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25 results on '"Schäffler, Martin"'

1. Colloidal Stability and Surface Chemistry Are Key Factors for the Composition of the Protein Corona of Inorganic Gold Nanoparticles

Author

Johnston, Blair D., primary, Kreyling, Wolfgang G., additional, Pfeiffer, Christian, additional, Schäffler, Martin, additional, Sarioglu, Hakan, additional, Ristig, Simon, additional, Hirn, Stephanie, additional, Haberl, Nadine, additional, Thalhammer, Stefan, additional, Hauck, Stefanie M., additional, Semmler-Behnke, Manuela, additional, Epple, Matthias, additional, Hühn, Jonas, additional, Del Pino, Pablo, additional, and Parak, Wolfgang J., additional

Published
2024
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4. Experimentierfeld DigiMilch: Digitalisierung in der Prozesskette Milcherzeugung.

Author

BOPPEL, MANUEL, HÖCHERL, SUSANNE, SCHNEIDER, MARIA, THURNER, STEFAN, BECKMANN, STEFAN, SCHÄFFLER, MARTIN, POTEKO, JERNEJ, WIRSCHING, JOHANNES, HARMS, JAN, SAUTER, SOPHIA, HERTLE, SARAH, HAIDN, BERNHARD, and LORENZINI, ISABELLA

Subjects
AGRICULTURE, DAIRY farms, MILK yield, DAIRY farming, DAIRY processing, DIGITAL technology, KNOWLEDGE transfer
Abstract

Copyright of Züchtungskunde is the property of Verlag Eugen Ulmer and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

5. Case Studies

Author

Schäffler, Martin, Thede, Anke, Leferink, Bastian, Kadner, Kay, Horch, Andrea, Kintz, Maximilien, Weidmann, Monika, Weiten, Moritz, Barros, Alistair, editor, and Oberle, Daniel, editor

Published
2012
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11. Colloidal Stability and Surface Chemistry Are Key Factors for the Composition of the Protein Corona of Inorganic Gold Nanoparticles

Author

Johnston, Blair D., primary, Kreyling, Wolfgang G., additional, Pfeiffer, Christian, additional, Schäffler, Martin, additional, Sarioglu, Hakan, additional, Ristig, Simon, additional, Hirn, Stephanie, additional, Haberl, Nadine, additional, Thalhammer, Stefan, additional, Hauck, Stefanie M., additional, Semmler‐Behnke, Manuela, additional, Epple, Matthias, additional, Hühn, Jonas, additional, Del Pino, Pablo, additional, and Parak, Wolfgang J., additional

Published
2017
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15. In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

Author

Kreyling, Wolfgang G, primary, Fertsch-Gapp, Stefanie, additional, Schäffler, Martin, additional, Johnston, Blair D, additional, Haberl, Nadine, additional, Pfeiffer, Christian, additional, Diendorf, Jörg, additional, Schleh, Carsten, additional, Hirn, Stephanie, additional, Semmler-Behnke, Manuela, additional, Epple, Matthias, additional, and Parak, Wolfgang J, additional

Published
2014
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17. Air–Blood Barrier Translocation of Tracheally Instilled Gold Nanoparticles Inversely Depends on Particle Size

Author

Kreyling, Wolfgang G., primary, Hirn, Stephanie, additional, Möller, Winfried, additional, Schleh, Carsten, additional, Wenk, Alexander, additional, Celik, Gülnaz, additional, Lipka, Jens, additional, Schäffler, Martin, additional, Haberl, Nadine, additional, Johnston, Blair D., additional, Sperling, Ralph, additional, Schmid, Günter, additional, Simon, Ulrich, additional, Parak, Wolfgang J., additional, and Semmler-Behnke, Manuela, additional

Published
2013
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20. Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Author

Geiser, Marianne, primary, Quaile, Oliver, additional, Wenk, Alexander, additional, Wigge, Christoph, additional, Eigeldinger-Berthou, Sylvie, additional, Hirn, Stephanie, additional, Schäffler, Martin, additional, Schleh, Carsten, additional, Möller, Winfried, additional, Mall, Marcus A, additional, and Kreyling, Wolfgang G, additional

Published
2013
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23. Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration.

Author

Schleh, Carsten, Semmler-Behnke, Manuela, Lipka, Jens, Wenk, Alexander, Hirn, Stephanie, Schäffler, Martin, Schmid, Günter, Simon, Ulrich, and Kreyling, Wolfgang G.

Subjects
NANOPARTICLES, INTESTINAL absorption, DRUG delivery systems industry, SPECTRUM analysis, PHARMACEUTICAL technology
Abstract

It is of urgent need to identify the exact physico-chemical characteristics which allow maximum uptake and accumulation in secondary target organs of nanoparticulate drug delivery systems after oral ingestion. We administered radiolabelled gold nanoparticles in different sizes (1.4-200 nm) with negative surface charge and 2.8 nm nanoparticles with opposite surface charges by intra-oesophageal instillation into healthy adult female rats. The quantitative amount of the particles in organs, tissues and excrements was measured after 24 h by gamma-spectroscopy. The highest accumulation in secondary organs was mostly found for 1.4 nm particles; the negatively charged particles were accumulated mostly more than positively charged particles. Importantly, 18 nm particles show a higher accumulation in brain and heart compared to other sized particles. No general rule accumulation can be made so far. Therefore, specialized drug delivery systems via the oral route have to be individually designed, depending on the respective target organ. [ABSTRACT FROM AUTHOR]

Published
2012
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24. Air–Blood Barrier Translocation of Tracheally Instilled Gold Nanoparticles Inversely Depends on Particle Size

Author

Kreyling, Wolfgang G., Hirn, Stephanie, Möller, Winfried, Schleh, Carsten, Wenk, Alexander, Celik, Gülnaz, Lipka, Jens, Schäffler, Martin, Haberl, Nadine, Johnston, Blair D., Sperling, Ralph, Schmid, Günter, Simon, Ulrich, Parak, Wolfgang J., and Semmler-Behnke, Manuela

Abstract

Gold nanoparticles (AuNP) provide many opportunities in imaging, diagnostics, and therapy in nanomedicine. For the assessment of AuNP biokinetics, we intratracheally instilled into rats a suite of 198Au-radio-labeled monodisperse, well-characterized, negatively charged AuNP of five different sizes (1.4, 2.8, 5, 18, 80, 200 nm) and 2.8 nm AuNP with positive surface charges. At 1, 3, and 24 h, the biodistribution of the AuNP was quantitatively measured by gamma-spectrometry to be used for comprehensive risk assessment. Our study shows that as AuNP get smaller, they are more likely to cross the air–blood barrier (ABB) depending strongly on the inverse diameter d–1of their gold core, i.e., their specific surface area (SSA). So, 1.4 nm AuNP (highest SSA) translocated most, while 80 nm AuNP (lowest SSA) translocated least, but 200 nm particles did not follow the d–1relation translocating significantly higher than 80 nm AuNP. However, relative to the AuNP that had crossed the ABB, their retention in most of the secondary organs and tissues was SSA-independent. Only renal filtration, retention in blood, and excretion viaurine further declined with d–1of AuNP core. Translocation of 5, 18, and 80 nm AuNP is virtually complete after 1 h, while 1.4 nm AuNP continue to translocate until 3 h. Translocation of negatively charged 2.8 nm AuNP was significantly higher than for positively charged 2.8 nm AuNP. Our study shows that translocation across the ABB and accumulation and retention in secondary organs and tissues are two distinct processes, both depending specifically on particle characteristics such as SSA and surface charge.

Published
2014
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25. Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Author

Kreyling, Wolfgang G., Hirn, Stephanie, Wenk, Alexander, Möller, Winfried, Mall, Marcus A., Eigeldinger-Berthou, Sylvie, Quaile, Oliver, Schleh, Carsten, Schäffler, Martin, Geiser, Marianne, and Wigge, Christoph

Subjects
570 Life sciences, biology, 610 Medicine & health, 3. Good health
Abstract

BACKGROUND: Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells.Diseased lungs are of specific interest, since these are the main recipients of inhalation therapy. We, therefore, used Scnn1b-transgenic (Tg) mice as a model of chronic obstructive pulmonary disease (COPD) and compared uptake and localization of inhaled AuNP in surface macrophages and lung tissue to wild-type (Wt) mice. METHODS: Scnn1b-Tg and Wt mice inhaled a 21-nm AuNP aerosol for 2 h. Immediately (0 h) or 24 h thereafter, bronchoalveolar lavage (BAL) macrophages and whole lungs were prepared for stereological analysis of AuNP by electron microscopy. RESULTS: AuNP were mainly found as singlets or small agglomerates of 100 nm). At 0 h after aerosol inhalation, 69.2+/-4.9% AuNP were luminal, i.e. attached to the epithelial surface and 24.0+/-5.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 35.3+/-32.2% AuNP were on the epithelium and 58.3+/-41.4% in macrophages. The percentage of luminal AuNP decreased from 0 h to 24 h in both groups. At 24 h, 15.5+/-4.8% AuNP were luminal, 21.4+/-14.2% within epithelial cells and 63.0+/-18.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 9.5+/-5.0% AuNP were luminal, 2.2+/-1.6% within epithelial cells and 82.8+/-0.2% in macrophages. BAL-macrophage analysis revealed enhanced AuNP uptake in Wt animals at 0 h and in Scnn1b-Tg mice at 24 h, confirming less efficient macrophage uptake and delayed clearance of AuNP in Scnn1b-Tg mice. CONCLUSIONS: Inhaled AuNP rapidly bound to the alveolar epithelium in both Wt and Scnn1b-Tg mice. Scnn1b-Tg mice showed less efficient AuNP uptake by surface macrophages and concomitant higher particle internalization by alveolar type I epithelial cells compared to Wt mice. This likely promotes AuNP depth translocation in Scnn1b-Tg mice, including enhanced epithelial targeting. These results suggest AuNP nanocarrier delivery as successful strategy for therapeutic targeting of alveolar epithelial cells and macrophages in COPD.

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