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Namen naše raziskave je bil ugotoviti, ali je koncentracija plazme zunajceličnih veziklov pri aktivni diabetični Charcotovi nevroartropatiji (CNA) povezana z vnetnimi označevalci, zvišano temperaturo v prizadetem stopalu in koncentracijo topnega receptorja za napredne končne produkte glikacije (RAGE). Zunajcelične vezikle smo izolirali iz periferne krvi 36 bolnikov z aktivno CNA in 25 zdravih kontrolnih oseb, nato so bili na podlagi pretočne citometrije prešteti po večkratnem centrifugiranju in izpiranju vzorcev. Temperatura stopala je bila izmerjena z infrardečim termometrom. Koncentracija topnega receptorja za napredne končne produkte glikacije (RAGE) je bila ugotovljena z encimsko imunoadsorpcijsko preiskavo (ELISA). Ugotovljene so bile statistično pomembne korelacije koncentracij zunajceličnih veziklov (ne pa tudi koncentracije topnega RAGE) s C-reaktivnim proteinom (CRP) in s temperaturnimi razlikami med prizadetim in kontralateralnim stopalom (r = 0,40, p = 0,032 oziroma r = 0,84, p < 10-8). Potrjeno je bilo, da je koncentracija zunajceličnih veziklov povezana s povišano vrednostjo vnetnih označevalcev (tj. CRP in razlike v temperaturi obeh stopal) pri preiskovancih z aktivno diabetično CNA. Zunajcelične vezikle bi bilo v prihodnje smiseln obravnavati kot potencialne označevalce za postavitev diagnoze aktivne CNA, kar bi zagotovo pripomoglo k zgodnji postavitvi diagnoze in zdravljenju bolezni. This study focuses on membrane microvesiculation and its possible connection to inflammation processes in diabetic Charcot Neuroarthropathy (CNA). It was our aim to determine whether the concentration of extracellular vesicles (EVs) in isolates from blood of patients with CNA is increased, and whether it is connected to the concentration of soluble receptor for advanced glycation end products (RAGE) and standard markers of inflammation. EVs were isolated from peripheral blood of 36 patients with active CNA and of 25 non-Diabetic control subjects. EVs were counted after by repetitive centrifugation and washing of samples, by flow cytometry. Concentration of soluble RAGE was determined by ELISA. Mean concentration of EVs was significntly higher in CN patients than in controls (73% higher p

Cerebral palsy (CP) is a consequence of non-progressive damage to the developing brain that affects the entire child's development. With the improved medical care the life span of people with CP tends to be comparable to the general population. This is giving rise to new needs and new aspects of quality of their life. Special outpatient offices for adults with cerebral palsy should be established with a team approach of different health care professionals in cooperation with nongovernmental organisations. Cerebralna paraliza (CP) nastane zaradi nenapredujoče okvare razvijajočih se možganov in vpliva na otrokov celotni razvoj. Življenjska doba oseb s CP se ob dobri zdravstveni oskrbi podaljšuje in postaja primerljiva splošni populaciji. Zato je tudi v obdobju odraščanja in v odrasli dobi potrebna skrb za njihovo zdravje. Potrebno je zagotoviti boljšo dostopnost do specialistov z ustreznimi znanji za obravnavo oseb s CP, tudi s sodelovanjem nevladnih organizacij in društev.

Medical records of all patients referred as urgent cases to the Orthopaedic Outpatient Clinic in Ljubljana in July 2009 were reviewed. ICD diagnoses, diagnostic imaging procedures, modalities of prescribed physical therapy (PT), referral to physical and rehabilitation medicine (PRM) specialists, and duration of problems before the visit were examined. At least one PT was prescribed in 43% of the cases. The patient was referred to a PRM specialist in only 3% of the cases. The problems had lasted from one day to several years (median 1 month). Because many non-urgent patients suffering from chronic musculoskeletal diseases are referred to orthopaedic surgeons, co-operation with PRM specialist should be improved. Data quality, especially coding the diagnoses according to the ICD, should also be ameliorated. Na podlagi pregleda dokumentacije smo ugotavljali, katere diagnoze po MKB so dobili bolniki, ki so bili napoteni v nujno ortopedsko ambulanto na Polikliniki v Ljubljani v juliju 2009, katere slikovne diagnostične preiskave in katere metode fizikalne terapije (FT) jim je ortoped predpisal, kako pogosto jih je napotil k specialistu fizikalne in rehabilitacijske medicine (FRM) ter kako dolgo so trajale bolnikove težave pred pregledom. Na 43% pregledov je bila predpisana vsaj ena FT. K specialistu FRM je bil bolnik napoten le na 3% pregledov. Težave so pred pregledom trajale od enega dne do več let (mediana 1 mesec). Ker smo potrdili, da so v nujno ortopedsko ambulanto pogosto napoteni bolniki s kroničnimi mišičnoskeletnimi boleznimi, bi bilo smiselno izboljšati sodelovanje med kirurgi ortopedi in specialisti FRM. Hkrati bi bilo potrebno izboljšati kakovost dokumentacije, zlasti dosledno dodeljevati diagnoze po MKB.

Background. In the presented study we rewieved the epidemiology of slipped capital femoral epiphysis (SCFE).The aim of the study was to evaluate the incidence and epidemiology of the disease. Material and methods. Between the years 1970-1994, 156 consecutive patients were admitted to the Department of Orthopaedic Surgery in Ljubljana. The incidence was calculated using the attack rate method, i.e. the sum of annual incidences in each one year group. Mean age and boys: girls ratio were calculated. The affected side was also observed. Results. In our study the attack rate per thousand patients was 0.488% (0.474% for boys, 0.502% for girls). The risk of physiolysis was 1:2110for boys, 1:1992 for girls and 1:2049 for both sexes. The average age atdiagnosis was higher in boys (13.6+-1.6(9.5-16.6) years) than in girls (11.9+-1.43(8-15.5) years) (p