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8. 57METHYLOMIC BIOMARKERS OF SCHIZOPHRENIA AND ANTIPSYCHOTIC MEDICATION EXPOSURE

Author

Hannon, Eilis, primary, Dempster, Emma, additional, Mansell, Georgina, additional, Schalkwyk, Leo, additional, Murray, Robin, additional, McQuillin, Andrew, additional, Kowalec, Kaarina, additional, Clair, David St., additional, Morris, Derek, additional, Sullivan, Patrick, additional, O'Donovan, Michael, additional, MacCabe, James, additional, Collier, David, additional, and Mill, Jonathan, additional

Published
2019
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9. AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA: EVIDENCE FOR CO-LOCALIZATION OF GENETIC ASSOCIATIONS AND DIFFERENTIAL DNA METHYLATION FROM A LARGE META-ANALYSIS OF WHOLE BLOOD DNA

Author

Hannon, Eilis, primary, Dempster, Emma, additional, Burrage, Joe, additional, McQuillin, Andrew, additional, Clair, David St., additional, Morris, Derek, additional, Di Forti, Marta, additional, Gaughran, Fiona, additional, MacCabe, James, additional, Breen, Gerome, additional, Collier, David, additional, Murray, Robin, additional, Schalkwyk, Leo, additional, and Mill, Jonathan, additional

Published
2019
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11. THE AUTHORS REPLY

Author

Hughes, Amanda, primary, Bao, Yanchun, additional, Smart, Melissa, additional, Gorrie-Stone, Tyler, additional, Hannon, Eilis, additional, Mill, Jonathan, additional, Burrage, Joe, additional, Schalkwyk, Leo, additional, and Kumari, Meena, additional

Published
2018
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16. Towards high resolution maps of the mouse and human genomes—a facility for ordering markers to 0.1 cM resolution

Author

Breen, Maria, primary, Deakln, Lisa, additional, Macdonald, Bernard, additional, Miller, Steve, additional, Sibson, Ross, additional, Tarttelln, Emma, additional, Avner, Philip, additional, Bourgade, Franck, additional, Guenet, Jean-Louis, additional, Montagutelli, Xavler, additional, Polrier, Christophe, additional, Simon, Dominique, additional, Tailor, Dillp, additional, Bishop, Martin, additional, Kelly, Maria, additional, Rysavy, Francis, additional, Rastan, Sohaila, additional, Norris, Dominic, additional, Shepherd, David, additional, Abbott, Cathy, additional, Pllz, Alison, additional, Hodge, Sarah, additional, Jackson, Ian, additional, Boyd, Yvonne, additional, Blair, Helen, additional, Maslen, Gareth, additional, A.Todd, John, additional, W.Reed, Peter, additional, Stoye, Jonathan, additional, Ashworth, Alan, additional, McCarthy, Linda, additional, Cox, Roger, additional, Schalkwyk, Leo, additional, Lehrach, Hans, additional, Klose, Joachim, additional, Gangadharan, Uma, additional, and Brown, Steve, additional

Published
1994
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17. The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase

Author

A.Jones, Karen, primary, M.Black, Donald, additional, A.Brown, Melissa, additional, L.Griffiths, Beatrice, additional, M.Nicolai, Hans, additional, A.Chambers, Julie, additional, Bonjardim, Marisa, additional, Xu, Chun-Fang, additional, Boyd, Marie, additional, MeFariane, Robert, additional, Korn, Bernhard, additional, Poustka, Annemarie, additional, A.North, Michael, additional, Schalkwyk, Leo, additional, Lehrach, Hans, additional, and Solomon, Ellen, additional

Published
1994
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18. Silencing of the WFS1gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage.

Author

Kõks, Sulev, Overall, Rupert W., Ivask, Marilin, Soomets, Ursel, Guha, Mithu, Vasar, Eero, Fernandes, Cathy, and Schalkwyk, Leo C.

Subjects
GENE silencing, WOLFRAM syndrome, GENE expression, NEURODEGENERATION, MITOCHONDRIAL pathology, NEUROPSYCHIATRY, GENOMES
Abstract

The gene WFS1encodes a protein with unknown function although its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study, we aimed to find the functional networks influenced by the time-dependent silencing of WFS1in HEK cells. We performed whole genome gene expression profiling (Human Gene 1.0 ST Arrays) in HEK cells 24, 48, 72, and 96 h after transfection with three different WFS1siRNAs. To verify silencing we performed quantitative RT-PCR and Western blot analysis. Analysis was conducted in two ways. First we analyzed the overall effect of the siRNA treatment on the gene expression profile. As a next step we performed time-course analysis separately for different siRNAs and combined for all siRNAs. Quantitative RT-PCR and Western blot analysis confirmed clear silencing of the expression of WFS1after 48 h. Significant (FDR value <10%) changes in the expression of 11 genes was identified with most of these genes being related to the mitochondrial dysfunction and apoptosis. Time-course analysis confirmed significant correlations between WFS1silencing and changes in the expression profiles of several genes. The pathways that were influenced significantly by WFS1silencing were related to mitochondrial damage and neurodegenerative diseases. Our findings suggest a role of WFS1gene in cell survival and its involvement in degenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2013
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19. AUTHORS REPLY.

Author

Hughes, Amanda, Bao, Yanchun, Smart, Melissa, Gorrie-Stone, Tyler, Hannon, Eilis, Mill, Jonathan, Burrage, Joe, Schalkwyk, Leo, and Kumari, Meena

Subjects
AGING, LEUCOCYTES, MATHEMATICAL models, PARENTING, SOCIAL classes, UNEMPLOYMENT, THEORY, SOCIOECONOMIC factors, DNA methylation
Published
2019
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20. THE AUTHORS REPLY.

Author

Hughes A, Bao Y, Smart M, Gorrie-Stone T, Hannon E, Mill J, Burrage J, Schalkwyk L, and Kumari M

Subjects
Socioeconomic Factors, DNA Methylation
Published
2019
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