390 results on '"Schürhoff, Franck"'
Search Results
2. History of learning disorders is associated with worse cognitive and functional outcomes in schizophrenia: results from the multicentric FACE-SZ cross-sectional dataset
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Dondé, Clément, Dubertret, Caroline, Fond, Guillaume, Andre, Myrtille, Berna, Fabrice, Boyer, Laurent, Capdevielle, Delphine, Chereau, Isabelle, Coulon, Nathalie, Dorey, Jean-Michel, Leignier, Sylvain, Llorca, Pierre-Michel, Misdrahi, David, Passerieux, Christine, Pignon, Baptiste, Rey, Romain, Schorr, Benoît, Schürhoff, Franck, Urbach, Mathieu, Polosan, Mircea, and Mallet, Jasmina
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- 2023
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3. The risk of hospitalization for psychotic disorders following hospitalization for COVID-19: a French nationwide longitudinal study
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Pignon, Baptiste, Decio, Valentina, Pirard, Philippe, Bouaziz, Olivier, Corruble, Emmanuelle, Geoffroy, Pierre A., Kovess-Masfety, Viviane, Leboyer, Marion, Lemogne, Cédric, Messika, Jonathan, Perduca, Vittorio, Schürhoff, Franck, Regnault, Nolwenn, and Tebeka, Sarah
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- 2023
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4. Clinical and cognitive characteristics of subjects with schizophrenia and childhood attention-deficit/hyperactivity disorder: Results from the multicentric FACE-SZ cross-sectional dataset
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Dondé, Clément, Coulon, Nathalie, Turbé, Hugo, Andre, Myrtille, Boyer, Laurent, Capdevielle, Delphine, Chereau, Isabelle, Dassing, Romane, Dorey, Jean-Michel, Dubertret, Caroline, Leignier, Sylvain, Llorca, Pierre-Michel, Misdrahi, David, Passerieux, Christine, Pignon, Baptiste, Rey, Romain, Schorr, Benoît, Schürhoff, Franck, Urbach, Mathieu, Fond, Guillaume, and Mallet, Jasmina
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- 2024
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5. Subtyping chronic catatonia: Clinical and neuropsychological characteristics of progressive periodic catatonia and chronic system catatonias vs. non-catatonic schizophrenia
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Schorr, Benoit, Clauss, Julie M.E., de Billy, Clément C., Dassing, Romane, Zinetti-Bertschy, Anna, Domergny-Jeanjean, Ludovic C., Obrecht, Alexandre, Mainberger, Olivier, Schürhoff, Franck, Foucher, Jack R., and Berna, Fabrice
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- 2024
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6. Predictors of medication adherence in a large 1-year prospective cohort of individuals with schizophrenia: insights from the multicentric FACE-SZ dataset
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Misdrahi, David, Dupuy, Maud, Dansou, Yecodji, Boyer, Laurent, Berna, Fabrice, Capdevielle, Delphine, Chereau, Isabelle, Coulon, Nathalie, D’Amato, Thierry, Dubertret, Caroline, Leignier, Sylvain, Llorca, Pierre Michel, Lançon, Christophe, Mallet, Jasmina, Passerieux, Christine, Pignon, Baptiste, Rey, Romain, Schürhoff, Franck, Swendsen, Joel, Urbach, Mathieu, Szöke, Andrei, Godin, Ophélia, and Fond, Guillaume
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- 2023
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7. Clinical and pharmacological correlates of caffeine consumption in subjects with schizophrenia – Data from the FACE-SZ cohort
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Andre, M., Andrieu-Haller, C., Aouizerate, B., Berna, F., Blanc, O., Bourguignon, E., Capdevielle, D., Chereau-Boudet, I., Clauss-Kobayashi, J., Coulon, N., Dassing, R., Dorey, J.M., Dubertret, C., Esselin, A., Fond, G., Gabayet, F., Jarroir, M., Lacelle, D., Leboyer, M., Leignier, S., Llorca, P.M., Mallet, J., Metairie, E., Michel, T., Misdrahi, D., Passerieux, C., Petrucci, J., Pignon, B., Peri, P., Portalier, C., Rey, R., Roman, C., Schorr, B., Schürhoff, F., Szoke, A., Tessier, A., Urbach, M., Wachiche, G., Zinetti-Bertschy, A., Szoke, Andrei, Richard, Jean-Romain, Fond, Guillaume, Misdrahi, David, Lajnef, Mohamed, Aouizerate, Bruno, Boyer, Laurent, Berna, Fabrice, Capdevielle, Delphine, André, Myrtille, Chereau, Isabelle, Clauss-Kobayashi, Julie, Coulon, Nathalie, Dubertret, Caroline, Leignier, Sylvain, Llorca, Pierre Michel, Mallet, Jasmina, Passerieux, Christine, Rey, Romain, Schorr, Benoit, Urbach, Mathieu, Leboyer, Marion, Pignon, Baptiste, and Schürhoff, Franck
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- 2023
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8. PM2.5 and PM10 air pollution peaks are associated with emergency department visits for psychotic and mood disorders
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Pignon, Baptiste, Borel, Cynthia, Lajnef, Mohamed, Richard, Jean-Romain, Szöke, Andrei, Hemery, François, Leboyer, Marion, Foret, Gilles, and Schürhoff, Franck
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- 2022
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9. Recommendations of the Schizophrenia Expert Center network for adequate physical activity in real-world schizophrenia (FACE-SZ)
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Sunhary De Verville, Pierre-Louis, Stubbs, Brendon, Etchecopar-Etchart, Damien, Godin, Ophélia, Andrieu-Haller, Christelle, Berna, Fabrice, Aouizerate, Bruno, Capdevielle, Delphine, Chereau, Isabelle, Clauss-Kobayashi, Julie, Coulon, Nathalie, Dorey, Jean-Michel, Dubertret, Caroline, Leignier, Sylvain, Mallet, Jasmina, Misdrahi, David, Passerieux, Catherine, Pignon, Baptiste, Rey, Romain, Urbach, Mathieu, Llorca, Pierre-Michel, Schürhoff, Franck, Lançon, Christophe, Boyer, Laurent, and Fond, Guillaume
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- 2022
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10. Religiosity and prevalence of suicide, psychiatric disorders and psychotic symptoms in the French general population
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Brito, Maria Alice, Amad, Ali, Rolland, Benjamin, Geoffroy, Pierre A., Peyre, Hugo, Roelandt, Jean-Luc, Benradia, Imane, Thomas, Pierre, Vaiva, Guillaume, Schürhoff, Franck, and Pignon, Baptiste
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- 2021
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11. No alteration of leukocyte telomere length in first episode psychosis
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Schürhoff, Franck, Corfdir, Cécile, Pignon, Baptiste, Lajnef, Mohamed, Richard, Jean-Romain, Marcos, Elisabeth, Pelissolo, Antoine, Leboyer, Marion, Adnot, Serge, Jamain, Stephane, and Szöke, Andrei
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- 2021
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12. Temporal variation in the incidence of treated psychotic disorders in young people
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Pignon, Baptiste, Eaton, Scott, Schürhoff, Franck, Szöke, Andrei, McGorry, Patrick, and O'Donoghue, Brian
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- 2021
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13. Season of birth and schizotypy in a sample of undergraduate students
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Szöke, Andrei, primary, Richard, Jean-Romain, additional, Ladea, Maria, additional, Ferchiou, Aziz, additional, Ouaknine, Elie, additional, Briciu, Victor Alexandru, additional, Pirlog, Mihai, additional, Bran, Mihai, additional, Pignon, Baptiste, additional, and Schürhoff, Franck, additional
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- 2024
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14. Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study
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D'Andrea, Giuseppe, primary, Quattrone, Diego, additional, Malone, Kathryn, additional, Tripoli, Giada, additional, Trotta, Giulia, additional, Spinazzola, Edoardo, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E, additional, Sideli, Lucia, additional, Stilo, Simona A, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Rossi Menezes, Paulo, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Sanjuán, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James B, additional, Jones, Peter B, additional, Rutten, Bart P, additional, Van Os, Jim, additional, Selten, Jean-Paul, additional, Vassos, Evangelos, additional, Schürhoff, Franck, additional, Szöke, Andrei, additional, Pignon, Baptiste, additional, O'Donovan, Michael, additional, Richards, Alexander, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Tarricone, Ilaria, additional, and Murray, Robin M, additional
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- 2024
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15. Relationship between childhood trauma and level of insight in schizophrenia: A path-analysis in the national FACE-SZ dataset
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Andrianarisoa, M.D., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Pignon, Baptiste, Lajnef, Mohamed, Godin, Ophélia, Geoffray, Marie-Maud, Rey, Romain, Mallet, Jasmina, Dubertret, Caroline, Roux, Paul, Passerieux, Christine, Marulaz, Laurent, Brunel, Lore, Dubreucq, Julien, Leignier, Sylvain, Capdevielle, Delphine, André, Myrtille, Aouizerate, Bruno, Misdrahi, David, Berna, Fabrice, Vidailhet, Pierre, Chereau, Isabelle, Llorca, Pierre-Michel, Fond, Guillaume, Lançon, Christophe, Leboyer, Marion, and Schürhoff, Franck
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- 2019
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16. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study
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Amoretti, Silvia, Arrojo, Manuel, Baudin, Grégoire, Beards, Stephanie, Bernardo, Miquel, Bobes, Julio, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Díaz-Caneja, Covadonga M, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, García Bernardo, Enrique, Garcia-Portilla, Paz, González, Emiliano, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Leboyer, Marion, López Montoya, Gonzalo, Lorente-Rovira, Esther, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Martínez, Covadonga, Matteis, Mario, Messchaart, Elles, Moltó, Ma Dolores, Nacher, Juan, Olmeda, Ma Soledad, Parellada, Mara, González Peñas, Javier, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rodríguez Solano, José Juan, Roldán Díaz, Laura, Ruggeri, Mirella, Sáiz, Pilar A., Sánchez, Emilio, Sanjuán, Julio, Sartorio, Crocettarachele, Schürhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Sideli, Lucia, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, van der Ven, Elsje, Di Forti, Marta, Quattrone, Diego, Freeman, Tom P, Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, Rutten, Bart PF, de Haan, Lieuwe, Sham, Pak C, van Os, Jim, Lewis, Cathryn M, Lynskey, Michael, Morgan, Craig, and Murray, Robin M
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- 2019
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17. Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment in schizophrenia: results from the multicenter FACE-SZ cohort.
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Vidal, Nathan, Roux, Paul, Urbach, Mathieu, Belmonte, Cristobal, Boyer, Laurent, Capdevielle, Delphine, Clauss-Kobayashi, Julie, D’Amato, Thierry, Dassing, Romane, Dubertret, Caroline, Dubreucq, Julien, Fond, Guillaume, Honciuc, Roxana-Mihaela, Leignier, Sylvain, Llorca, Pierre-Michel, Mallet, Jasmina, Misdrahi, David, Pignon, Baptiste, Rey, Romain, and Schürhoff, Franck
- Subjects
PARASYMPATHOLYTIC agents ,COGNITION disorders ,PSYCHIATRIC drugs ,LITERATURE reviews ,SCHIZOPHRENIA ,SCHIZOAFFECTIVE disorders - Abstract
Aim: The anticholinergic properties of medications are associated with poorer cognitive performance in schizophrenia. Numerous scales have been developed to assess anticholinergic burden and yet, there is no consensus indicating which anticholinergic burden scale is more relevant for patients with schizophrenia. We aimed to identify valid scales for estimating the risk of iatrogenic cognitive impairment in schizophrenia. Methods: We identified 27 scales in a literature review. The responses to neuropsychological tests of 839 individuals with schizophrenia or schizoaffective disorder in the FACE-SZ database were collected between 2010 and 2021. We estimated the association between objective global cognitive performance and the 27 scales, the number of psychotropic drugs, and chlorpromazine and lorazepam equivalents in bivariable regressions in a cross-sectional design. We then adjusted the bivariable models with covariates: the predictors significantly associated with cognitive performance in multiple linear regressions were considered to have good concurrent validity to assess cognitive performance. Results: Eight scales, the number of psychotropic drugs, and drug equivalents were significantly associated with cognitive impairment. The number of psychotropic drugs, the most convenient predictor to compute, was associated with worse executive function (Standardized β = -0.12, p = .004) and reasoning (Standardized β = -0.08, p = .037). Conclusion: Anticholinergic burden, the number of psychotropic drugs, and drug equivalents were weakly associated with cognition, thus suggesting that cognitive impairment in schizophrenia and schizoaffective disorder is explained by factors other than medication. The number of psychotropic drugs was the most parsimonious method to assess the risk of iatrogenic cognitive impairment. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Urbanicity and psychotic disorders: Facts and hypotheses
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Pignon, Baptiste, primary, Szöke, Andrei, additional, Ku, Benson, additional, Melchior, Maria, additional, and Schürhoff, Franck, additional
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- 2023
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19. Poverty and inequality in real-world schizophrenia: a national study
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Fond, Guillaume B., primary, Yon, Dong Keon, additional, Tran, Bach, additional, Mallet, Jasmina, additional, Urbach, Mathieu, additional, Leignier, Sylvain, additional, Rey, Romain, additional, Misdrahi, David, additional, Llorca, Pierre-Michel, additional, Schürhoff, Franck, additional, Berna, Fabrice, additional, and Boyer, Laurent, additional
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- 2023
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20. Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs
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Fond, Guillaume, primary, Mallet, Jasmina, additional, Urbach, Mathieu, additional, Benros, Michael Eriksen, additional, Berk, Michael, additional, Billeci, Martina, additional, Boyer, Laurent, additional, Correll, Christoph U, additional, Fornaro, Michele, additional, Kulkarni, Jayashri, additional, Leboyer, Marion, additional, Llorca, Pierre-Michel, additional, Misdrahi, David, additional, Rey, Romain, additional, Schürhoff, Franck, additional, Solmi, Marco, additional, Sommer, Iris E C, additional, Stahl, Stephen M, additional, Pignon, Baptiste, additional, and Berna, Fabrice, additional
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- 2023
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21. Psychiatric disability as mediator of the neurocognition-functioning link in schizophrenia spectrum disorders: SEM analysis using the Evaluation of Cognitive Processes involved in Disability in Schizophrenia (ECPDS) scale
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Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Roux, Paul, Urbach, Mathieu, Fonteneau, Sandrine, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubreucq, Julien, Faget-Agius, Catherine, Fond, Guillaume, Leignier, Sylvain, Perier, Claire-Cécile, Richieri, Raphaëlle, Schneider, Priscille, Schürhoff, Franck, Tronche, Anne-Marie, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, and Brunet-Gouet, Eric
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- 2018
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22. Isolement et contention mécanique dans les soins psychiatriques : modalités de prescription, prise en charge et surveillance
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Tezenas du Montcel, Chloé, Kowal, Célia, Leherle, Audrey, Kabbaj, Soraya, Frajerman, Ariel, Le Guen, Emmanuel, Hamdani, Nora, Schürhoff, Franck, Leboyer, Marion, Pelissolo, Antoine, and Pignon, Baptiste
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- 2018
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23. Sociodemographic and clinical correlates of psychotic symptoms in the general population: Findings from the MHGP survey
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Pignon, Baptiste, Schürhoff, Franck, Szöke, Andrei, Geoffroy, Pierre A., Jardri, Renaud, Roelandt, Jean-Luc, Rolland, Benjamin, Thomas, Pierre, Vaiva, Guillaume, and Amad, Ali
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- 2018
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24. Conscious and Subliminal Conflicts in Normal Subjects and Patients with Schizophrenia: The Role of the Anterior Cingulate
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Dehaene, Stanislas, Artiges, Eric, Naccache, Lionel, Martelli, Catherine, Viard, Armelle, Schürhoff, Franck, Recasens, Christophe, Leboyer, Marion, and Martinot, Jean-Luc
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- 2003
25. Childhood trauma and psychosis: Beyond the association
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Baudin, Grégoire, Szoke, Andrei, Richard, Jean-Romain, Pelissolo, Antoine, Leboyer, Marion, and Schürhoff, Franck
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- 2017
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26. Advanced Paternal Age is associated with earlier schizophrenia onset in offspring. Results from the national multicentric FACE-SZ cohort
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Fond, Guillaume, Godin, Ophélia, Boyer, Laurent, Llorca, Pierre-Michel, Andrianarisoa, Meja, Brunel, Lore, Aouizerate, Bruno, Berna, Fabrice, Capdevielle, Delphine, D’Amato, Thierry, Denizot, Hélène, Dubertret, Caroline, Dubreucq, Julien, Faget, Catherine, Gabayet, Franck, Mallet, Jasmina, Misdrahi, David, Passerieux, Christine, Rey, Romain, Richieri, Raphaelle, Schandrin, Aurélie, Urbach, Mathieu, vidailhet, Pierre, Leboyer, Marion, Bulzacka, Ewa, and Schürhoff, Franck
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- 2017
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27. Validation study of the Medication Adherence Rating Scale. Results from the FACE-SZ national dataset
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Fond, Guillaume, Boyer, Laurent, Boucekine, Mohamed, Aden, Latif A., Schürhoff, Franck, Tessier, Arnaud, Andrianarisoa, Meja, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Mallet, Jasmina, Denizot, Hélène, Dorey, Jean Michel, Dubertret, Caroline, Dubreucq, Julien, Faget, Catherine, Gabayet, Franck, Rey, Romain, Richieri, Raphaelle, Passerieux, Christine, Schandrin, Aurélie, Urbach, Mathieu, Vidailhet, Pierre, Llorca, Pierre Michel, and Misdrahi, David
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- 2017
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28. Correction to: Religiosity and prevalence of suicide, psychiatric disorders and psychotic symptoms in the French general population
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Brito, Maria Alice, Amad, Ali, Rolland, Benjamin, Geoffroy, Pierre A., Peyre, Hugo, Roelandt, Jean-Luc, Benradia, Imane, Thomas, Pierre, Vaiva, Guillaume, Schürhoff, Franck, and Pignon, Baptiste
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- 2021
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29. Psychotic, Mood, and Anxiety Disorders and Venous Thromboembolism: A Systematic Review and Meta-Analysis
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Kowal, Célia, Peyre, Hugo, Amad, Ali, Pelissolo, Antoine, Leboyer, Marion, Schürhoff, Franck, and Pignon, Baptiste
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- 2020
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30. Clinical and pharmacological correlates of caffeine consumption in subjects with schizophrenia – Data from the FACE-SZ cohort
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Szoke, Andrei, primary, Richard, Jean-Romain, additional, Fond, Guillaume, additional, Misdrahi, David, additional, Lajnef, Mohamed, additional, Aouizerate, Bruno, additional, Boyer, Laurent, additional, Berna, Fabrice, additional, Capdevielle, Delphine, additional, André, Myrtille, additional, Chereau, Isabelle, additional, Clauss-Kobayashi, Julie, additional, Coulon, Nathalie, additional, Dubertret, Caroline, additional, Leignier, Sylvain, additional, Llorca, Pierre Michel, additional, Mallet, Jasmina, additional, Passerieux, Christine, additional, Rey, Romain, additional, Schorr, Benoit, additional, Urbach, Mathieu, additional, Leboyer, Marion, additional, Pignon, Baptiste, additional, Schürhoff, Franck, additional, Andre, M., additional, Andrieu-Haller, C., additional, Aouizerate, B., additional, Berna, F., additional, Blanc, O., additional, Bourguignon, E., additional, Capdevielle, D., additional, Chereau-Boudet, I., additional, Clauss-Kobayashi, J., additional, Coulon, N., additional, Dassing, R., additional, Dorey, J.M., additional, Dubertret, C., additional, Esselin, A., additional, Fond, G., additional, Gabayet, F., additional, Jarroir, M., additional, Lacelle, D., additional, Leboyer, M., additional, Leignier, S., additional, Llorca, P.M., additional, Mallet, J., additional, Metairie, E., additional, Michel, T., additional, Misdrahi, D., additional, Passerieux, C., additional, Petrucci, J., additional, Pignon, B., additional, Peri, P., additional, Portalier, C., additional, Rey, R., additional, Roman, C., additional, Schorr, B., additional, Schürhoff, F., additional, Szoke, A., additional, Tessier, A., additional, Urbach, M., additional, Wachiche, G., additional, and Zinetti-Bertschy, A., additional
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- 2023
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31. Adjunctive agents to antipsychotics in schizophrenia:a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs
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Fond, Guillaume, Mallet, Jasmina, Urbach, Mathieu, Benros, Michael Eriksen, Berk, Michael, Billeci, Martina, Boyer, Laurent, Correll, Christoph U., Fornaro, Michele, Kulkarni, Jayashri, Leboyer, Marion, Llorca, Pierre-Michel, Misdrahi, David, Rey, Romain, Schürhoff, Franck, Solmi, Marco, Sommer, Iris E. C., Stahl, Stephen M., Pignon, Baptiste, Berna, Fabrice, Fond, Guillaume, Mallet, Jasmina, Urbach, Mathieu, Benros, Michael Eriksen, Berk, Michael, Billeci, Martina, Boyer, Laurent, Correll, Christoph U., Fornaro, Michele, Kulkarni, Jayashri, Leboyer, Marion, Llorca, Pierre-Michel, Misdrahi, David, Rey, Romain, Schürhoff, Franck, Solmi, Marco, Sommer, Iris E. C., Stahl, Stephen M., Pignon, Baptiste, and Berna, Fabrice
- Abstract
QUESTION: This umbrella review and guidelines aimed to provide evidence to support the rational choice of selected adjunctive therapies for schizophrenia.STUDY SELECTION AND ANALYSIS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and World Federation of Societies of Biological Psychiatry (WFSBP)-grading recommendations, 63 randomised control trials (RCTs) (of which 4219 unique participants have completed the RCTs) and 29 meta-analyses were analysed.FINDINGS: Provisional recommendations (WFSBP-grade 1) could be made for two molecules in augmentation to antipsychotics: (1) N-acetyl-cysteine (NAC, 1200-3600 mg/day, for >12 consecutive weeks) in improving negative symptoms, general psychopathology (positive and negative syndrome scale for schizophrenia (PANSS) general psychopathology factor (G)-G subscale), with the RCTs with the longer duration showing the most robust findings; (2) polyunsaturated fatty acids (3000 mg/day of eicosapentaenoic acid, for >12 weeks) in improving general psychopathology. Weaker recommendations (ie, WFSBP-grade 2) could be drawn for sarcosine (2 g/day) and minocycline (200-300 mg/day) for improving negative symptoms in chronic schizophrenia (not early schizophrenia), and NAC for improving positive symptoms and cognition. Weak recommendations are not ready for clinical practice. There is provisional evidence that oestrogens and raloxifene are effective in some patients, but further research is needed to determine their benefit/risk ratio.CONCLUSIONS: The results of this umbrella review should be interpreted with caution as the number of RCTs included in the meta-analyses was generally small and the effect sizes were weak or medium. For NAC, two RCTs with low risk of bias have provided conflicting results and the WFSBP-grade recommendation included also the results of meta-analyses. These drugs could be provisionally prescribed for patients for whom no other treatments h
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- 2023
32. Clinical utility of the Multiple Errands Test in schizophrenia: A preliminary assessment
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Bulzacka, Ewa, Delourme, Gwenaëlle, Hutin, Valérie, Burban, Nathalie, Méary, Alexandre, Lajnef, Mohamed, Leboyer, Marion, and Schürhoff, Franck
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- 2016
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33. Schizophrenia risk factors in exceptional achievers: a re-analysis of a 60-year-old database
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Szöke, Andrei, Pignon, Baptiste, and Schürhoff, Franck
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- 2019
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34. Obsessive-Compulsive Symptoms in Schizophrenia: an Up-To-Date Review of Literature
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Tezenas du Montcel, Chloé, Pelissolo, Antoine, Schürhoff, Franck, and Pignon, Baptiste
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- 2019
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35. Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study.
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Trotta, Giulia, Rodriguez, Victoria, Quattrone, Diego, Spinazzola, Edoardo, Tripoli, Giada, Gayer-Anderson, Charlotte, Freeman, Tom P, Jongsma, Hannah E, Sideli, Lucia, Aas, Monica, Stilo, Simona A, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Tortelli, Andrea, and Schürhoff, Franck
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SUBSTANCE abuse prevention ,ADVERSE childhood experiences ,CANNABIS (Genus) ,SUBSTANCE abuse ,PSYCHOSES ,CASE-control method ,QUESTIONNAIRES ,RESEARCH funding ,PSYCHOTHERAPY - Abstract
Background: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0–11 years), and late (12–17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. Results: The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. Conclusions: Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse. [ABSTRACT FROM AUTHOR]
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- 2023
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36. Nicotine dependence is associated with depression and childhood trauma in smokers with schizophrenia: results from the FACE-SZ dataset
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Rey, Romain, D’Amato, Thierry, Boyer, Laurent, Brunel, Lore, Aouizerate, Bruno, Berna, Fabrice, Capdevielle, Delphine, Chereau, Isabelle, Chesnoy-Servanin, Gabrielle, Denizot, Hélène, Dorey, Jean-Michel, Dubertret, Caroline, Dubreucq, Julien, Faget, Catherine, Gabayet, Franck, Lancon, Christophe, Mallet, Jasmina, Misdrahi, David, Passerieux, Christine, Schandrin, Aurélie, Schürhoff, Franck, Urbach, Mathieu, Vidailhet, Pierre, Llorca, Pierre-Michel, Fond, Guillaume, Andrianarisoa, M., Andrianarisoa, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D’Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilain, J., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., and The FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group
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- 2017
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37. History of learning disorders is associated with worse cognitive and functional outcomes in schizophrenia: results from the multicentric FACE-SZ cross-sectional dataset
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Dondé, Clément, primary, Dubertret, Caroline, additional, Fond, Guillaume, additional, Andre, Myrtille, additional, Berna, Fabrice, additional, Boyer, Laurent, additional, Capdevielle, Delphine, additional, Chereau, Isabelle, additional, Coulon, Nathalie, additional, Dorey, Jean-Michel, additional, Leignier, Sylvain, additional, Llorca, Pierre-Michel, additional, Misdrahi, David, additional, Passerieux, Christine, additional, Pignon, Baptiste, additional, Rey, Romain, additional, Schorr, Benoît, additional, Schürhoff, Franck, additional, Urbach, Mathieu, additional, Polosan, Mircea, additional, and Mallet, Jasmina, additional
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- 2022
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38. Subtyping chronic catatonia: Clinical and neuropsychological characteristics of progressive periodic catatonia and chronic system catatonias vs. non-catatonic schizophrenia
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Schorr, Benoit, primary, Clauss, Julie M.E., additional, de Billy, Clément C., additional, Dassing, Romane, additional, Zinetti-Bertschy, Anna, additional, Domergny-Jeanjean, Ludovic C., additional, Obrecht, Alexandre, additional, Mainberger, Olivier, additional, Schürhoff, Franck, additional, Foucher, Jack R., additional, and Berna, Fabrice, additional
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- 2022
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39. Association between cannabis use and schizotypal dimensions – A meta-analysis of cross-sectional studies
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Szoke, Andrei, Galliot, Anne-Marie, Richard, Jean-Romain, Ferchiou, Aziz, Baudin, Grégoire, Leboyer, Marion, and Schürhoff, Franck
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- 2014
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40. Small area-level variation in the incidence of psychotic disorders in an urban area in France: an ecological study
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Szoke, Andrei, Pignon, Baptiste, Baudin, Grégoire, Tortelli, Andrea, Richard, Jean-Romain, Leboyer, Marion, and Schürhoff, Franck
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- 2016
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41. Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort
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Foiselle, Marianne, primary, Barbosa, Susana, additional, Godin, Ophélia, additional, Wu, Ching-Lien, additional, Boukouaci, Wahid, additional, Andre, Myrtille, additional, Aouizerate, Bruno, additional, Berna, Fabrice, additional, Barau, Caroline, additional, Capdevielle, Delphine, additional, Vidailhet, Pierre, additional, Chereau, Isabelle, additional, Davidovic, Laetitia, additional, Dorey, Jean-Michel, additional, Dubertret, Caroline, additional, Dubreucq, Julien, additional, Faget, Catherine, additional, Fond, Guillaume, additional, Leigner, Sylvain, additional, Llorca, Pierre-Michel, additional, Mallet, Jasmina, additional, Misdrahi, David, additional, Martinuzzi, Emanuela, additional, Passerieux, Christine, additional, Rey, Romain, additional, Pignon, Baptiste, additional, Urbach, Mathieu, additional, Schürhoff, Franck, additional, Glaichenhaus, Nicolas, additional, Leboyer, Marion, additional, Tamouza, Ryad, additional, Berna, F., additional, Haffen, E., additional, Leboyer, M., additional, Llorca, P.M., additional, Schürhoff, F., additional, Barteau, V., additional, Bensalem, S., additional, Godin, O., additional, Laouamri, H., additional, Souryis, K., additional, Offerlin-Meyer, I., additional, Pignon, B., additional, Szöke, A., additional, Aouizerate, B., additional, Deloge, A., additional, Misdrahi, D., additional, Vilà, E., additional, Blanc, O., additional, Chéreau, I., additional, Denizot, H., additional, Honciuc, R.M., additional, Lacelle, D., additional, Pires, S., additional, Dubertret, C., additional, Mallet, J., additional, Portalier, C., additional, Dubreucq, J., additional, Fluttaz, C., additional, Gabayet, F., additional, Roman, C., additional, Chesnoy-Servanin, G., additional, D'Amato, T., additional, Dorey, J.M., additional, Rey, R., additional, Vehier, A., additional, Lançon, C., additional, Faget, C., additional, Metairie, E., additional, Peri, P., additional, Vaillant, F., additional, Boyer, L., additional, Fond, G., additional, Vidailhet, P., additional, Zinetti-Bertschy, A., additional, Capdevielle, D., additional, Yazbek, H., additional, Esselin, S., additional, Jarroir, M., additional, Passerieux, C., additional, and Urbach, M., additional
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- 2022
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42. Exploring the relationships between tobacco smoking and schizophrenia in first-degree relatives
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Ferchiou, Aziz, Szöke, Andrei, Laguerre, Audrey, Méary, Alexandre, Leboyer, Marion, and Schürhoff, Franck
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- 2012
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43. Genetic overlap between schizophrenia and bipolar disorder: A study with AKT1 gene variants and clinical phenotypes
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Karege, Félicien, Méary, Alexandre, Perroud, Nader, Jamain, Stéphane, Leboyer, Marion, Ballmann, Eladia, Fernandez, Raphael, Malafosse, Alain, and Schürhoff, Franck
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- 2012
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44. Shortening telomere is associated with psychotic dimensions in the general population
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Schürhoff, Franck, primary, Corfdir, Cécile, additional, Pignon, Baptiste, additional, Lajnef, Mohamed, additional, Richard, Jean-Romain, additional, Marcos, Elisabeth, additional, Leboyer, Marion, additional, Adnot, Serge, additional, Jamain, Stéphane, additional, and Szöke, Andreï, additional
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- 2022
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45. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)
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Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, De Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., Van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Hubbard, Kathryn, Beards, Stephanie, Reininghaus, Ulrich, Tripoli, Giada, Stilo, Simona A., Roldán, Laura, López, Gonzalo, Matteis, Mario, Rapado, Marta, González, Emiliano, Martínez, Covadonga, Cuadrado, Pedro, Solano, José Juan Rodríguez, Carracedo, Angel, Costas, Javier, Bernardo, Enrique García, Sánchez, Emilio, Olmeda, Ma Soledad, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Jamain, Stéphane, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Loureiro, Camila Marcelino, Shuhama, Rosana, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Gayer-Anderson, Charlotte [0000-0003-1636-889X], Apollo - University of Cambridge Repository, Gayer-Anderson C., Jongsma H.E., Di Forti M., Quattrone D., Velthorst E., de Haan L., Selten J.-P., Szoke A., Llorca P.-M., Tortelli A., Arango C., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Parellada M., Tarricone I., Berardi D., Ruggeri M., Lasalvia A., Ferraro L., La Cascia C., La Barbera D., Menezes P.R., Del-Ben C.M., Hubbard K., Beards S., Reininghaus U., Tripoli G., Stilo S.A., Roldan L., Lopez G., Matteis M., Rapado M., Gonzalez E., Martinez C., Cuadrado P., Solano J.J.R., Carracedo A., Costas J., Bernardo E.G., Sanchez E., Olmeda M.S., Cabrera B., Lorente-Rovira E., Garcia-Portilla P., Jimenez-Lopez E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schurhoff F., Baudin G., Ferchiou A., Pignon B., Jamain S., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Sideli L., Seminerio F., Sartorio C., Marrazzo G., Loureiro C.M., Shuhama R., Tosato S., Bonetto C., Cristofalo D., Rutten B.P., van Os J., Jones P.B., Murray R.M., Kirkbride J.B., Morgan C., Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Lui, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, MUMC+: Hersen en Zenuw Centrum (3), ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and APH - Mental Health
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Male ,Health (social science) ,Epidemiology ,Ethnic group ,Ethnic Group ,Gene-environment interactions ,Environment–environment interactions ,0302 clinical medicine ,Ethnicity ,10. No inequality ,First episode ,RISK ,biology ,Incidence (epidemiology) ,Incidence ,CANNABIS ,Middle Aged ,Case-control ,First-episode psychosis ,3. Good health ,Europe ,Psychiatry and Mental health ,Case–control Environment–environment interactions EU-GEI First-episode psychosis Gene–environment interactions Incidence ,Case–control ,EU-GEI ,Gene–environment interactions ,Schizophrenia ,Cohort ,Female ,Psychology ,Case-Control Studie ,Brazil ,Human ,Adult ,medicine.medical_specialty ,Social Psychology ,Adolescent ,Study Protocols and Samples ,DISORDERS ,Environment–environment interaction ,Representativeness heuristic ,03 medical and health sciences ,Young Adult ,PSYCHOSIS ,AGE ,First-episode psychosi ,Environment-environment interactions ,medicine ,Humans ,Gene–environment interaction ,Settore MED/25 - Psichiatria ,METAANALYSIS ,biology.organism_classification ,medicine.disease ,030227 psychiatry ,Case-Control Studies ,Gene-Environment Interaction ,Cannabis ,CHILDHOOD ADVERSITIES ,030217 neurology & neurosurgery ,Demography - Abstract
Funder: FP7 Ideas: European Research Council; doi: http://dx.doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2010-241909, Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.
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- 2020
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46. Psychotic Experiences Are Associated With Paternal Age But Not With Delayed Fatherhood in a Large, Multinational, Community Sample
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Schürhoff, Franck, Pignon, Baptiste, Lajnef, Mohamed, Denis, Romain, Rutten, Bart, Morgan, Craig, Murray, Robin M, Leboyer, Marion, van Os, Jim, Szöke, Andrei, EU-GEI WP2 Group Author, Ruggeri, Mirella, Tosato, Sarah, Pignon, Baptiste, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], King‘s College London, Groupe Henri Mondor-Albert Chenevier, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R2 - Mental Health, and MUMC+: Hersen en Zenuw Centrum (3)
- Subjects
Psychosis ,medicine.medical_specialty ,SYMPTOMS ,paternal age ,Schizotypy ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Population ,schizotypy ,03 medical and health sciences ,0302 clinical medicine ,SCHIZOTYPAL DIMENSIONS ,SCHIZOPHRENIA ,ADOLESCENTS ,Epidemiology ,risk factors ,Medicine ,media_common.cataloged_instance ,psychotic experiences ,European union ,education ,METAANALYSIS ,media_common ,Subclinical infection ,GENERAL-POPULATION ,education.field_of_study ,business.industry ,Confounding ,medicine.disease ,PARENTAL AGE ,CAPE ,030227 psychiatry ,MODEL ,Psychiatry and Mental health ,CONTINUUM ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Schizophrenia ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,RISK-FACTORS ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,epidemiology ,business ,030217 neurology & neurosurgery ,Regular Articles ,Demography - Abstract
Advanced paternal age has been consistently associated with an increased risk of schizophrenia. It is less known if such an association also exists with subclinical/attenuated forms of psychosis. Additionally, it has been suggested that it is not paternal age per se, but rather delayed fatherhood, as a marker of a genetic liability of psychosis, that is the cause of the association. The aim of the current study was to examine whether paternal age and/or delayed fatherhood (paternity age) predict self-reported positive, negative, and/or depressive dimensions of psychosis in a large sample from the general population. The sample (N = 1465) was composed of control subjects from the 6 countries participating in the European Union Gene-Environment Interaction study. The CAPE, a self-report questionnaire, was used to measure dimensions of subclinical psychosis. Paternal age at the time of respondents’ birth and age of paternity were assessed by self-report. We assessed the influence of the variables of interest (paternal age or paternity age) on CAPE scores after adjusting for potential confounders (age, gender, and ethnicity). Paternal age was positively associated with the positive dimension of the CAPE. By contrast, paternity age was not associated with any of the psychosis dimensions assessed by the CAPE. Thus, our results do not support the idea that delayed fatherhood explains the association between age of paternity and psychosis risk. Furthermore, our results provide arguments for the hypothesis of an etiologic continuum of psychosis.
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- 2020
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47. Overlap and Mutual Distinctions Between Clinical Recovery and Personal Recovery in People With Schizophrenia in a One-Year Study
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Dubreucq, Julien, Gabayet, Franck, Godin, Ophélia, Andre, Myrtille, Aouizerate, Bruno, Capdevielle, Delphine, Chereau, Isabelle, Clauss-Kobayashi, Julie, Coulon, Nathalie, D’amato, Thierry, Dorey, Jean-Michel, Dubertret, Caroline, Faraldo, Mégane, Laouamri, Hakim, Leigner, Sylvain, Lancon, Christophe, Leboyer, Marion, Llorca, Pierre-Michel, Mallet, Jasmina, Misdrahi, David, Passerieux, Christine, Rey, Romain, Pignon, Baptiste, Schorr, Benoit, Urbach, Mathieu, Schürhoff, Franck, Szoke, Andrei, Berna, Fabrice, Haffen, E, Barteau, V, Bensalem, S, Souryis, K, Petrucci, J, Wahiche, G, Bourguignon, E, Deloge, A, Vilà, E, Blanc, O, Denizot, H, Honciuc, R, Lacelle, D, Pires, S, Portalier, C, Leignier, S, Roman, C, Chesnoy-Servanin, G, Vehier, A, Faget, C, Metairie, E, Peri, P, Vaillant, F, Boyer, L, Fond, Guillaume, Vidailhet, P, Zinetti-Bertschy, A, Michel, T, Garbisson, A, Belmonte, C, Dubois, T, Esselin, S, Jarroir, M, Fondation FondaMental [Créteil], Centre Hospitalier Alpes Isère, IMRB - 'Biologie du système neuromusculaire' [Créteil] (U955 Inserm - UPEC), École nationale vétérinaire - Alfort (ENVA)-Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Charles Perrens, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne (UCA), Les Hôpitaux Universitaires de Strasbourg (HUS), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier le Vinatier [Bron], Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Pôle de psychiatrie et d'addictologie des Hôpitaux Universitaires Henri-Mondor [Créteil], Centre hospitalier universitaire Henri-Mondor [Créteil], Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg-Université de Strasbourg (UNISTRA), Centre de recherche en neurosciences de Lyon (CRNL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre hospitalier Charles Perrens [Bordeaux], Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
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Adult ,Male ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Meaningful life ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Full recovery ,personal recovery ,Medicine ,Humans ,psychosocial treatment ,030212 general & internal medicine ,full recovery ,Depression (differential diagnoses) ,Analysis of Variance ,Chi-Square Distribution ,business.industry ,Perspective (graphical) ,Recovery of Function ,Mental illness ,medicine.disease ,clinical recovery ,030227 psychiatry ,schizophrenia ,Psychiatry and Mental health ,Schizophrenia ,Quality of Life ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,business ,Psychosocial ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Regular Articles - Abstract
Recovery is a multidimensional construct that can be defined either from a clinical perspective or from a consumer-focused one, as a self-broadening process aimed at living a meaningful life beyond mental illness. We aimed to longitudinally examine the overlap and mutual distinctions between clinical and personal recovery. Of 1239 people with schizophrenia consecutively recruited from the FondaMental Advanced Centers of Expertise for SZ network, the 507 present at one-year did not differ from those lost to follow-up. Clinical recovery was defined as the combination of clinical remission and functional remission. Personal recovery was defined as being in the rebuilding or in the growth stage of the Stages of Recovery Instrument (STORI). Full recovery was defined as the combination of clinical recovery and personal recovery. First, we examined the factors at baseline associated with each aspect of recovery. Then, we conducted multivariable models on the correlates of stable clinical recovery, stable personal recovery, and stable full recovery after one year. At baseline, clinical recovery and personal recovery were characterized by distinct patterns of outcome (i.e. better objective outcomes but no difference in subjective outcomes for clinical recovery, the opposite pattern for personal recovery, and better overall outcomes for full recovery). We found that clinical recovery and personal recovery predicted each other over time (baseline personal recovery for stable clinical recovery at one year; P = .026, OR = 4.94 [1.30–23.0]; baseline clinical recovery for stable personal recovery at one year; P = .016, OR = 3.64 [1.31–11.2]). In short, given the interaction but also the degree of difference between clinical recovery and personal recovery, psychosocial treatment should target, beyond clinical recovery, subjective aspects such as personal recovery and depression to reach full recovery.
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48. Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
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Pardiñas, Antonio F., Smart, Sophie E., Corvin, Aiden, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S., Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Fanous, Ayman H., Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, Haan, Lieuwe de, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Frank, Josef, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Kelly, Brian, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, McQuillin, Andrew, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Keong, Jimmy Lee Chee, Lee, S. Hong, Melle, Ingrid, Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Mortensen, Preben B., Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Mowry, Bryan J., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Pato, Carlos N., Morris, Derek W., Mors, Ole, Murphy, Kieran C., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Periyasamy, Sathish, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O’Callaghan, Eadbhard, O’Dushlaine, Colm, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Os, Jim Van, Willcocks, Isabella R., Rietschel, Marcella, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Rujescu, Dan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Simonsen, Carmen, Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., St Clair, David, Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Tooney, Paul, Spencer, Chris C. A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Subramaniam, Mythily, Wu, Jing Qin, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Andreassen, Ole A., Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H. M., Kowalec, Kaarina, Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Blackwood, Douglas H. R., Sullivan, Patrick F., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Murray, Robin M., Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Holmans, Peter A., Owen, Michael J., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., Moran, Jennifer L., Nöthen, Markus M., Ophoff, Roel A., Palotie, Aarno, Petryshen, Tracey L., MacCabe, James H., Posthuma, Danielle, Riley, Brien P., Sham, Pak C., Sklar, Pamela, Clair, David St, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Agbedjro, Deborah, O’Donovan, Michael C., Stahl, Daniel, Kapur, Shitij, Millgate, Edward, Kepinska, Adrianna, Kravariti, Eugenia, Ajnakina, Olesya, Alameda, Luis, Barnes, Thomas R. E., Berardi, Domenico, Bonora, Elena, Walters, James T. R., Camporesi, Sara, Cleusix, Martine, Conus, Philippe, Crespo-Facorro, Benedicto, D’Andrea, Giuseppe, Demjaha, Arsime, Do, Kim Q., Doody, Gillian A., Eap, Chin B., Ferchiou, Aziz, Ripke, Stephan, Di Forti, Marta, Guidi, Lorenzo, Homman, Lina, Jenni, Raoul, Joyce, Eileen M., Kassoumeri, Laura, Khadimallah, Inès, Lastrina, Ornella, Muratori, Roberto, Noyan, Handan, Neale, Benjamin M., O’Neill, Francis A., Pignon, Baptiste, Restellini, Romeo, Richard, Jean-Romain, Schürhoff, Franck, Španiel, Filip, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Üçok, Alp, Farh, Kai-How, Vázquez-Bourgon, Javier, Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Dennison, Charlotte A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A ., Lynham, Amy J., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Legge, Sophie E., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C. K., Chen, Ronald Y. L., Chen, Eric Y. H., Cheng, Wei, Baune, Bernhard T., Cheung, Eric F. C., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Bigdeli, Tim B., Davis, Kenneth L., Degenhardt, Franziska, Favero, Jurgen Del, DeLisi, Lynn E., Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Cairns, Murray J., Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Farrell, Martilias S., Franke, Lude, Freedman, Robert, Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC), Ripke, S., Neale, B.M., Farh, K.H., Lee, P., Bulik-Sullivan, B., Collier, D.A., Huang, H., Pers, T.H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S.A., Begemann, M., Belliveau, R.A., Bene, J., Bergen, S.E., Bevilacqua, E., Black, D.W., Bruggeman, R., Buccola, N.G., Buckner, R.L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R.M., Carr, V.J., Carrera, N., Catts, S.V., Chambert, K.D., Chan, RCK, Chen, RYL, Chen, EYH, Cheng, W., Cheung, EFC, Chong, S.A., Cloninger, C.R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J.J., Curtis, D., Davidson, M., Davis, K.L., Degenhardt, F., Favero, J.D., DeLisi, L.E., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Farrell, M.S., Franke, L., Freedman, R., Freimer, N.B., Friedl, M., Friedman, J.I., Fromer, M., Genovese, G., Georgieva, L., Gershon, E.S., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J.I., Golimbet, V., Gopal, S., Gratten, J., Haan, L., Hammer, C., Hamshere, M.L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A.M., Henskens, F.A., Herms, S., Hirschhorn, J.N., Hoffmann, P., Hofman, A., Hollegaard, M.V., Hougaard, D.M., Ikeda, M., Joa, I., Julià, A., Kahn, R.S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M.C., Kennedy, J.L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J.A., Konte, B., Kucinskas, V., Kucinskiene, Z.A., Kuzelova-Ptackova, H., Kähler, A.K., Laurent, C., Keong, JLC, Lee, S.H., Lerer, B., Li, M., Li, T., Liang, K.Y., Lieberman, J., Limborska, S., Loughland, C.M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, PKE, Maher, B.S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R.W., McDonald, C., McIntosh, A.M., Meier, S., Meijer, C.J., Melegh, B., Melle, I., Mesholam-Gately, R.I., Metspalu, A., Michie, P.T., Milani, L., Milanova, V., Mokrab, Y., Morris, D.W., Mors, O., Murphy, K.C., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D.A., Nestadt, G., Nicodemus, K.K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., O'Neill, F.A., Oh, S.Y., Olincy, A., Olsen, L., Os, J.V., Pantelis, C., Papadimitriou, G.N., Papiol, S., Parkhomenko, E., Pato, M.T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D.O., Pietiläinen, O., Pimm, J., Pocklington, A.J., Powell, J., Price, A., Pulver, A.E., Purcell, S.M., Quested, D., Rasmussen, H.B., Reichenberg, A., Reimers, M.A., Richards, A.L., Roffman, J.L., Roussos, P., Ruderfer, D.M., Salomaa, V., Sanders, A.R., Schall, U., Schubert, C.R., Schulze, T.G., Schwab, S.G., Scolnick, E.M., Scott, R.J., Seidman, L.J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J.M., Sim, K., Slominsky, P., Smoller, J.W., So, H.C., Spencer, CCA, Stahl, E.A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R.E., Strengman, E., Strohmaier, J., Stroup, T.S., Subramaniam, M., Suvisaari, J., Svrakic, D.M., Szatkiewicz, J.P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B.T., Weiser, M., Wildenauer, D.B., Williams, N.M., Williams, S., Witt, S.H., Wolen, A.R., Wong, EHM, Wormley, B.K., Xi, H.S., Zai, C.C., Zheng, X., Zimprich, F., Wray, N.R., Stefansson, K., Visscher, P.M., Adolfsson, R., Blackwood, DHR, Bramon, E., Buxbaum, J.D., Børglum, A.D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P.V., Gill, M., Gurling, H., Hultman, C.M., Iwata, N., Jablensky, A.V., Jönsson, E.G., Kendler, K.S., Kirov, G., Knight, J., Lencz, T., Levinson, D.F., Li, Q.S., Liu, J., Malhotra, A.K., McCarroll, S.A., Moran, J.L., Mortensen, P.B., Nöthen, M.M., Ophoff, R.A., Palotie, A., Petryshen, T.L., Posthuma, D., Riley, B.P., Sham, P.C., Sklar, P., Clair, D.S., Weinberger, D.R., Wendland, J.R., Werge, T., Daly, M.J., Agbedjro, D., Stahl, D., Kapur, S., Millgate, E., Kepinska, A., Kravariti, E., Medical Research Council (UK), Cardiff University, Welsh Government, Health and Care Research Wales, European Commission, Academy of Medical Sciences (UK), Research Council of Norway, K. G. Jebsen Centres for Medical Research, National Institute for Health Research (UK), University College London, Government of Canada, University of Manitoba, Swedish Research Council, National Institute of Mental Health (US), Kings College London, Public Health Agency (Northern Ireland), The Psychiatry Research Trust, Maudsley Charity, Swiss National Science Foundation, Fondation Alamaya, Ministry of Health of the Czech Republic, Instituto de Salud Carlos III, Plan Nacional sobre Drogas (España), Fundació Seny, Fundación Marques de Valdecilla, Ministerio de Economía y Competitividad (España), Wellcome Trust, and Universidad de Cantabria
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Male ,endocrine system ,Multifactorial Inheritance ,animal structures ,Psychiatry and Behavioral Health ,Online First ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,Neurogenetics ,Medicinsk genetik ,Original Investigation ,Research ,Schizophrenia Sprectum and Other Psychotic Disorders ,Featured ,Genetics and genomics ,Psychiatry and Mental health ,Neurology ,Psychotic Disorders ,Schizophrenia ,Female ,Medical Genetics ,hormones, hormone substitutes, and hormone antagonists ,Comments ,Genome-Wide Association Study - Abstract
[Importance] About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying schizophrenia are largely unknown. Adequately powered genetic studies of TRS are scarce because of the difficulty in collecting data from well-characterized TRS cohorts., [Objective] To examine the genetic architecture of TRS through the reassessment of genetic data from schizophrenia studies and its validation in carefully ascertained clinical samples., [Design, Setting, and Participants] Two case-control genome-wide association studies (GWASs) of schizophrenia were performed in which the case samples were defined as individuals with TRS (n = 10 501) and individuals with non-TRS (n = 20 325). The differences in effect sizes for allelic associations were then determined between both studies, the reasoning being such differences reflect treatment resistance instead of schizophrenia. Genotype data were retrieved from the CLOZUK and Psychiatric Genomics Consortium (PGC) schizophrenia studies. The output was validated using polygenic risk score (PRS) profiling of 2 independent schizophrenia cohorts with TRS and non-TRS: a prevalence sample with 817 individuals (Cardiff Cognition in Schizophrenia [CardiffCOGS]) and an incidence sample with 563 individuals (Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances [STRATA-G])., [Main Outcomes and Measures] GWAS of treatment resistance in schizophrenia. The results of the GWAS were compared with complex polygenic traits through a genetic correlation approach and were used for PRS analysis on the independent validation cohorts using the same TRS definition., [Results] The study included a total of 85 490 participants (48 635 [56.9%] male) in its GWAS stage and 1380 participants (859 [62.2%] male) in its PRS validation stage. Treatment resistance in schizophrenia emerged as a polygenic trait with detectable heritability (1% to 4%), and several traits related to intelligence and cognition were found to be genetically correlated with it (genetic correlation, 0.41-0.69). PRS analysis in the CardiffCOGS prevalence sample showed a positive association between TRS and a history of taking clozapine (r2 = 2.03%; P = .001), which was replicated in the STRATA-G incidence sample (r2 = 1.09%; P = .04)., [Conclusions and Relevance] In this GWAS, common genetic variants were differentially associated with TRS, and these associations may have been obscured through the amalgamation of large GWAS samples in previous studies of broadly defined schizophrenia. Findings of this study suggest the validity of meta-analytic approaches for studies on patient outcomes, including treatment resistance., This work was supported by Medical Research Council Centre grant MR/L010305/1, Medical Research Council Program grant MR/P005748/1, and Medical Research Council Project grants MR/L011794/1 and MC_PC_17212 to Cardiff University and by the National Centre for Mental Health, funded by the Welsh Government through Health and Care Research Wales. This work acknowledges the support of the Supercomputing Wales project, which is partially funded by the European Regional Development Fund via the Welsh Government. Dr Pardiñas was supported by an Academy of Medical Sciences Springboard Award (SBF005\1083). Dr Andreassen was supported by the Research Council of Norway (grants 283798, 262656, 248980, 273291, 248828, 248778, and 223273); KG Jebsen Stiftelsen, South-East Norway Health Authority, and the European Union’s Horizon 2020 Research and Innovation Programme (grant 847776). Dr Ajnakina was supported by an National Institute for Health Research postdoctoral fellowship (PDF-2018-11-ST2-020). Dr Joyce was supported by the University College London Hospitals/UCL University College London Biomedical Research Centre. Dr Kowalec received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement (793530) from the government of Canada Banting postdoctoral fellowship programme and the University of Manitoba. Dr Sullivan was supported by the Swedish Research Council (Vetenskapsrådet, D0886501), the European Union’s Horizon 2020 programme (COSYN, 610307) and the US National Institute of Mental Health (U01 MH109528 and R01 MH077139). The Psychiatric Genomics Consortium was partly supported by the National Institute Of Mental Health (grants R01MH124873). The Sweden Schizophrenia Study was supported by the National Institute Of Mental Health (grant R01MH077139). The STRATA consortium was supported by a Stratified Medicine Programme grant to Dr MacCabe from the Medical Research Council (grant MR/L011794/1), which funded the research and supported Drs Pardiñas, Smart, Kassoumeri, Murray, Walters, and MacCabe. Dr Smart was supported by a Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital National Health Service Foundation Trust. The AESOP (US) cohort was funded by the UK Medical Research Council (grant G0500817). The Belfast (UK) cohort was funded by the Research and Development Office of Northern Ireland. The Bologna (Italy) cohort was funded by the European Community’s Seventh Framework program (HEALTH-F2-2010–241909, project EU-GEI). The Genetics and Psychosis project (London, UK) cohort was funded by the UK National Institute of Health Research Specialist Biomedical Research Centre for Mental Health, South London and the Maudsley National Health Service Mental Health Foundation Trust (SLAM) and the Institute of Psychiatry, Psychology, and Neuroscience at King’s College London; Psychiatry Research Trust; Maudsley Charity Research Fund; and the European Community’s Seventh Framework program (HEALTH-F2-2009-241909, project EU-GEI). The Lausanne (Switzerland) cohort was funded by the Swiss National Science Foundation (grants 320030_135736/1, 320030-120686, 324730-144064, 320030-173211, and 171804); the National Center of Competence in Research Synaptic Bases of Mental Diseases from the Swiss National Science Foundation (grant 51AU40_125759); and Fondation Alamaya. The Oslo (Norway) cohort was funded by the Research Council of Norway (grant 223273/F50, under the Centers of Excellence funding scheme, 300309, 283798) and the South-Eastern Norway Regional Health Authority (grants 2006233, 2006258, 2011085, 2014102, 2015088, and 2017-112). The Paris (France) cohort was funded by European Community’s Seventh Framework program (HEALTH-F2-2010–241909, project EU-GEI). The Prague (Czech Republic) cohort was funded by the Ministry of Health of the Czech Republic (grant NU20-04-00393). The Santander (Spain) cohort was funded by the following grants to Dr Crespo-Facorro: Instituto de Salud Carlos III (grants FIS00/3095, PI020499, PI050427, and PI060507), Plan Nacional de Drogas Research (grant 2005-Orden sco/3246/2004), SENY Fundatio Research (grant 2005-0308007), Fundacion Marques de Valdecilla (grant A/02/07, API07/011) and Ministry of Economy and Competitiveness and the European Fund for Regional Development (grants SAF2016-76046-R and SAF2013-46292-R). The West London (UK) cohort was funded by The Wellcome Trust (grants 042025, 052247, and 064607).
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49. PM2.5 and PM10 air pollution peaks are associated with emergency department visits for psychotic and mood disorders: an eleven-year study
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Pignon, Baptiste, primary, Borel, Cynthia, additional, Lajnef, Mohamed, additional, Richard, Jean-Romain, additional, Szöke, Andrei, additional, Hemery, François, additional, Leboyer, Marion, additional, Foret, Gilles, additional, and Schürhoff, Franck, additional
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50. History of ECT in Schizophrenia: From Discovery to Current Use
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de Mangoux, Gonzague Corbin, primary, Amad, Ali, additional, Quilès, Clélia, additional, Schürhoff, Franck, additional, and Pignon, Baptiste, additional
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- 2022
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