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25 results on '"Scandiuzzi, Lisa"'

4. Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex

Author

Garrett-Thomson, Sarah C., primary, Massimi, Aldo, additional, Fedorov, Elena V., additional, Bonanno, Jeffrey B., additional, Scandiuzzi, Lisa, additional, Hillerich, Brandan, additional, Seidel, Ronald D., additional, Love, James D., additional, Garforth, Scott J., additional, Guha, Chandan, additional, and Almo, Steven C., additional

Published
2020
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14. Structure and Cancer Immunotherapy of the B7 Family Member B7x

Author

Jeon, Hyungjun, primary, Vigdorovich, Vladimir, additional, Garrett-Thomson, Sarah C., additional, Janakiram, Murali, additional, Ramagopal, Udupi A., additional, Abadi, Yael M., additional, Lee, Jun Sik, additional, Scandiuzzi, Lisa, additional, Ohaegbulam, Kim C., additional, Chinai, Jordan M., additional, Zhao, Ruihua, additional, Yao, Yu, additional, Mao, Ying, additional, Sparano, Joseph A., additional, Almo, Steven C., additional, and Zang, Xingxing, additional

Published
2014
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15. Host B7x Promotes Pulmonary Metastasis of Breast Cancer

Author

Abadi, Yael M., primary, Jeon, Hyungjun, additional, Ohaegbulam, Kim C., additional, Scandiuzzi, Lisa, additional, Ghosh, Kaya, additional, Hofmeyer, Kimberly A., additional, Lee, Jun Sik, additional, Ray, Anjana, additional, Gravekamp, Claudia, additional, and Zang, Xingxing, additional

Published
2013
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18. Mouse Mast Cell Protease-4 Deteriorates Renal Function by Contributing to Inflammation and Fibrosis in Immune Complex-Mediated Glomerulonephritis

Author

Scandiuzzi, Lisa, primary, Beghdadi, Walid, additional, Daugas, Eric, additional, Åbrink, Magnus, additional, Tiwari, Neeraj, additional, Brochetta, Cristiana, additional, Claver, Julien, additional, Arouche, Nassim, additional, Zang, Xingxing, additional, Pretolani, Marina, additional, Monteiro, Renato C., additional, Pejler, Gunnar, additional, and Blank, Ulrich, additional

Published
2010
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23. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.

Author

Ruihua Zhao, Chinai, Jordan M., Buhl, Susan, Scandiuzzi, Lisa, Ray, Anjana, Hyungjun Jeon, Ohaegbulam, Kim C., Ghosh, Kaya, Zhao, Aimin, Scharff, Matthew D., and Xingxing Zang

Subjects
T cells, PROTEIN research, AMINO acids, CD4 antigen, CYTOKINES, CELL proliferation
Abstract

T-cell costimulation and coinhibition generated by engagement of the B7 family and their receptor CD28 family are of central importance in regulating the T-cell response, making these pathways very attractive therapeutic targets. Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family. HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families. HHLA2 protein is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation with LPS and IFN-γ. HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells. HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling. In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22. Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production. This unique human T-cell coinhibitory pathway may afford unique strategies for the treatment of human cancers, autoimmune disorders, infection, and transplant rejection and may help to design better vaccines. [ABSTRACT FROM AUTHOR]

Published
2013
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24. Commensal Microbiota: Powerful Immunological Tools for Gut Homeostasis.

Author

Scandiuzzi, Lisa

Subjects
*GUT microbiome, *HOMEOSTASIS, *IMMUNOLOGY, *BACTERIAL colonies, *SYMBIOSIS, *MICROBIAL diversity
Abstract

In recent years, several important findings in the fields of gut microbiology and immunology have emerged. An increasing number of studies have investigated the characteristics of commensal microbiota and how their symbiotic relationship with the host can be beneficial for gut health. It is becoming evident that gut microbiota and the intestinal immune system must achieve a complex and delicate balance in order to fight pathogenic bacteria and to protect those that contribute to intestinal homeostasis and functions. Although microbiota diversity is not fully understood, new evidence suggests that commensal colonization is dependent on dietary, environmental, host genetic and immunological factors. In addition, the recent characterization of the structure, function, and diversity of the healthy human microbiome will be extremely useful for further studies focused on clarifying the immunological and physiological roles of commensal microbiota. [ABSTRACT FROM AUTHOR]

Published
2013

25. T cell costimulation and coinhibition: genetics and disease.

Author

Scandiuzzi L, Ghosh K, and Zang X

Subjects
Animals, Autoimmunity genetics, Autoimmunity physiology, B7 Antigens genetics, B7 Antigens metabolism, CD28 Antigens genetics, CD28 Antigens metabolism, Humans, Lymphocyte Activation genetics, Lymphocyte Activation physiology, Signal Transduction genetics, Signal Transduction physiology, T-Lymphocytes immunology, T-Lymphocytes metabolism
Abstract

T cell costimulatory and coinhibitory pathways are essential orchestrators and regulators of the adaptive immune response. In recent years, the costimulatory CD28 receptor and B7 ligand families have been expanded to include a total of four and seven members, respectively. Several polymorphisms, mutations, and deletions in both regulatory and protein-coding regions of these genes have subsequently been discovered and evaluated for genetic linkage to various human diseases. Here, we review this evidence as we discuss T cell costimulation and coinhibition in the context of genetic susceptibility to autoimmunity, cancer, and other diseases. As we gain further insight into the functional significance and mechanism of these immunoregulatory pathways by both genetic and immunological approaches, these receptors and ligands are poised to become key targets for immunotherapy.

Published
2011

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