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1. High-performance versatile setup for simultaneous Brillouin-Raman micro-spectroscopy

Author

Scarponi, F., Mattana, S., Corezzi, S., Caponi, S., Comez, L., Sassi, P., Morresi, A., Paolantoni, M., Urbanelli, L., Emiliani, C., Roscini, L., Corte, L., Cardinali, G., Palombo, F., Sandercock, J. R., and Fioretto, D.

Subjects
Physics - Instrumentation and Detectors, Condensed Matter - Soft Condensed Matter
Abstract

Brillouin and Raman scattering spectroscopy are established techniques for the nondestructive contactless and label-free readout of mechanical, chemical and structural properties of condensed matter. Brillouin-Raman investigations currently require separate measurements and a site-matching approach to obtain complementary information from a sample. Here we demonstrate a new concept of fully scanning multimodal micro-spectroscopy for simultaneous detection of Brillouin and Raman light scattering in an exceptionally wide spectral range, from fractions of GHz to hundreds of THz. It yields an unprecedented 150 dB contrast, which is especially important for the analysis of opaque or turbid media such as biomedical samples, and a spatial resolution on sub-cellular scale. We report the first applications of this new multimodal method to a range of systems, from a single cell to the fast reaction kinetics of a curing process, and the mechano-chemical mapping of highly scattering biological samples., Comment: 18 pages, 4 figures

Published
2017
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2. When the practice does not meet the theory: results from an Italian survey on the clinical and pathway management of inpatients with decompressive craniectomy or cranioplasty admitted to rehabilitation

Author

La Porta, F, Formisano, R, Iaccarino, C, Lavezzi, S, Pompucci, A, Estraneo, A, De Tanti, A, Achilli, M, Acler, M, Antenucci, R, Avesani, R, Bagnato, S, Battistini, A, Bellaviti, G, Bertoni, M, Brianti, R, Carboncini, M, Castelli, E, Castronovo, G, Chiapparino, C, Colombo, V, Cosentino, E, De Cicco, D, Fassio, C, Felicita, P, Gambarelli, C, Gambrain, M, Gentile, S, Intiso, D, Lombardi, F, Lucca, L, Maggioni, G, Marino, S, Montis, A, Nardone, A, Perin, C, Premoselli, S, Romoli, A, Salvi, G, Scarponi, F, Tedesco, L, Vezzadini, G, La Porta F., Formisano R., Iaccarino C., Lavezzi S., Pompucci A., Estraneo A., De Tanti A., Achilli M. P., Acler M., Antenucci R., Avesani R., Bagnato S., Battistini A., Bellaviti G., Bertoni M., Brianti R., Carboncini M. C., Castelli E., Castronovo G., Chiapparino C., Colombo V., Cosentino E., De Cicco D., Fassio C., Felicita P., Gambarelli C., Gambrain M., Gentile S., Intiso D., Lombardi F., Lucca L. F., Maggioni G., Marino S., Montis A., Nardone A., Perin C., Premoselli S., Romoli A. M., Salvi G. P., Scarponi F., Tedesco L., Vezzadini G., La Porta, F, Formisano, R, Iaccarino, C, Lavezzi, S, Pompucci, A, Estraneo, A, De Tanti, A, Achilli, M, Acler, M, Antenucci, R, Avesani, R, Bagnato, S, Battistini, A, Bellaviti, G, Bertoni, M, Brianti, R, Carboncini, M, Castelli, E, Castronovo, G, Chiapparino, C, Colombo, V, Cosentino, E, De Cicco, D, Fassio, C, Felicita, P, Gambarelli, C, Gambrain, M, Gentile, S, Intiso, D, Lombardi, F, Lucca, L, Maggioni, G, Marino, S, Montis, A, Nardone, A, Perin, C, Premoselli, S, Romoli, A, Salvi, G, Scarponi, F, Tedesco, L, Vezzadini, G, La Porta F., Formisano R., Iaccarino C., Lavezzi S., Pompucci A., Estraneo A., De Tanti A., Achilli M. P., Acler M., Antenucci R., Avesani R., Bagnato S., Battistini A., Bellaviti G., Bertoni M., Brianti R., Carboncini M. C., Castelli E., Castronovo G., Chiapparino C., Colombo V., Cosentino E., De Cicco D., Fassio C., Felicita P., Gambarelli C., Gambrain M., Gentile S., Intiso D., Lombardi F., Lucca L. F., Maggioni G., Marino S., Montis A., Nardone A., Perin C., Premoselli S., Romoli A. M., Salvi G. P., Scarponi F., Tedesco L., and Vezzadini G.

Abstract

BACKGROUND: Cranioplasty (CP) is supposed to improve the functional outcome of severe acquired brain injury (sABI) patients with decompressive craniectomy (DC). However, ongoing controversies exist regarding its indications, optimum materials, timing, complications, and relationships with hydrocephalus (HC). For these reasons, an International Consensus Conference (ICC) on CP in traumatic brain injury (TBI) was held in June 2018 to issue some recommendations. AIM: The aims of this study were: to investigate cross-sectionally before the ICC the prevalence of DC/CP in sABI inpatients admitted to neu- rorehabilitation units in Italy; to assess the perception of Italian clinicians working in the sABI neurorehabilitation settings on the management of inpatients with DC/CP during their rehabilitation stay. DESIGN: Cross-sectional. SETTING AND POPULATION: Physiatrists or neurologists working in 38 Italian rehabilitation centers involved in the care of sABI, giving a pooled sample of 599 inpatients. METHODS: Survey questionnaire consisting of 21 closed-ended questions with multiple-choice answers. Sixteen questions regarded the respondents' opinions and experiences regarding the clinical and management aspects of patients. Survey data were collected via e-mail between April and May 2018. RESULTS: About 1/3 of the 599 inpatients had either a DC (18.9%) or a CP (13.5%). TBI and cerebral hemorrhage were strongly associated with DC/CP, although the association was much stronger for TBI. Significant discrepancies were uncovered between some of the recommendations of the ICC and the corresponding perceptions of the respondents, especially regarding the clinical management of patients (i.e., CP timing). Clear guidelines were perceived as the most crucial factor in improving clinical pathways. CONCLUSIONS: Early collaboration between the neurosurgical and the neurorehabilitation teams is crucial to optimize all clinical and organizational factors, which could expedite CP and minimi

Published
2023

3. Bed Rest Syndrome

Author

Scarponi, F., Zampolini, M., Maggi, Stefania, Series editor, Masiero, Stefano, editor, and Carraro, Ugo, editor

Published
2018
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4. Effect of Rehabilitation Treatments on Disability in Persons With Disorders of Consciousness: A Propensity Score Study

Author

Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., Semerjian M., Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, and Semerjian, M

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Propensity score, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Disorders of consciousness, Severity of Illness Index, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Severity of illness, medicine, Humans, Longitudinal Studies, Aged, Vegetative state, Rehabilitation, business.industry, Minimally conscious state, Recovery of Function, Disability Rating Scale, Middle Aged, medicine.disease, Treatment Outcome, Italy, Propensity score matching, Physical therapy, Consciousness Disorders, Female, Observational study, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract

To evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and Disability Rating Scale (DRS) scores, adjusted for a number of potential confounders measured at baseline, in a large cohort of patients with disorders of consciousness across time.An observational, longitudinal (2 evaluations), multicenter project was made in 90 Italian centers.Patients (N=364) with a diagnosis of disorders of consciousness.Primary outcome was the severity of diagnosis, expressed on an ordinal scale (OtherMCSVSdeath). In the Other group were included patients who emerged from an MCS and recovered consciousness. The secondary outcome was the DRS score (range of 0-30 with 30 being the worst value). The DRS is a tool used to define the level of residual disability, commonly used to classify the level of functional impairment in patients with acquired brain injury. Both outcomes were measured for each wave.A total of 364 subjects having a complete set of demographic, clinical, and pharmacologic data were included in the propensity score (PS) analysis. Results showed that the rehabilitation treatments (physical and cognitive) reduced the clinical worsening over time in both severity diagnosis and DRS (around 6.5 points) in patients with disorders of consciousness across different propensity score strategies (ie, PS matching, PS adjustment, and PS-weighted procedures). In addition, cognitive protocols seem to be limited to patients with a median value of DRS=23.Our propensity score analysis suggests that rehabilitation treatment protocols seem effective and should be applied to a broader spectrum of patients with disorders of consciousness.

Published
2020
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5. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies

Author

Estraneo, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, De Bellis, F, Estraneo A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., De Bellis F., Estraneo, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, De Bellis, F, Estraneo A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., and De Bellis F.

Abstract

Aim: to assess overall clinical complexity of patients with acquired disorders of consciousness (DoC) in vegetative state/unresponsive wakefulness syndrome (VS/UWS) vs. minimally conscious state- MCS) and in different etiologies. Design: Multi-center cross-sectional observational study. Setting: 23 intensive neurorehabilitation units. Subjects: 264 patients with DoC in the post-acute phase: VS/UWS = 141, and MCS = 123 due to vascular (n = 125), traumatic (n = 83) or anoxic (n = 56) brain injury. Main Measures: Coma Recovery Scale-Revised, and Disability Rating Scale (DRS); presence of medical devices (e.g., for eating or breathing); occurrence and severity of medical complications. Results: patients in DoC, and particularly those in VS/UWS, showed severe overall clinical complexity. Anoxic patients had higher overall clinical complexity, lower level of responsiveness/consciousness, higher functional disability, and higher needs of medical devices. Vascular patients had worse premorbid clinical comorbidities. The two etiologies showed a comparable rate of MC, higher than that observed in traumatic etiology. Conclusion: overall clinical complexity is significantly higher in VS/UWS than in MCS, and in non-traumatic vs. traumatic etiology. These findings could explain the worse clinical evolution reported in anoxic and vascular etiologies and in VS/UWS patients and contribute to plan patient-tailored care and rehabilitation programmes.

Published
2021

6. Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness

Author

Estraneo, A, Pascarella, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, Trojano, L, Estraneo A., Pascarella A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A. M., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., Trojano L., Estraneo, A, Pascarella, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, Trojano, L, Estraneo A., Pascarella A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A. M., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., and Trojano L.

Abstract

Aims: to assess occurrence and clinical correlates of neurogenic heterotopic ossifications (NHO) in patients with prolonged disorder of consciousness (DoC). Design: multi-center cross-sectional observational study. Setting: 23 intensive neurorehabilitation units. Subjects: 287 patients with prolonged disorder of consciousness (DoC; 150 in vegetative state, VS, and 128 in minimally conscious state, MCS) of different etiology (vascular = 125, traumatic = 83, anoxic = 56, others = 14). Main Measures: clinical evidence of NHO confirmed by standard radiological and/or sonographic evaluation; Coma Recovery Scale-Revised; Disability Rating Scale (DRS); Early Rehabilitation Barthel Index; presence of ventilator support, spasticity, bone fractures and paroxysmal sympathetic hyperactivity. Results: 31 patients (11.2%) presented NHO. Univariate analyses showed that NHO was associated with VS diagnosis, traumatic etiology, high DRS category and total score, and high occurrence of limb spasticity and bone fractures. A cluster-corrected binary logistic regression model (excluding spasticity available in a subset of patients) showed that only lower DRS total score and presence of bone fractures were independently associated with NHO. Conclusions: NHO are relatively frequent in patients with DoC, and are independently associated with functional disability, bone fractures and spasticity. These findings contribute to identifying patients with DoC prone to develop NHO and requiring special interventions to improve functional recovery.

Published
2021

8. Effect of Rehabilitation Treatments on Disability in Persons With Disorders of Consciousness: A Propensity Score Study

Author

Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, Semerjian, M, Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., Semerjian M., Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, Semerjian, M, Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., and Semerjian M.

Abstract

Objective: To evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and Disability Rating Scale (DRS) scores, adjusted for a number of potential confounders measured at baseline, in a large cohort of patients with disorders of consciousness across time. Design and Setting: An observational, longitudinal (2 evaluations), multicenter project was made in 90 Italian centers. Participants: Patients (N=364) with a diagnosis of disorders of consciousness. Main Outcome Measures: Primary outcome was the severity of diagnosis, expressed on an ordinal scale (Other

Published
2020

11. Identifying clinical complexity in patients affected by severe acquired brain injury in neurorehabilitation: A cross sectional survey

Author

Scarponi, F, Zampolini, M, Zucchella, C, Bargellesi, S, Fassio, C, Pistoia, F, Bartolo, M, Raggi, R, Beatrici, M, Macchetta, C, Cocchini, L, Benedetti, A, Bianconi, F, Bramanti, P, Marino, S, Corallo, F, Brambilla, M, Carboncini M, C, Spina, V, Cervigni, G, Cimenti, F, Previaio, C, Semerjian, M, Colombari, M, De Cicco, D, De Tanti, A, Iardella, L, Diverio, M, Grifoni, C, Carl, V, Pasqualone, E, Estraneo, A, Formisano, R, Ciurli M, P, Galardi, M, Santangelo, A, Giorgini, T, Biasutti, E, Iaia, V, Intiso, D, Lamberti, G, Antoniono, E, Lanfranchi, M, Lavezzi, S, Chiavaroli, R, Lucca L, F, Maggioni, G, Mancuso, M, Canova, S, Mandala, G, Melizza, G, Montis, A, Pilia, F, Mulè, C, Navarro, J, Lanzillotti, C, Perin, C, Petrozzino, S, Schierano, G, Battistini, A, Premoselli, S, Salvi, P, Simonini, M, Sara, M, Serafini, P, Fortuna, R, Sergio M, A, Volanti, P, Scarponi F., Zampolini M., Zucchella C., Bargellesi S., Fassio C., Pistoia F., Bartolo M, Raggi R, Beatrici M, Macchetta C, Cocchini L, Benedetti A, Bianconi F, Bramanti P, Marino S, Corallo F, Brambilla M, Carboncini M C., Spina V, Cervigni G, Cimenti F, Previaio C, Semerjian M, Colombari M, De Cicco D, De Tanti A, Iardella L, Diverio M), Grifoni C, Carl V, Pasqualone E, Estraneo A, Formisano R, Ciurli M P., Galardi M, Santangelo A, Giorgini T, Biasutti E, Iaia V, Intiso D, Lamberti G, Antoniono E, Lanfranchi M, Lavezzi S, Chiavaroli R, Lucca L F., Maggioni G, Mancuso M, Canova S, Mandala G, Melizza G, Montis A, Pilia F, Mulè C., Navarro J, Lanzillotti C, Perin C, Petrozzino S, Schierano G, Battistini A, Premoselli S, Salvi P, Simonini M, Sara M Pardo M, Serafini P, Fortuna R, Sergio M A., Volanti P, Scarponi, F, Zampolini, M, Zucchella, C, Bargellesi, S, Fassio, C, Pistoia, F, Bartolo, M, Raggi, R, Beatrici, M, Macchetta, C, Cocchini, L, Benedetti, A, Bianconi, F, Bramanti, P, Marino, S, Corallo, F, Brambilla, M, Carboncini M, C, Spina, V, Cervigni, G, Cimenti, F, Previaio, C, Semerjian, M, Colombari, M, De Cicco, D, De Tanti, A, Iardella, L, Diverio, M, Grifoni, C, Carl, V, Pasqualone, E, Estraneo, A, Formisano, R, Ciurli M, P, Galardi, M, Santangelo, A, Giorgini, T, Biasutti, E, Iaia, V, Intiso, D, Lamberti, G, Antoniono, E, Lanfranchi, M, Lavezzi, S, Chiavaroli, R, Lucca L, F, Maggioni, G, Mancuso, M, Canova, S, Mandala, G, Melizza, G, Montis, A, Pilia, F, Mulè, C, Navarro, J, Lanzillotti, C, Perin, C, Petrozzino, S, Schierano, G, Battistini, A, Premoselli, S, Salvi, P, Simonini, M, Sara, M, Serafini, P, Fortuna, R, Sergio M, A, Volanti, P, Scarponi F., Zampolini M., Zucchella C., Bargellesi S., Fassio C., Pistoia F., Bartolo M, Raggi R, Beatrici M, Macchetta C, Cocchini L, Benedetti A, Bianconi F, Bramanti P, Marino S, Corallo F, Brambilla M, Carboncini M C., Spina V, Cervigni G, Cimenti F, Previaio C, Semerjian M, Colombari M, De Cicco D, De Tanti A, Iardella L, Diverio M), Grifoni C, Carl V, Pasqualone E, Estraneo A, Formisano R, Ciurli M P., Galardi M, Santangelo A, Giorgini T, Biasutti E, Iaia V, Intiso D, Lamberti G, Antoniono E, Lanfranchi M, Lavezzi S, Chiavaroli R, Lucca L F., Maggioni G, Mancuso M, Canova S, Mandala G, Melizza G, Montis A, Pilia F, Mulè C., Navarro J, Lanzillotti C, Perin C, Petrozzino S, Schierano G, Battistini A, Premoselli S, Salvi P, Simonini M, Sara M Pardo M, Serafini P, Fortuna R, Sergio M A., and Volanti P

Abstract

BACKGROUND: Literature shows that occurrence of comorbidities in people with severe acquired brain injury (sABI) is a common problem in rehabilitation stay. Consequently, patients could require an increase of interventions for diagnosis and treatment of clinical conditions, with a reduction of the rehabilitative take in charge for both clinical and organizational aspects. AIM: The first aim was to evaluate the rate of clinical conditions of sABI patients at admission in rehabilitation and the types of rehabilitative interventions performed in the first week; second objective was to explore the impact of clinical conditions on real rehabilitative take in charge. DESIGN: Cross sectional study. SETTING: Inpatient rehabilitation centers. POPULATION: The study included data from 586 sABI patients. METHODS: Collected data regarded anamnestic information, functional status assessed by means of Glasgow Outcome Scale, Levels of cognitive functioning, Early Rehabilitation Barthel Index, comorbidities at admission and type of rehabilitative interventions carried out in first week of rehabilitation stay. Spearman correlation coefficients were applied to detect possible correlations between the number of treatments in first week and clinical variables; through a multiple regression analysis the effect of patient’s characteristics on rehabilitative take in charge was explored. RESULTS: Data from the sABI patients: mean age 55.1±17.1 years; etiology of sABI was vascular in 315 patients (53.8%), anoxic in 83 (14.2%), neoplastic in 17 (2.9%), infectious in 15 (2.6%), traumatic in 150 (25.6%); 6 subjects (1%) presented a mixed etiology. Need of cardiorespiratory monitoring, pressure sores, infections or presence of multi drug resistant bacteria were the most frequent comorbidities. Passive mobilization, sitting positioning, arousal/awareness stimulation, evaluation and management of dysphagia were the interventions most frequently carried out in the first week. The regression analysi

Published
2019

12. Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic

Author

Bartolo, M., Intiso, D., Lentino, C., Sandrini, G., Paolucci, S., Zampolini, M., Alfonsi, E., Antonucci, G., Baricich, A., Casu, G., Ciancarelli, I., Cisari, C., De Tanti, A., Estraneo, A., Ferraro, F., Gandolfi, M., Invernizzi, M., Iolascon, G., Martinuzzi, A., Morelli, D., Morone, G., Munari, D., Nordio, S., Picelli, A., Scarponi, F., Pingue, V., Solaro, C., Trompetto, C., Bartolo, M., Intiso, D., Lentino, C., Sandrini, G., Paolucci, S., Zampolini, M., Alfonsi, E., Antonucci, G., Baricich, A., Casu, G., Ciancarelli, I., Cisari, C., De Tanti, A., Estraneo, A., Ferraro, F., Gandolfi, M., Invernizzi, M., Iolascon, G., Martinuzzi, A., Morelli, D., Morone, G., Munari, D., Nordio, S., Picelli, A., Scarponi, F., Pingue, V., Solaro, C., and Trompetto, C.

Subjects
Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, medicine.medical_treatment, Phase (combat), lcsh:RC346-429, epidemic, rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Documentation, Intensive care, Health care, Pandemic, medicine, 030212 general & internal medicine, COVID-19, rehabilitation, neurorehabilitation, epidemic, infection, health care, organization, lcsh:Neurology. Diseases of the nervous system, Neurorehabilitation, neurorehabilitation, Rehabilitation, business.industry, COVID-19, health care, infection, organization, medicine.disease, Neurology, Perspective, Neurology (clinical), Medical emergency, business, Choking, 030217 neurology & neurosurgery
Abstract

COVID-19 has rapidly become a pandemic emergency, distressing health systems in each affected country. COVID-19 determines the need for healthcare in a large number of people in an extremely short time and, like a tsunami wave, overruns emergency, infectious diseases, and pneumology departments as well as intensive care units, choking healthcare services. Rehabilitation services are also affected by this epidemic which forces radical changes both in the organization and in the operating methods. In the absence of reference literature on this issue, this report aims to provide a background documentation to support physicians and healthcare personnel involved in neurorehabilitation and rehabilitation care.

Published
2020
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13. Identifying clinical complexity in patients affected by severe acquired brain injury in neurorehabilitation: a cross sectional survey

Author

Scarponi F., Zampolini M., Zucchella C., Bargellesi S., Fassio C., Pistoia F., Bartolo M, Raggi R, Beatrici M, Macchetta C, Cocchini L, Benedetti A, Bianconi F, Bramanti P, Marino S, Corallo F, Brambilla M, Carboncini M C., Spina V, Cervigni G, Cimenti F, Previaio C, Semerjian M, Colombari M, De Cicco D, De Tanti A, Iardella L, Diverio M), Grifoni C, Carl V, Pasqualone E, Estraneo A, Formisano R, Ciurli M P., Galardi M, Santangelo A, Giorgini T, Biasutti E, Iaia V, Intiso D, Lamberti G, Antoniono E, Lanfranchi M, Lavezzi S, Chiavaroli R, Lucca L F., Maggioni G, Mancuso M, Canova S, Mandala G, Melizza G, Montis A, Pilia F, Mulè C., Navarro J, Lanzillotti C, Perin C, Petrozzino S, Schierano G, Battistini A, Premoselli S, Salvi P, Simonini M, Sara M Pardo M, Serafini P, Fortuna R, Sergio M A., Volanti P, Scarponi, F, Zampolini, M, Zucchella, C, Bargellesi, S, Fassio, C, Pistoia, F, Bartolo, M, Raggi, R, Beatrici, M, Macchetta, C, Cocchini, L, Benedetti, A, Bianconi, F, Bramanti, P, Marino, S, Corallo, F, Brambilla, M, Carboncini M, C, Spina, V, Cervigni, G, Cimenti, F, Previaio, C, Semerjian, M, Colombari, M, De Cicco, D, De Tanti, A, Iardella, L, Diverio, M, Grifoni, C, Carl, V, Pasqualone, E, Estraneo, A, Formisano, R, Ciurli M, P, Galardi, M, Santangelo, A, Giorgini, T, Biasutti, E, Iaia, V, Intiso, D, Lamberti, G, Antoniono, E, Lanfranchi, M, Lavezzi, S, Chiavaroli, R, Lucca L, F, Maggioni, G, Mancuso, M, Canova, S, Mandala, G, Melizza, G, Montis, A, Pilia, F, Mulè, C, Navarro, J, Lanzillotti, C, Perin, C, Petrozzino, S, Schierano, G, Battistini, A, Premoselli, S, Salvi, P, Simonini, M, Sara, M, Serafini, P, Fortuna, R, Sergio M, A, and Volanti, P

Subjects
Patient admission, Male, 030506 rehabilitation, medicine.medical_specialty, Cross-sectional study, medicine.medical_treatment, Population, Glasgow Outcome Scale, Physical Therapy, Sports Therapy and Rehabilitation, Comorbidity, Brain injuries, Rehabilitation Centers, Brain injurie, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Acute care, medicine, Humans, education, Paroxysmal sympathetic hyperactivity, Acquired brain injury, Neurorehabilitation, Cross-Sectional Studie, Rehabilitation Center, Inpatients, Health Services Needs and Demand, education.field_of_study, Rehabilitation, business.industry, Neurological Rehabilitation, Middle Aged, medicine.disease, Brain Injuries, Cross-Sectional Studies, Female, Physical therapy, Inpatient, 0305 other medical science, business, 030217 neurology & neurosurgery, Human
Abstract

Background Literature shows that occurrence of comorbidities in people with severe acquired brain injury (sABI) is a common problem in rehabilitation stay. Consequently, patients could require an increase of interventions for diagnosis and treatment of clinical conditions, with a reduction of the rehabilitative take in charge for both clinical and organizational aspects. Aim The first aim was to evaluate the rate of clinical conditions of sABI patients at admission in rehabilitation and the types of rehabilitative interventions performed in the first week; second objective was to explore the impact of clinical conditions on real rehabilitative take in charge. Design Cross sectional study. Setting Inpatient rehabilitation centers. Population The study included data from 586 sABI patients. Methods Collected data regarded anamnestic information, functional status assessed by means of Glasgow Outcome Scale, Levels of cognitive functioning, Early Rehabilitation Barthel Index, comorbidities at admission and type of rehabilitative interventions carried out in first week of rehabilitation stay. Spearman correlation coefficients were applied to detect possible correlations between the number of treatments in first week and clinical variables; through a multiple regression analysis the effect of patient's characteristics on rehabilitative take in charge was explored. Results Data from the sABI patients: mean age 55.1±17.1 years; etiology of sABI was vascular in 315 patients (53.8%), anoxic in 83 (14.2%), neoplastic in 17 (2.9%), infectious in 15 (2.6%), traumatic in 150 (25.6%); 6 subjects (1%) presented a mixed etiology. Need of cardiorespiratory monitoring, pressure sores, infections or presence of multi drug resistant bacteria were the most frequent comorbidities. Passive mobilization, sitting positioning, arousal/awareness stimulation, evaluation and management of dysphagia were the interventions most frequently carried out in the first week. The regression analysis showed that severe neurological and clinical conditions, acute organ failure, cardio-respiratory instability and paroxysmal sympathetic hyperactivity significantly limit access to rehabilitative sessions. Conclusions In sABI patients clinical comorbidities requiring elevated care assistance are frequent at admission in rehabilitation from acute wards and may interfere with rehabilitative take in charge. Clinical rehabilitation impact The knowledge of clinical complexity of sABI patients may improve their care pathways, promoting early and appropriate transition from acute care to rehabilitation settings.

Published
2019
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15. Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness

Author

Estraneo, A, primary, Pascarella, A, additional, Masotta, O, additional, Bartolo, M, additional, Pistoia, F, additional, Perin, C, additional, Marino, S, additional, Lucca, L, additional, Pingue, V, additional, Casanova, E, additional, Romoli, AM, additional, Gentile, S, additional, Formisano, R, additional, Salvi, GP, additional, Scarponi, F, additional, De Tanti, A, additional, Bongioanni, P, additional, Rossato, E, additional, Santangelo, A, additional, Diana, AR, additional, Gambarin, M, additional, Intiso, D, additional, Antenucci, R, additional, Premoselli, S, additional, Bertoni, M, additional, and Trojano, L, additional

Published
2021
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16. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies

Author

Estraneo, A, primary, Masotta, O, additional, Bartolo, M, additional, Pistoia, F, additional, Perin, C, additional, Marino, S, additional, Lucca, L, additional, Pingue, V, additional, Casanova, E, additional, Romoli, A, additional, Gentile, S, additional, Formisano, R, additional, Salvi, GP, additional, Scarponi, F, additional, De Tanti, A, additional, Bongioanni, P, additional, Rossato, E, additional, Santangelo, A, additional, Diana, AR, additional, Gambarin, M, additional, Intiso, D, additional, Antenucci, R, additional, Premoselli, S, additional, Bertoni, M, additional, and De Bellis, F, additional

Published
2020
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17. A Multi-Centric Observational Study on Heterotopic Ossification in Severely Brain-Injured Patients with Disorders of Consciousness: Preliminary Data

Author

Masotta, O, Pascarella, A, Loreto, V, Trojano, L, Formisano, R, Bartol, M, Aabid, H, Perin, C, Pistoia, F, Sara, M, Nardone, A, Berlusconi, M, Marino, S, Lucca, L, Gentile, S, Piperno, R, Casanova, E, Romoli, A, Scarponi, F, Patriarca, E, Carboncini, M, Avesani, R, Sant'Angelo, N, Intiso, D, Diana, A, Pilia, F, Salvi, G, Gambarin, M, Premoselli, S, De Tanti, A, Bertoni, M, Biacchi, D, Antenucci, R, Estraneo, A, Romoli, AM, Carboncini, MC, Diana, AR, Salvi, GP, Masotta, O, Pascarella, A, Loreto, V, Trojano, L, Formisano, R, Bartol, M, Aabid, H, Perin, C, Pistoia, F, Sara, M, Nardone, A, Berlusconi, M, Marino, S, Lucca, L, Gentile, S, Piperno, R, Casanova, E, Romoli, A, Scarponi, F, Patriarca, E, Carboncini, M, Avesani, R, Sant'Angelo, N, Intiso, D, Diana, A, Pilia, F, Salvi, G, Gambarin, M, Premoselli, S, De Tanti, A, Bertoni, M, Biacchi, D, Antenucci, R, Estraneo, A, Romoli, AM, Carboncini, MC, Diana, AR, and Salvi, GP

Published
2019

19. Acoustic excitations in glassy sorbitol and their relation with the fragility and the boson peak.

Author

Ruta, B., Baldi, G., Scarponi, F., Fioretto, D., Giordano, V. M., and Monaco, G.

Subjects
SORBITOL, GLASS, BOSONS, X-ray scattering, LIGHT scattering, FLUCTUATIONS (Physics), MATHEMATICAL models, SUPERCOOLED liquids
Abstract

We report a detailed analysis of the dynamic structure factor of glassy sorbitol by using inelastic X-ray scattering and previously measured light scattering data [B. Ruta, G. Monaco, F. Scarponi, and D. Fioretto, Philos. Mag. 88, 3939 (2008)]. The thus obtained knowledge on the density-density fluctuations at both the mesoscopic and macroscopic length scale has been used to address two debated topics concerning the vibrational properties of glasses. The relation between the acoustic modes and the universal boson peak (BP) appearing in the vibrational density of states of glasses has been investigated, also in relation with some recent theoretical models. Moreover, the connection between the elastic properties of glasses and the slowing down of the structural relaxation process in supercooled liquids has been scrutinized. For what concerns the first issue, it is here shown that the wave vector dependence of the acoustic excitations can be used, in sorbitol, to quantitatively reproduce the shape of the boson peak, supporting the relation between BP and acoustic modes. For what concerns the second issue, a proper study of elasticity over a wide spatial range is shown to be fundamental in order to investigate the relation between elastic properties and the slowing down of the dynamics in the corresponding supercooled liquid phase. [ABSTRACT FROM AUTHOR]

Published
2012
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20. Hydrophobic hydration of tert-butyl alcohol studied by Brillouin light and inelastic ultraviolet scattering.

Author

Lupi, L., Comez, L., Masciovecchio, C., Morresi, A., Paolantoni, M., Sassi, P., Scarponi, F., and Fioretto, D.

Subjects
HYDRATION, BUTANOL, BRILLOUIN scattering, ULTRAVIOLET spectra, VISCOSITY, DYNAMICS, HYDROGEN bonding
Abstract

The longitudinal viscosity of diluted water-tert-butyl alcohol solutions in the 10 GHz frequency region has been measured by means of Brillouin light scattering and inelastic ultraviolet scattering. The main advantage of our hypersonic investigation compared to more traditional ultrasonic measurements is that in the gigahertz frequency range slow relaxation processes involving the alcohol dynamics are completely unrelaxed, so that the measured viscosity mainly originates from the hydrogen bond restructuring of water. In contrast with previous determinations, we estimate an activation energy which is independent from the alcohol mole fraction up to X = 0.1, and comparable to that of bulk water. A simple two-component model is used to describe the steep increase of viscosity with increasing alcohol mole fraction, and a retardation factor 1.7 ± 0.2 is found between the relaxation times of hydration and bulk water. These findings endorse a dynamic scenario where the slowing down of hydration water is mainly due to a reduction of configurational entropy and does not involve an arrested, icelike, dynamics. [ABSTRACT FROM AUTHOR]

Published
2011
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21. Communication: High-frequency acoustic excitations and boson peak in glasses: A study of their temperature dependence.

Author

Ruta, B., Baldi, G., Giordano, V. M., Orsingher, L., Rols, S., Scarponi, F., and Monaco, G.

Subjects
GLASS, SORBITOL, MESOSCOPIC phenomena (Physics), NANOSTRUCTURED materials, FLUCTUATIONS (Physics)
Abstract

The results of a combined experimental study of the high-frequency acoustic dynamics and of the vibrational density of states (VDOS) as a function of temperature in a glass of sorbitol are reported here. The excess in the VDOS at ∼4.5 meV over the Debye, elastic continuum prediction (boson peak) is found to be clearly related to anomalies observed in the acoustic dispersion curve in the mesoscopic wavenumber range of few nm-1. The quasiharmonic temperature dependence of the acoustic dispersion curves offers a natural explanation for the observed scaling of the boson peak with the elastic medium properties. [ABSTRACT FROM AUTHOR]

Published
2010
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22. Onset of the α-relaxation in the glass-forming solution LiCl–6H2O revealed by Brillouin scattering techniques.

Author

Santucci, S. C., Comez, L., Scarponi, F., Monaco, G., Verbeni, R., Legrand, J.-F., Masciovecchio, C., Gessini, A., and Fioretto, D.

Subjects
WATER of crystallization, LIGHT beating spectroscopy, BRILLOUIN scattering, PHYSIOLOGICAL effects of ultraviolet radiation, RELAXATION (Nuclear physics)
Abstract

We measured the dynamic structure factor of the liquid and glassy phases of the LiCl–6H2O solution by means of inelastic scattering of radiation in the visible, UV, and x-ray range, between 1 GHz and 10 THz, and by means of photon-correlation spectroscopy, between 0.01 Hz and 20 kHz. The measurements were performed in the temperature range between 353 and 80 K. Our data show that a single-relaxation process exists at high temperature, which has features similar to those of the single relaxation of pure water. Upon cooling the system below ∼220 K, this single mode starts to differentiate two processes, a structural (α-) and a secondary (β-) relaxation. As the temperature is decreased, the β-relaxation is the vanishing continuation of the single, high-temperature process, while the onset of the α-relaxation occurs at the expense of the β-process. [ABSTRACT FROM AUTHOR]

Published
2009
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23. La cartografia delle acque nel primo atlante ambientale della Campania 2003

Author

Onorati, G., Di Meo, T., Giovinazzi, F., Imperatrice, M. L., Mainolfi, P., and Scarponi, F.

Subjects
water monitoring, monitoraggio acque, Thematic mapping, ambiente, Environment, Cartografia tematica
Abstract

L'Atlante Ambientale della Campania è uno strumento di sintesi della II Relazione sullo Stato dell'Ambiente volto a fornire, in modo diretto e leggibile, le informazioni ambientali legate al territorio. La georeferenziazione dei dati ambientali è infatti ormai il presupposto per qualsiasi analisi territoriale dello stato degli ecosistemi e delle pressioni antropiche sulle risorse naturali. Nell'ottica di politiche mirate ad uno sviluppo sostenibile è pertanto fondamentale disporre di informazioni sull'ambiente che consentano di valutare gli effetti della programmazione. In questo contesto l'Atlante costituisce la sintesi di un percorso, seguito dall'ARPAC, che in due anni ha consentito di realizzare un sistema conoscitivo strutturato per dare a cittadini, tecnici, decisori, il riferimento territoriale sulla situazione ambientale. Nell'Atlante sono riportate 48 carte tematiche di sintesi in scala 1:500.000 della Campania, 15 carte descrivono lo stato delle acque superficiali, sotterranee e marino-costiere, nonché le reti di monitoraggio attivate e le pressioni antropiche sugli ecosistemi. Gli elaborati cartografici sono stati costruiti a partire da oltre 50.000 dati analitici sulla qualità delle acque, tramite un approccio basato sull'integrazione fra competenze cartografiche, ambientali e di diffusione delle informazioni, quindi rappresentano una forma estremamente sintetica ed efficace di comunicazione ambientale. The Environmental Atlas of the Campania Region is a summary of the Il State of the Environment Report aiming at the presentation of environmental information about the territory in a direct and easily readable manner Georeferencing environmental data is the prerequisite for every kind of analysis concerning land use, ecosystems and human pressures on natural resources. The availability of information on the environment, useful for the evaluation of the effects of planning, is very important in the framework of policies devoted to a sustainable development. In this context the Atlas represents the synopsis of a path followed by ARPAC, which in two years realised a knowledgesystem created to offer to citizens, experts, stakeholder, the territorial reference about the state of the environment. In the Atlas 48 thematic maps at 1:500,000 scale are included, 15 maps illustrate coastal, Surficial and groundwater, as well as the monitoring networks activated and the human pressures on the ecosystems. The cartography has been build up starting from more than 50,000 analytical data concerning water quality following an approach centred on the integration of cartographic, environmental and communicational skills and hence is a very compact and efficient tool

Published
2016

25. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy

Author

Scarponi, F., primary, Mattana, S., additional, Corezzi, S., additional, Caponi, S., additional, Comez, L., additional, Sassi, P., additional, Morresi, A., additional, Paolantoni, M., additional, Urbanelli, L., additional, Emiliani, C., additional, Roscini, L., additional, Corte, L., additional, Cardinali, G., additional, Palombo, F., additional, Sandercock, J. R., additional, and Fioretto, D., additional

Published
2017
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27. Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres: A cross-sectional survey

Author

Pisa, Federica Edith, Cosano, Giorgia, Giangreco, Manuela, Giorgini, Tullio, Biasutti, Emanuele, Barbone, Fabio, Formisano, R., Buzzi, M. G., Pistarini, C., Aiachini, B., Basaglia, Nino, Montis, A., Lucca, L. F., Lombardi, F., Ranza, E., Vallasciani, M., Celentano, A., Naldi, A., Castellani, G., Lamberti, G., Lanzillo, B., Posteraro, F., Logi, F., Molteni, F., Lanfranchi, M., Gramigna, C., Bertagnoni, G., Dell'Oste, P., Tonin, P., Iaia, V., Sagliocco, L., Beatrici, M., Giunta, N., Dore, T., Galardi, G., Sant'Angelo, N., Piperno, R., Battistini, A., Zampolini, M., Scarponi, F., Sanna, V., Biella, A. M., Premoselli, S., Zaro, F., Bernasconi, K., Carnovali, M., Chierici, S., Antenucci, R., Salvi, G. P., Mazzini, N., Ventura, F., Lonati, M. C., Brianti, R., Mammi, P., Molinero, G., De Tanti, A., Bertolino, C., Boldrini, P., Bargellesi, S., and Tessari, A.

Subjects
Adult, Male, medicine.medical_specialty, Cross-sectional study, medicine.medical_treatment, Neuroscience (miscellaneous), Practice Patterns, Logistic regression, Off-label use, Rehabilitation Centers, NO, Pharmacotherapy, Arts and Humanities (miscellaneous), medicine, Antiepileptic agents, Prevalence, Developmental and Educational Psychology, Antipsychotics, Humans, Practice Patterns, Physicians', Psychiatry, Survey, Psychotropic Drugs, Rehabilitation, Physicians', Off-label, business.industry, Pharmacoepidemiology, Acquired brain injuries, Antidepressants, Prescribing, Psychotropic medications, Brain Injuries, Cross-Sectional Studies, Female, Italy, Middle Aged, Off-Label Use, Neurology (clinical), Odds ratio, Confidence interval, Emergency medicine, business
Abstract

Guidance on pharmacotherapy of neurobehavioural sequelae post-acquired brain injury (ABI) is limited. Clinicians face the choice of prescribing off-label. This survey assesses prescribing practice and off-label use of psychotropic medications in Italian brain injury rehabilitation centres and factors associated with atypical antipsychotics use.Centres were identified through the roster of the Italian Society for Rehabilitation Medicine. Information was collected through a structured questionnaire. This study calculated the prevalence of centres reporting to use off-label individual medications and unconditional logistic regression Odds Ratio (OR), with 95% confidence interval (95% CI) of atypical antipsychotics use.Psychotropic medications were commonly used. More than 50% of the 35 centres (participation ratio 87.5%) reported to use off-label selected antipsychotics, mostly for agitation (90.5%) and behavioural disturbances (19.0%), and antidepressants, mostly for insomnia (37.5%) and pain (25.0%). Atypical antipsychotic use was directly associated with age40 years (OR = 2.68; 95% CI = 1.25-5.76), recent ABI (1.74; 0.74-4.09), not with reported off-label use (0.98; 0.44-2.18).In clinical practice, the effectiveness and safety of medications, in particular off-label, should be systematically monitored. Studies are needed to improve the quality of evidence guiding pharmacotherapy and to evaluate effectiveness and safety of off-label prescribing.

Published
2015

28. Early rehabilitation for severe acquired brain injury in intensive care unit: Multicenter observational study

Author

Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Citerio, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C, Lorini, F, Zucchella, C., LORINI, FERDINANDO LUCA, CITERIO, GIUSEPPE, Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Citerio, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C, Lorini, F, Zucchella, C., LORINI, FERDINANDO LUCA, and CITERIO, GIUSEPPE

Abstract

Background: The increased survival after a severe acquired brain injury (sABI) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit (NICU), also integrating rehabilitation care. Despite previous studies reported that early mobilization in ICU was effective in preventing complications and reducing hospital stay, few studies addressed the rehabilitative management of sABI patients in ICU/NICU. Aim: To collect clinical and functional data about the early rehabilitative management of sABI patients during ICU/NICU stay. Design. Prospective, observational, multicenter study. Setting: Fourteen facilities supplied by intensive neurorehabilitation units and ICU/NICUs. Population : Consecutive sABI patients admitted to ICU/NICU. Methods: Patients were evaluated at admission and then every 3-5 days. Clinical, functional and rehabilitative data, including Glasgow Coma Scale (GCS), Disability Rating Scale (DRS), The Rancho Los Amigos Levels of Cognitive Functioning Scale (LCF), Early Rehabilitation Barthel Index (ERBI), Glasgow Outcome scale (GOS) and Functional Independence Measure (FIM) were collected. Results : One hundred and two patients (F/M 44/58) were enrolled. The mean duration of ICU stay was 24.7±13.9 days and the first rehabilitative evaluation occurred after 8.7±8.8 days. Regular postural changes and multijoint mobilization were prescribed in 63.7% and 64.7% cases, respectively. The mean session duration was 38±11.5 minutes. Swallowing evaluation was performed in 14.7% patients, psychological support was provided to 12.7% of patients' caregivers, while 17.6% received a psycho-educational intervention, and 28.4% were involved in interdisciplinary team meetings. The main discharge destinations were Severe Acquired Brain Injury rehabilitation units for 43.7%, intensive neurorehabilitation units for 20.7%. Conclusions: Data showed that early rehabilitation was not diffusely performed in sABI subjects in ICU/NICU

Published
2016

33. Origin of the lambda transition in liquid sulfur

Author

Scopigno, T, Yannopoulos, SN, Scarponi, F, Andrikopoulos, KS, Fioretto, D, and Ruocco, G

Subjects
SULPHUR, EQUILIBRIUM POLYMERIZATION, MOLTEN SULFUR, TEMPERATURE, VISCOSITY
Abstract

Developing a novel experimental technique, we applied photon correlation spectroscopy using infrared radiation in liquid sulfur around T-lambda, i.e., in the temperature range where an abrupt increase in viscosity by 4 orders of magnitude is observed upon heating within few degrees. This allowed us-overcoming photoinduced and absorption effects at visible wavelengths-to reveal a chain relaxation process with characteristic time in the millisecond range. These results do rehabilitate the validity of the Maxwell relation in sulfur from an apparent failure, allowing rationalizing of the mechanical and thermodynamic behavior of this system within a viscoelastic scenario.

Published
2007
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41. Density fluctuations of water–glucose mixtures studied by inelastic ultra-violet scattering

Author

Gallina, M.E., primary, Comez, L., additional, Perticaroli, S., additional, Morresi, A., additional, Cesàro, A., additional, De Giacomo, O., additional, Di Fonzo, S., additional, Gessini, A., additional, Masciovecchio, C., additional, Palmieri, L., additional, Paolantoni, M., additional, Sassi, P., additional, Scarponi, F., additional, and Fioretto, D., additional

Published
2008
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48. Early rehabilitation for severe acquired brain injury in intensive care unit: Multicenter observational study

Author

Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C., LORINI, FERDINANDO LUCA, CITERIO, GIUSEPPE, Bartolo, Michelangelo, Bargellesi, Stefano, Castioni, Carlo A, Bonaiuti, Donatella, Antenucci, Roberto, Benedetti, Angelo, Capuzzo, Valeria, Gamna, Federica, Radeschi, Giulio, Citerio, Giuseppe, Colombo, Carolina, Del Casale, Laura, Recubini, Elena, Toska, Saimir, Zanello, Marco, D'Aurizio, Carlo, Spina, Tullio, Del Gaudio, Alredo, Di Rienzo, Filomena, Intiso, Domenico, Dallocchio, Giulia, Felisatti, Giovanna, Lavezzi, Susanna, Zoppellari, Roberto, Gariboldi, Valentina, Lorini, Luca, Melizza, Giovanni, Molinero, Guido, Mandalà, Giorgio, Pignataro, Amedeo, Montis, Andrea, Napoleone, Alessandro, Pilia, Felicita, Pisu, Marina, Semerjian, Monica, Pagliaro, Giuseppina, Nardin, Lorella, Scarponi, Federico, Zampolini, Mauro, Zava, Raffaele, Massetti, Maria A, Piccolini, Carlo, Aloj, Fulvio, Antonelli, Sergio, Zucchella, Chiara, Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Citerio, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C, and Lorini, F

Subjects
Male, Critical Care, health care facilities, manpower, and services, Intensive Care Unit, Rehabilitation, Recovery of Function, Middle Aged, Early mobilization, Hospitalization, Prospective Studie, Intensive Care Units, Treatment Outcome, Italy, Brain Injurie, Brain Injuries, Humans, Female, Glasgow Coma Scale, Prospective Studies, Brain injury, Human, Aged
Abstract

Background: The increased survival after a severe acquired brain injury (sABI) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit (NICU), also integrating rehabilitation care. Despite previous studies reported that early mobilization in ICU was effective in preventing complications and reducing hospital stay, few studies addressed the rehabilitative management of sABI patients in ICU/NICU. Aim: To collect clinical and functional data about the early rehabilitative management of sABI patients during ICU/NICU stay. Design. Prospective, observational, multicenter study. Setting: Fourteen facilities supplied by intensive neurorehabilitation units and ICU/NICUs. Population : Consecutive sABI patients admitted to ICU/NICU. Methods: Patients were evaluated at admission and then every 3-5 days. Clinical, functional and rehabilitative data, including Glasgow Coma Scale (GCS), Disability Rating Scale (DRS), The Rancho Los Amigos Levels of Cognitive Functioning Scale (LCF), Early Rehabilitation Barthel Index (ERBI), Glasgow Outcome scale (GOS) and Functional Independence Measure (FIM) were collected. Results : One hundred and two patients (F/M 44/58) were enrolled. The mean duration of ICU stay was 24.7±13.9 days and the first rehabilitative evaluation occurred after 8.7±8.8 days. Regular postural changes and multijoint mobilization were prescribed in 63.7% and 64.7% cases, respectively. The mean session duration was 38±11.5 minutes. Swallowing evaluation was performed in 14.7% patients, psychological support was provided to 12.7% of patients' caregivers, while 17.6% received a psycho-educational intervention, and 28.4% were involved in interdisciplinary team meetings. The main discharge destinations were Severe Acquired Brain Injury rehabilitation units for 43.7%, intensive neurorehabilitation units for 20.7%. Conclusions: Data showed that early rehabilitation was not diffusely performed in sABI subjects in ICU/NICU and rehabilitative interventions were variable; one-third of subjects were not referred to dedicated rehabilitation unit at discharge. Clinical Rehabilitation Impact : The study stresses the need to spread and implement a rehabilitative culture also for critical ill patients due to neurological diseases.

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