inhibitors (TKIs) often induces complete remission and these patients subsequently undergo an autologous stem cell transplantation (ASCT). However, 20% of subjects experience a relapse associated with the selection of point-mutations in the BCR-ABL kinase domain. We report the clinical evolution of a Philadelphia-positive ALL patient co-expressing the e1a2 and e14a2 BCR-ABL transcript at diagnosis., Materials and Methods: Multiplex reverse transcriptase (RT)-PCR was used to detect BCR-ABL transcripts and their levels were measured by quantitative Real Time PCR. Clonal sequencing and next-generation sequencing (NGS) were used to identify mutations., Results: Although the patient underwent ASCT following treatment with multiple TKIs, he relapsed twice. The first time he exhibited the e1a2 transcript and the second time he presented only the e14a2 variant. Mutation analysis, performed by clonal sequencing and NGS, detected two alterations after the first relapse and a single mutation at the time of the second relapse., Conclusion: The observed shift from the e1a2 to the e14a2 variant and the selection of TKI-resistant clones heavily contributed to the fatal evolution of the disease., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2019
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