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426 results on '"Scapigliati G"'

4. Lymphocytes of Teleosts

Author

Scapigliati, G., Miccoli, A., Buonocore, F., Fausto, A. M., Picchietti, S., Buchmann, Kurt, editor, and Secombes, Christopher J., editor

Published
2022
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13. An Altered Metabolism in Leukocytes Showing in vitro igG Memory From SARS-CoV-2-Infected Patients

Author

De Molfetta, Federica Gevi, Giuseppina Fanelli, M Tiberi, Scapigliati G, Anna Maria Timperio, and Gianpaolo Zarletti

Subjects
Sarcosine, Arginine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biology, Peripheral blood mononuclear cell, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, In vitro, chemistry.chemical_compound, Immune system, Downregulation and upregulation, chemistry, Antigen, Immunology, Molecular Biology
Abstract

Coronavirus disease 2019 (COVID 19) is a systemic infection that exerts a significant impact on cell metabolism. In this study we performed metabolomic profiling coupled with multivariate statistics analysis obtained from 43 in vitro cultures of peripheral blood mononuclear cells (PBMC), 19 of which displaying IgG memory for spike-S1 antigen 60-90 days after infection. By using mass spectrometry analysis, a significant up regulation of S-adenosyl-Homocysteine, Sarcosine and Arginine was found in leukocytes showing IgG memory. These metabolites are known to be involved in physiological recovering from viral infections and immune activities, and our findings might represent a novel and easy measure that could be of help in understanding SARS-Cov-2 effects on leukocytes.

Published
2022
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18. Cellular and molecular immune responses of the sea bass ( Dicentrarchus labrax) experimentally infected with betanodavirus

Author

Scapigliati, G., Buonocore, F., Randelli, E., Casani, D., Meloni, S., Zarletti, G., Tiberi, M., Pietretti, D., Boschi, I., Manchado, M., Martin-Antonio, B., Jimenez-Cantizano, R., Bovo, G., Borghesan, F., Lorenzen, N., Einer-Jensen, K., Adams, S., Thompson, K., Alonso, C., Bejar, J., Cano, I., Borrego, J.J., and Alvarez, M.C.

Published
2010
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21. Transcriptomic adaptations of Cryonotothenioidea to the antarctic environment and response to heat stress

Author

Greco, S., Gaetano, A. S., Ansaloni, F., Santovito, G., Scapigliati, G., Miccoli, A., Pallavicini, A., Giulianini, P. G., Gerdol, M., Greco, S., Gaetano, A. S., Ansaloni, F., Santovito, G., Scapigliati, G., Miccoli, A., Pallavicini, A., Giulianini, P. G., and Gerdol, M.

Subjects
transcriptomics, Antarctica, Climate change, transcriptomic, bioinformatics, Adaptation, Cryonotothenioidea
Abstract

Antarctic fishes adopted a wide set of adaptations that allow them to thrive in the extreme antarctic environment. For example due to the high solubility of gases in cold waters some Channichthydae such as Chionodraco hamatus have completely lost hemoglobin and gasses are simply dissolved in their colorless blood. Although other adaptations, such as an increased activity of carbonic anhydrase activity in gills, have been previously described from a biochemical point of view, these have not been investigated from a genomic perspective. Here we explore cold adaptations of Cryonotothenioidea at a transcriptomic level in a multi-species comparison. Moreover we investigate the transcriptomic response of Trematomus bernacchii to a slight heat stress. Whole transcriptome sequencing data from 14 fish species were collected from NCBI or generated de novo. A bioinformatic approach based on gene expression anlalysis was used to identify peculiar transcriptomic features of antarctic species compared with species living in temperate environments, and to assess the response of Trematomus bernacchii to a +1.5°C environmental heat stress in 3 different tissues (brain, gill, muscle) of a 6H, 7D and 20D duration. We identified 130 upregulated genes in the gills of Cryonotothenioidea, including two carbonic anhydrases displaying high gill-specificity. Moreover molecular signatures of cobalamin deficiency, which could be linked with the high parasite loads found in these species, were observed. The heat stress experiment revealed gills as most sensible tissue in the 7 days time period and the brain as the most sensible tissue after 20 days of exposure to the exprimental conditions, with protein metabolism, vescicular transport, coagulation and cytoskeleton assembly being the most impacted processes. Comparatively, the gills and muscle tissues displayed an earlier and weaker transcriptomic response. Interestingly, several HSPs were regulated in response to stress resulting both from heat and stabling. This study allowed us to identify peculiar transcriptomic markers of cold adaptation in Cryonotothenioidea and to understand which may be their likely response to rising ocean temperature in a global warming scenario.

Published
2020

29. Targeted disease prophylaxis in European fish farming (TargetFish): P-296

Author

Wiegertjes, G., Lorenzen, G., Secombes, C., Collet, B., Fischer, U., Tafalla, C., Parra, D., Scapigliati, G., Boudinot, P., Evensen, Ø., Adams, A., Toffan, A., Buchmann, K., Vesely, T., David, L., Mulero, V., Smith, P., Aspehaug, V., Engell-Sørensen, K., Sober, J., Wallis, T., Rød, T., Flores, M., March, J., Stratmann, A., Christofilogiannis, P., Tobar, J., Henriksen, N. H., Sigholt, T., and de las Heras, A.

Published
2013
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